Applied Clinical Pharmacokinetics - ajprd PDF
Preview Applied Clinical Pharmacokinetics - ajprd
APPLIED CLINICAL PHARMACOKINETICS NOTICE Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The author and the publisher of this work have checked with sources believed to be reliable in their efforts to provide informa- tion that is complete and generally in accord with the standards accepted at the time of publica- tion. However, in view of the possibility of human error or changes in medical sciences, neither the author nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accu- rate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. APPLIED CLINICAL PHARMACOKINETICS Second Edition LARRY A. BAUER, PharmD Professor Departments of Pharmacy and Laboratory Medicine Schools of Pharmacy and Medicine University of Washington Seattle, Washington New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto Copyright © 2008 by The McGraw-Hill Companies, Inc. All rights reserved. Manufactured in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval sys- tem, without the prior written permission of the publisher. 0-07-159372-1 The material in this eBook also appears in the print version of this title: 0-07-147628-8. All trademarks are trademarks of their respective owners. Rather than put a trademark symbol after every occur- rence of a trademarked name, we use names in an editorial fashion only, and to the benefit of the trademark owner, with no intention of infringement of the trademark. Where such designations appear in this book, they have been printed with initial caps. McGraw-Hill eBooks are available at special quantity discounts to use as premiums and sales promotions, or for use in corporate training programs. For more information, please contact George Hoare, Special Sales, at Professional Want to learn more? We hope you enjoy this McGraw-Hill eBook! If you’d like more information about this book, its author, or related books and websites, please click here. For all of the late dinners, all of the even later bedtimes, and all of the understanding, forgiveness, unconditional love, and support, I continue to be eternally grateful to my wife (S.P.B.) and my daughters (L.A.B. and L.E.B.) for allowing me the time and effort to produce another edition. Isn’t it supposed to get easier each time? —L.A.B. This page intentionally left blank For more information about this title, click here CONTENTS About the Author ix Preface xi From Applied Clinical Pharmacokinetics, First Edition xiii PART I BASIC CONCEPTS 1 Clinical Pharmacokinetic and Pharmacodynamic Concepts 3 2 Clinical Pharmacokinetic Equations and Calculations 28 3 Drug Dosing in Special Populations: Renal and Hepatic Disease, Dialysis, Heart Failure, Obesity, and Drug Interactions 52 PART II ANTIBIOTICS 4 The Aminoglycoside Antibiotics 97 5 Vancomycin 207 PART III CARDIOVASCULAR AGENTS 6 Digoxin 301 7 Lidocaine 356 vii viii Contents 8 Procainamide/N-Acetyl Procainamide 398 9 Quinidine 448 PART IV ANTICONVULSANTS 10 Phenytoin 485 11 Carbamazepine 548 12 Valproic Acid 563 13 Phenobarbital/Primidone 599 14 Ethosuximide 626 PART V IMMUNOSUPPRESSANTS 15 Cyclosporine 649 16 Tacrolimus 682 PART VI OTHER DRUGS 17 Lithium 711 18 Theophylline 745 Index 803
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