Arthritis and Allied Conditions; A Textbook of Rheumatology (14th Ed.) – Lippincott Williams & Wilkins

1530 Pages·2016·27.33 MB·English

by  McCarty D.J.

Arthritis and Allied Conditions: A Textbook of Rheumatology 12th edition: by Daniel J. McCarty, William J. Koopman By Lea & Febiger Publishers
By OkDoKeY
Arthritis and Allied Conditions
CONTENTS
Contributing Authors
Foreword
Preface
Acknowledgments
VOLUME ONE
I. INTRODUCTION TO THE STUDY OF THE RHEUMATIC DISEASES
Chapter 1 Epidemiology of the Rheumatic Diseases
David T. Felson
Chapter 2 Differential Diagnosis of Arthritis: Analysis of Signs and Symptoms
Daniel J. McCarty
Chapter 3 Clinical Evaluation in the Rheumatic Diseases
Nicholas Bellamy and W. Watson Buchanan
Chapter 4 Synovial Fluid
Daniel J. McCarty
Chapter 5 Arthroscopy
Kenneth C. Kalunian, Paul H. Brion, and Larry W. Moreland
Chapter 6 Magnetic Resonance Imaging in Arthritis
Charles G. Peterfy and Harry K. Genant
II. SCIENTIFIC BASIS FOR THE STUDY OF THE RHEUMATIC DISEASES
Chapter 7 Structure and Function of Joints
Eric L. Radin
Chapter 8 Synovial Physiology
Peter A. Simkin
Chapter 9 What Is a Collagen?
Richard Mayne
Chapter 10 Structure, Function, and Biology of Joint Proteoglycans
John R. Couchman
Chapter 11 Cartilage in Health and Disease
A. Robin Poole
Chapter 12 Structure and Function of Synoviocytes
Ulf MÜller-Ladner, Renate E. Gay, Steffen Gay
Chapter 13 Immunoglobulins and Their Genes
Harry W. Schroeder, Jr.
Chapter 14 Structure and Function of Monocytes/Macrophages and Other Antigen-Presenting Cells
Mary K. Crow
Chapter 15 Structure and Function of Lymphocytes
Robert H. Carter and Casey T. Weaver
Chapter 16 Structure and Function of Neutrophils
Mark R. Philips and Bruce N. Cronstein
Chapter 17 Eosinophil Structure and Function
Peter F. Weller
Chapter 18 Mast Cells and Rheumatic Diseases
Barry L. Gruber and Allen P. Kaplan
Chapter 19 Platelets in Rheumatic Diseases
Mansoor N. Saleh and Albert F. Lobuglio
Chapter 20 Cytokines and Their Receptors
Martin K. Lotz
Chapter 21 Cell Adhesion Molecules in the Rheumatic Diseases
Christopher G. Kevil and Daniel C. Bullard
Chapter 22 Molecular Biology of the Complement System
John E. Volanakis
Chapter 23 Acute-Phase Proteins in Rheumatic Disease
John E. Volanakis
Chapter 24 Eicosanoids
Charles N. Serhan
Chapter 25 Nitric Oxide and Related Compounds
Gary S. Gilkeson
Chapter 26 Characteristics of Immune Complexes and Principles of Immune Complex Diseases
Robert P. Kimberly
Chapter 27 Apoptosis and Autoimmunity
John D. Mountz and Tong Zhou
Chapter 28 Structure, Function, and Genetics of the Hla Complex in Rheumatic Disease
Barbara S. Nepom
Chapter 29 Genetic Basis of Rheumatic Disease
John B. Harley and Courtney Gray-McGuire
Chapter 30 Arthritis and Autoimmunity in Animals
Leslie J. Crofford and Ronald L. Wilder
Chapter 31 Infectious Agents in Chronic Rheumatic Diseases
Robert D. Inman, Andras Perl, and Paul E. Phillips
III. THERAPEUTIC APPROACHES IN THE RHEUMATIC DISEASES
Chapter 32 Aspirin and Other Nonsteroidal Antiinflammatory Drugs
Daniel E. Furst and Jan Hillson
Chapter 33 Gold and D-Penicillamine
W. Winn Chatham
Chapter 34 Antimalarial Drugs
Robert I. Fox
Chapter 35 Methotrexate: Its Use for the Treatment of Rheumatoid Arthritis and Other Rheumatic Disorders
Graciela S. Alarcón
Chapter 36 Sulfasalazine and Minocycline
Christopher G. Jackson and Daniel O. Clegg
Chapter 37 Leflunomide
Joel M. Kremer and Robert I. Fox
Chapter 38 Cytotoxic Drugs
Allen D. Sawitzke and Grant W. Cannon
Chapter 39 Combination Drug Therapy
Michael J. Battistone and H. James Williams
