at L a S of touch a t Pr EPa r at ion L An Imprint of Springer Publishing a S o c y toPat hoL og y f t o Liron Pantanowitz, MD u c h Juan Xing, MD at L a S o f t o u c h P Sara E. Monaco, MD r E P a r a This is the first atlas dedicated to touch preparation cytopathology. Written by established pathologists who P r E Pa r at i o n t are at the cutting edge of this minimally-invasive practice, the Atlas of Touch Preparation Cytopathology i o presents a comprehensive overview and visual reference guide to the diagnostic applications of touch n preparations. This visually-stunning book reviews touch preparations corresponding to all major body systems c and includes chapters on specimen handling and processing, intraoperative use during frozen sections, as well y as on ancillary testing using touch preps. While most cytopathology atlases have images of smears and fluids, t c y t o Pat h o L o g y o they have very little discussion of touch preparations making this volume a one-of-a-kind resource. P a The authors, using many picturesque examples in the text, not only include detailed visual and textual t h discussion of touch preparations but also provide comparative presentations to facilitate correlation with o histopathology, FNA smears and ancillary test results. This total coverage illuminates key findings and L important considerations of this technique that pathologists can learn from. Written with the practicing o pathologist in mind, the Atlas of Touch Preparation Cytopathology is an invaluable book in today’s pathology g y practice where there is increasing utilization of small biopsies that can benefit from intraprocedural evaluation and assessment to maximize diagnostic yield. Key Features: P a n n Covers various methods of touch preparation and addresses measures to t a avoid pitfalls. n o w n Includes techniques that can serve as helpful tricks during intraprocedural i t evaluation of small biopsies and at the time of frozen section. z • n Comprehensive coverage of different body systems that are typically sampled with X L i r o n Pa n ta n o w i t z i small biopsies and amenable to touch preparations. n g n Contains over 500 touch preparation images and includes corresponding • M J u a n X i n g histopathologic figures and ancillary studies. o n a Recommended c Shelving Category: o S a r a E . M o n a c o Pathology An Imprint of Springer Publishing 11 W. 42nd Street New York, NY 10036 www.demosmedical.com Atlas of Touch Preparation Cytopathology Atlas of Touch Preparation Cytopathology Liron Pantanowitz, MD Professor of Pathology and Biomedical Informatics Director of Cytopathology UPMC Shadyside Director of Pathology Informatics Fellowship Program Director of the Pathology Informatics Division University of Pittsburgh Medical Center Pittsburgh, Pennsylvania Juan Xing, MD Assistant Professor of Pathology University of Pittsburgh Medical Center Pittsburgh, Pennsylvania Sara E. Monaco, MD Associate Professor of Pathology Director of Cytopathology Fellowship Program Director of Fine Needle Aspiration Clinic University of Pittsburgh Medical Center Pittsburgh, Pennsylvania An Imprint of Springer Publishing Visit our website at www.demosmedical.com ISBN: 9781620700686 ebook ISBN: 9781617052378 Acquisitions Editor: David D’Addona Compositor: diacriTech Copyright © 2018 Springer Publishing Company. Demos Medical Publishing is an imprint of Springer Publishing Company, LLC. All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our under- standing of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Library of Congress Cataloging-in-Publication Data Names: Pantanowitz, Liron, author. | Xing, Juan (Of University of Pittsburgh Medical Center (2003- )), author. | Monaco, Sara E., author.s Title: Atlas of touch preparation cytopathology / Liron Pantanowitz, Juan Xing, Sara E. Monaco. Description: New York : Demos, [2018] | Includes bibliographical references and index. Identifiers: LCCN 2017017714| ISBN 9781620700686 | ISBN 9781617052378 (e-book) Subjects: | MESH: Cytodiagnosis–methods | Histocytological Preparation Techniques–methods | Atlases Classification: LCC RB43 | NLM QY 17 | DDC 616.07/582—dc23 LC record available at https://lccn.loc.gov/2017017714 Contact us to receive discount rates on bulk purchases. We can also customize our books to meet your needs. For more information please contact: [email protected] Printed in the United States of America by Bang Printing. 