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NOTE TO USERS This reproduction is the best copy available. ® UMI Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. UNIVERSITY OF NEBRASKA LIBRARIES MANUSCRIPT THESIS Permission to use this thesis has been given by the author or department under whose direction it was written. Approved by author Approved by department.................................................................................................................. It is expected that proper credit will be given for any quotations taken from this work. Extensive copying or publication of the thesis in whole or in part requires the written consent of the author or department. This thesis has been used by the following persons, whose signatures attest their accept­ ance of the above restrictions. A library which borrows this thesis for use by its patrons is expected to secure the signature of each user. NAME AND ADDRESS DATE Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. ARSETUCALS DRHIVSI) from 161 TO PHIMOSIS W Rofeert Long Clark Preaanted fe© th« Faewlty of The Graduate Collogo la the Univeraity of foferaatea In Partial Fulfillment of lofulranaata for fh# B©©f*» ©f Bootof of ?MLt*«»plqr Do par tuum t o f C^MMtto%P|f Lincoln, Metoroaka January i t , 1342 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. UMI Number: DP13707 INFORMATION TO USERS The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleed-through, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. ® UMI UMI Microform DP13707 Copyright 2006 by ProQuest Information and Learning Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. ProQuest Information and Learning Company 300 North Zeeb Road P.O. Box 1346 Ann Arbor, Ml 48106-1346 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. A # w it® r grafcofally acknowledge® to Dr. G. S. Mm&lltm h ii ay^ssstw t& ss who suggested th is fsoh tes*' «;td*d Is It® a tody, and offered syiapatheti® and help­ fu l suggest ioo a, and to Park® Bawl® and yff §m liinlp'MTi ilflnlflft iiH|W «—•- III iga^flflllMi Mil ■^'*1 gtedjS jMmm**. mA mA.twa» jpfa. pbbbjUwmOtki *p* *#*w Mi rati the grant of ® research fellow ship. 396006 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. TaBLS qw mwmmm In ioi **•**•»* # **'»***•****#*»*******#*#**♦■»■ Dls cusai OB. . . . . . . . . * . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . .3 (xFftpn&oo* • • . • • * . • • • • • • • • . • • • . • • » * • * • • • • *iG • ♦ » * • * * * • * * * * * • ♦ * * * * * . * # * * * 1 9 i * 4*jM om w toiftN ftm •*»**#*#*•#*#***••**♦* *19 f • 4*A49tylpl»«Mar&61 oUUnrotrnitt# ******* * ****** .13 3. ***...»* ** . .14 4. ^«Gfal®i»o»4-aP8®ri©ftC®topli#non# 3®micarbazoB0. . . . . . . . . . . . . . . . . . . . . . . . . 1 5 i * u **•»«*»* 4adn» * * * * * * * 1 0 4* of PfaiHiylfefiiPanln# and ^•C Jfel® i*o-4-ai*ao?ioao0toplioiioa«*. . • . . . *1® i * ' ^*^yd'i*©jqr-4-si*soi»oao«toph«Boii# ************1? S* a^ tyA m g^ ^ nM anom toptaoa* ■ Somiearbazon©.......... . . . . . . . . . . . . . . . 