August 26-30, 2002 - Annales de Toxicologie Analytique

200 Pages·2009·23.07 MB·English

Annal es de
Toxicologie
Analytique
Société Française de Volume XIV - Numéro 3 - 2002
Toxicologie Analytique ISSN 0768-598X
RECUEIL DES ABSTRACTS
RÉSUMÉS BOOK
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August 26 - 30, 2002
Hôtel Le Méridien Etoile • Paris, France
Article available at http://www.ata-journal.org or http://dx.doi.org/10.1051/ata/2002012
Under the auspices of :
* Ministère de la Jeunesse, de l'Éducation Nationale et de la Recherche
• Ministère de la Justice
With the support of :
• Société Française de Toxicologie Analytique
• Compagnie Nationale des Biologistes et Analystes Experts
• Société de Toxicologie Clinique
• Société de Médecine Légale et de Criminologie de France
• TIAFT 2000, Helsinki
• TIAFT 2001, Prague
This congress is sponsored by :
• Dade Behring
• Abbott
• Microgenics
• Biosite
• Beckman
• Roche Diagnostics
• Applied Biosystems
• Laboratoire Toxlab
• Waters
• Cozart Bioscience Ltd
• Thermo Finnigan
• Drug Free Enterprises
• Agilent
• Uldmed
• Lipomed
• Bruker Daltonique
• Medichem/Promochem
• Life Point
• Micromass
• Elsevier
• Varían
• Bio-Rad Laboratories
• Orasure
• Bionisis
Annales de Toxicologie Analytique, vol. XIV, n° 3,2002
The International Association of Forensic Toxicologists
40th International Meeting
August 26-30, 2002 • Paris, France
TIAFT executive committee
President : Prof. Robert WENNIG
Secretary : Mark B. LEWIS
Treasurer : Prof. Olaf H. DRUMMER
TIAFT 2002 organising committee in PARIS
Pascal KINTZ, chairman
Institut de Médecine Légale, Strasbourg pascal, kintz @ wanadoo.fr
Marc DEVEAUX, secretary
Institut de Médecine Légale, Lille mdeveaux® easynet.fr
Jean-Pierre GOULLÉ, secretary
Groupe Hospitalier, Le Havre jgoulle @ ch-havre.fr
Jean-Pierre ANGER, treasurer
Faculté de Pharmacie, Rennes anger @ univ-rennesl.fr
Michel LHERMÏTTE, scientific co-ôrdinator
Faculté de Pharmacie, Lille mlhermitte @ chru-lille.fr
Pierre MARQUET, proceedings editor
Centre Hospitalier Universitaire, Limoges marquet @ unilim.fr
Patrick MURA, sponsors' contacts
Centre Hospitalier Universitaire, Poitiers p.mura@ chu-poitiers.fr
Véronique DUMESTRE-TOULET, Internet
Laboratoire BlOffice, Bordeaux [email protected]
Marie-Hélène GHYSEL, social events
Laboratoire de Police Scientifique, Lille maheghy @ wa ika9. com
Gilbert PEPIN, public relations
Laboratoire Toxlab, Paris labtoxlab @aol. com
FOREWORD
The 40th Meeting of the International Association of Forensic Toxicologists, so-called Paris-2002, will
be the first in France and one of the largest in term of number of attendees and scientific presentations.
Numerous abstracts were received, and the work of the scientific committee was difficult, due to their
overall qualities. In consequence, selection of the oral papers was particularly hard, but all presentations
(oral and poster) will allow valuable scientific discussion.
The present volume contains 222 abstracts (73 oral and 149 poster presentations), including various
topics, such as drugs of abuse, new analytical tools, clinical forensic toxicology, alternative specimens,
alcohol drugs and driving, postmortem toxicology and free topics.
We hope that the TIAFT Paris-2002 meeting will be the right place for scientific and friendship
exchanges.
Enjoy your stay in Paris ! !
