Aspects of Praematurity and Dysmaturity: Groningen 10–12 May 1967

364 Pages·1968·11.89 MB·English

by  John W. Reynolds (auth.), J. H. P. Jonxis M.D., H. K. A. Visser M.D., J. A. Troelstra M.D. (eds.)

ASPECTS OF PRAEMATURITY AND DYSMATURITY
Nu tricia Symposium
ASPECTS OF PRAEMATURITY AND
DYSMATURITY
Groningen IO-12 May 1967
EDITORS:
J. H. P. JO NXIS, M.D., H. K. A. VISSER, M.D. AND
J. A. TROELSTRA, M.D.
19 68
H. E. STENFERT KROESE N.V. - LEIDEN
COPYRIGHT 1968
SOFTCOVER REPRINT OF THE HARDCOVER 1ST EDITION 1968
BY H. E. STENFERT KROESE N.V.
LEIDEN, HOLLAND
All rights reserved.
No part of this book may be reproduced in any form,
by print, photop rint, microfilm, or any other means
without written permission from the publisher.
ISBN-13: 978- 94- 010 -3430 -2 e-ISBN-13: 978- 94-010-3428-9
DOl: 10.1007/978-94-010-3428-9
CONTENTS
SESSION I
ROLE OF THE PLACENTA
J. W. REYNOLDS, Aspects of steroid metabolism in the foetoplacental
unit and the newborn infant . . . . . . . . . . . . . . .. 3
P. GRUENWALD, Problems in the pathologic study of the placenta 21
Discussion . . . . . . . . . . 25
SESSION II
ASSESSMENT OF FOETAL DEVELOPMENT
P. GRUENWALD, Growth pattern of the normal and the deprived fetus 37
A. MINKOWSKI, S. SAINT-ANNE DARGASSIES, C. DREYFUs-BRISAC,
J. CL. LARROCHE, J. VIGNAUD and C. AMIEL, The assessment of
foetal age by the examination of the central nervous system . 46
H. C. SCHWARTZ, T. J. GRIBBLE, F. WELLAND, W. NIJHOFF and
J. H. P. JONXIS, Developmental changes in fetal hemoglobin. .. 57
F. SERENI and B. LUPPIS, Developmental changes in liver enzyme
activities with special reference to the perinatal period of life. .. 68
O. KOLDOVSKY, A. HERINGOVA, V.JIRSOVA,J. KRAML, H. PELICHOVA
and J. U HER, Development of enzymes and absorption processes
in the small intestine of human fetus 91
Discussion . . . . . . . . . . . . . . . . . . . . . . . .. 99
SESSION III
·EXPERIMENTAL ASPECTS OF DYSMATURITY
J. S. WIGGLESWORTH, Dysmaturity in the experimental animal. 119
E. M. WIDDOWSON, Effects of prematurity and dysmaturity in animals 127
Discussion . . . . . . . . . . . . . . . . . . . . . . . .. 139
VI CONTENTS
SESSION IV
HEREDITARY AND ENVIRONMENTAL ASPECTS
OF LOW BIRTHWEIGHT
L. O. LUBCHENCO, C. HANSMAN and L. BACKSTROM, Factors influen-
cing fetal growth . . . . . . . . . . . 149
M. OUNSTED, The regulation of foetal growth 167
Discussion . . . . . . . . . . . . . . . 189
SESSION V
ADAPTATION OF THE LOW BIRTHWEIGHT INFANT
TO EXTRA-UTERINE LIFE
J. H. P. JONXIS, J. J. VAN DER VLUGT, C. J. DE GROOT, E. R. BOERSMA
and E. D. K. MEI]ERS, The metabolic rate in praemature, dysma-
ture and sick infants in relation to environmental temperature. . 201
R. SCHWARTZ, P. A.J. ADAM, K. KING and D. KORNHAUSER, Glucose
control in the newborn infant. . . . . . . . . . . . . . .. 210
S. J. STRICH, Neuropathological findings in severe neonatal hypogly-
caemia with remarks concerning lesions due to hypoxia. . . . . 228
J. I. DE BRUI]NE, Hyperbilirubinaemia in dysmature versus premature
infants. 235
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . 245
