lain A M Hennessey MBCha (Ho,n)'" IH='I M'eS Senior House Officer, Ne()nol<lllnlens;lIe Core Royol United HosPIIaI, Bath, UK Alan G Japp MIlCh. iHoNl SS< IHomI MlCP Clinical Research Fellow in Cordiology University 01 Edinburgh, UK bLSEVlFR CHURCHILL LNTNGSTONE CLSEVlER Cl2OO'l, Dsorvitr l.I.n,tro. AU rip'" ~ No part of th'''I'"bhcation may u.. ..."rodll<.Wt. !;I,,,....j in ~ rWicval ~)'I~, 0< tnnmUnl~11tlany form or try .ny meam, el".:tn...ue, mf!<:hanica1.I'OOtooop)'i1le;.. t«Oidi"g or oct.......-be....,ltnut tht prior ' .....1IlUIIioon ci ttr PubbIhen Pen",,,,,,,,,,,, may be .>Ught directly hu'" FJSorrier"s Hrolth Scie>c6 Right>. U'1,aliment, 1600 luhn F. J(ennedy RlIUI""'ard. Suit(' IHOO,Philadelphia, FA 191W-2IW9. USft.: phc:lne: (+1) 21 <; 2.19 3804; law' (• I) 215 2:)9 3lI05; or, ...m.1.il; IIIlIII1tJtpa.- e k_~ ,,'" IN'\' abo C'<lIJ\f'to.w yOW" ~ n.>-broe ''101 !he~ homrpIo~{h"P'1 ! _ ...·,~-.'""l,b,- oIekctuq; 'Support and CQnt<K1" lind lhotn 'Copy"g1'1 and rermiso!.. ~" fSDN·13, 978-().-41::1-1{).l14-S (M,,,,, Echboo) 1SllN-13, 9'lS-Il-«3-1041311 (lnn-'.....l>l)na/ E.dih'"') Brili$h 1.......uyCatAl..S'''''1l. in .....bllc"ho.. Oau Acnto'lngue r«ord fc.w tillS book is ....a,Loble from the KTlt~<Jl Libruy l.ibrwy 01 Consn- e.taJosb's in f>ublicatiM D..... AQtalos n-o:<oN for thd booll '" unbbie from ItoP t...ibrary of c.-W"M """'" N("Ott- the publisher ..... 1ho! ltuthon. _l.U'ne' any ~....bility 1m any Ie,.. or inJurY ./CK~ 10~ or i"'OjA' Ii ari$mS' "'I 01 or n'Latl:'d 10 M<' use of the mal<T>~1coot.>ined If1 thos book. It is thr.o n:sp<JnlIibility of t1.. laallng prKti~"'lyin,l; on indcpl~ldenl~''''Kl knowl~ge of U'" pat~t. to OtlaDWv-lhe mllreatrn<..,1 and method of applKatlOll foe tht",,"IHnL 7\rPtoW...... ~L:lE"IFR WO,.king together to grow libraries in developing countries --.doc¥icr.cocn I WW'W boob.,J.~ I __OAbK org yoursoun:. fw boolu. jo.-na& and ndtio,..... In tt.. tMotth sclenc:es _etse\fierheoltb.com .. ll'l'? .. P*Y_"_ ,.,., •• r I ..... II "II: I Preface If you've taken the time to open Arfnwl Blood Gases Mnd, l-:tJsy, you must believe that artenal blood gases (AHtJi) are unportant. but not Pntirely:,lraightforward. We ft>rtamly agn..~ on the first pomt: ABC analysis now play:. il/1 indispensablf' role in the assessment and manilKcmcnt of pahf'nh; wltll a huge range of acute moollal and surgu"al problems. AccuratE' ABG interpretation is undoubtedly a fundamental skill U1 modem clink'" medianl::. On the SI.'('ond pomt, we hope this book ran bto of a~sislance. Throughout. our aim~ have ~,\ to emphasi<:l' the key concept~, fnrus on priKtical and useful aspects ofABG analysi!! and dvoid extrant"Ous detal1. \Vc believe lThlny medical and nursing students, JWlior doctors and specmhst nurses will benefit from a dear, roncise guide to performing thl? te<:hnl4uc and interpN>tmg the results lain A M HeJUlCSSCY Alan Glapp • Contents Prefcx:e v Acknowledgements V" Port 1 The ABG explained 1 1.1 Introduction 3 1.2 Pulmonary gas excnange: the basics 4 1.3 Disorders of gas exchange 18 1.4 Acid-bose balance: the basics 26 • 1.5 Disorders of ocid--bo$e balance 36 1 6 ABG $Ompliog technique 42 1.7 When and why IS on ABG required? 48 1.8 Common values 50 19 Making ABG inlefprctolion easy 52 Appendix 56 Pori 2 The ABG in practice 57 Cases 1-25 58 Answers 109 l<>de. 135 1. 1 .. INTRODUCTION Arterial blOOl"l ~,\S (ABC) analysis ~fers 10 the mcasuremE'nt of pi I and the partial pn:s~.m:s of oxygen (Oz) and carbon dioxide (Co,) in artt>rial blood. From these values we can ass....s ttwo state oftJdJ--buse bolanCt in blood and how well lungs are ~riormingtheir job of gll5 ,:xc}Ul11gt. Already the~ afC questions: what is meant by 'acid-base status'? What is.:l 'partial pressure'? Why do they matter? It helps to break things cJown. Part 1 of this book is designed to answer the:;e questions. We start with a few p<lg~ covering the b.1sic CSSli:Jlhals of respiratory and aad base physIology: plel1St' do not skip them! If you understand these