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Annual Review of CyberTherapy and Telemedicine Virtual Healing: Designing Reality Editors-in-Chief Brenda K. Wiederhold, PhD, MBA, BCIA Interactive Media Institute, San Diego, CA, USA Stéphane Bouchard, PhD Université du Québec en Outaouais, Canada Giuseppe Riva, PhD, MS, MA Istituto Auxologico Italiano, Verbania, Italy Volume 4 Interactive Media Institute Annual Review of CyberTherapy and Telemedicine Copyright © 2006 Interactive Media Institute 6160 Cornerstone Court East San Diego, CA 92121 ISBN: ISSN: 1554-8716 All rights reserved. Printed in the United States of America Interactive Media Institute Website: www.interactivemediainstitute.com LEGAL NOTICE The publisher is not responsible for the use which might be made of the following information. Editors-in-Chief Brenda K. Wiederhold, Ph.D., MBA, BCIA Interactive Media Institute Stéphane Bouchard, Ph.D. Université du Quebéc en Outaouais Assistant Editors Albert "Skip" Rizzo, Ph.D. University of Southern California Giuseppe Riva, Ph.D., M.S., M.A. Applied Technology for Neuro-Psychology Laboratory, Istituto Auxologico Italiano Editorial Assistant Ruth Kogen Interactive Media Institute Editorial Board Nathan Appel, Ph.D. Maressa H. Orzack, Ph.D. National Institute on Drug Abuse (NIH) Computer Addiction Clinic Maria Teresa Arredondo-Waldmeyer, Ph.D. Patrice Renaud, Ph.D. Universidad Politecnica de Madrid Universite du Quebec en Outaouais Cristina Botella, Ph.D. Richard Satava, M.D., FACS Universitat Jaume I University of Washington Alex H. Bullinger, M.D., MBA Ben Sawyer Center of Applied Tech. in Neuroscience Serious Games Initiative James A. Carter, Ph.D. Susan Schneider, Ph.D., R.N., AOCN Harvard Medical School Duke University Joann Difede, Ph.D. Heidi Sveistrup, Ph.D. Weill Cornell Medical Center University of Ottawa Walter Greenleaf, Ph.D. Ioannis Tarnanas Greenleaf Medical Peopleware - Kozani University CATLab Hunter Hoffman, Ph.D. David Thomas, Ph.D. University of Washington National Institute on Drug Abuse Kay Howell Cheryl Trepagnier, Ph.D. Federation of American Scientists The Catholic University of America Ashfaq Ishaq, Ph.D., FRSA David Walshe, Ph.D. International Child Art Foundation University College Cork Sun I. Kim, Ph.D. Patrice (Tamar) Weiss, Ph.D. Hanyang University University of Haifa Harvey Magee Mark D. Wiederhold, M.D., Ph.D., FACP Telemedicine & Adv Tech Research Center Virtual Reality Medical Center Fabrizia Mantovani, Ph.D. Christine Youngblut, Ph.D. Istituto Auxologico Italiano Institute for Defense Analyses Greg T. Mogel, M.D. Telemedicine & Adv Tech Research Center West General Information Annual Review of CyberTherapy and Telemedicine (ARCTT – ISSN: 1554-8716) is published an- nually (once per year) by the Interactive Media Institute (IMI), a 501c3 non profit organization, dedi- cated to incorporating interdisciplinary researchers from around the world to create, test, and develop clinical protocols for the medical and psychological community. IMI realizes that the mind and body work in concert to affect quality of life in individuals and works to develop technology that can be ef- fectively used to improve the standards and reduce the cost of healthcare delivery. Interactive Media Institute, 6160 Cornerstone Court East, Suite 161, San Diego, CA, USA. Telephone: (858) 642-0267, Fax: (858) 642-0285, E-mail: [email protected] IMI Web site: http://www.interactivemediainstitute.com Copyright © 2006 by Interactive Media Institute. Printed in the United States of America About the journal ARCTT is a peer-reviewed all-purpose journal covering a wide variety of topics of interest to the men- tal health, neuroscience, and rehabilitation communities. The mission of ARCTT is to provide system- atic, periodic examinations of scholarly advances in the field of CyberTherapy and Telemedi- cine through original investigations in the telemedicine and cybertherapy areas, novel experimental clinical studies, and critical authoritative reviews. It is directed to healthcare providers