SESSION VI
OBSTETRICAL AND PREVENTIVE ASPECTS OF DYSMATURITY
G. J. KLOOSTERMAN, The obstetrician and dysmaturity 263
Discussion . . . . . . . . . . . . . . . . . . . 281
SESSION VII
DEVELOPMENTAL ASPECTS
C. M. DRILLIEN, Causes of handicap in the low weight infant 287
H. F. R. PRECHTL, Neurological findings in newborn infants after pre-
and paranatal complications 303
Discussion . . . . . . . . . . . . . . . . . . . . . . . . . 323
CONTENTS VII
CLOSING SESSION
SUMMING-UP AND GENERAL DISCUSSION
Summing-up by H. K. A. VISSER . . 331
Summing-up by G. J. KLOOSTERMAN. 337
General discussion. . . . . . . 339
Summing-up by N. C. R. RA.IHA 341
Summing-up by R. SCHWARTZ 342
General discussion. . . . . . 344
Summing-up by A. MINKOWSKI 345
Index of authors 349
Index of subjects 352
I
LIST OF PARTICIPANTS
Mme. D. BLUM-BRACHET, Clinique de Medecine Infantile, Hopital
Universitaire St. Pierre, Bruxelles.
J. H. VAN BOLHUIS, Dept. of Paediatrics, St. Joseph's Hospital, Deventer
J. I. DE BRUIJNE, Dept. of Physiology and Pathology of the Newborn,
University of Amsterdam
C. B. F. DAAMEN, Laboratory of Pathology, Dijkzigt Hospital, Rotterdam
N. J. DELBEKE, Dept. of Paediatrics, State University, Gent
M. DlWANY, Children's Hospital, Mounira, Cairo
J. DODION-FRANSEN, Clinique de Medecine Infantile, Hopital Universitaire
St. Pierre, Bruxelles
C. DREYFUs-BRISAC, Centre de Recherches Biologiques Neonatales, Hopital
de Port-Royal, Paris
C. DRILLIEN, Dept. of Child Life and Health, University of Edinburgh
A. C. DROGENDIJK, Dept. of Obstetrics, Vrije Universiteit, Amsterdam
E. EGGERMONT, Lab. de Chimie Physiologique, Universite de Louvain
J. ENGELHARDT, Dept. of Paediatrics, Zuiderziekenhuis, Rotterdam
R. FRANQOIS, Clinique de Pediatrie, Hopital Edouard Herriot, Lyon
P. GRUENWALD, Dept. of Pathology, Sinai Hospital of Baltimore
R. GRUTTNER, Dept. of Paediatrics, State University, Hamburg
P. HADDAD, Maternite Alexandre Khoury, Beirut
P. G. HART, Dept. of Obstetrics, State University, Utrecht
R. HEFFINCK, Paediatrician, Aalst, Belgium
J. JANSSENS, Dept. of Obstetrics, Vrije Universiteit, Amsterdam
J. H. P.JONXIS, Dept. of Paediatrics, State University, Groningen
L. A. JOOSSE, Dept. of Obstetrics, State University, Groningen
B. E. KINGMA, Wilhelmina Children's Hospital, Utrecht
G. J. KLOOSTERMAN, Dept. of Obstetrics, University of Amsterdam
O. KOLDOVSKY, Laboratory of Developmental Nutrition, Prague
F. KUIPERS, Emma Children's Hospital, Amsterdam
A. LAMBRECHTS, Clinique et Policlinique des Maladies d'Enfance, Hopital
de Baviere, Liege
R. DE LEEUW, Dept. of Paediatrics, University of Amsterdam
H. LOEB, Clinique de Medecine Infantile, Hopital Universitaire St. Pierre,
Bruxelles
x LIST OF PARTICIPANTS
L. O. LUBCHENCO, Dept. of Paediatrics, Medical Center, University of
Colorado, Denver
B. LUPPIS, Dept. of Paediatrics, University of Milano
A. S. MA]A], Augusta Victoria Hospital, Jerusalem
J. L. MASTBOOM, Dept. of Obstetrics, Catholic University, Nijmegen
N. MATSANIOTIS, Dept. of Paediatrics, University of Athens
A. MINKOWSKI, Centre de Recherches Biologiques Neonatales, Hopital de
