AutismOne 2008 – part 1 of 3 - Dr Amy Yasko

182 Pages·2009·53.37 MB·English

An Individualized Approach
to Autism
•
Adaptability of the program for integration into other autism programs that
individuals may already be using. Two in depth case studies to illustrate the
practical dynamics of following the Yasko protocol
••
The second hour will be devoted to looking at several of the pieces of the
puzzle of autism, again with an eye toward dovetailing this program with
other existing therapies.
•
The third hour of the symposium will focus on the nutrigenomic aspects of
the Yasko program with specific examples of the use of biochemical
feedback to monitor progress based on a program of supplementation
designed around nutrigenomic testing.
•
The remaining time will be allocated for questions and answers.
The long term goal of both molecular
medicine as well as molecular
nutrition is to have personalized
medicine that takes into account an
individuals genetic, environmental and
infectious disease profile.
This is not unique to alternative healthcare, and this tool of genetic testing is
being used in standard medicine to help to individualize traditional therapies.
The beauty of genetic information is that it is so individual and reflective of the
person.
Improved diagnostics permit better drug dosing to
identify the percentage of patients that will respond to
customized treatments.
“Though the cost and logistics of implementing
individualized therapy may appear to be prohibitive…the
value of targeted therapy ..and the appeal of customized
therapy is evident.”
(Nature Medicine, June 2004).
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patients with a certain genetic makeup gain any benefit
from particular commonly prescribed drugs. The study
helps to support the concept of personalized medicine,
the choice of drugs that work best for an individual
patient based on genetic testing.
(Chasman, D., JAMA, Sept. 2004)
Standard allopathic medicine
Four basic steps have been outlined to work from
information in our genes to developing
personalized medicine.
• Defining the functional elements of the human
genome
• Determining which genes or pathways are
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• Discovering inherited sequence patterns
contributing to disease
• Applying genomics information to improve
clinical practices”
(Wills, R, Modern Drug Discovery, June 2004).
Standard allopathic medicine
Nutrigenomic analysis is a powerful tool that will eventually
be used in standard medical issues
While it may take 15 to 20
years for standard medicine
to provide personalized
treatments, natural
approaches to healthcare
allow us to do this today
Molecular nutrition uses natural products to effect
cellular and molecular processes.
“Most chronic diseases are related to
cellular alterations which can, in part, be
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International Society for Molecular Nutrition and Therapy.
What we are doing with this program is to combine molecular
nutrition with genetic information about nutritional pathways to allow
for truly personalized programs
Personalized Medicine
Dr. Bruce Ames*:
“ This is especially relevant in the dawning era of genomics, in
which it will someday become routine to screen individuals for
polymorphisms and thus treat persons more efficaciously by
genotype, rather than just phenotype… Nutritional interventions to
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era…It will soon be possible to identify the complete set of genes
having cofactor binding sites and the polymorphisms that fall into
these regions, with an end goal of using vitamins, and possibly
amino acids, hormones and minerals to effect a metabolic tune up.”
*Professor Biochemistry and Molecular Biology, University California, Berkeley,
23rd most cited scientist in all fields.
The beauty of nutrigenomic testing is that it focuses on
weaknesses in known, characterized nutritional pathways.
Knowledge of these pathways lends itself to providing
nutritional “bypasses” for genetic mutations.
Nutrigenomic testing is also very amenable to follow up
biochemical testing.
• Genetic testing
• Biochemical follow up tests to
assess how well we are doing to
bypass the mutations
My personal background is research oriented and have
brought that approach to the program for autism
This program focuses on molecular and biochemical pathways involved
in autism.
Using a data oriented approach and relies heavily on testing.
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