Chapter 40 Corticosteroids
Dimitrios T. Boumpas and Ronald L. Wilder
Chapter 41 Arthrocentesis Technique and Intraarticular Therapy
Gerald F. Moore
Chapter 42 Cyclosporine and Other Experimental Immunomodulatory Agents
David E. Yocum
Chapter 43 Biologic Response Modifiers for Treating Musculoskeletal Disorders
Larry W. Moreland and William J. Koopman
Chapter 44 Bone Marrow Transplantation or Hematopoietic Stem Cell Transplantation
Lynell W. Klassen
Chapter 45 Gene Therapy for the Rheumatic Diseases
John D. Mountz and Huang-Ge Zhang
Chapter 46 Rehabilitation for Persons with Arthritis and Rheumatic Disorders
Victoria A. Brander and Rowland W. Chang
Chapter 47 Diets, Other Complementary and Alternative Therapies, and the Rheumatic Diseases
Richard S. Panush
IV. SURGICAL INTERVENTION IN THE RHEUMATIC DISEASES
Chapter 48 Surgery of Arthritic Deformities of the Hand
Angela A. Wang and Andrew J. Weiland
Chapter 49 Surgery of Shoulder Arthritis
Shawn W. O’driscoll
Chapter 50 Surgery of Elbow Arthritis
Shawn W. O’driscoll
Chapter 51 Correction of Arthritic Deformities of the Spine
James P. Hollowell and Sanford J. Larson
Chapter 52 Correction of Arthritic Deformities of the Hip
Charles L. Nelson and Robert H. Fitzgerald, Jr.
Chapter 53 Surgical Treatment of Knee Arthritis
John M. Cuckler
Chapter 54 Arthritis of the Foot and Ankle
Greg A. Horton and Charles L. Saltzman
V. RHEUMATOID ARTHRITIS
Chapter 55 Etiology and Pathogenesis of Rheumatoid Arthritis
David A. Fox
Chapter 56 Pathology of Rheumatoid Arthritis and Associated Disorders
Laura P. Hale and Barton F. Haynes
Chapter 57 Mechanisms of Tissue Damage in Rheumatoid Arthritis
Hugo E. Jasin
Chapter 58 Rheumatoid Arthritis: The Clinical Picture
James R. O’dell
Chapter 59 Extraarticular Rheumatoid Arthritis
Harvinder S. Luthra
Chapter 60 Laboratory Findings in Rheumatoid Arthritis
Warren D. Blackburn, Jr. and W. Winn Chatham
Chapter 61 Rheumatoid Factor
S. Louis Bridges, Jr.
Chapter 62 Treatment of Rheumatoid Arthritis
Michael E. Weinblatt
VI. OTHER INFLAMMATORY ARTHRITIS SYNDROMES
Chapter 63 Seronegative Polyarthritis
Jan Tore Gran and Gunnar Husby
Chapter 64 Juvenile Idiopathic Arthritis (Juvenile Rheumatoid Arthritis)
Robert W. Warren, Maria D. Perez, Martha R. Curry, Andrew P. Wilking, and Barry L. Myones
Chapter 65 Treatment of Juvenile Rheumatoid Arthritis
Edward H. Giannini and Ross E. Petty
Chapter 66 Ankylosing Spondylitis
Frank C. Arnett
Chapter 67 Reiter’s Syndrome and Reactive Arthritis
John J. Cush and Peter E. Lipsky
Chapter 68 Psoriatic Arthritis
Robert M. Bennett
Chapter 69 Enteropathic Arthritis
Herman Mielants, Filip De Keyser and Eric M. Veys
Chapter 70 Arthritis and Liver Disease
Joseph Duffy
Chapter 71 Intermittent and Periodic Arthritic Syndromes
Daniel L. Kastner
VOLUME TWO
VII. SYSTEMIC RHEUMATIC DISEASES
Chapter 72 Undifferentiated Connective Tissue Diseases, Overlap Syndromes, and Mixed Connective Tissue Diseases
Morris Reichlin
Chapter 73 Systemic Lupus Erythematosus: Clinical Aspects
Michelle A. Petri
Chapter 74 Autoantibodies in Systemic Lupus Erythematosus
Westley H. Reeves and Minoru Satoh
Chapter 75 Systemic Lupus Erythematosus: Pathogenesis
Karin S. Peterson and Robert J. Winchester
Chapter 76 The Treatment of Systemic Lupus Erythematosus
John D. Reveille
Chapter 77 Antiphospholipid Antibody Syndrome
Robert A. S. Roubey
Chapter 78 Inflammatory Myopathies: Polymyositis, Dermatomyositis, and Related Conditions
Frederick W. Miller
Chapter 79 Systemic Sclerosis (Scleroderma): Clinical Aspects
Thomas A. Medsger, Jr.