Port-Royal, Paris
N. NICOLOPOULOS, Children's Hospital Aghia Sophia, Athens
M. OUNSTED, Nuffield Dept. of Obstetrics and Gynaecology, Radcliffe
Infirmy, Oxford
C. PAPADATOS, Dept. of Paediatrics, University of Athens
H. F. R. PRECHTL, Dept. of Developmental Neurology, State University,
Groningen
N. C. R. RAIHA, Dept. of Paediatrics, University of Helsinki
R. RAPPAPORT, Hopital des Enfants Malades, Paris
J. W. REYNOLDS, c/o Hormonlaboratoriet, Karolinska Sjukhuset, Stockholm
J. H. Ruys, Dept. of Paediatrics, State University, Leiden
A. L. C. SCHMIDT, Dept. of Obstetrics, Dijkzigt Ziekenhuis, Rotterdam
E. D. A. M. SCHRETLEN, Dept. of Paediatrics, Catholic University, Nijmegen
H. SCHWARTZ, Dept. of Pediatrics, Stanford Medical School, Palo Alto
R. SCHWARTZ, Dept. of Pediatrics, Cleveland Metropolitan General
Hospital, Cleveland
F. SERENI, Dept. of Paediatrics, University of Milano
A. SIKKEL, Dept. of Obstetrics, State University, Leiden
T. D. STAHLIE, Dept. of Paediatrics, Vrije Universiteit, Amsterdam
H. STOLLEY, Institute of Research for Children's Nutrition, Dortmund
S. J. STRICH, Institute of Psychiatry, Dept. of Neurology, London
W. SWOBODA, Children's Hospital, Vienna
J. A. TROELSTRA, Dept. of Paediatrics, State University, Groningen
T. VALAES, The Anne-Marie Institute of Child Health, Athens
G. H. M. VEENEKLAAS, Dept. Paediatrics, State University, Leiden
W. VERHOEVEN, Nutricia Co., Zoetermeer
H. K. A. VISSER, Dept. of Paediatrics, Medical School, Rotterdam
E. M. WIDDOWSON, Medical Research Council, Infant Nutrition Research
Division, University of Cambridge
J. S. WIGGLESWORTH, Dept. of Child Health, Hammersmith Hospital.
London
J. C. H. N. WI]FFELS, Dept. of Paediatrics, University of Amsterdam
W. VAN ZEBEN, Juliana Children's Hospital, The Hague
OPENING
PROF. DR. J. H. P. JONXIS
I am happy to welcome you at this second Nutricia Symposium and I
am glad that you all arrived safely here in Groningen. The first
Nutricia Symposium dealt with a related subject. I see some faces
belonging to participants of that meeting and many new ones. I hope
that we shall have as good a time as we had three years ago here.
When I look around I see a group of very quiet people in front of
me. Yet we are interested in revolutions, for we are studying the most
revolutionary moment in mammalian life: birth. In all forms of
mammals, whether small or large litters are concerned, or animals
born more or less maturely or praematurely, each time birth is a
very dangerous moment in the surviving of the species. In the human
being, especially in recent years, birth has become a rather safe
event thanks to our neighbours, the obstetricians. Still many of us
doubt whether always the nervous central system ends up completely
undamaged whereas that very system is the most precious possession
of man. So there are also in man still many problems about birth
we might discuss. I hope that this meeting will not only be one where
we enjoy ourselves and that opens possibilities to exchange scientific
views, but also one of some practical results.