Aromatic Hydroxyketones: Preparation & Physical Properties: Aromatic Hydroxyketones from Butanone (C4) to Dotriacontanone (C32)

1456 Pages·2015·10.27 MB·English

by  Robert Martin

Robert Martin · Jean-Pierre Buisson
Aromatic
Hydroxyketones:
Preparation &
Physical Properties
Aromatic Hydroxyketones from
Butanone (C4) to Dotriacontanone (C32)
Aromatic Hydroxyketones: Preparation
& Physical Properties

Robert Martin • Jean-Pierre Buisson
Aromatic Hydroxyketones:
Preparation & Physical
Properties
Aromatic Hydroxyketones from Butanone
(C4) to Dotriacontanone (C32)
RobertMartin(deceased) Jean-PierreBuisson
FormerlyInstitutCurie InstitutCurie-ParisV
ParisV,Antony,France Sartrouville,France
Dr Martin wrote this book with Dr Buisson further to their cooperation while at Institut
Curie, Paris,France, and couldcomplete ita few months before passingaway.
ISBN978-3-319-14184-8 ISBN978-3-319-14185-5 (eBook)
DOI10.1007/978-3-319-14185-5
LibraryofCongressControlNumber:2014958588
SpringerChamHeidelbergNewYorkDordrechtLondon
©SpringerInternationalPublishingSwitzerland2015
Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart
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Printedonacid-freepaper
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(www.springer.com)
This book is dedicated to Canon Joseph
Clerc priest at Montmorot (Jura, France,
1899–1985) who in 1944 gave a home to the
Martin brothers, young Parisian refugees.
Robert Martin

Foreword
Two centuries of organic chemistry have already yielded millions of molecules,
eithersynthesizedorisolatedasnaturalproductscreatedbybiosynthesis,butmuch
stillremainstobedone.Therefore,fromtimetotime,itisprobablyusefultogather
andclassifythescattereddataconcerningthisorthatclassofcompoundsinorderto
savetimeforchemistsplanningnewsynthesesornaturalproductsisolations.
Inthiswork,specialefforthasbeenmadetoselectmaterialsuitabletomeetthe
needsofchemistswhodonotbenefitfromunlimitedtimeforspecializedresearch
inthefieldofhydroxyketones.
These compounds are precursors of substituted aromatic derivatives which are
often not straightforwardly obtained but have many potential applications in fine
andmedicinalchemistry.
In this book, Aromatic Hydroxyketones, Preparation and Physical Properties
the reader will find more than 5,200 hydroxyketones from butanone C to
4
dotriacontanoneC .
32
This work will primarily be of great value to professional chemists, from
physicists to pharmacists, who are often called upon to solve problems about the
synthesisofthiskindofaromaticcompounds.
InstitutCurieResearchUnit Jean-ClaudeFlorent
“Conception,SynthesisandTargeting
ofBiomolecules”,InstitutCurie
Paris,France
vii

Preface
Aromatichydroxyketonesarewidelyusedasstartingmaterialsinorganicsynthesis
toobtainmedicines,dyes,perfumes,etc.,andmanyofthemhavealsospecificuses.
This Handbook contains information on aromatic hydroxyketones from C to
4
C ,collectingmorethan5,200ketonesofwhichanindicatedpreparationaswellas
32
theirphysicochemicalandspectrochemicaldataarepresented.
This book is presented in dictionary style, with a logical classification of the
ketones,whichmakestheinformationeasilyavailableforconsultation.Ketonesare
classified methodically. They are easily accessible to the reader from three tables
providedattheendofthebook:
– Themolecularformulaindex
– TheChemicalAbstractsRegistryNumbers
– Theusualnamesindex
Since hydroxyketones are widely utilized, themselves or as intermediates, in
numerous interestingsyntheses,amongothers,pharmaceuticals, dyes,agrochemi-
cals, perfumes and plastic preservatives, this handbook will be of great value for
bothacademicandindustrialresearchchemists.Themultiplewaysofhydroxyben-
zophenones syntheses herein described will certainly help chemists, as most of
these methods can be applied to prepare analogues in aromatic and even in some
heterocyclicseries.
This compilation will supply helpful and easy-to-read informations for the
organicchemist.
Antony,France RobertMartin
Sartrouville,France Jean-PierreBuisson
ix