For the Scientific Committee
Prof Michel Lhermitte
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Annales de Toxicologie Analytique, vol. XIV, n° 3,2002
Program TIAFT 2002
Monday, August 26
08.30 - 17.30 : IATDM-CT council, Hôtel Méridien
14.00 - 18.00 : registration opens, Hôtel Méridien
19.00 - 22.00 : welcome reception offered by SFTA, Tour Eiffel
Tuesday, August 27
08.30 - 18.00 : registration opens, Hôtel Méridien
08.30 - 10.00 : IATDM-CT AGM, Hôtel Méridien
08.30 - 10.00 : TIAFT executive board meeting, Hôtel Méridien, room Gauguin
10.00 - 11.30 : TIAFT regional representatives meeting, Hôtel Méridien, room Gauguin
10.00 - 12.00 : TIAFT young scientists meeting, Hôtel Méridien, room Corot
12.00 - 13.30 : IATDM-CT drugs of abuse committee meeting, Hôtel Méridien
All the scientific oral program will take place rooms Dufy and Derain
14.00 -14.30 : opening ceremony, Hôtel Méridien
14.30 - 15.45 : scientific session : Drugs of abuse 1, Hôtel Méridien
15.45 - 16.00 : TIAFT 40th birthday, Hôtel Méridien
16.00 - 16.30 : coffee break, Hôtel Méridien
16.30 - 18.15 : scientific session : Drugs of abuse 2, Hôtel Méridien
19.30 : official welcome address, Cour de Cassation
Wednesday, August 28
08.30 - 12.00 : registration opens, Hôtel Méridien
All the poster program will take place room Maillot
08.30 - 14.45 : poster session 1 - 2 -3
Clinical toxicology
Alternative specimens
Alcohol, drugs and driving
09.00 - 10.45 : scientific session : New analytical tools 1, Hôtel Méridien
10.45 - 11.15 : coffee break sponsored by Waters, Hôtel Méridien
11.15 - 13.00 : scientific session : New analytical tools 2, Hôtel Méridien
13.00 - 14.00 : lunch, Hôtel Méridien with aperitif sponsored by Drug Free Entreprises
14,00 : departure to Château de Versailles, Hôtel Méridien
15.00 - 17.30 : exhibition preparation, Hôtel Méridien
20.00 : dinner in a guinguette sponsored by Abbott, Joinville le Pont
23.00 - 24,00 : return from the dinner
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Annales de Toxicologie Analytique, vol. XIV, n° 3, 2002
Thursday, August 29
08.30- 18.00 : registration opens, Hôtel Méridien
08.30 - 18.15 : poster session 4 - 5
New analytical tools
Postmortem toxicology
Joint session with the International Association of Therapeutic Drug Monitoring and Clinical
Toxicology (IATDM-CT)
09.00 - 10.30 : scientific session : Clinical forensic toxicology 1, Hôtel Méridien
10.30 - 11.00 : coffee break sponsored by Applied Biosystems, Hôtel Méridien
11.00 - 12.30 : scientific session : Clinical forensic toxicology 2, Hôtel Méridien
12.30 - 14.00 : lunch sponsored by Lipomed, Hôtel Méridien
Joint session with the Society of Hair Testing
14.00 - 15.45 : scientific session : Alternative specimens, Hôtel Méridien
15.45 - 16.15 : coffee break sponsored by Biorad, Hôtel Méridien
16.15 - 18.00 : scientific session : Alcohol, drugs and driving, Hôtel Méridien
19.00 - 21.45 : Wine tasting sponsored by Microgenics, Musée du vin
(19.00 to 20.15 : Group 1 and 20.30 to 21.45 : Group 2)
Friday, August 30
08.00 - 12.00 : registration opens, Hôtel Méridien
08.00 - 16.00 : poster session 6 - 7
Drugs of abuse
Free topics
08.30 - 10.30 : scientific session : Postmortem toxicology, Hôtel Méridien
10.30 - 11.00 : coffee break sponsored by Orasure, Hôtel Méridien
11.00 - 12.30 : scientific session : Free topics 1, Hôtel Méridien
12.30 - 14.00 : lunch, Hôtel Méridien
14.00 - 15.45 : scientific session : Free topics 2, Hôtel Méridien
15.45 - 16.00 : coffee break, Hôtel Méridien
16.00 - 18.30 : business meeting, Hôtel Méridien
20.00 : farewell banquet sponsored by Dade Behring, Pavillon Dauphine
Annales de Toxicologie Analytique, vol. XIV, n° 3, 2002
SCIENTIFIC PROGRAM
Tuesday, August 27
Drugs of abuse 1 : 14.30 to 15.45
Chair : Marilyn Huestis and Laurent Rivier
i
Impact factors of forensic science and toxicology journals - what do the numbers really mean?
