Atlas of Cell Organelles Fluorescence PDF
Preview Atlas of Cell Organelles Fluorescence
ATLAS OF CELL ORGANELLES FLUORESCENCE 1440_C00.fm Page ii Wednesday, November 19, 2003 7:33 AM ATLAS OF CELL ORGANELLES FLUORESCENCE Elli Kohen René Santus Joseph G. Hirschberg Nuri Özkütük CRC PR ESS Boca Raton London New York Washington, D.C. CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2004 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20130919 International Standard Book Number-13: 978-0-203-49073-0 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the valid- ity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or uti- lized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopy- ing, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http:// www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com 1440_C00.fm Page v Wednesday, November 19, 2003 7:33 AM Preface The idea of an atlas on (cid:223)uorescence of cell organelles was (cid:222)rst inspired by Professor Feroze Nevroze Ghadially(cid:146)s Ultrastructural Pathology of Cells and Matrix. This unique book describes the ultrastructural makeup and alterations of cell organelles in the context of over a thousand pathological conditions. It became somewhat of a challenge to build on the foundations of images obtained from dead and (cid:222)xed cells an equivalent body of images obtained from living and func- tioning cells under various physiopathological conditions and in the context of treatment with carcinogens, xenobiotics, chemotherapeutic drugs, and photosensitizers. The idea of pursuing such studies was born out of the perspectives envisioned by another giant in the (cid:222)eld, Professor Albert Policard, one of the (cid:222)rst proponents of microcompartmentation. The links of the research expounded in this book are an odyssey of collaborative visits, travels, and interactions. Historically it passes from the thresholds of the Laboratoire de Pathologie Cellulaire, Kremlin BicŒntre run by Marcel Bessis to the Laboratoire de Photobiologie, MusØum National d(cid:146)Histoire Naturelle in Paris, and then (cid:222)nally to the Papanicolaou Cancer Research Institute and University of Miami. In the historical context, Professor Bessis and Bo Thorell, my professor at the Karolinska, Stockholm, were quite good friends from their prime years. Another link in this chain of research is that Thorell and Britton Chance, my professor in Philadelphia, were lifelong friends. Thorell(cid:146)s dream was a dynamic pathology of the living cell. Chance(cid:146)s own dream, and the object of my work in his foundation, was the synthesis of biophysics and cellular pathology. In my sabbatical year I planned to retrace this parable which justi(cid:222)ably should be called (cid:147)My Scienti(cid:222)c Odyssey from Philadelphia to Miami through Paris and Stockholm.(cid:148) The endpoint of the vision projected by Policard leads to the birth of three new disciplines in cellular biology: microecology, the science of microecosystems; microethology, behavior in micro- scopic systems; and microrheology, the science of microcurrents or microcirculation in living cells. All these interactions and visions are not without their symbolism. The chain extends from Policard to his student Bessis and Bessis(cid:146) students Giuliana Moreno and Christian Salet. I would like therefore to introduce some memorabilia of my French connection. In his conversations, Bessis often used to say (cid:147)Mon ma(cid:238)tre Policard avait dit(cid:133)(cid:148) Thus I have found it appropriate to include here a facsimile of Policard(cid:146)s book cover and his dedication to Moreno (Figure I and Figure II). In the last year of his life, Bessis attempted the realization of one of Policard(cid:146)s dreams, the founding of a center for microecological studies, as documented by the letter announcing the news of his untimely death (Figure V). At this juncture it seems pertinent to recall a very special tradition in the life of French academicians: the award of an academic sword to new members of the French Academy of Science on the occasion of their joining this august assembly. As expressed in the address at the occasion of this award, the academic sword carries the aura of aristocracy: the aristocracy of talent and spirit. As the emblem of a certain spirit, the sword expresses ornamental prodigality, beauty of material, voluptuousness of form, and artistic creativity. Scienti(cid:222)c friends and colleagues of the recipient from all over the world are asked to contribute components that are then artistically combined in the design of the sword (Figure III, Figure IV). 1440_C00.fm Page vi Wednesday, November 19, 2003 7:33 AM FIGURE I Front cover of Professor Albert Policard’s book. Policard has been the innovator and the promoter who started this unbroken chain of scienti(cid:222)c endeavors. The path goes from cellular ultrastructure to cellular pathology, imaging of organelles in living cells in the dynamic context of physiopathological processes, to the triple disciplines of microecology(cid:150)microethology(cid:150)microrheology. The current book of (cid:223)uorescent cell organelles is a precursor that should lead to further questions and works, leading to subsequent books on cellular pathology and cellular pharmacology. 1440_C00.fm Page vii Wednesday, November 19, 2003 7:33 AM FIGURE II Professor Albert Policard’s dedication to second-generation researcher Giuliana Moreno. 1440_C00.fm Page viii Wednesday, November 19, 2003 7:33 AM FIGURE III Professor Marcel Bessis(cid:146) academic sword. 1440_C00.fm Page ix Wednesday, November 19, 2003 7:33 AM FIGURE IV The book on Professor Marcel Bessis(cid:146) academic sword.
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