Applications of Functional Foods and Nutraceuticals for Chronic Diseases While disease is inevitable in humankind, the current century has been bur- dened with many chronic diseases, most of which are lifestyle mediated and which, in part, can be controlled by consuming foods with specific functions. Functional foods are a special category of natural food or nutrient-derived pharmaceutical products containing beneficial biochemicals and phytochemi- cals beyond their basic nutritional functions. The first of two volumes, Applications of Functional Foods and Nutraceuticals for Chronic Diseases, collects information on the associa- tion between functional foods and chronic diseases. The burden of escalating chronic diseases is discussed in the first chapter, and the remaining four- teen chapters summarize the effect of functional foods on a range of chronic diseases. Key Features: • Discusses the clinical application of functional foods for the manage- ment of a wide range of chronic diseases • Covers chronic diseases, including obesity, arthritis, cardiovascular diseases, endocrinal and hormonal diseases, among others • Explores beneficial effects of nutraceuticals on chronic diseases Contributors hail from different geographical locations around the world and possess many years of research and scholarly experience in functional foods, nutraceuticals, and biology. The world’s leading wellness centers for chronic diseases are using functional foods and nutraceuticals in their practice and discovering their useful applications, and this book is a great reference for practitioners, scientists, and clinicians in the management of chronic diseases. Nutraceuticals: Basic Research and Clinical Applications Series Editor: Yashwant Pathak, PhD Marine Nutraceuticals: Prospects and Perspectives Se-Kwon Kim Nutrigenomics and Nutraceuticals: Clinical Relevance and Disease Prevention edited by Yashwant Pathak and Ali M. Ardekani Food By-Product Based Functional Food Powders edited by Özlem Tokuşoğlu Flavors for Nutraceuticals and Functional Foods M.Selvamuthukumaran and Yashwant Pathak Antioxidant Nutraceuticals: Preventive and Healthcare Applications Chuanhai Cao, Sarvadaman Pathak, and Kiran Patil Advances in Nutraceutical Applications in Cancer: Recent Research Trends and Clinical Applications edited by Sheeba Varghese Gupta, Yashwant Pathak Flavor Development for Functional Foods and Nutraceuticals M.Selvamuthukumaran and Yashwant Pathak Nutraceuticals for Prenatal, Maternal and Offspring’s Nutritional Health, Priyanka Bhatt, Maryam Sadat Miraghajani, Sarvadaman Pathak, Yashwant Pathak Bioactive Peptides: Production, Bioavailability, Health Potential and Regulatory Issues, edited by John Oloche Onuh, M. Selvamuthukumaran, Yashwant Pathak Nutraceuticals for Aging and Anti-Aging: Basic Understanding and Clinical Evidence, edited by Jayant Lokhande, Yashwant Pathak Marine-Based Bioactive Compounds: Applications in Nutraceuticals, edited by Stephen T. Grabacki, Yashwant Pathak, Nilesh H. Joshi Applications of Functional Foods and Nutraceuticals for Chronic Diseases, Volume I, edited by Syam Mohan, Shima Abdollahi, and Yashwant Pathak Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2, edited by Karam F.A. Soliman and Yashwant Pathak For more information about this series, please visit: https://www.crcpress.com/ Nutraceuticals/book-series/CRCNUTBASRES Applications of Functional Foods and Nutraceuticals for Chronic Diseases Volume I Edited by Syam Mohan, Shima Abdollahi, and Yashwant V. Pathak First edition published 2023 by CRC Press 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742 and by CRC Press 4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN CRC Press is an imprint of Taylor & Francis Group, LLC © 2023 selection and editorial matter, Syam Mohan, Shima Abdollahi, and Yashwant V. Pathak; individual chapters, the contributors Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all mate- rial reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, repro- duced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, access www.copy- right.com or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. For works that are not available on CCC please contact mpkbooksper- [email protected] Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging‑in‑Publication