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CLINICAL GASTROINTESTINAL ATLAS OF ENDOSCOPY CLINICAL GASTROINTESTINAL ATLAS OF ENDOSCOPY Third Edition C. Mel Wilcox, MD, MSPH Professor of Medicine Divisionof Gastroenterologyand Hepatology University ofAlabamaat Birmingham Birmingham,Alabama USA Miguel Mun˜oz-Navas, MD, PhD Professor of Medicine Director of Gastroenterology Division and Endoscopy Unit Division of Gastroenterology University Hospital ofNavarra University of Navarra Pamplona Spain Joseph Sung, MD, PhD MokHing YiuProfessor ofMedicine Vice Chancellor and President The Chinese University of HongKong Shatin,Hong Kong China 1600JohnF.KennedyBlvd. Ste1800 Philadelphia,PA19103-2899 ATLASOFCLINICALGASTROINTESTINALENDOSCOPY,THIRDEDITION ISBN:978-1-4377-1909-3 Copyright#2012,2007,1995bySaunders,animprintofElsevierInc. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronic ormechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem, withoutpermissioninwritingfromthepublisher.Detailsonhowtoseekpermission,furtherinformation aboutthePublisher’spermissionspoliciesandourarrangementswithorganizationssuchasthe CopyrightClearanceCenterandtheCopyrightLicensingAgency,canbefoundatourwebsite: www.elsevier.com/permissions. ThisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythePublisher (otherthanasmaybenotedherein). Notices Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperience broadenourunderstanding,changesinresearchmethods,professionalpractices,ormedicaltreatment maybecomenecessary. Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingand usinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformation ormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesfor whomtheyhaveaprofessionalresponsibility. Withrespecttoanydrugorpharmaceuticalproductsidentified,readersareadvisedtocheckthemost currentinformationprovided(i)onproceduresfeaturedor(ii)bythemanufacturerofeachproducttobe administered,toverifytherecommendeddoseorformula,themethodanddurationofadministration, andcontraindications.Itistheresponsibilityofpractitioners,relyingontheirownexperienceand knowledgeoftheirpatients,tomakediagnoses,todeterminedosagesandthebesttreatmentforeach individualpatient,andtotakeallappropriatesafetyprecautions. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeany liabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligence orotherwise,orfromanyuseoroperationofanymethods,products,instructions,orideascontainedin thematerialherein. LibraryofCongressCataloging-in-PublicationData Wilcox,C.Mel. Atlasofclinicalgastrointestinalendoscopy/CharlesWilcox,MiguelMun˜oz-Navas,JosephJ.Y.Sung. –3rded. p.;cm. Includesindex. ISBN978-1-4377-1909-3(hardcover:alk.paper) I.Mun˜oz-Navas,Miguel.II.Sung,JosephJ.Y.(JosephJaoYiu),1959-III.Title. [DNLM:1.Endoscopy,Gastrointestinal–Atlases.2.GastrointestinalDiseases–pathology–Atlases.WI17] 616.33075450022’3–dc23 2011040113 SeniorContentStrategist:KateDimock SeniorContentSupportCoordinator:KateCrowley PublishingServicesManager:PatriciaTannian SeniorProjectManager:SharonCorell DesignManager:StevenStave PrintedinChina Lastdigitistheprintnumber: 9 8 7 6 5 4 3 2 1 To all those whohelped mecollectthese images aswellas tomy wonderfulfamily for providingme the timeto compile thislabor oflove. C.Mel Wilcox, MD,MSPH This book is dedicated to my wife, Lucia,my children,Miguel, Javier, and Ina, for theirlove, patience, and support, and my granddaughter, Ema, who has given me so much joy. I must especially thank my parents, Calixto and Maria (may they rest inpeace),towhomIowewhatIam,andmylatefather-inlaw,Antonio,whowouldbe veryproud ofthis publication. Miguel Mun˜oz-Navas,MD,PhD Tomy wife, Rebecca Wong. Joseph Sung, MD,PhD A C K N O W L E D G M E N T S IwouldliketothankmycolleaguesoftheEndoscopyUnitoftheUniversityofNavarra Clinic—Dr.JoseCarlosSubtil,Dr.CristinaCarretero,Dr.MaiteBetes,Dr.MaiteHerraiz, Dr.SusanadelaRiva,Dr.CesarPrieto,andDr.RamonAngos—fortheirinvaluable