Apparatus and method to control an implant

36 Pages·2014·3.02 MB·English

US008718776B2
(12) United States Patent (10) Patent N0.: US 8,718,776 B2
Mashiach et a]. (45) Date of Patent: May 6, 2014
(54) APPARATUS AND METHOD TO CONTROL 5,070,535 A 12/1991 Hochmair et a1.
AN IMPLANT 5,094,242 A 3/1992 Gleason et a1.
5,174,287 A 12/1992 Kallok et a1.
(71) Applicants:Adi Mashiach, Mont-St-Guibert (BE); 5,178,156 A 1/1993 Takishima et a1.
5,193,539 A 3/1993 Schulman et a1.
Carsten Mueller, Erfurt (DE) 5,335,657 A 8/1994 Terry et a1.
5,413,596 A * 5/1995 Kronberg ...................... .. 607/51
(72) Inventors: Adi Mashiach, Mont-St-Guibert (BE); 5,485,851 A 1/1996 Erickson
Carsten Mueller, Erfurt (DE) 5,540,733 A 7/1996 Testerman et a1.
5,591,216 A 1/1997 Testerman et a1.
(73) Assignee: Nyxoah SA, Mont-St-Guibert (BE) (Continued)
( * ) Notice: Subject to any disclaimer, the term of this FOREIGN PATENT DOCUMENTS
patent is extended or adjusted under 35
U.S.C. 154(b) by 0 days. DE 10 2009027997 1/2011
WO W02007/098200 8/2007
(21) App1.No.: 13/629,819 (Continued)
OTHER PUBLICATIONS
(22) Filed: Sep. 28, 2012
Brindley, G.S., Transmission of electrical stimuli along many inde
(65) Prior Publication Data
pendent channels through a fairly small area of intact skin, Proceed
US 2013/0085544 A1 Apr. 4, 2013 ings of the Physiological Society, Dec. 1964, pp. 44-46.
Related US. Application Data (Continued)
(60) Provisional application No. 61/541,651, ?led on Sep. Primary Examiner * Carl H Layno
30, 2011, provisional application No. 61/657,424,
Assistant Examiner * Ankit Tejani
?led on Jun. 8, 2012.
(74) Attorney, Agent, or Firm * Finnegan, Henderson,
FaraboW, Garrett & Dunner LLP
(51) Int. Cl.
A61N 1/00 (2006.01)
(57) ABSTRACT
(52) US. Cl.
A device according to some embodiments of the present
USPC .......................................................... .. 607/42
(58) Field of Classi?cation Search disclosure includes a housing con?gured to retain a battery, a
None primary antenna associated With the housing, and at least one
See application ?le for complete search history. processor in electrical communication With the battery and
the primary antenna. In some embodiments, the at least one
(56) References Cited processor may be con?gured to cause transmission of a pri
mary signal from the primary antenna to an implantable
U.S. PATENT DOCUMENTS device during a treatment session of at least three hours in
duration, Wherein the primary signal is generated using power
3,796,221 A 3/1974 Hagfors supplied by the battery and includes a pulse train, the pulse
3,870,051 A 3/1975 Brindley
train including a plurality of modulation pulses.
4,765,983 A 8/1988 Takayanagi et al.
4,830,008 A 5/1989 Meer
4,837,049 A 6/1989 Byers et al. 17 Claims, 15 Drawing Sheets
US 8,718,776 B2
Page 2
(56) References Cited 2007/0073357 A1 3/2007 Rooney et a1.
2007/0112404 A1 5/2007 Mann eta1.
U_g_ PATENT DQCUMENTS 2007/0150022 A1 6/2007 Ujhazy eta1.
2007/0173893 A1 7/2007 Pitts
5,697,076 A 12/1997 Troyket 31‘ 2007/0185546 A1 8/2007 Tseng et a1.
5,895,360 A 4/1999 Christopherson eta1. 2007/0221231 A1 9/2007 Macken _
5,948,006 A 9/1999 Mann 2007/0222560 A1 9/2007 Posamentler
6,024,702 A 2/2000 Iversen 2007/0233204 A1 10/2007 L11nz_1et a1.
