Arachidonate Remodeling and Inflammation

247 Pages·2004·6.044 MB·English

by  Alfred N. Fonteh (auth.), Alfred N. Fonteh, Robert L. Wykle (eds.)

progress in Inflammation Research
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Arachidonate Remodeling and Inflammation
Alfred N. Fonteh
Robert L. Wykle
Editors
Springer Basel AG
Editors
Alfred N. Fonteh Robert L. Wykle
Huntington Medical Research Institutes Wake Forest University
Molecular Neurology Program School of Medicine
99 North EI Molino Avenue Department of Biochemistry
Pasadena, CA 91101-1830 Medical Center Boulevard
USA Winston-Salem, NC 27157-1016
USA
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ISBN 978-3-0348-9594-1 ISBN 978-3-0348-7848-7 (eBook)
DOI 10.1007/978-3-0348-7848-7
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© 2004 Springer Basel AG
Originally published by Birkhăuser Verlag in 2004
Softcover reprint of the hardcover 1s t Edition 2004
Printed on acid-free paper produced from chlorine-free pulp. TCF 00
Cover design: Markus Etterich, Basel
Cover illustration: Arachidonic acid bound to P450BM-3, described in: Graham-Lorence SE et al (1997) J 8iol Chem
272,1127-1135. With the friendly permission of Julian A. Peterson, University of Texas, Southwestern Medical Center
at Dallas, USA
ISBN 978-3-0348-9594-1
987654321 www.birkhauser-science.com
Contents
List of contributors vii
Preface .. xi
Alfred N. Fonteh
An outline of arachidonate remodeling and its biological significance . 1
Suzanne E. Barbour, Salma AI-Darmaki and Alex D. Manguikian
Phospholipase A2 and remodeling in inflammatory cells . 13
Chad R. Marion and Alfred N. Fonteh
Enzymatic and receptor mediated effects of secretory phospholipase A2
on the pathophysiology of inflammatory diseases 37
Jesus Balsinde, Rebeca Perez, Yolanda Saez and Marfa A. Balboa
Control of arachidonic acid levels in resting and activated U937
phagocytic cells by Ca2+ -independent phospholipase A2 61
Robert L. Wykle
Arachidonate remodeling and PAF synthesis in human neutrophils . 73
Allen M. McAlexander, Brooke 1. Barham, Margaret Johnson
and Alfred N. Fonteh
Control of long chain polyunsaturated fatty acid levels and the
role of inhibitors of incorporation and remodeling on the biosynthesis
of lipid mediators. . 89
Massimo Triggiani, Giorgio Giannattasio, Francescopaolo Granata,
Stefania Loffredo, Francesca W Rossi, Salvatore Salzano and Gianni Marone
Remodeling of arachidonic acid in inflammatory cells of the human lung . 115
Royal D. Saunders and Nicolas G. Bazan
Arachidonate remodeling, platelet-activating factor signaling, and the
inflammatory response in the central nervous system 131
Alfred N. Fonteh and Michael G. Harrington
Remodeling of arachidonate and other polyunsaturated fatty acids in
Alzheimer's disease ........................................... 145
Charles N. Serhan and Nan Chiang
Lipoxins and resolvins: local mediators in endogenous anti-inflammation
and resolution . . . . . . . . . . . . 169
Takayuki Sugiura, Seishi Kishimoto, Saori Oka, Maiko Gokoh
and Keizo Waku
Metabolism and physiological significance of anandamide and
2-arachidonoylglycerol, endogenous cannabinoid receptor ligands. 211
Index 239
List of contributors
Salma AI-Darmaki, Department of Microbiology and Immunology, Virginia Com
monwealth University, Box 980678, Richmond, VA 23298-0678, USA
Maria A. Balboa, Institute of Molecular Biology and Genetics (IBGM-CSIC), Uni
versity of Valladolid School of Medicine, Avenida Ramon y Cajal 7, E-47005 Valla
dolid, Spain; e-mail: [email protected]
Jesus Balsinde, Institute of Molecular Biology and Genetics (IBGM-CSIC), Univer
sity of Valladolid School of Medicine, Avenida Ramon y Cajal 7, E-47005 Valla
do lid, Spain; e-mail: [email protected]
Suzanne E. Barbour, Department of Biochemistry, Virginia Commonwealth Univer
sity, Box 980614, Richmond, VA 23298-0614, USA;
e-mail: [email protected]
Nicolas G. Bazan, Neuroscience Center of Excellence, Louisiana State University
Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112,
USA; e-mail: [email protected]
Brooke J. Barham, Comprehensive Center for Inflammatory Diseases, Department
of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA;
e-mail: [email protected]
Nan Chiang, The Center for Experimental Therapeutics and Reperfusion Injury,
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and
Women's Hospital, Harvard Medical School, Boston, MA 02115, USA;
e-mail: [email protected]
Alfred N. Fonteh, Molecular Neurology Program, Huntington Medical Research
Institutes, 99 North EI Molino Avenue, Pasadena, CA 91101, USA;
e-mail: [email protected]
vii