Chapter 80 Variant Forms of Scleroderma
Richard M. Silver and Marcy B. Bolster
Chapter 81 Pathogenesis of Systemic Sclerosis
Joseph H. Korn
Chapter 82 Vasculitis
Gene V. Ball and Robert M. Gay, Jr.
Chapter 83 Cerebral Vasculitis
Leonard H. Sigal
Chapter 84 Mimickers of Vasculitis
Kenneth E. Sack
Chapter 85 Sjögren’s Syndrome
Roland Jonsson, Hans-Jacob Haga, and Tom P. Gordon
Chapter 86 Rheumatic Fever: Etiology, Diagnosis, and Treatment
Allan Gibofsky and John B. Zabriskie
Chapter 87 Relapsing Polychondritis
Clement J. Michet
Chapter 88 Polymyalgia Rheumatica and Giant Cell Arteritis
Cornelia M. Weyand and Jörg J. Goronzy
Chapter 89 Pregnancy and Rheumatic Diseases
Michael D. Lockshin
VIII. MISCELLANEOUS RHEUMATIC DISEASE
Chapter 90 Fibromyalgia
Laurence A. Bradley and Graciela S. Alarcón
Chapter 91 Neuropathic Joint Disease (Charcot Joints)
Michael H. Ellman
Chapter 92 Amyloidosis
Merrill D. Benson
Chapter 93 Sarcoidosis
H. Ralph Schumacher, Jr.
Chapter 94 Arthritis Associated with Hematologic Disorders, Storage Diseases, Disorders of Lipid Metabolism, and Dysproteinemias
Louis W. Heck, Jr.
Chapter 95 Heritable and Developmental Disorders of Connective Tissue and Bone
Reed Edwin Pyeritz
Chapter 96 Hypertrophic Osteoarthropathy
Roy D. Altman
IX. REGIONAL DISORDERS OF JOINTS AND RELATED STRUCTURES
Chapter 97 Traumatic Arthritis and Allied Conditions
Robert S. Pinals
Chapter 98 Mechanical Disorders of the Knee
Dennis W. Boulware
Chapter 99 Painful Feet
Joseph J. Biundo and Perry J. Rush
Chapter 100 Cervical Spine Syndromes
Joe G. Hardin, Jr. and James T. Halla
Chapter 101 Temporomandibular Disorders
M. Franklin Dolwick
Chapter 102 Low Back Pain
Nortin M. Hadler
Chapter 103 Spinal Stenosis
J. D. Bartleson and J. Desmond O’duffy
Chapter 104 Fibrosing Syndromes: Dupuytren’s Contracture, Diabetic Stiff Hand Syndrome, Plantar Fasciitis, and Retroperitoneal Fibrosis
Wilmer L. Sibbitt, Jr. and Randy R. Sibbitt
Chapter 105 Nerve Entrapment Syndromes
Nortin M. Hadler
Chapter 106 Tumors of Joints and Related Structures
Juan J. Canoso
Chapter 107 Painful Shoulder and the Reflex Sympathetic Dystrophy Syndrome
Jean G. Gispen
Chapter 108 Osteonecrosis
John Paul Jones, Jr.
X. OSTEOARTHRITIS
Chapter 109 Pathology of Osteoarthritis
Aubrey J. Hough, Jr.
Chapter 110 Etiopathogenesis of Osteoarthritis
Jean-Pierre Pelletier, Johanne Martel-Pelletier, and David S. Howell
Chapter 111 Clinical and Laboratory Findings in Osteoarthritis
Roland W. Moskowitz and Daniel Holderbaum
Chapter 112 Management of Osteoarthritis
Carlos J. Lozada and Roy D. Altman
Chapter 113 Articular Cartilage Repair
Robert L. Sah, Albert C. Chen, Silvia S. Chen, Kelvin W. Li, Michael A. Dimicco, Melissa S. Kurtis, Lisa M. Lottman, and John D. Sandy
XI. METABOLIC BONE AND JOINT DISEASES
Chapter 114 Clinical Gout and the Pathogenesis of Hyperuricemia
Michael A. Becker
Chapter 115 Management of Hyperuricemia
N. Lawrence Edwards
Chapter 116 Pathogenesis and Treatment of Crystal-Induced Inflammation
Robert A. Terkeltaub
Chapter 117 Calcium Pyrophosphate Crystal Deposition Disease, Pseudogout, and Articular Chondrocalcinosis
Ann K. Rosenthal and Lawrence M. Ryan
Chapter 118 Basic Calcium Phosphate (Apatite, Octacalcium Phosphate, Tricalcium Phosphate) Crystal Deposition Diseases and Calcinosis
Paul B. Halverson
Chapter 119 Calcium Oxalate and Other Crystals or Particles Associated with Arthritis