6,026,818 A 2/2000 Blairetal‘ 2007/0255379 A1 11/2007 W1111ams_et_al.
6,038,480 A 3/2000 Hrdlickaetal‘ 2007/0265606 A1 11/2007 DeBened1ct1s Ct 211.
6,051,017 A 4/2000 Loeb etal‘ 2007/0290859 A1 12/2007 Heldetal.
6,126,611 A 10/2000 Bourgeois et al‘ 2008/0021506 A1 1/2008 Grocela
6,163,725 A 12/2000 Peckhametal, 2008/0027503 A1 1/2008 Marrosn eta1.
6,185,296 B1 2/2001 Sal-t0}, 2008/0030363 A1 2/2008 Rezvam et a1.
6,210,326 B1 4/2001 Ehwald 2008/0041398 A1 2/2008 Hegde et al.
6,240,316 B1 5/2001 Richmondetal‘ 2008/0081982 A1 4/2008 Slmon etal.
6,275,737 B1 @2001 Mann 2008/0103407 A1 5/2008 Bo1ea eta1.
6,345,202 B2 2/2002 Richmond et al‘ 2008/0109046 A1 5/2008 L1maeta1.
6,535,767 B1 3/2003 Kronberg ...................... .. 607/72 2008/0109047 A1 5/2008 Pless
6,572,543 B1 6/2003 Christopherson eta1. 2008/0119911 A1 5/2008 Rosero
6,587,725 B1 7/2003 Dnrand eta1. 2008/0132962 A1 6/2008 DiUbaidi eta1.
6,587,728 B2 7/2003 Fang eta1. 2008/0140152 A1 6/2008 1nrraneta1.
6,625,494 B2 9/2003 Fang eta1. 2008/0165058 A1 7/2008 Ayaohitnia eta1.
6,636,767 B1 10/2003 KHUdSOIl et al~ 2008/0243014 A1 10/2008 Moussaviet a1.
6,643,552 B2 11/2003 Edell er a1~ 2008/0300654 A1 12/2008 Larnbert eta1.
6,770,022 B2 8/2004 Mechlenburg etal~ 2008/0319506 A1 12/2008 Cauller
6,814,706 B2 11/2004 B99911 etal~ 2009/0018611 A1* 1/2009 Campbell et a1. ............. .. 607/48
7,062,330 B1 6/2006 BQVGJaetaL 2009/0024189 A1* 1/2009 Lee eta1. ...................... .. 607/66
7,155,278 B2 12/2006 141.11% “A 2009/0048647 A1 2/2009 Tingey
7,272,443 B2 900‘” Mm etal' 2009/0062675 A1 3/2009 Weigand eta1
7,277,749 B2 10/2007 Gordonetai. 2009/0069648 A1 wow I . t 1'
7,295,132 B2 11/2007 Steiner razoqu‘e 3'
7,367,935 B2 5/2008 Mechlenburg eta1. 2009/0078274 A1 3/2009 B1?“ et 3.1'
7,371,220 B1 5,2008 Koh et a1, 2009/0132018 A1 5/2009 D1Ubald1 eta1.
7,447,551 B2 11/2008 Kuo etal, 2009/0157150 A1 6/2009 Caniier
7,623,929 B1 11/2009 Grif?th 2009/0173351 A1 7/2009 S21h1netal.
7,644,714 B2 1/2010 Atkinson et 31, 2009/0281595 A1 11/2009 K1ng et :11.
7,667,511 B2 2/2010 Staszewskietal, 2010/0030298 A1 2/2010 Martens etal.
7,680,538 B2 3/2010 Dnrant et a1. 2010/0076523 A1 3/2010 Howard eta1.
7,697,990 B2 4/2010 Ujhazy eta1. 2010/0087896 A1 4/2010 McCreery
7,709,961 B2 5/2010 Greenberg et al. 2010/0094379 A1 4/2010 Meadows et a1.
