Artificial Intelligence in Medicine: 15th Conference on Artificial Intelligence in Medicine, AIME 2015, Pavia, Italy, June 17-20, 2015. Proceedings PDF
Preview Artificial Intelligence in Medicine: 15th Conference on Artificial Intelligence in Medicine, AIME 2015, Pavia, Italy, June 17-20, 2015. Proceedings
John H. Holmes · Riccardo Bellazzi Lucia Sacchi · Niels Peek (Eds.) 5 Artificial Intelligence 0 1 9 I in Medicine A N L 15th Conference on Artificial Intelligence in Medicine, AIME 2015 Pavia, Italy, June 17–20, 2015 Proceedings 123 Lecture Notes in Artificial Intelligence 9105 Subseries of Lecture Notes in Computer Science LNAISeries Editors RandyGoebel UniversityofAlberta,Edmonton,Canada YuzuruTanaka HokkaidoUniversity,Sapporo,Japan WolfgangWahlster DFKIandSaarlandUniversity,Saarbrücken,Germany LNAIFoundingSeries Editor JoergSiekmann DFKIandSaarlandUniversity,Saarbrücken,Germany Moreinformationaboutthisseriesathttp://www.springer.com/series/1244 · John H. Holmes Riccardo Bellazzi · Lucia Sacchi Niels Peek (Eds.) Artificial Intelligence in Medicine 15th Conference on Artificial Intelligence in Medicine, AIME 2015 Pavia, Italy, June 17–20, 2015 Proceedings ABC Editors JohnH.Holmes LuciaSacchi UniversityofPennsylvania UniversityofPavia Philadelphia Pavia Pennsylvania Italy USA RiccardoBellazzi NielsPeek UniversityofPavia UniversityofManchester Pavia Manchester Italy UK ISSN 0302-9743 ISSN1611-3349 (electronic) LectureNotesinArtificialIntelligence ISBN 978-3-319-19550-6 ISBN978-3-319-19551-3 (eBook) DOI10.1007/978-3-319-19551-3 LibraryofCongressControlNumber:2015940570 LNCSSublibrary:SL7–ArtificialIntelligence SpringerChamHeidelbergNewYorkDordrechtLondon (cid:2)c SpringerInternationalPublishingSwitzerland2015 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthe material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformationstor- age and retrieval, electronic adaptation, computer software, orbysimilar ordissimilar methodology now knownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher, theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthisbook arebelievedtobetrueandaccurateatthedateofpublication. Neitherthepublishernortheauthorsorthe editorsgiveawarranty,expressorimplied,withrespecttothematerialcontainedhereinorforanyerrorsor omissionsthatmayhavebeenmade. Printedonacid-freepaper SpringerInternationalPublishingAGSwitzerlandispartofSpringerScience+BusinessMedia (www.springer.com) Preface The EuropeanSocietyforArtificialIntelligencein Medicine(AIME)wasestablished in1986followingaverysuccessfulworkshopheldinPavia,Italy,theyearbefore.The principal aims of AIME are to foster fundamental and applied research in the appli- cation of artificial intelligence (AI) techniquesto medical care and medical research, andto providea forumatbiennialconferencesfordiscussinganyprogressmade.For thisreasonthemainactivityofthesocietywastheorganizationofaseriesofbiennial conferences, held in Marseilles, France (1987), London,UK (1989), Maastricht, The Netherlands (1991), Munich, Germany (1993), Pavia, Italy (1995), Grenoble, France (1997),Aalborg,Denmark(1999),Cascais, Portugal(2001),Protaras,Cyprus(2003), Aberdeen,UK(2005),Amsterdam,TheNetherlands(2007),Verona,Italy(2009),Bled, Slovenia (2011),and Murcia, Spain (2013).This volume contains the proceedingsof AIME2015,the15thConferenceonArtificialIntelligenceinMedicine,heldinPavia, Italy,June17–20,2015. TheAIME2015goalsweretopresentandconsolidatetheinternationalstateofthe artofAIinbiomedicalresearchfromtheperspectivesoftheory,methodology,systems, and applications. AIME 2015 focused on AI methods and approachesto address big biomedicaldatachallenges.Theconferenceincludedtwoinvitedlectures,fullandshort papers,tutorials,workshops,andadoctoralconsortium. In the conference announcement, authors were invited to submit original contri- butions regarding the development of theory, methods, systems, and applications for solvingproblemsinthebiomedicalfield,includingAIapproachesinbiomedicalinfor- matics,molecularmedicine,andhealth-careorganizationalaspects.Authorsofpapers addressingtheorywererequestedtodescribethepropertiesofnovelAImodelspoten- tiallyusefulforsolvingbiomedicalproblems.Authorsofpapersaddressingtheoryand