Jones A.W.
2
The first documented fatality in London due to GHB overdose
Lemos N.P.. Lee T.D., Holt D.W.
3
Simple extraction of gamma-hydroxybutyrate in human whole blood by headspace solid-
phase microextraction (SPME)
Ishii A.. Kurihara R., Hirata K., Hirata Y., Hamajima M., Watanabe-Suzuki K., Suzuki O.,
Katsumata Y.
4
Characteristics of cocaine using patients presenting to an inner city emergency department
Blaho K.E.. Park L.J., Gresham H.W.
5
Ethyl ecgonidine and nor-ecgonidine, two new metabolites of cocaine smoking, in human urine
Paul B.D.. Addison J. W.
Drugs of abuse 2 : 16.30 to 18.15
Chair : Vina Spiehler and Alain Verstraete
6
Analytical aspects of Volatile Substance Abuse (VSA): about a case report
Gaulier J.M.. Faict T.W., Sayer H., Fabre M., Lachâtre G.
Determination of nalbuphine in samples from nalbuphine abusers and rat
Chung H.. Park M., Han E., Choi H., Sohn H., Choi C, Yoo Y.
8
Substance abuse and in-custody deaths
Blaho K.E.. Beauvois E. J.
9
A nine-years experience of workplace drug testing in Brazil
Wong A.. Tawil N., Yonamine M., Silva O.A.
10
4-mcthoxY amphetamine on the illicit Belgian drug market as a brown powder: synthesis
and correlations with findings in the deceased's body fluids
Waumans P.. Bruneel N., Tytgat J.
11
Urinary excretion profiles of ll-nor-9-carboxy-A9-tetrahydrocannabinol : a A9-THC-
COOH to creatinine ratio study
Fraser A.D.. Worth D.
12
Comparison of daily saliva, urine, sweat, and skin wipes, among cocaine users
Smith F.P.. Kidwell D.A., Kidwell J.D., Shinohara F., Harper C, Roarty K., Bernadt K.,
McCaulley R.A.
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Annales de Toxicologie Analytique, vol. XIV, n° 3, 2002
Wednesday, August 28
New Analytical tools 1 : 09.00 to 10.45
Chair : Akira Ishii and Franco Tagliaro
13
Comparative study of simplified sample preparation on ionization efficiency of ESI and
APCI and development of a sensitive LC-MS/MS method for the analysis of multiple drugs
of abuse in biological fluids
Dams R.. Murphy C, Choo R., Lambert W., Huestis M.
14
Equivalence testing between commercial SPE sorbents for the sample clean-up in systema
tic toxicological analysis using LC-MS/MS
Decaestecker T.. Coopman E., Van Peteghem C, Van Bocxlaer J.
15
LC/MS/MS and GC/MS determination of codeine disposition in classical and alternative
biological matrices
Kolber I., Labarthe A., Schneider S., Yegles M., Wennig R.
16
Potentials of ion trap collisional spectroscopy for the LC-ESI-MS-MS determination of
buprenorphine and nor-buprenorphine in blood, urine and hair samples
Favretto P.. Tedeschi L., Maietti S., Castagna R, Frison G., Ferrara S.D.
17
Screening, identification and validated quantification of fourteen neuroleptics and their
metabolites in plasma by APCI-LC-MS
Kratzsch C Weber A.A., Kraemer T., Maurer H.H.
18
Transfer of a general unknown screening procedure for drugs and toxic compounds on a
prototype hybrid RF/DC quadrupole-linear ion-trap mass spectrometer
Marquer P.. Saint-Marcou F., Gamble T.N., Leblanc J.C.Y., Guiller A.
19
LC-MS analyses for the screening, confirmation and quantification of about 60 drugs in
whole blood from autopsy cases
Krogh M.. Syversen P.V., Hasvold I., Gulliksen M., Johansen U., Johnsen L., Olsen L.H., Ripel
A., Christophersen A.S.