7,725,195 B2 5/2010 Limaet a1. 2010/0114190 A1 5/2010 Bendett eta1.
7,729,772 B2 6/2010 WilliamsetaL 2010/0114199 A1 5/2010 Krause eta1.
E; 25818 gwoyertet 181- 2010/0121413 A1 5/2010 Wi11erton eta1.
r r ragoe a~ 2010/0125304 A1 5/2010 Fal s
7,756,583 B2 7/2010 Demmisetal' 2010/0131029 A1 5/2010 Dngndetai.
7,773,695 B2 8/2010 Z110“ etaL 2010/0137948 A1 6/2010 Aghassian eta1.
9%?ng 3% 13/5818 3211121111221“ 31' 2010/0139667 A1 6/2010 Atkinson eta1.
7,845,357 B2 12/2010 Buscemi et a1. 5818/8332; :1 $5818 wgigdetal'
£33322???) 3% $81} etal' 2010/0196744 A1 8/2010 Tnohoiski eta1.
2001/0018547 A1 8/2001 Mechlenburg eta1. 2010/0198305 A1 8/2010 FarbaHk
2002/0188333 A1 12/2002 Nowicketal‘ 2010/0228313 A1 9/2010 Starkebaumetal.
2003/0225403 A1 12/2003 Woloszko eta1. 2010/0234924 A1 9/2010 Willis
2004/0049245 A1 3/2004 Gass et a1. 2010/0241195 A1 9/2010 Meadows et a1.
2004/0059392 A1 3/2004 Parrarnon eta1. 2010/0254436 A1 10/2010 Larsson
2004/0085792 A1 5/2004 Lin eta1. 2010/0292527 A1 11/2010 Schneider eta1.
2004/0102820 A1 5/2004 Moune eta1. 2010/0312320 A1 12/2010 Faltys et a1.
2004/0153127 A1 8/2004 Gordon et a1~ 2010/0331634 A1 12/2010 Muller et a1.
2004/0162501 A1 8/2004 Imran ~~~~~~~~~~~~~~~~~~~~~~~~~ ~- 600/547 2011/0065979 A1 3/2011 Lehrrnan eta1.
2004/0172089 A1 9/2004 Whltehurstet 3.1. 2011/0071591 A1 3/2011 BoleaetaI‘
gggg/ggigggg 2} 5588; 22111111533810 “1’11 2011/0112601 A1 5/2011 Meadows et a1.
zoos/0070971 A1 3/2005 Fgwlerag?ta' 2011/0152965 A1 6/2011 Mashiachetal.
zoos/0075694 Al 4/2005 S h 1. ' 2011/0152966 A1 6/2011 Bo1eaeta1.
0 me 1ng et a1. .
2005/0075695 A1 4/2005 Schommer 2011/0172733 A1 700“ L‘maetal'
2006/0009820 A1 1/2006 Royle 2011/0213438 A1 9/2011 L1maet £11.
2006/0062580 A1 3/2006 Mahbobi 2011/0230702 A1 9/2011 Honour
2006/0093923 A1 5/2006 Howard eta1. ............. .. 429/322 2011/0264163 A1 10/2011 Tracey etal~
2006/0114104 A1 6/2006 scammozzino 2011/0301670 A1 12/2011 Gross etal.
2006/0145878 A1 7/2006 Lehrman et a1. 2012/0123498 A1 5/2012 Gross
2006/0180647 A1 8/2006 Hansen
2006/0217779 A1 9/2006 Ransbury et a1. FOREIGN PATENT DOCUMENTS
2006/0224211 A1 10/2006 Dnrand eta1.
2006/0265034 A1 11/2006 Aknine eta1. W0 W0 2007/098202 8/2007
2006/0271110 A1 11/2006 Vernonet a1. W0 W0 2008/039921 4/2008
US 8,718,776 B2
Page 3
(56) References Cited Proceedings of the 26th Annual International Conference of the IEEE
EMBS, San Francisco, CA, USA, Sep. 2004.