methodswereaskedtodescribethedevelopmentortheextensionofAImethods,toad- dresstheassumptionsandlimitationsoftheproposedtechniques,andto discusstheir noveltywith respectto the state of the art. Authorsof papersaddressing systemsand applicationswereaskedtodescribethedevelopment,implementation,orevaluationof newAI-inspiredtoolsandsystemsinthebiomedicalfield.Theywereaskedtolinktheir worktounderlyingtheory,andeitheranalyzethepotentialbenefitstosolvebiomedical problemsorpresentempiricalevidenceofbenefitsinclinicalpractice. AIME2015received110abstractsubmissions,99thereofwereeventuallysubmit- ted as complete papers. Submissions came from 25 countries, including five outside Europe. All papers were carefully peer-reviewed by experts from the Program Com- mittee with the supportof additionalreviewers. Each submission was reviewed by at leasttwo,andinmostcasesthreereviewers.Thereviewersjudgedtheoverallqualityof thesubmittedpapers,togetherwiththeirrelevancetotheAIMEconference,technical correctness,noveltywithrespecttostateoftheart,scholarship,andqualityofpresenta- tion.Inaddition,thereviewersprovideddetailedwrittencommentsoneachpaper,and statedtheirconfidenceinthesubjectarea. VI Preface AsmallcommitteeconsistingoftheAIME2015ScientificChairJohnH.Holmes, theLocalOrganizationCo-chairsRiccardoBellazziandLuciaSacchi,andNielsPeek, DoctoralConsortiumChairandAIME2013ScientificChair,madethefinaldecisions regardingtheAIME2015scientificprogram.Thisprocessbeganwithvirtualmeetings heldweeklystartinginJanuary2015.Theprocessendedwithaface-to-facemeetingof thecommitteeinPaviatoassemblethefinalprogram. As a result, 19 long papers(with an acceptance rate of 25%) and 24 short papers were accepted. Each long paper was presented in a 25-minute oral presentation dur- ingtheconference.Eachshortpaperwaspresentedina 5-minutepresentationandby a poster. The papers were organized according to their topics in the following main themes: (1) Data Mining and Machine Learning; (2) Knowledge Representation and Guidelines; (3) Prediction in Clinical Practice; (4) Process Mining and Phenotyping; (5)TemporalDataMining;(6)TextMining;and(7)UncertaintyandBayesianMeth- ods. AIME2015hadtheprivilegeofhostingtwoinvitedspeakers:GeorgeM.Hripcsak, fromColumbiaUniversity,USA, andGoran Nenadic,fromthe Universityof Manch- ester,UK. GeorgeHripcsakdiscussedtheimportanceofdealingwiththetemporalna- tureoftheelectronicmedicalrecordinusingthesedataforstudies.Hecalledforfurther study ofthe “physicsofthe medicalrecord,”health-careprocesses,andnew methods foranalyzingelectronicmedicalrecorddata.GoranNenadic’skeynotefocusedonthe useofandchallengespresentedbytextminingofhealthdatafromavarietyofsources, includingthe medicalrecordaswell aspatient-generateddata.He called forthe inte- gration of spatiotemporaland reasoning under uncertainly models to be incorporated intothetextminingparadigm. TheDoctoralConsortiumprovidedanopportunityforsixPhDstudentstopresent theirresearchgoals,proposedmethods,andpreliminaryresults.Ascientificpanelcon- sistingofexperiencedresearchersinthefield(AmeenAbu-Hanna,JohnHolmes,José Juarez,GoranNenadic,DavidRiaño,LuciaSacchi,StephenSwift,Annetteten Teije, and Blaz Zupan)providedconstructivefeedbackto the studentsin an informalatmo- sphere.TheDoctoralConsortiumwaschairedbyNielsPeek. Three full-day workshopswere organizedafter the AIME 2015 main conference. Theseincludedthe7thInternationalWorkshoponKnowledgeRepresentationforHealth Care (KRH4C) and the 8th International Workshop on Process-oriented Information Systems in Healthcare (ProHealth), joined together for the first time at AIME 2015. ThisworkshopincludedakeynoteaddresspresentedbyRobertGreenesfromArizona State University, “Evolution and Revolution in Knowledge-Driven Health IT: A 50- Year Perspective and a Look Ahead.” This workshop was chaired by Richard Lenz, Silvia Miksch, Mor Peleg, Manfred Reichert, David Riaño, and Annette ten Teije. A secondfull-dayworkshopwastheFirstWorkshoponMatrixComputationsforBiomed- icalInformatics,chairedbyRiccardoBellazzi,JimengSun,andPingZhang.Thethird workshopwas the 4th InternationalWorkshopon Artificial Intelligenceand Assistive Medicine,chairedbyConstantineSpyropoulosandAldoFrancoDragoni. Inadditiontotheworkshops,threeinteractivetutorialswerepresentedpriortothe AIME2015mainconference:“Data FusionofEverything”(MarinkaZitnikandBlaz