Applications of Minimally Invasive Nanomedicine-Based Therapies in 3D in vitro Cancer Platforms

111 Pages·2020·9.211 MB·English

by  Layla Mohammad-Hadi, Marym Mohammad-Hadi

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Synthesis Lectures on M
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Mobile and Pervasive Computing -H
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Applications of Minimally Invasive Nanomedicine-Based A
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Therapies in 3D in vitro Cancer Platforms IC
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Layla Mohammad-Hadi, University College London S
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Marym Mohammad-Hadi, University College London F M Minimally Invasive
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Minimally invasive techniques such as Photodynamic Therapy (PDT) and Photochemical A
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Internalisation (PCI) have for years been under investigation for the treatment of solid cancers. Y
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A significant number of the recent research studies have applied PDT and PCI to biological V
A Nanomedicine-Based
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three-dimensional (3D) cancer platforms with many of the studies also involving the use of IV
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nanoparticles in order to enhance the efficacy of these light-based therapies. Interest in the N
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employment of 3D cancer platforms has increased considerably due to the ability of the platforms O
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to mimic in vivo models better than the conventional two-dimensional (2D) cultures. Some of E
D Therapies in 3D in vitro
the advantages of the 3D cancer systems over their 2D counterparts include improved interaction IC
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between cancer cells and the surrounding extracellular matrix (ECM) as well as restricted drug E
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penetration which would allow optimization of treatments prior to undertaking of in vivo studies. S
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The different chapters of this book will discuss photosensitizers and nanoparticles used in PDT TH Cancer Platforms
and PCI in addition to the applications of these treatments in various 3D cancer models. E
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About SYNTHESIS L Marym Mohammad-Hadi
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This volume is a printed version of a work that appears in the Synthesis O
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Digital Library of Engineering and Computer Science. Synthesis
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books provide concise, original presentations of important research and
development topics, published quickly, in digital and print formats. M
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store.morganclaypool.com P
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Applications of Minimally
Invasive Nanomedicine-Based
Therapies in 3D in vitro
Cancer Platforms

Synthesis Lectures on
Materials and Optics
ApplicationsofMinimallyInvasiveNanomedicine-BasedTherapiesin3DinvitroCancer
Platforms
LaylaMohammad-HadiandMarymMohammad-Hadi
2020
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GhanshyamPilania,PrasannaV.Balachandran,JamesE.Gubernatis,andTurabLookman
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Copyright©2021byMorgan&Claypool
Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmittedin
anyformorbyanymeans—electronic,mechanical,photocopy,recording,oranyotherexceptforbriefquotations
inprintedreviews,withoutthepriorpermissionofthepublisher.
ApplicationsofMinimallyInvasiveNanomedicine-BasedTherapiesin3DinvitroCancerPlatforms
LaylaMohammad-HadiandMarymMohammad-Hadi
www.morganclaypool.com
ISBN:9781681739694 paperback
ISBN:9781681739700 ebook
ISBN:9781681739717 hardcover
DOI10.2200/S01047ED1V01Y202009MOP006
APublicationintheMorgan&ClaypoolPublishersseries
SYNTHESISLECTURESONMATERIALSANDOPTICS
Lecture#6
SeriesISSN
SynthesisLecturesonMaterialsandOptics
Print2691-1930 Electronic2691-1949
Applications of Minimally
Invasive Nanomedicine-Based
Therapies in 3D in vitro
Cancer Platforms
Layla Mohammad-Hadi and Marym Mohammad-Hadi
UniversityCollegeLondon
SYNTHESISLECTURESONMATERIALSANDOPTICS#6
M
&C Morgan &cLaypool publishers
ABSTRACT
Minimally invasive techniques such as Photodynamic Therapy (PDT) and Photochemical In-
ternalisation (PCI) have for years been under investigation for the treatment of solid cancers.
A significant number of the recent research studies have applied PDT and PCI to biological
three-dimensional (3D) cancer platforms with many of the studies also involving the use of
nanoparticlesinordertoenhancetheefficacyoftheselight-basedtherapies.Interestintheem-
ploymentof3Dcancerplatformshasincreasedconsiderablyduetotheabilityoftheplatformsto
mimicinvivomodelsbetterthantheconventionaltwo-dimensional(2D)cultures.Someofthe
advantages of the 3D cancer systems over their 2D counterparts include improved interaction
betweencancercellsandthesurroundingextracellularmatrix(ECM)aswellasrestricteddrug
penetrationwhichwouldallowoptimizationoftreatmentspriortoundertakingofinvivostud-
ies. The different chapters of this book will discuss photosensitizers and nanoparticles used in
PDTandPCIinadditiontotheapplicationsofthesetreatmentsinvarious3Dcancermodels.
KEYWORDS
light therapy, non-invasive medicine, 3D models, nanomedicine, photodynamic
therapy,photochemicalinternalization
vii
We dedicate this book to our beloved parents
for their endless love, support, and sacrifice over the years.