1 8 19* u> •Iydi»03ty-4-a3E»8oa®aeofc@pl«i»oiii« Phenylhydrezona........ . . . . . . . . . . . . . . . 1 8 11 * ' ^^4waqr-»4*ai*»«ao:*#«'i«.%otli»«iO ********* *19 If. (o »!)i®t;liylgtffiiB0«*4*ara0ft0»©#t©ph®R0ii® Hydrochloride. . . . . . . . . . . . . * ***** * * * * * *19 13 • ^•lorpho 1 la ®*»4» ar» ©a m e« fcoph#B ©a # flptotftlftM riM k**** * * • * • • * * * * * * • * * * * * * * **fO 14. ^«Plp0Fl&o»yl-4-ars0BQae®t0f>liimoi3« Hydro chloride. . . . . . . . . . . . . . , * * ........2 1 AKalytttaft * * **•*•**#****••**»***•»*****• * * * * * * * * *«• WmWi*^m m Vi^ni'MfM*r * # *#.****•*»# *# *********» # **# **♦ *# *•# # -# *** <-tmmSkwmK. 9tbll»gr «|Aqr ♦**•**•*«#*••••**#*••«••*♦*•*#**** * * *94 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. INTRODUCTION fh* char«ct«ri»tlc action of a eheaieal substance, used as a drug, is apparently related to lit efeomieal . structure. Consequently, the study of the relationship between chemical structure and »»i action has led to tte synthesis of many valueble therapeutic agents. f t was hoped that toy changing the chemical OOllf jLf^iiy ftp’ll 499 41 4M93® JMSi 5lM0 tefay® 05*®®n91 £199*9 W^yi3l3L^li surpass previotsly lenoen drags so t treetsMNtt of tpiro* cheatal end txnritaftaaisaiS!! dis eases • As s resu lt twtwdfiiHlB mmmw ss ^^s*se s^poioss* ea^sf B^r^seepspsseippsfr sie^ea tPk’ ©■ ss jb ewsision^pssc ^ssepsst^ 4felf Q1»g4tl9il!l»4^ ®> 5 t9 5 ®(®*9l®®k£®^ 19444N® £^®H®3® ^®^4l|pllMF4N3l SI'S»«KI'4MB ^51^^9414^14^39^ 49^10944^ Tho objeofc of thia investigation, thorofor®, waa d»lffr SI ItUlitiP ' A • JfcWC'J SS ftkH^ AtMt A-ttWi ® Jk ^i|aSfcCiM 4t it**l AAieiAA %VWfcl4fi w$fe4 A%s ,^eer pa*1 'ea^a^ehjfie ©e ^bf^Pfsip eeaF1 ur ©f Sjt^we^a,we ^wms* Wsaw^^aF ©raw^a* essepssayessNeiepr©jrae ■SetMl' tSsA^Se SSittsSft<Se4l jiuis *1 %eaS'^SMS ws^^iSs'SSjiKe^awtHi jtibnsti *^1. drags used si present if-we for tins treatment of splnoehaebal and trypanoaoinal diseases tSAlSWS'dik' Sfc4 VIS telWaJSWfaiJtdlSt^Awfc1*.WA^^^W' m*S- WSSMSSI©'dK* aBe®ett3*$* MSS©SS gJWpMr K5MPW^wl^.kp'tif^|KP 0-’5 5 SaSIIt®ltWKte'®Jfc « AfhSAWSlwfcj^MBSt®SiSwtt weimt mmw* ma*m ^x . .. tmaAni.jtM^»..-, Jk. ... -,-^ik^, ©a#rtn «■!®-'ia #ie iPf©t* iap>‘mnitati ia^'Wi® Mh®im •Si 1 a.wia-lP gjMatiaktlftk e|hwmehwnai oate4r® fftllll In th® tx»ftftfcm®ttt #jf feViAMA dll®®®#® 1fr##iftf®# £9 liAA th» iydrtxyl pretsat in d-arson©-* ^•ph»nyl-» thanol, AWS^I .d^teiAi ' " <WIMWKVI ' WSSS^S ^S .^SWS d ** . At ^MSSl e^SSS^ jn jfj **' SSWS*fcfcSS%lk JfiWSS ik: # we^se'^^ a* 'Weepe aa^eese^jp 091^^ a, wgr Sp':,S ^WMSt ^s. ^as ape^F ep epe^^peie^p^es^^e'Ap' StlS la st two ©ottpotmdt have ©hoiootfeerapoati© value Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Xa-ft ©iiiilar Manner, au effective trig Might he procured hy faaviag the earfceayl. group 'eat the a»t»© group ia the muse compound t© f@r» sai®ga**Mia#' derivative* ©f 4*ars© »© s® e© efht*i© »#V Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.