and researchers who are interested in the applications of ad- vanced media for improving the delivery and efficacy of mental healthcare and rehabilitative services. Manuscript Proposal and Submission Because Annual Review papers examine either novel therapeutic methods and trials or a specific clinical application in depth, they are written by experienced researchers upon invitation from our Edi- torial Board. The editors nevertheless welcome suggestions from our readers. Questions or com- ments about editorial content or policies should be directed to the editors only. Manuscript Preparation Manuscripts should be submitted in electronic format on CD-Rom or floppy disks as well as on 8½ x 11-in. paper (three copies), double-spaced format. Authors should prepare manuscripts according to the Publication Manual of the American Psychological Association (5th Ed.). Original, camera-ready artwork for figures is required. Original color figures can be printed in color at the editors' discretion and provided the author agrees to pay in full the associated production costs; an estimate of these costs is available from the ARCTT production office on request. ARCTT policy prohibits an author from submitting the same manuscript for concurrent consideration by two or more publications. Authors have an obligation to consult journal editors concerning prior publica- tion of any data upon which their article depends. As this journal is a primary journal that publishes original material only, ARCTT policy prohibits as well publication of any manuscript that has already been published in whole or substantial part elsewhere, unless authorized by the journal editors. Disclaimer All the published papers, editorial news and comments, opinions, findings, conclusions, or recom- mendations in ARCTT are those of the author(s), and do not necessarily reflects or constitute the opinions of the Journal, its Publisher, and its editorial staff. Table of Contents Volume 4 Editorials 9 B. K. Wiederhold, G. Riva, S. Bouchard CRITICAL REVIEWS From SIT to PTSD: Developing a Continuum of Care for the Warfighter 13 B. K. Wiederhold, M. D. Wiederhold Virtual Standardized Patients for Training Health Professionals on Chemical and 19 Biological Agent Exposures D. L. Sticha, M. J. Roy, D. E. Olsen Coping with stress using Virtual Reality: a new perspective 25 D. Villani, A. Preziosa, G. Riva EVALUATION STUDIES The use of a visible and/or an invisible marker Augmented Reality System for 33 the treatment of phobia to small animals M. C. Juan, D. Joele, C. Botella, R. Baños, M. Alcañiz, Ch. van der Mast Randomized Controlled Trial of CBT with Virtual Reality Exposure Therapy 39 for PTSD M. J. Roy, W. Law, I. Patt, J. Difede, A. Rizzo, Institute K. Graap, B. Rothbaum Efficacy of Sensory Integration Treatment based on Virtual Reality - Tangible 45 Interaction for Children with Autism K-E. Jung, H-J. Lee, Y-S. Lee, J-H. Lee The Usefulness of Virtual Reality Stress Inoculation Training for Military 51 Medical Females: A Pilot Study M. C. Stetz, R. M. Wildzunas, B. K. Wiederhold, T. A. Stetz, M. P. Hunt The virtual classroom: An ecological version of the continuous performance 59 test – A pilot study G. Moreau, M-C. Guay, A. Achim, A. Rizzo, P. Lageix A study of Active Navigation and Object Recognition in Virtual Environments 67 J. Hahm, K. Lee, S-L. Lim, S-Y. Kim, H-T. Kim, J-H. Lee ORIGINAL RESEARCH Optic Flow With a Stereoscopic Display: Sustained Influence on Speed of 73 Locomotion W. A. Powell, S. Hand, B. Stevens, M. Simmonds Simulation-based training of communication and emotional competence for the 79 improvement of physician-patient relationship L. Anolli, A. Vescovo, A. Agliati, F. Mantovani, V. Zurloni Sexual presence as determined by fractal oculomotor dynamics 87 P. Renaud, S. Chartier, M-P. Bonin, P. de Courville Nico, J. Proulx, J-L. Rouleau, L-G Cournoyer, P. Fedoroff, J. Bradford, S. Bouchard Physiological and Momentary Assessment for Identifying Tobacco Use Patterns 95 P. J. Jordan, L. W. Jerome, N. Faraj Implicit Learning of an