FOREIGN PATENT DOCUMENTS Jow, Uei-Ming; Ghovanloo, Maysam, Design and Optimization of
Printed Spiral Coils for Ef?cient Transcutaneous Inductive Power
WO WO2008/048471 4/2008
Transmission, IEEE Transactions on Biomedical Circuits and Sys
W0 WO 2011/077433 6/2011
tems, vol. 1, No. 3, Sep. 2007.
OTHER PUBLICATIONS Steiglitz, Thomas, Polymer-based Substrates and Flexible Hybrid
Assembly Techniques for Implantable Active Microdevices, Busi
Tran W.H., First Subject Evaluated with Simulated BION Treatment ness Brie?ng: Medical Device Manufacturing & Technology, 2002.
in Posterior Genioglossus to Prevent Obstructive Sleep Apnea, Pro Jarvis, Jonathan; Salmons, Stanley, The Application and Technology
ceedings of the 26th Annual International Conference of IEEE of Implantable Neuromuscular StimulatorsL an introduction and
overview, Medical Engineering and Physics 23, 2001.
EMBS, Sep. 2004, pp. 4287-4289.
Manola, Ljubomir; Holsheimer, Jan; Veltink, Peter; Bradley, Kerry;
Schwartz, Alan R., Therapeutic Stimulation of the Hypoglossal
Peterson, David, Theoretical Investigation Into Longitudinal
Nerve in Obstructive Sleep Apnea, Archives of Otolaryngology Head
and Neck Surgery, vol. 127, Oct. 2001, pp. 1216-1223. Cathodal Field Steering in Spinal Cord Stimulation, Neurmodula
Eastwood, P.R., Treatment of Obstructive Sleep Apnea with Unilat tion: Technology at the Neural Interface, vol. 10, No. 2, 2007.
eral Hyopglossal Nerve Stimulation, American Journal of Respira Joho, Dominik, Plagemann, Christian, Burgard, Wolfram, Modeling
tory Critical Care Medicine, vol. 181, May 2010, pp. 5393-5394. RFID Signal Strength and Tag Detection for Localization and Map
Eisele, David W., Tongue neuromuscular and direct hypoglossal ping, Proceedings of the IEEE International Conference on Robotics
nerve stimulation for obstructive sleep apnea, Otolaryngologic Clin and Automation, Kobe Japan, May 2009.
ics ofNorth America, Jun. 2003, pp. 501-510. Werber, D.; Schwentner, A.; Biebl, E.M., Investigation of RF Trans
Robblee, L.S., Studies of the electrochemistry of stimulating elec mission Properties of Human Tissues, Advances in Radio Science,
trodes, National Institutes of Health, Contract No. N01-NS-8-2313, vol. 4, 2006.
Nov. 1991, pp. 6-8. Cameron, Tracy; Loeb, Gerald; Peck, Raymond; Schulman, Joseph;
Levin, Morris, Nerve Blocks in the Treatment of Headaches, Strojnik, Primoz; Troyk, Philip, Micromodular Implants to Provide
Neurotherapeutics: The Journal of the American Society for Experi Electrical Stimulation of Paralyzed Muscles and Limbs, IEEE Trans
mental NeuroTherapeutics, Apr. 2010, pp. 197-203. actions on Biomedical Engineering, vol. 44, No. 9, Sep. 1997.
Lundy, Larry, Ear, Nose, and Throat Journal, Cochlear Implant Fixa Mokwa, Wilfried; Schnakenberg, Uwe, Micro -Transponder Systems
tion Using Resorbable Mesh, Jul. 1, 2011, 4 pages. for Medical, IEEE Transactions on Instrumentation and Measure
Upson, James; King, Frederick; Roberts, Lamar; A constant ampli ment, vol. 50, No. 6, Dec. 2001.
tude transistorized unit for remote brain stimulation, Grill, Warren; Veraart, Claude; Mortimer, Thomas, Selective Activa
Electroencephalography and Clinical Neurophysiology, Jun. 11, tion of Peripheral Nerve Fascicles: Use of Field Steering Currents,
1962. Annual International Conference of the IEEE Engineering in Medi
Brindley, G.S., An implant to empty the bladder or close the urethra, cine and Biology Society, vol. 13, No. 2, 1991.