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Arsenicals derived from acetophenone PDF

33 Pages·02.84 MB·English
by  Clark, Robert Long
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NOTE TO USERS This reproduction is the best copy available. ® UMI Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. UNIVERSITY OF NEBRASKA LIBRARIES MANUSCRIPT THESIS Permission to use this thesis has been given by the author or department under whose direction it was written. Approved by author Approved by department.................................................................................................................. It is expected that proper credit will be given for any quotations taken from this work. Extensive copying or publication of the thesis in whole or in part requires the written consent of the author or department. This thesis has been used by the following persons, whose signatures attest their accept­ ance of the above restrictions. A library which borrows this thesis for use by its patrons is expected to secure the signature of each user. NAME AND ADDRESS DATE Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. ARSETUCALS DRHIVSI) from 161 TO PHIMOSIS W Rofeert Long Clark Preaanted fe© th« Faewlty of The Graduate Collogo la the Univeraity of foferaatea In Partial Fulfillment of lofulranaata for fh# B©©f*» ©f Bootof of ?MLt*«»plqr Do par tuum t o f C^MMtto%P|f Lincoln, Metoroaka January i t , 1342 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. UMI Number: DP13707 INFORMATION TO USERS The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleed-through, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. ® UMI UMI Microform DP13707 Copyright 2006 by ProQuest Information and Learning Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. ProQuest Information and Learning Company 300 North Zeeb Road P.O. Box 1346 Ann Arbor, Ml 48106-1346 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. A # w it® r grafcofally acknowledge® to Dr. G. S. Mm&lltm h ii ay^ssstw t& ss who suggested th is fsoh tes*' «;td*d Is It® a tody, and offered syiapatheti® and help­ fu l suggest ioo a, and to Park® Bawl® and yff §m liinlp'MTi ilflnlflft iiH|W «—•- III iga^flflllMi Mil ■^'*1 gtedjS jMmm**. mA mA.twa» jpfa. pbbbjUwmOtki *p* *#*w Mi rati the grant of ® research fellow ship. 396006 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. TaBLS qw mwmmm In ioi **•**•»* # **'»***•****#*»*******#*#**♦■»■ Dls cusai OB. . . . . . . . . * . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . .3 (xFftpn&oo* • • . • • * . • • • • • • • • . • • • . • • » * • * • • • • *iG • ♦ » * • * * * • * * * * * • ♦ * * * * * . * # * * * 1 9 i * 4*jM om w toiftN ftm •*»**#*#*•#*#***••**♦* *19 f • 4*A49tylpl»«Mar&61 oUUnrotrnitt# ******* * ****** .13 3. ***...»* ** . .14 4. ^«Gfal®i»o»4-aP8®ri©ftC®topli#non# 3®micarbazoB0. . . . . . . . . . . . . . . . . . . . . . . . . 1 5 i * u **•»«*»* 4adn» * * * * * * * 1 0 4* of PfaiHiylfefiiPanln# and ^•C Jfel® i*o-4-ai*ao?ioao0toplioiioa«*. . • . . . *1® i * ' ^*^yd'i*©jqr-4-si*soi»oao«toph«Boii# ************1? S* a^ tyA m g^ ^ nM anom toptaoa* ■ Somiearbazon©.......... . . . . . . . . . . . . . . . 