Atlas of Alzheimer's Disease

159 Pages·2007·11.58 MB·English

by  Howard Feldman

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Atlas of Alzheimer’s Disease
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Atlas of Alzheimer’s Disease
Edited by
Howard H Feldman MD FRCP(C)
Professor and Head, Division of Neurology,
Department of Medicine, University of British Columbia
and
Director, UBC Hospital Clinic for Alzheimer’s Disease and Related Disorders,
Vancouver, British Columbia, Canada
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© 2007 Informa UK Ltd
First published in the United Kingdom in 2007 by Informa Healthcare, Telephone House, 69-77 Paul Street, London EC2A 4LQ. Informa
Healthcare is a trading division of Informa UK Ltd. Registered Office: 37/41 Mortimer Street, London W1T 3JH. Registered in England and Wales
number 1072954.
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to acknowledge in subsequent reprints or editions any omissions brought to our attention.
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responsibility rests with the prescribing physician. Neither the publishers nor the authors can be held responsible for errors or for any consequences
arising from the use of information contained herein. For detailed prescribing information or instructions on the use of any product or procedure
discussed herein, please consult the prescribing information or instructional material issued by the manufacturer.
A CIP record for this book is available from the British Library.
Library of Congress Cataloging-in-Publication Data
Data available on application
ISBN-10: 0 415 39045 1
ISBN-13: 978 0 415 39045 3
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Dedication
This book is dedicated to all of the patients, and families that we have served at the UBC Hospital Clinic for
Alzheimer’s Disease and Related Disorders for the past 25 years. It has been your inspiration that continually
motivates us to advance our research and clinical acumen that we may provide ever better care to you.
The authors also express their appreciation to all of the current and past staff at the Clinic for their helpful support
and collaborations over many years.
The editor gratefully acknowledges the support of his wife Gail and his children Ben and Samantha without whose
understanding and patience this book would certainly have not been possible.
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Contents
List of contributors ix
Foreword xi
Serge Gauthier
Preface xiii
1. Historical concepts of Alzheimer’s disease and dementia 1
Jacob Grand and Howard H Feldman
2. Epidemiology of Alzheimer’s disease and dementia 27
Ging-Yuek Robin Hsiung
3. The diagnosis of Alzheimer’s disease and dementia 41
Najeeb Qadi and Howard H Feldman
4. Pathophysiology of Alzheimer’s disease 59
Najeeb Qadi, Sina Alipour, and B Lynn Beattie
5. Neuropathology of Alzheimer’s disease 71
Ian RA Mackenzie
6. Prevention of Alzheimer’s disease 83
Claudia Jacova, Benita Mudge, and Michael Woodward
7. Treatment of Alzheimer’s disease 105
Najeeb Qadi, Michele Assaly, and Philip E Lee
8. Alzheimer’s disease: the future 125
Joyce Lin H Yeo and Howard H Feldman
Index 137
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Contributors
Sina Alipour BSc Philip E Lee MDFRCP(C)
Research Assistant, Division of Neurology, Department of Assistant Professor, Division of Geriatric Medicine,
Medicine, University of British Columbia, Vancouver, Department of Medicine, University of British Columbia; and
BC, Canada Providence Health Care, Vancouver, BC, Canada
Michele Assaly MA Ian RA Mackenzie MDFRCP(C)
Research Coordinator, UBC Hospital Clinic for Alzheimer’s Professor, Department of Pathology, Vancouver General
Disease and Related Disorders, Vancouver, BC, Canada Hospital, University of British Columbia, Vancouver, BC,
Canada
B Lynn Beattie MDFRCP(C)
Professor Emeritus, Division of Geriatric Medicine, Benita Mudge BSc
Department of Medicine, University of British Columbia; and Research Coordinator, UBC Hospital Clinic for Alzheimer’s
UBC Hospital Clinic for Alzheimer’s Disease and Related Disease and Related Disorders, UBC Hospital, Vancouver,
Disorders, Vancouver, BC, Canada BC, Canada
Howard H Feldman MDFRCP(C) Najeeb Qadi MD
Professor and Head, Division of Neurology, Department of Clinical Fellow, Division of Neurology, Department of
Medicine, University of British Columbia; and, Director, Medicine, University of British Columbia, Vancouver, BC,
UBC Hospital Clinic for Alzheimer’s Disease and Related Canada
Disorders, Vancouver, BC, Canada
Michael Woodward MD
Jacob Grand BSc Associate Professor, Director, Aged Care Services, Austin
Research Assistant, Division of Neurology, Department of Health, University of Melbourne, Melbourne, Australia
Medicine, University of British Columbia, Vancouver,
Joyce Lin H Yeo MD
BC, Canada
Clinical Research Fellow, Division of Neurology, Department
Ging-Yuek Robin Hsiung MDMHSc FRCP(C) of Medicine, University of British Columbia, Vancouver, BC,
Assistant Professor, Division of Neurology, Department of Canada
Medicine, University of British Columbia and Providence
Health Care, Vancouver, BC, Canada
Claudia Jacova PhD
Assistant Professor, Division of Neurology, Department of
Medicine, University of British Columbia, Vancouver,
BC, Canada
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