Zupan, University of Ljubljana, Slovenia); “Big Data Analytics for Healthcare” (Ji- meng Sun, Georgia Institute of Technology); and “Evaluation of Prediction Models Preface VII in Medicine” (Ameen Abu-Hanna,Academic Medical Center, Amsterdam, and Niels Peek,UniversityofManchester). We wouldlike to thank everyonewho contributedto AIME 2015.First of all, we would like to thank the authorsof the papers submitted and the membersof the Pro- gram Committee together with the additional reviewers. Thanks are also due to the invitedspeakersaswellastotheorganizersoftheworkshopsandthetutorialanddoc- toral consortium. Many thanks go to the local Organizing Committee, who managed all the work making this conference possible. The free EasyChair conference system (http://www.easychair.org/)wasanimportanttoolsupportingusinthemanagementof submissions,reviews,selectionofacceptedpapers,andpreparationoftheoverallma- terialforthefinalproceedings.WewouldliketothanktheUniversityofPavia,which hostedAIME2015,andoursponsors,whosogenerouslysupportedtheconference. Finally, we thank the Springer team for helpingus in the final preparationof this LNCSbook. June2015 JohnH.Holmes RiccardoBellazzi LuciaSacchi NielsPeek Organization ProgramCommittee SyedSibteRazaAbidi DalhousieUniversity,Canada AmeenAbu-Hanna AcademicMedicalCenter, UniversityofAmsterdam,TheNetherlands KlausPeterAdlassnig MedicalUniversityofVienna,Austria RiccardoBellazzi UniversityofPavia,Italy BrianChapman UniversityofUtah,USA CarloCombi UniversitàdegliStudidiVerona,Italy AmarDas DartmouthInstitute,USA MichelDojat INSERM,France PauloFelix USC,Spain CatherineGarbay CNRS-LIG,France AdelaGrando ArizonaStateUniversity,USA MilosHauskrecht UniversityofPittsburgh,USA JohnHolmes UniversityofPennsylvania,USA ArjenHommersom UniversityofNijmegen,TheNetherlands ValJones UniversityofTwente,TheNetherlands JoseM.Juarez UniversityofMurcia,Spain KatharinaKaiser UniversityofAppliedSciencesSt.Poelten,Austria ElpidaKeravnou-Papailiou UniversityofCyprus,Cyprus PedroLarranaga UniversityofMadrid,Spain NadaLavracˇ JozefStefanInstitute,Slovenia HelenaLindgren UmeåUniversity,Sweden PeterLucas RadboudUniversityNijmegen,TheNetherlands MarMarcos UniversitatJaumeI,Spain MichaelMarschollek PeterL.ReichertzInstitutsfürMedizinische Informatik,Germany RoqueMarín UniversityofMurcia,Spain PaolaMello UniversityofBologna,Italy SilviaMiksch ViennaUniversityofTechnology,Austria StefaniaMontani UniversityPiemonteOrientale,Italy BarbaraOliboni UniversityofVerona,Italy NielsPeek CentreforHealthInformatics MorPeleg UniversityofHaifa,Israel ChristianPopow MedicalUniversityofVienna,Austria SilvanaQuaglini UniversityofPavia,Italy X Organization DavidRiaño UniversitatRoviraiVirgili,Spain PedroRodrigues UniversityofPorto,Portugal LuciaSacchi UniversityofPavia,Italy StefanSchulz MedicalUniversityofGraz,Austria BrigitteSeroussi AssistancePublique-HôpitauxdeParis,France YuvalShahar BenGurionUniversity,Israel BrettSouth UniversityofUtah,USA ConstantineSpyropoulos NCSRDemokritos,Greece GregorStiglic UniversityofMaribor,Slovenia AnnetteTenTeije VrijeUniversiteitAmsterdam,TheNetherlands PaoloTerenziani UniversityofTurin,Italy SamsonTu StanfordUniversity,USA AllanTucker BrunelUniversity,UK FrankVanHarmelen VrijeUniversiteitAmsterdam,TheNetherlands AlfredoVellido UniversitatPolitecnicadeCatalunya,Spain DongwenWang BiomedicalInformaticsProgram SzymonWilk PoznanUniversityofTechnology,Poland BlazZupan UniversityofLjubljana,Slovenia PierreZweigenbaum LIMSI-CNRS,France Additional Reviewers Anselma,Luca Krithara,Anastasia Bacelar-Silva,Gustavo Liu,Manxia Bohanec,Marko Liu,Zitao Bonfietti,Alessio Lombardi,Michele Bottrighi,Alessio Martinez-Salvador,Begoña Bueno,MarcosLuizDePaula Mowery,Danielle Büsching,Felix Orphanou,Kalia Campos,Manuel Riguzzi,Fabrizio Chapman,Wendy Sa-Couto,Carla Chesani,Federico Sarker,Abeed Dias,ClaudiaCamila Sernani,Paolo Dragoni,AldoFranco Seyfang,Andreas Ferrandez,Oscar Skeppstedt,Maria Fung,Nick Smailovic,Jasmina Gamberger,Dragan Stassopoulou,Athena Giannakopoulos,George Teijeiro,Tomás Giannakopoulos,Theodoros Torres-Sospedra,Joaquín Haarbrandt,Birger vanderHeijden,Maarten Hong,Charmgil Vavpetic,Anze Huang,Zhisheng Wenzina,Reinhardt Jiang,Guoqian
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