1 8 19* u> •Iydi»03ty-4-a3E»8oa®aeofc@pl«i»oiii« Phenylhydrezona........ . . . . . . . . . . . . . . . 1 8 11 * ' ^^4waqr-»4*ai*»«ao:*#«'i«.%otli»«iO ********* *19 If. (o »!)i®t;liylgtffiiB0«*4*ara0ft0»©#t©ph®R0ii® Hydrochloride. . . . . . . . . . . . . * ***** * * * * * *19 13 • ^•lorpho 1 la ®*»4» ar» ©a m e« fcoph#B ©a # flptotftlftM riM k**** * * • * • • * * * * * * • * * * * * * * **fO 14. ^«Plp0Fl&o»yl-4-ars0BQae®t0f>liimoi3« Hydro chloride. . . . . . . . . . . . . . , * * ........2 1 AKalytttaft * * **•*•**#****••**»***•»*****• * * * * * * * * *«• WmWi*^m m Vi^ni'MfM*r * # *#.****•*»# *# *********» # **# **♦ *# *•# # -# *** <-tmmSkwmK. 9tbll»gr «|Aqr ♦**•**•*«#*••••**#*••«••*♦*•*#**** * * *94 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. INTRODUCTION fh* char«ct«ri»tlc action of a eheaieal substance, used as a drug, is apparently related to lit efeomieal . structure. Consequently, the study of the relationship between chemical structure and »»i action has led to tte synthesis of many valueble therapeutic agents. f t was hoped that toy changing the chemical OOllf jLf^iiy ftp’ll 499 41 4M93® JMSi 5lM0 tefay® 05*®®n91 £199*9 W^yi3l3L^li surpass previotsly lenoen drags so t treetsMNtt of tpiro* cheatal end txnritaftaaisaiS!! dis eases • As s resu lt twtwdfiiHlB mmmw ss ^^s*se s^poioss* ea^sf B^r^seepspsseippsfr sie^ea tPk’ ©■ ss jb ewsision^pssc ^ssepsst^ 4felf Q1»g4tl9il!l»4^ ®> 5 t9 5 ®(®*9l®®k£®^ 19444N® £^®H®3® ^®^4l|pllMF4N3l SI'S»«KI'4MB ^51^^9414^14^39^ 49^10944^ Tho objeofc of thia investigation, thorofor®, waa d»lffr SI ItUlitiP ' A • JfcWC'J SS ftkH^ AtMt A-ttWi ® Jk ^i|aSfcCiM 4t it**l AAieiAA %VWfcl4fi w$fe4 A%s ,^eer pa*1 'ea^a^ehjfie ©e ^bf^Pfsip eeaF1 ur ©f Sjt^we^a,we ^wms* Wsaw^^aF ©raw^a* essepssayessNeiepr©jrae ■SetMl' tSsA^Se SSittsSft<Se4l jiuis *1 %eaS'^SMS ws^^iSs'SSjiKe^awtHi jtibnsti *^1. drags used si present if-we for tins treatment of splnoehaebal and trypanoaoinal diseases tSAlSWS'dik' Sfc4 VIS telWaJSWfaiJtdlSt^Awfc1*.WA^^^W' m*S- WSSMSSI©'dK* aBe®ett3*$* MSS©SS gJWpMr K5MPW^wl^.kp'tif^|KP 0-’5 5 SaSIIt®ltWKte'®Jfc « AfhSAWSlwfcj^MBSt®SiSwtt weimt mmw* ma*m ^x . .. tmaAni.jtM^»..-, Jk. ... -,-^ik^, ©a#rtn «■!®-'ia #ie iPf©t* iap>‘mnitati ia^'Wi® Mh®im •Si 1 a.wia-lP gjMatiaktlftk e|hwmehwnai oate4r® fftllll In th® tx»ftftfcm®ttt #jf feViAMA dll®®®#® 1fr##iftf®# £9 liAA th» iydrtxyl pretsat in d-arson©-* ^•ph»nyl-» thanol, AWS^I .d^teiAi ' " <WIMWKVI ' WSSS^S ^S .^SWS d ** . At ^MSSl e^SSS^ jn jfj **' SSWS*fcfcSS%lk JfiWSS ik: # we^se'^^ a* 'Weepe aa^eese^jp 091^^ a, wgr Sp':,S ^WMSt ^s. ^as ape^F ep epe^^peie^p^es^^e'Ap' StlS la st two ©ottpotmdt have ©hoiootfeerapoati© value Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Xa-ft ©iiiilar Manner, au effective trig Might he procured hy faaviag the earfceayl. group 'eat the a»t»© group ia the muse compound t© f@r» sai®ga**Mia#' derivative* ©f 4*ars© »© s® e© efht*i© »#V Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.

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