Antonio J. Reginato
Chapter 120 Metabolic Diseases of Muscle
Robert L. Wortmann
Chapter 121 Ochronosis, Hemochromatosis, and Wilson’s Disease
H. Ralph Schumacher, Jr.
Chapter 122 Osteopenic Bone Diseases
Sarah L. Morgan, Kenneth G. Saag, Bruce A. Julian, and Harry Blair
Chapter 123 Paget’s Disease of Bone
Roy D. Altman
Chapter 124 Rheumatic Aspects of Endocrinopathies
Mary E. Cronin
XII. INFECTIOUS ARTHRITIS
Chapter 125 Principles of Diagnosis and Treatment of Joint Infections
Ara H. Dikranian and Michael H. Weisman
Chapter 126 Bacterial Arthritis
Robert W. Ike
Chapter 127 Gonococcal Arthritis and Other Neisserial Infections
Don L. Goldenberg
Chapter 128 Arthritis due to Mycobacteria, Fungi, and Parasites
Maren Lawson Mahowald
Chapter 129 Lyme Disease
Stephen E. Malawista
Chapter 130 Viral Arthritis
Stanley J. Naides
Chapter 131 Retrovirus-Associated Rheumatic Disorders
Luis R. Espinoza and Marta L. Cuéllar
/P>
CONTRIBUTING AUTHORS
Graciela S. Alarcón, M.D., M.P.H. Jane Knight Lowe Professor, Division of Rheumatology, Department of Medicine, University of Alabama, Associate Director,
Multipurpose Arthritis and Musculoskeletal Disease Center, Birmingham, Alabama
Roy D. Altman, M.D. Professor of Medicine and Chief, Director Clinical Research, GRECC, Miami Veterans Affairs Medical Center, Department of Rheumatology
and Immunology, University of Miami Medical Center, Miami, Florida
Frank C. Arnett, M.D. Professor, Department of Internal Medicine, University of Texas-Houston Medical School, Chief, Rheumatology Service, Department of
Internal Medicine, Memorial Hermann Hospital, Houston, Texas
Gene V. Ball, M.D. Professor of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama,
J. D. Bartleson, M.D. Associate Professor, Department of Neurology, Mayo Clinic, Rochester, Minnesota
Michael J. Battistone, M.D. Assistant Professor, Department of Internal Medicine, University of Utah College of Medicine, Staff Physician, Medical Care Center, Salt
Lake City Veterans Affairs Medical Center, Salt Lake City, Utah
Michael A. Becker, M.D. Professor, Department of Medicine, University of Chicago, Chicago, Illinois
Nicholas Bellamy, M.D., F.R.C.P. Director, Centre of National Research on Disability and Rehabilitation Medicine, Department of Medicine, Block 6-F Floor, Royal
Brisbane Hospital, Brisbane, Queensland, Australia
Robert M. Bennett, M.D. Professor, Department of Medicine, Chairman, Division of Arthritis and Rheumatic Disease, Oregon Health Sciences University, Portland,
Oregon
Merrill D. Benson, M.D. Professor, Departments of Medicine and Pathology and Laboratory Medicine, Indiana University School of Medicine, and, Departments of
Medicine and Pathology, Indiana University Medical Center, Indianapolis, Indiana
Joseph J. Biundo, M.D. Chief, Section of Physical Medicine and Rehabilitation, Department of Physical Medicine and Rehabilitation, Louisiana State University
Medical Center, New Orleans, Louisiana
Warren D. Blackburn, Jr., M.D. Clinical Professor, Rheumatology Section VA 111-F, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama
Harry Blair, M.D. Associate Professor, Department of Pathology, The University of Alabama, Birmingham, Alabama
Marcy B. Bolster, M.D. Assistant Professor, Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston,
South Carolina
Dennis W. Boulware, M.D. Professor, Department of Medicine, University of Alabama, Birmingham, Alabama
Dimitrios Boumpas, M.D. Arthritis and Rheumatism Branch, NIAMS, National Institutes of Health, Bethesda, Maryland
Laurence A. Bradley, M.D. Professor of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama
Victoria A. Brander, M.D. Assistant Professor of Physical Medicine and Rehabilitation, Northwestern University Medical School, Director, Arthritis Center,
Rehabilitation Institute of Chicago, Chicago, Illinois
S. Louis Bridges, Jr., M.D., Ph.D. Assistant Professor, Departments of Medicine and Microbiology, University of Alabama, Staff Physician, Departments of Medicine
and Rheumatology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama
Paul H. Brion, M.D. Clinical Instructor, Division of Rheumatology, UCLA School of Medicine, Los Angeles, California
W. Watson Buchanan, M.D. Emeritus Professor and Consultant Physician, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Daniel C. Bullard, Ph.D. Assistant Professor, Department of Comparative Medicine, University of Alabama, Birmingham, Alabama