Embedded Regularity in Older Adults using a SRT 103 Reaching Task in a Virtual Reality Medium R. Martini, L. Aquilino, S. Buissé, A. Dumais, V. Pion, E. St. Rose, H. Sveistrup, D. M. Ste-Marie Presence: Head Mounted Display vs. Translucid Screen 111 P. Gamito, D. Morais, J. Oliveira, L. Gamito, M. Anastácio Evaluation of Group Performance in a Mediated Environment 117 L. W. Jerome, P. J. Jordan, N. Faraj Changes in P300 Amplitude in Smokers in Response to Cigarette- 127 Craving Cues K-W. Jang, J-S. Lee, B-H. Yang, J-H. Lee Smokers’ attentional bias to smoking-related cues in eye movement 131 S-M. Kwak, D. L. Na, GHo Kim, J-H Lee Low-Cost Telerehabilitation Using Force Feedback Joysticks 137 H. Sugarman, J. Tiran, A. Weisel-Eichler, E. Dayan Reaching out to the youth suffering from idiopathic tinnitus via the Internet 145 J. Baribeau Sexual Preference Classification from Gaze Behavior Data using a Multilayer 153 Perceptron S. Chartier, P. Renaud, S. Bouchard, J. Proulx, J. L. Rouleau, P. Fedoroff, J. Bradford Application of Virtual Reality-Cue Exposure Therapy for Reducing Alcohol 161 Craving H. Kwon, J. Choi, S. Roh, B-H Yang, J-H Lee CLINICAL OBSERVATIONS Evaluating the Interaction of Blind Learners with Audio-Based Virtual 167 Environments J. Sánchez, M. Zúñiga Generic virtual reality treatment applied to space-related phobias 175 F. Znaidi, I. Viaud-Delmon, R. Jouvent Virtual Therapy in Patients with Depression. Preliminary Observation 181 V. ChiriŃă, M. Ilinca, R. ChiriŃă, M. Bîşcă, G. Chele Abstracts from CyberTherapy 2006, June 13-15, 2006, Gatineau, Canada 187 7 8 Editorials I am honored to welcome you to the fourth volume of Annual Review of CyberTherapy and Telemedi- cine. This year’s theme, “Virtual Healing: Designing Reality,” acknowledges the importance of two related types of scientific studies: clinical applications of virtual reality (VR) and other technologies, and experimental research on why it has such a powerful impact on behavioral healthcare, medicine, and neuroscience. The theme also highlights changes that have occurred in the past decade; that which was once in the ream of science-fiction has now increasingly become part of our reality. As readers, you will therefore have the opportunity to play a role in designing the future. By utilizing technology for training and therapy, we are able to improve existing protocols, and disseminate care to a wider segment of the population. Much has changed over the past eleven years since the inception of the CyberTherapy Conference. We have now tapped further into the potential of VR than many of us could have ever imagined. An exciting body of research regarding the utilization of advanced technologies in behavioral healthcare has emerged over the past decade, revealing the continuous advances and discoveries made by over 450 investigators to help patients with both mental and physical disorders. I am proud to report that as VR’s use in behavioral healthcare has grown, so have submissions to the Annual Review of CyberTherapy and Telemedicine. For the first seven years, CyberTherapy was represented by a spe- cialized symposium at the Medicine Meets Virtual Reality (MMVR) Conference featuring presenta- tions that dealt primarily with conceptual matters and future possibilities. Over the years, the sympo- sium continued to grow in both size and scientific evidence. In 2003, the symposium spun off into a separate three-day conference. The 10th Annual CyberTherapy Conference, held in June 2005, highlighted the largest program ever presented on controlled clinical trials of VR and other cutting- edge technologies in the areas of mental health, rehabilitation, disabilities, training, and education. It involved representatives from 21 countries, reflecting its truly international character. I sincerely hope that you will find this year’s volume to be an interesting and intellectually stimulating read. I continue to believe that together we can change the future of healthcare. Sincerely, Brenda K. Wiederhold, Ph.D., MBA, BCIA Co-Editor-in-Chief 