Journal of Neurology, Neurosurgery, and Psychiatry, 1977. Loeb, G.E.; Zamin, C.J.; Schulman, J.H.; Troyk, P.R., Injectable
Kaplan, Hilton; Loeb, Gerald; Design and Fabrication ofan Injection Microstimulator for Functional Electrical Stimulation, Med. and
Tool for Neuromuscular Microstimulators, Annals of Biomedical Biol. Eng. & Comput. 1991.
Engineering, vol. 37, No. 9., Jun. 24, 2009. Young, Darrin, Wireless Powering and Data Telemetry for Biomedi
Troyk, Philip; Schwan, Martin; Closed-Loop Class E Transcutaneous cal Implants, 31st Annual International Conference of the IEEE
Power and Data Link for MicroImplants. IEEE Transactions on Bio EMBS, Minnesota, USA, Sep. 2009.
medical Engineering, vol. 39, No. 6, Jun. 1992. Han, J.H.; Lim, H.G.; Kim, J.M.; Lee, C.W.; Park, I.Y.; Cho, J.H.,
Mithun, Joe; Rajkumar, Vikram; Shanmugapriya; Apnea Detecting Inductively-Coupled Control Unit for Fully Implantable Middle Ear
Sensors; Sathyabama Deemed University, 2006. Hearing Devices, Proceedings of the 2005 IEEE Engineering in
Babak, Ziaie; Nardin, Mark; Coghlan, Anthony; Naja?, Khalil, A Medicine and Biology 27th Annual Conference, China, Sep. 2005.
Single-Channel Implantable Microstimulator for Functional Oliven, A; Kaufman, E.; Kaynan, R.; Golboda, T.; Oliven, R.; Geitini,
Neuromuscular Stimulation, IEEE Transactions on Biomedical L.; Odeh, M.; Tov, N.; Schwartz, A.R.; Kimel, E., Effects of Cross
Engineering, vol. 44, No. 10, Oct. 1997. Sectional Area, Compliance and External Pressure on Pharyngeal
Robin, S; Sawan, M.; Harvey, J .F.; Abdel-Gawad, M.; Abdel-Baky, Collapsibility in Patients With Obstructive Sleep Apnea, A68 Upper
T.M.; Elhili, M.M., A New Implantable Microstimulator Dedicated Airway and Repiratory Physiology, 2010.
to Selective Stimulation of the Bladder, 19th International Confer Yoo, Paul B.; Durand, Dominique, Effects of Selective Hypoglossal
ence, IEEE/EMBS Oct. 30-Nov. 2, 1997. Nerve Stimulation on Canine Upper Airway Mechanics, Journal of
Troyk, PR.; Donaldson N. de N.; Implantable FES Stimulation Sys Applied Physiology, 2005.
tems: What is Needed, 2001 Neuromodulation Society, Huang, Jingtao; Sahin, Mesut; Durand, Dominique, Dilation of the
Neuromodulation, vol. 4, No. 4, 2001. oropharynx via selective stimulation of the hypoglossal nerve, Jour
Loeb, Gerald; Richmond, Frances; Moore, W. Henry; Peck, nal of Neural Engineering, 2005.
Raymond, 1st Annual International IEEE-EMBS Special Topic Con Oliven, A; Tov, N.; Geitini, L.; Steinfeld, U.; Oliven, R.; Schwartz,
ference on Microtechnologies in Medicine & Biology, Oct. 2000. A.R.; Odeh, M., Effect of Genioglossus Contraction on Pharyngeal
Harrison, Reid, Designing Ef?cient Inductive Power Links for Lumen and Air?ow in Sleep Apnoea Patients, European Respiratory
Implantable Devices, University of Utah, 2007. Journal, 2007.