Grant W. Cannon, M.D. Professor, Division of Rheumatology, Department of Medicine, University of Utah, Associate Chief of Staff for Academic Affiliations, Veterans
Affairs Medical Center, Salt Lake City, Utah
Juan J. Canoso, M.D. Adjunct Professor, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, and, Rheumatologist,
American-British Cowdray Hospital, Mexico City, Mexico
Robert H. Carter, M.D. Associate Professor of Medicine, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama,
Birmingham, Alabama
Rowland W. Chang, M.D., M.P.H. Professor of Preventive Medicine, Medicine and Physical Medicine and Rehabilitation, Northwestern University Medical School,
Chicago, Illinois
W. Winn Chatham, M.D. Associate Professor, Departments of Medicine and Rheumatology, University of Alabama, Staff Physician, Veterans Affairs Medical Center,
Birmingham, Alabama
Albert C. Chen, Ph.D. Post-Doctoral Researcher, Department of Bioengineering, University of California at San Diego, La Jolla, California
Silvia S. Chen, Ph.D. Post-Doctoral Researcher, Department of Bioengineering, University of California at San Diego, La Jolla, California
Daniel O. Clegg, M.D. Professor and Chief, Division of Rheumatology, Department of Medicine, University of Utah School of Medicine, Chief, Rheumatology Section,
Medical Service, Salt Lake City Veterans Affairs Medical Center, Salt Lake City, Utah
John R. Couchman, Ph.D. Professor, Department of Cell Biology, University of Alabama, Birmingham, Alabama
Leslie J. Crofford, M.D. Associate Professor, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan
Mary E. Cronin, M.D. Associate Professor of Medicine Division of Rheumatology, Medical College of Wisconsin, Milwaukee, Wisconsin
Bruce N. Cronstein, M.D. Professor of Medicine and Pathology, Department of Medicine, New York University School of Medicine, New York, New York
Mary K. Crow, M.D. Professor of Medicine, Department of Medicine, Weill Medical College of Cornell University, New York, New York, Attending Physician,
Department of Rheumatology, Hospital for Special Surgery, New York, New York
John M. Cuckler, M.D. Professor and Director, Division of Orthopedics, University of Alabama, Birmingham, Alabama
Marta L. Cuéllar, M.D. Assistant Professor, Section of Rheumatology, Department of Medicine, Tulane University School of Medicine, Tulane Hospital and Clinic,
New Orleans, Louisiana
Martha R. Curry, M.S., R.N.C., P.N.P. Instructor, Division of Rheumatology, Texas Children’s Hospital, Houston, Texas
John J. Cush, M.D. Associate Professor, Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Arthritis Center, Presbyterian
Hospital/Dallas, Dallas, Texas
Filip de Keyser, M.D. Department of Rheumatology, University Hospital, Gent, Belgium
Ara H. Dikranian, M.D. Fellow, Division of Rheumatology, University of California, San Diego, La Jolla, California
Michael A. DiMicco, M.S. Graduate Student, Department of Bioengineering, University of California at San Diego, La Jolla, California
M. Franklin Dolwick, D.M.D., Ph.D. Professor, Department of Oral and Maxillofacial Surgery, University of Florida, Gainesville, Florida
Joseph Duffy, M.D. Associate Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Mayo Medical School, Mayo Clinic, Rochester,
Minnesota
N. Lawrence Edwards, M.D. Professor of Medicine, Department of Medicine, Division of Rheumatology, University of Florida, Gainesville Florida
Michael H. Ellman, M.D. Professor of Clinical Medicine, Department of Medicine, University of Chicago, Chicago, Illinois
Luis R. Espinoza, M.D. Professor and Chief, Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans,
Louisiana
David T. Felson, M.D., M.Ph. Professor, Departments of Medicine and Public Health, Boston University School of Medicine, Boston, Massachusetts
Robert H. Fitzgerald, Jr., M.D. Paul B. Magnuson Professor, Department of Orthopedic Surgery, University of Pennsylvania, Hospital of the University of
Pennsylvania, Philadelphia, Pennsylvania
David A. Fox, M.D. Professor, Department of Internal Medicine, Chief, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan
Robert I. Fox, M.D., Ph.D. Associate Member, Department of Immunology, The Scripps Research Institute, Rheumatologist, Department of Rheumatology, Scripps
Memorial Hospital, La Jolla, California
Daniel E. Furst, M.D. Clinical Professor, Department of Medicine, Division of Rheumatology, University of Washington, Director, Arthritis Clinical Research Unit,
Virginia Mason Research Center, Seattle, Washington