9 Editorials According to recent reports presented by IST Advisory Group (ISTAG) - the Unit within the European Union providing independent advice concerning the strategy, content, and direction of research work to be carried out in Information and Communication Technologies (ICT) (http://cordis.europa.eu/ist/ istag-reports.htm) - the evolution of technology in support of the Knowledge Society of the 2010s will be rooted within three dominant trends: − Pervasive diffusion of intelligence in the space around us, through the development of net- work technologies and intelligent sensors toward so-called “Ambient Intelligence” (AmI); − The increasingly relevant role of mobility through the development of mobile communica- tions, moving from the Universal Mobile Telecommunications System (UMTS) to "Beyond 3rd Generation" (B3G); − Increase of the range, accessibility, and comprehensiveness of communications, through the development of multi-channel multimedia technologies. The convergence of AmI, B3G, and multi channel multimedia technologies manifests itself as the next frontier of ICT. This convergence stimulates a change in the way health care is carried out, making it a globally distributed process in which communication and collaboration between geo- graphically dispersed users plays a key role. In reaching this goal, "Immersive Virtual Telepresence" (IVT) will be essential. In IVT tools, distrib- uted virtual reality (VR) systems are combined with wireless multimedia facilities (real-time video) and innovative input devices (tracking sensors, biosensors, brain-computer interfaces). In general, the IVT perspective is reached through: − Widening of the input channel through the use of biosensors (brain-computer interface, psy- cho-physiological measurements, etc.) and advanced tracking systems (wide body tracking, gaze analysis, etc.). − Induction of a sense of “presence” or “telepresence” through multimodal human/machine communication in the dimensions of sound, vision, and touch-and-feel (haptics). Typically, a sense of presence is achieved through multisensorial stimula, such that actual reality is ei- ther hidden or substituted via a synthetic scenario, (i.e. made virtual through audio and 3-D video analysis, and modelling procedures). In high-end IVT systems, multimedia data- streams, such as live stereo-video and audio, are transmitted and integrated into the virtual space of another participant remotely, allowing geographically separated groups to meet in a common virtual space while maintaining eye-contact, gaze awareness and body language. A sense of presence with other people who may be at distant sites is achieved through ava- tar representations using data about body movement streamed over a high-speed network. Since distance learning and e-health are principally involved with handling and transmission of medi- cal information, IVT has the potential to enhance their user experience through the expansion of hu- man input and output channels. The two principle ways in which IVT can be applied are: − as an interface, which enables a more intuitive manner of interacting with information, and − as an extended communicative environment that enhances the feeling of presence during the interaction. These approaches will be strengthened by the development of 3rd generation IVT systems including biosensors, mobile communication, and mixed reality. Introducing IVT in cybertherapy will provide significant advantages: − IVT-based treatment differs from traditional therapy in that computer graphics and various display and input/output technologies are integrated to provide the patient with a sense of 10

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Albert "Skip" Rizzo, Ph.D. Mark D. Wiederhold, M.D., Ph.D., FACP . R. Martini, L. Aquilino, S. Buissé, A. Dumais, V. Pion, E. St. Rose, . Widening of the input channel through the use of biosensors (brain-computer interface, psy- communication in the dimensions of sound, vision, and touch-and-
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