Mohtashami, Saba, Electrochemical Properties of Flexible Elec Davis, Ross; Cosendai, Gregoire; Arcos, Isabel; Kushner, Douglas;
trodes for Implanted Neuromuscular Excitation Applications, Mishler, Delta; Decker, Christopher; Ripley, Anne-Marie; Maceri,
McMaster University, Oct. 1, 2011. Dennis; Sanderson, Donna; Zilberman, Yitzhak; Schulman, Joseph,
Baker, Michael; Sarpeshkar, Rahul, Feedback Analysis and DEsign Development of the BION Microstimulator for Treatment in
of RF Power Links for Low-Power Bionic Systems, IEEE Transac Obstructive Sleep Apnea, Alfred Mann Foundation.
tions on Biomedical Circuits and Systems, vol. 1, No. 1, Mar. 2007. Eastwood, PR.; Barnes, M.; McEvoy, R.D; Wheatley, J; Walsh, J.H.;
Zierhofer, Clemens, HOchmair, Erwin, High-Ef?ciency Coupling O’Donoghue, F.J.; Catcheside, P.; Tyler, L.; Maddison, K.J.;
Insensitive Transcutaneous Power and Data Transmission Via an Rochford, P.D.; Antic, N.; Worsnop C.; Churchward, T,; Eckert, D.J.;
Inductive Link, IEEE Transactions on Biomedical Engineering, vol. Campbell, M.C., Hee, G.; Palme, C.E., Robinson, S.H.; Kezirian, E.;
37, No. 3, Jul. 1990. Goding, G.; Jordan, A.S.; Smith, PL.; Schwartz, A.R.; Malhotra, A.;
Tran, W.H., Loeb, G.E., Richmond, F.J.R.; Ahmed, R.; Clark, G.T.; Hillman, D.R., Feasibility of Hypoglossal Nerve Stimulation
Haberman, P.B., First Subject Evaluated with Simulated BION Treat Therapy to Treat Obstructive Sleep Apnea, Am. J. Respir Crit Care
ment in Posterior Genioglossus to Prevent Obstructive Sleep Apnea, Med, 2010.
US 8,718,776 B2
Page 4
(56) References Cited Mwenge, Gimbada; Rombaux, Phillippe; Dury, Myriam; Lengele,
Benoit; Rodenstein, Daniel, Targeted Hypoglossal Neurostimulation
OTHER PUBLICATIONS for Obstructive Sleep Apnea. A 1 year pilot study, ERJ Express, May
17, 2012.
Randerath, Winfried, Electrical Stimulation of the Upper Airways Mann, Eric; Burnett, Theresa; Cornell, Sonia; Ludlow, Christy, The
Muscles, Institute for Pheumology at the University Written/ Effect of Neuromuscular Stimulation of the Genioglossus on the
Hypopharyngeal Airway, The Laryngoscope, 2002.
Herdecke, 2006.
Oliven, Arie; O’Hearn, Daniel; Boudewyns, An; Odeh, Majed; De
Schwartz, Alan; Eisele, David; Han, Anil; Testerman, Roy; Erickson,
Backer, Wilfried; van de Heyning, Paul; Smith, Philip; Eisele, David;
Donald; Smith, Philip, Electrical Stimulation of the Lingual Muscu
Allan, Larry; Schneider, Hartmut; Testerman, Roy; Schwartz, Alan,
lature in Obstructive Sleep Apnea, Johns Hopkins Asthma and Upper Airway Response to Electrical Stimulation of the Genioglos
Allergy Center, Feb. 1996. sus in Obstructive Sleep Apnea, J. Appl. Physiol. vol. 95, 2003.