Renate E. Gay, M.D. Chief of Staff, Dean’s Office, Medical Faculty, University of Zurich, Zurich, Switzerland
Robert M. Gay, Jr., M.D. Cornerstone Medical Specialties, High Point, North Carolina
Steffen Gay, M.D. Professor, Department of Rheumatology, University Hospital, Zurich, Switzerland
Harry K. Genant, M.D. Professor of Radiology Medicine, Epidemiology and Orthopaedic Surgery, Department of Radiology, Executive Director, Osteoporosis and
Arthritis Research Group, University of California San Francisco, San Francisco, California
Edward H. Giannini, M.Sc., Dr.PH. Professor, Department of Pediatrics, University of Cincinnati College of Medicine, Clinical Epidemiology, Department of
Rheumatology, Children’s Hospital Medical Center, Cincinnati, Ohio
Allan Gibofsky, M.D. Professor, Departments of Medicine and Public Health, Weill Medical College of Cornell University, Attending Rheumatologist, Department of
Rheumatology, Hospital for Special Surgery, New York, New York
Gary S. Gilkeson, M.D. Associate Professor of Medicine/Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina
Jean G. Gispen, M.D. Private Practice, Internal Medicine Associates, Oxford, Mississippi
Don L. Goldenberg, M.D. Private Practice, Division of Rheumatology, Newton-Wellesley Hospital, Boston, Massachusetts
Tom P. Gordon, M.D., Ph.D. Professor and Director, Department of Immunology, Allergy, and Arthritis, Flinders University of South Australia, Flinders Medical
Centre, Bedford Park, South Australia, Australia
Jörg J. Goronzy, M.D. Professor of Medicine and Immunology, Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota
Jan Tore Gran, M.D. Professor and Head of Department, Department of Rheumatology, University of Tromso, Tromso, Norway
Courtney Gray-McGuire, M.D. Predoctoral Fellow, Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
Barry L. Gruber, M.D. Associate Professor of Medicine and Dermatology, Chief, Division of Rheumatology, State University of New York at Stony Brook, Northport
Veterans Affairs Medical Center, Stony Brook, New York
Nortin M. Hadler, M.D. Professor of Medicine and Microbiology/Immunology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill,
North Carolina
Hans-Jacob Haga, M.D. Professor, Division of Rheumatology, University of Bergen, Consultant, Department of Rheumatology, Haubeland Hospital, Bergen, Norway
Laura P. Hale, M.D. Assistant Professor, Department of Pathology, Duke University Medical Center, Durham, North Carolina
James T. Halla, M.D. Private Practice, Abilene, Texas
Paul B. Halverson, M.D. Professor of Medicine, Department of Rheumatology, Medical College of Wisconsin, Milwaukee, Wisconsin
Joe G. Hardin, Jr., M.D. Professor, Department of Medicine, University of South Alabama, Attending Physician, Department of Medicine, University of South
Alabama Medical Center, Mobile, Alabama
John B. Harley, M.D., Ph.D. Professor, Department of Medicine, Member, Arthritis and Immunology Program, University of Oklahoma, Oklahoma Medical Research
Foundation, Staff Physician, Medical Service, U.S. Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma
Barton F. Haynes, M.D. Chair, Department of Medicine, Duke University Medical Center, Durham, North Carolina
Louis W. Heck, Jr., M.D. Professor, Department of Medicine, University of Alabama School of Medicine, University of Alabama Hospitals, Birmingham, Alabama
Jan Hillson, M.D. Arthritis Clinical Research Unit, Virginia Mason Research Center, Seattle, Washington
Daniel Holderbaum, M.D. Senior Research Unit, Associate, Division of Rheumatology, Department of Medicine, Adjunct Assistant Professor, Case Western Reserve
University School of Medicine, University Hospitals, Cleveland, Ohio
James P. Hollowell, M.D. Associate Professor, Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin
Greg A. Horton, M.D. Assistant Professor, Orthopaedic Surgery, Kansas University Medical Center, Kansas City, Kansas
Aubrey J. Hough, Jr., M.D. Professor and Chairman, Department of Pathology, University of Arkansas for Medical Sciences, Chief of Services, Department of
Pathology, University Hospital, Little Rock, Arkansas
David S. Howell, M.D. Emeritus Professor of Medicine, Division of Immunology and Rheumatology, Department of Medicine, University of Miami School of Medicine,
Staff Physician, Division of Immunology and Rheumatology, Department of Medicine, University of Miami Health Center/Jackson Memorial Hospital, Miami, Florida
Gunnar Husby, M.D. Professor, Rikshospitalet, University of Oslo, Head, Center for Rheumatic Diseases, The National Hospital, Oslo, Norway
