Atlas of Liver Pathology PDF
Preview Atlas of Liver Pathology
ATLAS OF LIVER PATHOLOGY This page intentionally left blank ATLAS OF LIVER PATHOLOGY Third Edition Gary C. Kanel, M.D. Professor of Clinical Pathology Keck School of Medicine University of Southern California Associate Pathologist Los Angeles County + USC Medical Center and USC University Hospital Los Angeles, California Jacob Korula, M.D. Comprehensive Liver Disease Center St. Vincent Medical Center Los Angeles, California 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 ATLAS OF LIVER PATHOLOGY THIRD EDITION ISBN: 978-1-4377-0765-6 Copyright © 2011, 2005, 1992 by Saunders, an imprint of Elsevier Inc. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notice Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data Kanel, Gary C. Atlas of liver pathology / Gary C. Kanel, Jacob Korula. -- 3rd ed. p. ; cm. Liver pathology Includes bibliographical references and index. ISBN 978-1-4377-0765-6 (hardcover : alk. paper) 1. Liver--Diseases--Atlases. I. Korula, Jacob. II. Title. III. Title: Liver pathology. [DNLM: 1. Liver Diseases--pathology--Atlases. 2. Biopsy--Atlases. 3. Diagnosis, Differential--Atlases. WI 17] RC846.9.K35 2011 616.3’62--dc22 2010034856 Executive Publisher: William Schmitt Senior Developmental Editor: Andrew Hall Publishing Services Manager: Patricia Tannian Senior Project Manager: Kristine Feeherty Design Direction: Steven Stave Printed in the United States of America Last digit is the print number: 9 8 7 6 5 4 3 2 1 To our families who support us and our colleagues who teach us much This page intentionally left blank PREFACE Although over a decade passed between the publication of correlation with the light microscopy. In addition, the total the first and second editions of the Atlas of Liver Pathology, number of images has increased by approximately 50% from the rapid development in understanding the pathophysi- the second edition. What has also been added is a second ologic concepts of diseases and identifying variations in mor- section addressing specific morphologic changes in table phologic features of these diseases necessitates a third edition format and listing the various liver diseases associated with over a much shorter time span. these changes. This section, which has been updated from The new diagnostic tools leading to more sophisticated our previous book, Liver Biopsy Evaluation, specifically aids laboratory testing have been a hallmark in learning the etiol- the reader in arriving at diagnoses and differential possibili- ogy and pathophysiology of diseases. Where before morpho- ties solely on morphology, then referring the reader to the logic changes were ascribed to various liver disorders without text and images of the specific diseases in the first part of a good understanding of their significance, the advent of new the book. testing procedures such as genome sequencing much better We hope that this new edition will be successful in pro- helps us understand what we see under light microscopy. An viding pathologists, clinicians, and students a better under- excellent example is the ongoing research in liver tumors that standing of liver pathology and disease concepts and will be examines cellular signaling pathways and molecular profil- a useful practical tool. The overall aim does not change from ing, identifies individual genes and gene groups associated the previous editions: to offer a concise illustrative text in with higher instances of the development of hepatocellular liver and hepatobiliary pathology. carcinoma in cirrhotic livers, and correlates all of the above Gary Kanel, M.D. with the morphology seen in liver biopsy specimens. Jacob Korula, M.D. The changes in the updated third edition include the Los Angeles, California use of gross images of various liver diseases with direct vii This page intentionally left blank CONTENTS PART I Liver and Hepatobiliary Pathology with Clinical Correlations Chapter 1 General Aspects of the Liver and Liver Diseases 3 Chapter 2 Viral Hepatitis 16 Chapter 3 Cholestasis and Biliary Tract Disorders 52 Chapter 4 Alcoholic and Non-Alcoholic Fatty Liver Diseases 71 Chapter 5 Drug- and Toxin-Induced Liver Cell Injury 93 Chapter 6 Vascular Disorders 134 Chapter 7 Infectious Disorders, Non-Viral 154 Chapter 8 Developmental, Familial, and Metabolic Disorders 194 Chapter 9 Diseases of Hepatic Iron and Copper Metabolism 236 Chapter 10 Neoplasms and Related Lesions 249 Chapter 11 Transplantation 321 Chapter 12 Miscellaneous Conditions 353 PART II Liver Biopsy Evaluation: Morphology with Differential Diagnoses Introduction 379 Tables of Morphology 381 Appendix Chronic Liver Diseases: Staging and Grading Systems 489 Index 495 ix
The list of books you might like