New Analytical tools 2 : 11.15 to 13.00
Chair : Carmen Jurado and Patrice Mangin
20
Determination of LSD, iso-LSD, nor-LSD and 2-oxo-3-hydroxy-LSD in blood and urine
samples by liquid chromatography-electrospray-ion trap multiple mass spectrometry
Favretto P.. Frison G., Maietti L., Tedeschi L., Ferrara S.D.
21
Simultaneous determination of eight drugs of abuse and codeine in saliva by liquid chro
matography tandem mass spectrometry
Mortier K.A.. Lambert W.E., Van Bocxlaer J.F, Deforce D.L., Van Peteghem CH.,
De Leenheer A.P.
22
Fully automated gas chromatographic / mass spectrometric detection of cannabinoids in
hair samples using headspace solid-phase microextraction or headspace solid-phase dyna
mic extraction
Musshoff F.. Lachenmeier D.W., Kroener L. Madea B.
}
Annales de Toxicologie Analytique, vol. XIV, n° 3, 2002
23
GC-MS determination of eleven amphetamine analogs and ephedrines in plasma, urine
and hair samples after derivatization with 2,2,2 trichloroethyl chloroformate
Frison G.. Tedeschi L., Favretto D., Ferrara S.D.
24
Contribution of the Raman spectroscopy in the characterization of ecstasy derivatives
Belhadj-Tahar H.. Molnar Y.G., Payoux P., Coulais Y., Costes J.P., Robert L.,
Esquerre J.P., Bousseksou A.
25
Detection of quaternary amines by capillary electrophoresis-UV
Scott F.J.. Miller M.L.
26
NMR spectroscopy as a useful tool for diagnosis of poisonings
Imbenotte M.. Azaroual N., Cartigny B., Vermeersch G., Lhermitte M.
Session 1
Clinical Forensic Toxicology
i
Enzymatic hydrolysis improves the sensitivity of EMIT screening for urinary benzodiazepines
Borrey D., Meyer E., Duchateau L., Lambert W.. Van Peteghem C, De Leenheer A.P
2
A simple and rapid method for the determination of carboxyhemoglobin and total hemo
globin in toxicological laboratories.
Cruz A., Bal M.J., Quíntela O., Concheiro M., Gallardo E., López-Rivadulla M.
3
Determination of local anesthetics in human plasma using solid phase microextraction and
GC-MS
Gallardo E., Quíntela O., Cruz A., López-Rivadulla M.
4
HPLC/Photodiode array detection combined with ESI/MS detection : a powerful tool for
large screening of bioactive molecules in complex biological matrices. Elaboration of an
UV/ESI/MS spectra library enabling fast and reliable compound identification
Humbert L.. Grisel F., Bondoux G., Lhermitte M.
5
Effects of intestinal motility on ethanol absorption
Isobe E.. Tsukamoto S., Hirose M., Nagoya T.
6
On-column derivatization for determination of amphetamine and methamphetamine in
biological materials by GO MS
Nishida M,» Namera A., Yashiki M., Kojima T.
7
A fatal forensic intoxication study with Fenarimol: comparative analysis by HPLC/DAD
and HPLC/DAD/MSD.
Proenca P.. Pinho Marques E., Teixeira H., Castanheira F., Barroso M., Ávila S., Vieira D.N.
8
LC-MS determination of urinary 5-hydroxytryptophol glucuronide
Stephanson N.. Beck O., Dahl H., Helander A.
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Annales de Toxicologie Analytique, vol. XIV, n° 3, 2002
9
The mortality structure in cases of acute searing liquids poisonings (1992-2001)
Tchernov N.V.. Sarmanaev S.Kh., Akhmetov I.R., Kondrashova S.R., Salmanov A.A,
Bessolitzina A.M., Akhmerova O.P., Teregulova Z.S.
10
Tissue and plasma determination of 4-methyl-pyrazole in methanol acute poisoning
Wallemacq P., Di Fazio V., Vanbinst R., Kônig J., Hantson Ph.
il
Detection of massive cephazolin concentrations in CSF associated with neurotoxicity
Wallemacq P.. Di Fazio V., Cartier E., Govaerts D.