collaborationandsupport.Ialsowishtoexpressmygratitudetomycolleaguesandfriends whogaveussomeexcellentpictures:Dr.OnofreAlarcon,Dr.FernandoAlberca, Dr.BartolomeGarcia-Perez,Dr.IgnacioFernandez-Urie´n,Dr.CristianGheorghe, Dr.PedroGonzalez-Carro,Dr.JuanManuelHerrerias,Dr.JavierJimenez-Perez,Dr.Sacha Loiseau,Dr.AkikoOno,Dr.JavierPardo-Mindan,Dr.FranciscoPerez-Roldan,Dr.Pedro Redondo,Dr.JesusJavierSola,Dr.AlbertoTomas,Dr.JoseLuisVazquez-Iglesias, Dr.FranciscoVida,Dr.MichaelWallace,andDr.JoseLuisZubieta. Miguel Mun˜oz-Navas,MD,PhD Myheartfelt gratitude tomy colleaguesat the Institute ofDigestive Diseases who contributedtothepicturesinthisproject:Dr.JamesLau,Dr.Y.T.Lee,Dr.JustinWu,and Dr. Larry Lai.I would also like to thank Mr.Alan Fokand Ms. Ashur Lam for their assistance indigitizing these pictures. Joseph Sung, MD,PhD ix 1 CHAPTER Oropharynx and Hypopharynx INTRODUCTION Theoropharynxisthegatewaytotheproximalgastrointestinaltract.Al- though visualized daily by endoscopists, a thorough examination may not be routine. With the expanding patient base of immunocompro- mised patients, inspection of the oropharynx, particularly in patients with esophageal symptoms, should be part of every examination. Oro- pharyngealabnormalitiescansuggestunderlyingesophagealdiseasein thesepatients,andoropharyngeallesionsmaybethefirstmanifestation of an underlying systemic disorder. Asymptomatic malignant disease mayalsobedetected.Withincreasingappreciationoftheextraesopha- gealmanifestationsofgastroesophagealrefluxdisease,hypopharyngeal examination assumes an even greater role. A thorough knowledge of hypopharyngeal anatomy is thus essential for all endoscopists. 2 Atlas of Clinical Gastrointestinal Endoscopy Uvula and FIGURE1.1 OROPHARYNX soft palate Normalpharynxasviewedwithanendoscope,demonstratingthe junctionofthehardandsoftpalate,uvula,andposteriorpharynx. Palatopharyngeal arch Hard palate Palatoglossal arch Palatine tonsil Epiglottis Vocal cords Aryepiglottic fold Piriform sinus FIGURE1.2 LANDMARKSOFTHEOROPHARYNXANDHYPOPHARYNX Withtheendoscopeadvancedunderdirectvision,theinferiorportionoftheuvulaisseenatthebaseofthetongue.Noticethatthe imageisinverted(topleft).Withfurtheradvancement,thesuperiorportionoftheepiglottisisidentified(topright).Advancement anteriorlyendsattheattachmentoftheepiglottis,termedthevalleculae(bottomleft).Toenterthehypopharynx,theendoscopeis advancedposteriorlybehindtheepiglottisintothehypopharynx(bottomright).Theepiglottisappearstoformaroofoverthe hypopharynx.Thevocalcordsaresurroundedbythearyepiglotticfoldsanteriorly.Inthisposition,thepiriformrecessesorsinusesare onthelateralsideofthearyepiglotticfolds.Thecricopharyngeusandentrancetotheesophagusareinthemidlineposteriorly. Atlas of Clinical Gastrointestinal Endoscopy 3 FIGURE1.3 DIRECTIONTO CRICOPHARYNGEUS Theendoscopeispassedoverthetongue anduvula(upperleft).Oncepasttheuvula, theepiglottisandhypopharynxareseen inthedistance.Anasogastricfeedingtube isnowpresent(upperright).The arytenoidsarenowvisiblewiththe feedingtubeseenposteriorinthemidline (bottomleft).Thearytenoidsareopenand thevocalcordsvisible.Again,thefeeding tubeisposteriorinthemidlineshowing thelocationofthecricopharyngeus (bottomright). FIGURE1.4 VOCALCORDS Normalvocalcordsandsurroundingstructuresasseenfromthe arytenoids. 4 Atlas of Clinical Gastrointestinal Endoscopy A B FIGURE1.5 HYPOPHARYNX A,Normal-appearinghypopharynxasseenonhigh-definitionendoscopy.B,Narrow bandimagingofthehypopharynx. FIGURE1.6 HYPOPHARYNXWITH ENDOTRACHEALTUBE Notetheanatomyofthehypopharynx withendotrachealintubation. FIGURE1.7 PATENTUPPERESOPHAGEAL SPHINCTER Afterendoscoperemoval,theupper esophagealsphincterremainedpatulous. Noteitslocationrelativetothe cricopharyngeus,confirmingtheposterior locationoftheupperesophagealsphincter. Alsonotetheerythemaofthehypopharynx andarytenoids. Upper esophageal sphincter FIGURE1.8 TRACHEAANDCARINA Viewofthe(A)tracheaand(B)carinaat endoscopy.Notetheringlikearchitecture ofthetrachea. A B

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