Robert W. Ike, M.D. Associate Professor, Division of Rheumatology, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan,
Robert D. Inman, M.D. Professor of Medicine and Immunology, University of Toronto, Director, Arthritis Center of Excellence, Department of Medicine, Toronto
Western Hospital, Toronto, Ontario, Canada
Christopher G. Jackson, M.D. Associate Professor, Director of Clinical Trials, Division of Rheumatology, University of Utah School of Medicine, University of Utah
Health Sciences Center, Salt Lake City Department of Veterans Affairs Medical Center, Salt Lake City, Utah
Hugo E. Jasin, M.D. Professor of Internal Medicine, Department of Medicine, Division of Rheumatology, University of Arkansas, Medical Sciences Center, Little
Rock, Arkansas
John Paul Jones, Jr., M.D. President, Diagnostic Osteonecrosis Center and Research Foundation, Kelseyville, California
Roland Jonsson, D.M.D., Ph.D. Professor, Broegelman Research Laboratory, University of Bergen, Consultant, Department of Otolaryngology, Haukeland
University Hospital, Bergen, Norway
Bruce A. Julian, M.D. Professor of Medicine and Transplant Surgery, The University of Alabama, Birmingham, Alabama
Kenneth C. Kalunian, M.D. Associate Professor of Clinical Medicine, Department of Medicine, Division of Rheumatology, UCLA School of Medicine, Los Angeles,
California
Allen P. Kaplan, M.D. Professor and Co-Director, Asthma and Allergy Center, Department of Medicine, Medical University of South Carolina, Charleston, South
Carolina
Daniel L. Kastner, M.D., Ph.D. Chief, Genetics Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases,
National Institutes of Health, Bethesda, Maryland
Christopher G. Kevil, Ph.D. Research Fellow, Department of Comparative Medicine, University of Alabama, Birmingham, Alabama
Robert P. Kimberly, M.D. Howard L. Holley Professor of Medicine, Department of Medicine, University of Alabama, Director, Division of Clinical Immunology and
Rheumatology, Director, Multipurpose Arthritis and, Musculoskeletal Diseases Center, University of Alabama Hospital, Birmingham, Alabama
Lynell W. Klassen, M.D. Stokes-Shackleford Professor, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska
William J. Koopman, M.D. Professor and Chairman, Department of Medicine, Spencer Chair in Medical Science Leadership, University of Alabama, Birmingham,
Alabama
Joseph H. Korn, M.D. Professor, Department of Medicine, Boston University School of Medicine, Chief, Rheumatology Division, Department of Medicine, Boston
Medical Center, Boston, Massachusetts
Joel M. Kremer, M.D. Professor of Medicine, Head, Division of Rheumatology, Department of Medicine, Albany Medical College, Attending Physician, Albany
Medical Center Hospital, Albany, New York
Melissa S. Kurtis, M.S. Graduate Student, Department of Bioengineering, University of California at San Diego, La Jolla, California
Sanford J. Larson, M.D., Ph.D. Professor of Neurosurgery, Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin
Kelvin W. Li, M.S Graduate Student, Department of Bioengineering, University of California at San Diego, La Jolla, California
Peter E. Lipsky, M.D. Scientific Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
Albert F. LoBuglio, M.D. Director, Comprehensive Cancer Center, Evalina B Spencer Professor of Oncology, Associate Dean, University of Alabama, Wallace
Tumor Center, Birmingham, Alabama
Michael D. Lockshin, M.D. Professor, Department of Medicine, Weill Medical College of Cornell University, Director, Barbara Volcker Center, Hospital for Special
Surgery, New York, New York
Lisa M. Lottman, B.S. Staff Research Associate II and Lab Manager, Department of Bioengineering, University of California at San Diego, La Jolla, California
Martin K. Lotz, M.D. Professor and Head, Division of Arthritis Research, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla,
California
Carlos J. Lozada, M.D. Assistant Professor of Medicine, Director, Rheumatology Fellowship Program, Division of Rheumatology and Immunology, University of
Miami School of Medicine, Attending Physician, Department of Medicine, Jackson Memorial Hospital, Miami, Florida
Harvinder S. Luthra, M.D Professor of Medicine, Mayo Medical School, Chair, Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester,
Minnesota
Maren L. Mahowald, M.D. Professor of Medicine, Department of Internal Medicine, University of Minnesota, Chief, Rheumatology Section, Department of Medicine,