12
Simultaneous quantification of psychotherapeutic drugs in human plasma and whole blood
by tandem mass spectrometry
Wood M.. Morris M.
13
Three complicated body packer cases in Loghman Hospital in Tehran
Abolmasoumi Z.. Mahshid A., Hossein H,,
14
Application of acetone, methanol and isopropanol for recognition of people addicted to
alcohol
Zuba P.. Gubala W., Parczewski A., Piekoszewski W.
Session 2
Alternative specimens
15
Detection of the use of low doses of benzodiazepines using oral fluid by the Cozart
RapiScan System and Microplate EIA
Baldwin P., Hussain M., Jehanli A., Hand C.
16
Hair analysis for opiates. Evaluation of washing and incubation procedures
Balíková M. A.. Habrdová V.
17
Buprenorphine in saliva
De Giovanni N„ Fucci N.. Chiarotti M.
18
Effect of oral fluid collection method on speed of salivation and drug recovery following
codeine administration
Fernandes V., Baldwin D., Jehanli A.
19
The chiral analysis of methadone and its two main metabolites (EDDP and EMDP) in bio
logical matrices by LC-MS-MS and CE
Kelly T.. Dawson M., Poble P., Conn C.
20
Influx and efflux of drugs in pigmented and non-pigmented melanocytes
Martin S., Borges C, Rollins P., Wiikins P.
21
Rapid detection of opiates in oral fluid using the VPUnk™ System: a new technology plat
form for on-site drug testing
Niedbala R.S.. Burton J., Fasolka S., Feindt H.H., Jinks C, Kuntz C, Parmar G., Waga J.,
Salamone SJ.
Annales de Toxicologie Analytique, vol. XIV, n° 3, 2002
22
Windows of detection for opiates using oral fluids
Niedbala R.S.. Salamone S.J., Hunter P., Clarke J., Feeley B.
23
Inter-individual dose/concentration relationship for methadone in hair
Paterson S.. Cordero R., McPhillips M., Carman S.
24
Rapid and sensitive cocaine analysis in hair using ChromatoProbe device.
Pieraccini G., Moneti G., Villanelli F, Marsili R., Chiarotti M.
25
Incorporation of toluene and xylene metabolites into rat hair
Saito T.. Kusakabe T., Takeichi S.
26
Investigation into the hair analysis of eight benzodiazepines and their incorporation rates
into rat hair
Scott K.S.. Nakahara Y.
27
Tandem mass spectrometry for the analysis of drugs of abuse in human hair
Sims D.N.. Stockham P.C.
28
Determination of opiates and amphetamine in hair of detoxification and methadone treat
ment patients addicted to home made polish heroin"
Stanaszek R.. Piekoszewski W., Karakiewicz B, Kozielec T.
29
Hair analysis for detection of drugs: the use of multiple and single sections on the inter
pretation of drug use for medical-legal purposes
Tsanaciis L.M.. Wicks J.F.C.
30
Gestational drug exposure profile in neonates by GC-MS hair analysis and prediction of
withdrawal syndrome
Vinner E^Vignau J., Thibault D., Codaccioni X., Brassart C, Humbert L., Lhermitte M.
31
SPME-GC/MS and headspace-GC analyses of THC, amphetamine, methamphetamine,
cocaine and ethanol in saliva samples
Yonamine M.. Moreau R.L.M., Silva O.A.
Session 3
Alcohol, Drugs and Driving
32
Ethyl glucuromde concentrations in two successive urinary voids from drinking drivers ;
relationship to creatinine content, blood-and urine-ethanol and phase of ethanol metabo
lism
Bergstrôm J.. Helander A., Jones A.W.
33
Carbohydrate deficient transferrin (CDT) as a predictor of "drunk driving" risk
Bortolotti F.. Trettene M., Gottardo R., Bernini M., Ricossa C, Ferrari A., Tagliaro F.
34
Turbidimetric determination of carbohydrate-deficient transferrin on Roche/Hitachi ana
lyzers - results of a multicenter evaluation
Domke I.. Helander A., Janssens P., Van Pelt J., Schwarz M., Soyka M., Springer B., Weigl G.
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