Atlas of Pulmonary Cytopathology

219 Pages·2017·38.865 MB·English

by  Syed Ameer Ali, Anil Parwani, Yener Erozan, Dorothy Rosenthal

Atlas of Pulmonary
Cytopathology
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Christopher J. VandenBussche, Paul E. Wakely, Jr., MD
MD, PhD
Professor of Pathology
Assistant Professor of Pathology and Cytopathology Ohio State University Medical Center
Fellowship Director Columbus, Ohio
The Johns Hopkins University School of Medicine
Baltimore, Maryland
Joyce E. Johnson, MD
Professor of Pathology, Microbiology, and
Syed Z. Ali, MD, FRCPath, FIAC
Immunology
Professor of Pathology and Radiology and Director
Director, Anatomic Pathology,
of Cytopathology
VA Medical Center
The Johns Hopkins University School of Medicine
Vanderbilt University School of Medicine
Baltimore, Maryland
Nashville, Tennessee
Morgan L. Cowan, MD
Assistant of Pathology
The Johns Hopkins University School of Medicine
Baltimore, Maryland
Atlas of Pulmonary
Cytopathology
With Histopathologic Correlations
An Imprint of Springer Publishing
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ISBN: 9781936287161
ebook ISBN: 9781617050459
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Library of Congress Cataloging-in-Publication Data
Names: VandenBussche, Christopher J., author. | Ali, Syed Z., author. |
Cowan, Morgan L., author. | Wakely, Paul E., Jr., 1949- author. | Johnson,
Joyce E., 1958- author.
Title: Atlas of pulmonary cytopathology with histopathologic correlations /
Christopher J. VandenBussche, Syed Z. Ali, Morgan L. Cowan, Paul E.
Wakely, Jr., Joyce E. Johnson.
Description: New York: Demos Medical Publishing, [2017] | Includes
bibliographical references and index.
Identifiers: LCCN 2017016470| ISBN 9781936287161 | ISBN 9781617050459 (e-ISBN)
Subjects: | MESH: Lung Diseases—pathology | Lung Diseases—diagnosis |
Cytodiagnosis | Atlases
Classification: LCC RC756 | NLM WF 17 | DDC 616.2/4—dc23
LC record available at https://lccn.loc.gov/2017016470
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17 18 19 20 21 / 5 4 3 2 1
To my mother, Carol, and her parents, William and Katharine (“Vicki”). –CJV
To my parents, Bano and Mazhar. –SZA
To my first microscope, monocular and mirror-illuminated, passed on to my childhood self by my mother (and from
Dr. E. L. Caudil of Elizabethton, Tennessee, before her), by which the animated cellular mysteries of the otherwise
still and muddy pond behind my childhood home were first illuminated. And always, for Travis. –MLC
To my former cytopathology fellows in appreciation of the knowledge and stimulation I have received from them. –PEW
To residents and fellows, who are the future; and to patients with lung diseases, who are the reason. –JEJ
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Contents
Foreword Fernando Schmitt, MD, PhD, FIAC ix
Share Atlas of Pulmonary Cytopathology: With Histopathologic Correlations
1. Lung Radiology 1

2. Normal Lung 31

3. Reactive Changes and Benign Lung Lesions 41

4. Infectious Lung Lesions 65

5. Benign Lung Neoplasms 81

6. Malignant Lung Neoplasms 93

7. Unusual and Metastatic Lesions 153

Index 205
vii
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Foreword
The practice of cytopathology has undergone significant a full range of non neoplastic and neoplastic lung diseases.
evolution in the last 50 years. Cytopathology is a diagnostic In addition, there is excellent documentation of the histo-
method, not simply a screening method, in most of the areas pathology and gross examination in some cases, providing
in which it is applied and has become an integral part of morphologic correlations useful for cytopathologists and
pathology. The importance of cytological techniques for the surgical pathologists. The inclusion of a chapter dedicated
investigation of respiratory conditions has been recognized to radiology is of paramount importance. In the era where
since the earliest days of clinical cytology. The study of cel- clinical-pathologic correlation is becoming more and more
lular specimens from the respiratory tract is established as a important in the management of patients, the knowledge
vital diagnostic procedure in the evaluation of patients with of how an expert radiologist deals with these correlations
suspected lung inflammatory/infectious or neoplastic diseases. brings an additional value to the Atlas that will be very well
The study of sputum, bronchial washings, bronchial aspirates, recognized and accepted for the readers. From the cytopa-
bronchial brushings, bronchoalveolar lavage specimens, and thology perspective, knowing the imaging characteristics of
fine needle aspirates (FNAs) provides the morphologic basis for lung lesions is extremely valuable in the interpretation of
these diagnoses. With the advent of targeted therapy for lung specimens.
cancer, ancillary testing of specimens derived from the lower The richness of the Atlas content will be very helpful for
respiratory tract has obtained greater importance. Traditionally, general pathologists, lung pathologists, cytopathologists, and
ancillary testing was confined to culture techniques for micro- trainees in their daily practice. Moreover, the work reflects the
biologic organisms, flow cytometry for lymphoid p roliferations, extensive practice of cytopathology at Johns Hopkins, espe-
and immunohistochemical stains for the classification of pul- cially by Drs. VandenBussche and Ali, internationally recog-
monary neoplasms. Targeted therapy has expanded the need nized experts and respected cytopathologists. I am confident
for ancillary and, in particular, molecular testing to document that this book will aid pathologists in their routine by provid-
the presence or absence of certain mutations, amplifications, ing essential information for better diagnosis and management
inversions, and translocations that indicate a carcinoma sus- of patients. Now it is time to enjoy the text and the illustrations
ceptibility to specific targeted therapies. In fact, in lung cancer, of this Atlas that presents, in a didactic way, up-to-date knowl-
small biopsies and cytologic specimens are the primary materi- edge in lung cytopathology.
als for establishing the diagnosis in most cases, as well as for
studying markers driving tumor classification and providing Fernando Schmitt, MD, PhD, FIAC
prognostic and predictive information. Despite all of these new Professor of Pathology at Medical Faculty of Porto University
advances, the foundation of cytopathology is based in a correct Head of the Molecular Laboratory and Senior Researcher
and precise morphologic interpretation. Instituto de Patologia e Imunologia Molecular da
This Atlas of Pulmonary Cytopathology is an outstanding Universidade do Porto, Porto, Portugal
work with more than 500 high-quality images documenting General Secretary of the International Academy of Cytology
ix
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