17 18 19 20 21 / 5 4 3 2 1 To Heidi, Joshua & Maya for their support and giving me the time to write this book. Liron Pantanowitz To my lovely husband Guodong and our two amazing daughters, Catherine and Sarah, for their unconditional love and support. Juan Xing To my parents, husband, and children (Eddie, Julia, and Nicholas) for their endless support and love. Sara E. Monaco Contents Contributors ix 6. Hematopathology 83 Preface xi Liron Pantanowitz Share Atlas of Touch Preparation Cytopathology Introduction 83 Normal 84 1. Introduction 1 Benign Entities 90 Sara E. Monaco and Liron Pantanowitz Malignant Entities 98 Background 1 7. Genitourinary System 133 Accuracy and Performance 6 6 Anil V. Parwani and Liron Pantanowitz Advantages and Disadvantages Introduction 133 Billing 7 Normal 133 Conclusion 7 Benign and Malignant Lesions 141 2. Preparation Techniques 9 Testis 146 Liron Pantanowitz Tumors of the Penis 159 Introduction 9 8. Pancreatobiliary, Liver, and Slide Preparation 10 Gastrointestinal Tract 161 Fixation and Staining 14 Reetesh K. Pai Problems and Pitfalls 14 Introduction 161 3. Intraoperative Cytology 19 Normal 161 Liron Pantanowitz and Juan Xing Benign Entities 165 Malignant Entities 166 Introduction 19 Primary Tumors of the Liver 175 Imprint Technique 19 21 Fixation and Staining Methods 9. Head and Neck 177 Suitable Samples 23 Juan Xing and Deborah J. Chute Unsuitable Samples 29 Introduction 177 Diagnostic Errors 30 Normal 177 Benign Entities 179 4. Gynecological System 33 Malignant Entities 184 Zaibo Li and Chengquan Zhao Introduction 33 10. Bone and Soft Tissue 195 Normal 33 Liron Pantanowitz Benign Entities 33 Introduction 195 Malignant Entities 37 Bone Tissue 195 Soft Tissue 210 5. Respiratory System 49 Sara E. Monaco 11. Central Nervous System 243 Julia Kofler Introduction 49 Normal 49 Introduction 243 Benign Entities 58 Sellar Region 243 Malignant Entities 63 vii viii Contents Extra-Axial Lesions 256 13. Ancillary Testing 291 Intra-Axial Lesions 263 Sara E. Monaco 12. Mediastinum, Retroperitoneum, and Introduction 291 Adrenal Glands 275 Material for Ancillary Testing 291 Juan Xing Types of Ancillary Testing 295 Pitfalls of Ancillary Testing 302 Introduction 275 Normal 275 Index 305 Benign Entities 277 Malignant Entities 282 Contributors Deborah J. Chute, MD Anil V. Parwani, MD, PhD Staff Pathologist Professor of Pathology Assistant Professor of Pathology Vice Chair of Anatomic Pathology RJ-Tomsich Institute of Pathology and Director of Pathology Informatics Laboratory Medicine The Ohio State University Wexner Medical Center Cleveland Clinic Columbus, Ohio Cleveland, Ohio Chengquan Zhao, MD Julia Kofler, MD Professor of Pathology Assistant Professor of Pathology Codirector of Cytopathology and Director of Fine University of Pittsburgh Medical Center Needle Aspiration at Magee-Women’s Hospital, Pittsburgh, Pennsylvania and Chief of Pathology, UPMC-China Enterprise University of Pittsburgh Medical Center Zaibo Li, MD, PhD Pittsburgh, Pennsylvania Assistant Professor of Pathology The Ohio State University Wexner Medical Center Columbus, Ohio Reetesh K. Pai, MD Associate Professor of Pathology Director of the Gastrointestinal Pathology Center of Excellence Director of the Gastrointestinal Pathology Fellowship University of Pittsburgh Medical Center Pittsburgh, Pennsylvania ix