Kezirian, Eric J.; Boudewyns, An; Eisele, David; Schwartz, Alan; Guillemenivalt, Christian; Powell, Nelson; Bowman, Bruce; Stoohs,
Philip, Smith; Van de Heyning, Paul; De Backer, Wilfried, Electrical Riccardo, The Effect of Electrical Stimulation on Obstructive Sleep
Stimulation of the Hypoglossal Nerve in the Treatment of Obstruc Apnea Syndrome, Chest, Jan. 1995.
tive Sleep Apnea, Sleep Medicine Reviews, 2009. Eastwood, Peter; Barnes, Maree; Walsh, Jennifer; Maddison,
Kathleen; Hee, Geoffrey; Schwartz, Alan; Smith, Philip; Malhotra,
Isono, S.; Tanaka, A.; Nishino, T., Effects of Tongue Electrical Stimu
Atul; McEvoy, Douglas; Wheatley, John; O’Donoghue, Fergal;
lation on Pharyngeal Mechanics in Anaesthetized Patients with
Rochford, Peter; Churchward, Tom; Campbell, Matthew; Palme,
Obstructive Sleep Apnoea. Eur Respir J, 1999. Carsten; Robinson, Sam; Goding, George; Eckert, Danny; Jordan,
Fregosi, Ralph, In?uence of Tongue Muscle Contraction and Amy; Catcheside, Peter; Tyler, Louise; Antic, Nick; Worsnop, Chris
Dynamic Airway Pressure on Velopharyngeal Volume in the Rat, J. topher; Kezirian, Eric; Hillman, David, Treating Obstructive Sleep
Appl. Physiol, Dec. 2007. Apnea with Hypoglossal Nerve Stimulation, Sleep vol. 34, No. 11,
Van de Heyning, Paul; Badr, M. Safwan; Baskin, Jonathan Z.; 201 1.
Bornemann, Michael Cramer; De Backer, WilfriedA.; Dotan, Yaniv; Schwartz, Alan; Bennet, Marc; Smith, Philip; De Backer, Wilfried;
Hohenhorst, Winfried; Knaack, Lennart; Lin, Ho-Sheng, Maurer, Hedner, Jan; Boudewyns, An; Van de Heyning, Paul; Enjnell, Hasse;
Joachim T.; Netzer, Aviram; Odland, Rick M.; Oliven, Arie; Strohl, Hochban, Walter; Knaack, Lennart; Podszus, Thomas; Penzel, Tho
Kingman P.; Vanderveken, Olivier M.; Verbraecken, Johan; mas; Peter, J. Hermann; Goding, George; Erickson, Donald; Tester
Woodson, B. Tucker, Implanted Upper Airway Stimulation Device man, Roy; Ottenhoff, Frans; Eisele, David, Therapeutic Electrical
for Obstructive Sleep Apnea, The Laryngoscope, Jul. 2012. Stimulation of the Hypoglossal Nerve in Obstructive Sleep Apnea,
Oliven, Ron; Tov, Naveh; Odeh, Majed; Gaitini, Luis; Steinfeld, Uri; Arch Otolaryngol Head Neck Surg, vol. 127, Oct. 2001.
Schwartz, Alan; Oliven, Arie, Interacting Effects of Genioglossus Randerath, Winfried, Galetke, Wolfgang; Domanski, Uinke;
Stimulation and Mandibular Advancements in Sleep Apnea, J. Appl. Weitkunat, Rolf; Ruhle, Karl-Heinz, Tongue-Muscle Training by
Physiol, 2009. Introral Electrical Neurostimulation in Patients with Obstructive
Peng, Chih-Wei; Chen, Jia-Jin Jason; Lin, Chou-Ching K.; Poon, Sleep Apnea, Sleep, vol. 27, No. 2, 2004.
Paul Wai-Fung; Liang, Chih-Kuo; Lin, Kang-Ping, High Frequency Eastwood, PR.; Walsh, J.H.; Maddison, K.J.; Baker, V.A.;
Block of Selected Axons Using an Implantable Microstimulator, Tesfayesus, W.; Hillman, D.R., Treatment of Obstructive Sleep
2004. Apnea With Unilateral Hypo glossal Nerve Stimulation, Am J Respir
Burnett, Theresa; Mann, Eric; Cornell, Sonia; Ludlow, Christy, Crit Care Med 181, 2010.