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota
Stephen E. Malawista, M.D. Professor of Medicine, Yale University School of Medicine, Department of Internal Medicine, Section of Rheumatology, New Haven,
Connecticut
Johanne Martel-Pelletier, Ph.D. Professor of Medicine, Department of Medicine, University of Montreal, Director, Osteoarthritis Research Unit, Notre Dame Hospital,
Montreal, Quebec, Canadac
Richard Mayne, Ph.D. Professor, Department of Cell Biology, University of Alabama, Birmingham, Alabama
Daniel J. McCarty, M.D. Will and Cava Ross Professor of Medicine, Department of Medicine, Medical College of Wisconsin, Senior Attending Physician, Department
of Medicine, Froedtent Memorial Lutheran Hospital, Milwaukee, Wisconsin
Thomas A. Medsger, Jr., M.D. Gerald P. Rodnan Professor of Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh,
Pennsylvania
Clement J. Michet, M.D., M.P.H. Consultant, Mayo Clinic, Rochester, Minnesota
Herman Mielants, M.D. Professor, Department of Rheumatology, Ghent University, Ghent University Hospital, Ghent, Belgium
Frederick W. Miller, M.D. Senior Investigator, Laboratory of Molecular and Developmental Immunology, Center for Biologics Evaluation and Research, Food and
Drug Administration, Bethesda, Maryland
Gerald F. Moore, M.D. Professor of Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska
Larry W. Moreland, M.D. Professor of Medicine, Department of Medicine, University of Alabama, Birmingham, Alabama
Sarah L. Morgan, M.D., R.D., F.A.D.A., F.A.C.P. Associate Professor, Departments of Nutrition Sciences and Medicine, University of Alabama at Birmingham,
Medical Director, Osteoporosis Prevention and Treatment Clinic, The Kirklin Clinic, Birmingham, Alabama
Roland W. Moskowitz, M.D. Professor of Medicine, Division of Rheumatology, Department of Medicine, Case Western Reserve University School of Medicine,
Director, Division of Rheumatic Diseases, University Hospitals, Cleveland, Ohio
John D. Mountz, M.D., Ph.D. Professor, Department of Medicine, University of Alabama, Birmingham, Alabama
Ulf Müller-Ladner, M.D. Attendant, Department of Internal Medicine I, University of Regendsburg, Regensburg, Bavaria, Germany
Barry L. Myones, M.D. Associate Professor, Departments of Pediatrics and Microbiology/Immunology, Baylor College of Medicine, Director of Research, Pediatric
Rheumatology Center, Texas Children’s Hospital, Houston, Texas
Stanley J. Naides, M.D. Thomas B. Hallowell Professor of Medicine, Professor of Microbiology and Immunology, Chief, Division of Rheumatology, Milton S. Hershey
Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Charles L. Nelson, M.D. Assistant Professor, Attending Surgeon, Department of Orthopaedic Surgery, University of Pennsylvania, Hospital of the University of
Pennsylvania, Philadelphia, Pennsylvania
Barbara S. Nepom, M.D. Research Associate Member, Immunology Program, Virginia Mason Research Center, Research Associate Professor, Department of
Pediatrics, University of Washington School of Medicine, Seattle, Washington
James R. O’Dell, M.D. Professor of Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska
Shawn W. O’Driscoll, M.D., Ph.D. Professor of Orthopedics, Department of Orthopedics, Mayo Clinic, Rochester, Minnesota
J. Desmond O’Duffy, M.B. Sarasota, Florida
Richard S. Panush, M.D. Clinical Professor of Medicine Mount Sinai School of Medicine, New York, New York, and, Chairman, Department of Medicine, Saint
Barnabas Medical Center, Livingston, New Jersey
Jean-Pierre Pelletier, M.D. Professor, Department of Medicine, University of Montreal, Head, Arthritis Division, Notre Dame Hospital, Montreal, Quebec, Canada
Maria D. Perez, M.D. Assistant Professor, Division of Rheumatology, Texas Children’s Hospital, Houston, Texas
Andras Perl, M.D., Ph.D. Professor of Medicine and of Microbiology and Immunology, Department of Medicine, State University of New York Upstate Medical
University, Syracuse, New York
Charles G. Peterfy, M.D., Ph.D. Assistant Clinical Professor of Radiology, Osteoporosis and Arthritis Research Group, University of California at San Francisco,
Chief Scientific Officer, Synarc, Inc., San Francisco, California
Karin S. Peterson, M.D. Assistant Professor, Department of Pediatrics, Columbia University, New York New York
Michelle A. Petri, M.D., M.P.H. Associate Professor of Medicine, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine,
Director, Lupus Center, Johns Hopkins Hospital, Baltimore, Maryland