Data Names: Mohan, Syam, editor. | Abdollahi, Shima, editor. | Pathak, Yashwant, editor. Title: Applications of functional foods and nutraceuticals for chronic diseases / edited by Syam Mohan, Shima Abdollahi, and Yashwant V. Pathak. Description: First edition. | Boca Raton : CRC Press, 2023. | Series: Nutraceuticals | Includes bibliographical references and index. Identifiers: LCCN 2022032399 (print) | LCCN 2022032400 (ebook) | ISBN 9781032072951 (volume 1 ; hardback) | ISBN 9781032114774 (volume 1 ; paperback) | ISBN 9781003220053 (volume 1 ; ebook) Subjects: LCSH: Functional foods--Therapeutic use. | Chronic diseases--Diet therapy. Classification: LCC RM217 A745 2023 (print) | LCC RM217 (ebook) | DDC 613.2--dc23/eng/20221021 LC record available at https://lccn.loc.gov/2022032399 LC ebook record available at https://lccn.loc.gov/2022032400 ISBN: 9781032072951 (hbk) ISBN: 9781032114774 (pbk) ISBN: 9781003220053 (ebk) DOI: 10.1201/9781003220053 Typeset in Garamond by KnowledgeWorks Global Ltd. This book is dedicated to the students, professors, researchers, and clinicians who use this text. We also appreciate the authors for sharing their wisdom, knowledge, experience, and insights. We also thank CRC Press, Dr. Steve Zollo, other T&F staff, our families, and our institutions. —The Editors Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi About the Editors . . . . . . . . . . . . . . . . . . . . . . . . . . xiii List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . . xv SECTION I Burden of Chronic Diseases 1 Global Trends in Growth of Chronic Diseases . . . . 3 Janefar Eva and Yashwant Pathak 2 Importance of Integrative Health Sciences in the Therapy of Chronic Diseases . . . . . . . . . . . 17 Ghazaleh Eslamian, Arman Ghorbani, and Morvarid Noormohammadi SECTION II Effect of Functional Foods in Treating Chronic Diseases 3 Safety and Efficacy Determination in Functional Foods and Nutraceuticals . . . . . . . . . 37 Arun Soni, Tulsi Patil, Sanjeev Acharya, and Niyati Acharya vii 4 Global Burden of Disease, the Heavy Cost of Sun Deprivation: Implications for Mass Food Fortification with Vitamin D . . . . . . . . . . . . 67 Zahra Yari, Bahareh Nikooyeh, Samira Ebrahimof, and Tirang R. Neyestani 5 Functional Vegetables and Medicinal Uses: Cure and Curse . . . . . . . . . . . . . . . . . . . . . . . . 117 Sivakumar S. Moni 6 Dietary Supplements and Functional Foods in the Management of Endocrine Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 Elham Razmpoosh, Shima Abdollahi, and Sepideh Soltani 7 Changes in the Regulation of Energy Metabolism in Chronic Diseases Using Functional Foods and Nutraceuticals . . . . . . . . 167 Aparoop Das, Manash Pratim Pathak, Kalyani Pathak, Urvashee Gogoi, and Riya Saikia 8 Functional Foods for the Prevention and Treatment of Cardiovascular Diseases Including Hypertension . . . . . . . . . . . . . . . . . . 197 Nahid Ramezani-Jolfaie and Mohammad Mohammadi 9 Functional Foods and Natural Products for Obesity Management . . . . . . . . . . . . . . . . . . . 231 Idris Adewale Ahmed, Najihah Mohd Hashim, and Rozana Othman 10 Noncommercial Plant-Based Edible Oil for Prevention and Treatment of Chronic Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249 Der Jiun Ooi, Yun Ping Neo, Yin Sim Tor, and Jhi Biau Foo viii Contents 11 Oral Health Challenges during Chronic Diseases: Prevention and Treatment Using Functional Foods and Nutraceuticals . . . . . . . . 293 Sangeeta Jayant Palaskar, Rasika Balkrishna Pawar, and Darshana Rajesh Shah 12 Urogenital System Disorders and Functional Foods and Nutraceuticals . . . . . . . . . . . . . . . . . 317 Manish P. Patel, Arya S. Vyas, Praful D. Bharadia, Jayvadan K. Patel, and Dipti H. Patel 13 Functional Foods and Nutraceuticals and Respiratory Diseases . . . . . . . . . . . . . . . . . . . . 341 Azadeh Dehghani and Mehran Rahimlou 14 Strategies Using Functional Food and Nutraceuticals to Prevent and Treat Arthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361 Shikha Sharma, Ramesh Bhonde, and Kalpana Joshi 15 Functional Foods of Polyphenolics for Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . 375 Hanish Singh Jayasingh Chellammal and Dhani Ramachandran Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 409 Contents ix