Laryngeal Elevation Achieved by Neuromuscular Stimulation at Loeb, Gerald; Richmond, Frances; Baker, Lucinda, The BION
Rest, J. Appl. Physiol. 94, 2003. devices: injectable interfaces with peripheral nerves and muscles,
Hu, Linggang; Xu, Xiaomei; Gong, Yongsheng; Fan, Xiaofang; Neurosurgery Focus 20, 2006.
Wang, Liangxing; Zhang, Jianhua, Percutaneous Biphasic Electrical Co-Pending U.S. Appl. No. 13/629,686, ?led Sep. 28, 2012.
Stimulation for Treatment of Obstructive Sleep Apnea Syndrom, Co-Pending U.S. Appl. No. 13/629,694, ?led Sep. 28, 2012.
IEEE Transactions on Biomedical Engineering, vol. 55, No. 1, Jan. Co-Pending U.S. Appl. No. 13/630,392, ?led Sep. 28, 2012.
2008. Co-Pending U.S. Appl. No. 13/629,762, ?led Sep. 28, 2012.
Dotan, Y.; Goliboda, T.; Netzer, A.; Geitini, L.; Oliven, A., Param Co-Pending U.S. Appl. No. 13/629,793, ?led Sep. 28, 2012.
eters Affecting the Mechanical Effect of Electrical Stimulation (ES) Co-Pending U.S. Appl. No. 13/629,690, ?led Sep. 28, 2012.
of the Tongue Muscles in Patients with Obstructive Sleep Apnea Co-Pending U.S. Appl. No. 13/629,748, ?led Sep. 28, 2012.
(OSA), Am. J. Respir. Crit Care Med, 2010. Co-Pending U.S. Appl. No. 13/629,757, ?led Sep. 28, 2012.
Yoo, Paul Byong-Suk, Selective Stimulation and Recording of the Co-Pending U.S. Appl. No. 13/629,712, ?led Sep. 28, 2012.
Canine Hypoglossal Nerve for the Treatment of Obstructive Sleep Co-Pending U.S. Appl. No. 13/629,701, ?led Sep. 28, 2012.
Apnea, Case Western Reserve University, May 2004. Co-Pending U.S. Appl. No. 13/629,725, ?led Sep. 28, 2012.
Oliven, Arie, Treating Obstructive Sleep Apnea With Hypoglossal Co-Pending U.S. Appl. No. 13/629,730, ?led Sep. 28, 2012.
Nerve Stimulation, Curr. Opin. Pulm. Med. 2011. Co-Pending U.S. Appl. No. 13/629,741, ?led Sep. 28, 2012.
Goding, George; Eisele, David; Testerman, Roy; Smith, Philip; Co-Pending U.S. Appl. No. 13/629,721, ?led Sep. 28, 2012.
Roertgen, Karen; Schwartz, Alan, Relief of Upper Airway Obstruc Youbok Lee, “Antenna Circuit Design for RFID Applications,”
tion With Hypoglossal Nerve Stimulation in the Canine, Microchip Technology Inc., Dec. 5, 2002. pp. 1-50.
Laryngoscope, 1998. PCT International Search Report for International Application PCT/
Oliven, Arie; Schnall, Robert; Pillar, Giora; Gavriely, Noam; Oden, IB12/02920, mailed Aug. 22, 2013, 4 pages.
Majed, Sublingual Electrical Stimulation of the Tongue During
Wakefulness and Sleep, Respiration Physiology, 127, 2001. * cited by examiner
US. Patent May 6, 2014 Sheet 1 0f 15 US 8,718,776 B2
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US. Patent May 6, 2014 Sheet 2 0f 15 US 8,718,776 B2
Fig“ 2
US. Patent May 6, 2014 Sheet 3 0f 15 US 8,718,776 B2
Fig. 3
US. Patent May 6, 2014 Sheet 4 0f 15 US 8,718,776 B2
US. Patent May 6, 2014 Sheet 5 0f 15 US 8,718,776 B2
158a
158b
US. Patent May 6, 2014 Sheet 6 0f 15 US 8,718,776 B2