List of contributors
Giorgio Giannattasio, Division of Clinical Immunology and Allergy, University of
Naples Federico II, Via Pansini 5, 80131 Naples, Italy;
e-mail: [email protected]
Maiko Gokoh, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko,
Tsukui-gun, Kanagawa 199-0195, Japan
Francescopaolo Granata, Division of Clinical Immunology and Allergy, University
of Naples Federico II, Via Pansini 5, 80131 Naples, Italy;
e-mail: [email protected]
Michael G. Harrington, Molecular Neurology Program, Huntington Medical
Research Institutes, Pasadena, CA 91101-1830, USA;
e-mail: [email protected]
Margaret Johnson, Department of Medicine, Mayo Clinic, Jacksonville, Florida
32224, USA; e-mail: [email protected]
Seishi Kishimoto, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko,
Tsukui-gun, Kanagawa 199-0195, Japan; e-mail: [email protected]
Stefania Loffredo, Division of Clinical Immunology and Allergy, University of
Naples Federico II, Via Pansini 5, 80131 Naples, Italy;
e-mail: [email protected]
Alex D. Manguikian, Department of Biochemistry, Virginia Commonwealth Uni
versity, Richmond, VA 23298-0614, USA
Chad R. Marion, Infectious Diseases, Department of Internal Medicine, Wake For
est University School of Medicine, Winston-Salem, North Carolina, 27157, USA;
e-mail: [email protected]
Gianni Marone, Division of Clinical Immunology and Allergy, University of Naples
Federico II, Via Pansini 5,80131 Naples, Italy: e-mail: [email protected]
Allen M. McAlexander, Department of Biology and Health Sciences, Meridith Col
lege, Raliegh, NC 27607, USA; e-mail: [email protected]
Saori Oka, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko,
Tsukui-gun, Kanagawa 199-0195, Japan
viii
List of contributors
Rebeca PereZ, Institute of Molecular Biology and Genetics (IBGM-CSIC), Universi
ty of Valla do lid School of Medicine, Avenida Ramon y Cajal 7, E-47005 Valladolid,
Spain; e-mail: [email protected]
Francesca W. Rossi, Division of Clinical Immunology and Allergy, University of
Naples Federico II, Via Pansini 5,80131 Naples, Italy
Yolanda Saez, Institute of Molecular Biology and Genetics (IBGM-CSIC), Universi
ty of Valla do lid School of Medicine, Avenida Ramon y Cajal 7, E-47005 Valladolid,
Spain; e-mail: [email protected]
Salvatore Salzano, Experimental Endocrinology and Oncology Center, Consiglio
Nazionale delle Ricerche (CNR), Italy
Royal D. Saunders, Department of Biology, Xavier University of Louisiana, 1 Drex
el Drive, Box 85B, New Orleans, LA 70125, USA; e-mail: [email protected]
Charles N. Serhan, The Center for Experimental Therapeutics and Reperfusion
Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham
and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA;
e-mail: [email protected]
Takayuki Sugiura, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko,
Tsukui-gun, Kanagawa 199-0195, Japan; e-mail: [email protected]
Massimo Triggiani, Division of Clinical Immunology and Allergy, University of
Naples Federico II, Via Pansini 5, 80131 Naples, Italy, e-mail: [email protected]
Keizo Waku, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko,
Tsukui-gun, Kanagawa 199-0195, Japan; e-mail: [email protected]
Robert L. Wykle, Department of Biochemistry, Wake Forest University School of
Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA;
e-mail: [email protected]
ix
Preface
Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids
(PUFAs) are precursors of signaling molecules that are critical in disease processes
and in regulating normal cell function. Remodeling is critical in homeostatic control
and in dictating how PUFAs are converted to mediators. Thus, understanding
remodeling will unravel better therapeutic targets for controlling inflammatory dis
eases.
The review chapters associate AA remodeling and the biosynthesis of mediators
of inflammation or pain. By following the movement of AA rather than discussing
a single enzyme and its product, the influence of upstream biosynthetic pathways on
the formation of lipid mediators and interrelationship between all AA-derived medi
ators are examined in a comprehensive fashion. This approach innovates AA metab
olism by describing new inhibitors, mode of action of these inhibitors and poten
tially efficacious targets not previously examined.
This volume is written by experts in the field to serve as a rich resource of knowl
edge for scientists and clinicians in academia, and researchers in the pharmaceutical
industry involved in inflammation and pain research. Since AA is derived from
essential fatty acids, this volume is also of interest to nutritionists.
July 2003 A.N. Fonteh
R.L. Wykle
xi