Apoptosis: physiology and pathology PDF
Preview Apoptosis: physiology and pathology
This page intentionally left blank APOPTOSIS Apoptosis,orcelldeath,canbepathological,asignofdiseaseanddamage,orphysiologic,a processessentialfornormalhealth.Thispathologicaldysregulationofcelldeathcanbecharac- terizedbyeithertoomuchlossofessentialcellsintheheart,brain,andothertissueswithlittle regenerativecapacityortoolittlecellturnoverinself-renewingtissues,givingrisetocancer andothermaladies.Thisisaprocessoffundamentalimportancefordevelopmentandnormal health,whichisalteredinmanydiseaseconditions.Thisbook,withcontributionsfromexperts inthefield,providesatimelycompilationofreviewsofmechanismsofapoptosis.Thebookis organizedintothreeconvenientsections.Thefirstsectionexploresthedifferentprocessesof cell death and how they relate to each other. The second section focuses on organ-specific apoptosis-relateddiseases.Thethirdsectionexplorescelldeathinnonmammalianorganisms thathaveservedaspopularmodelsforresearch.Thiscomprehensivetextisamust-readforall researchersandscholarsinterestedinapoptosisandcelldeath. JohnC.ReedisChiefExecutiveOfficeroftheSanford-BurnhamMedicalResearchInstitute. Dr.ReedisalsoProfessorandDonaldBrenExecutiveChairatSanford-Burnham,withadjunct professor appointments at several universities. Dr. Reed and his research team have con- tributedmorethan800researchpublicationstotheliterature.Theirworkisamongthemost highly cited in all of science worldwide. Dr. Reed is the recipient of numerous awards and honorsandhasbeenawardedmorethaneightyresearchgrantsforhiswork.Heisanamed inventorfornearly100patentsandthefounderorcofounderoffourbiotechnologycompanies. Dr.Reedhasservedontheeditorialboardsofnumerousjournals;asanadvisortonumerous public,private,andgovernmentalorganizations;andontheboardsofdirectorsofseveralpub- licandprivatebiotechnologycompaniesandlife-sciencesorganizations. DouglasR.GreenisChairoftheDepartmentofImmunologyatSt.JudeChildren’sResearch Hospital,wherehealsoholdsthePeterDohertyEndowedChair.Dr.GreencametoSt.Judein 2005,priortowhichhewasHeadoftheDivisionofCellularImmunologyattheLaJollaInstitute ofAllergyandImmunology.Dr.Greenservesasaneditorforanumberofleadingjournalsand isEditor-in-ChiefofthejournalOncogene. A P O P TO S I S PHYSIOLOGY AND PATHOLOGY Editedby JOHNC.REED Sanford-BurnhamMedicalResearchInstitute DOUGLASR.GREEN St.JudeChildren’sResearchHospital cambridgeuniversitypress Cambridge,NewYork,Melbourne,Madrid,CapeTown, Singapore,Sa˜oPaulo,Delhi,Tokyo,MexicoCity CambridgeUniversityPress 32AvenueoftheAmericas,NewYork,NY10013-2473,USA www.cambridge.org Informationonthistitle:www.cambridge.org/9780521886567 (cid:2)C CambridgeUniversityPress2011 Thispublicationisincopyright.Subjecttostatutoryexception andtotheprovisionsofrelevantcollectivelicensingagreements, noreproductionofanypartmaytakeplacewithoutthewritten permissionofCambridgeUniversityPress. Firstpublished2011 PrintedintheUnitedStatesofAmerica AcatalogrecordforthispublicationisavailablefromtheBritishLibrary. LibraryofCongressCataloginginPublicationdata Apoptosis:physiologyandpathology/[editedby]JohnC.Reed, DouglasR.Green. p.;cm. Includesbibliographicalreferences. ISBN978-0-521-88656-7(hardback) 1.Apoptosis. I.Reed,JohnC.,1958–editor. II.Green,DouglasR., 1955–editor. III.Title. [DNLM:1.Apoptosis. 2.Apoptosis–physiology. 3.CellDeath.QU375] QH671.A6594 2011 611(cid:3).01815–dc22 2010045696 ISBN978-0-521-88656-7Hardback CambridgeUniversityPresshasnoresponsibilityforthepersistenceor accuracyofURLsforexternalorthird-partyInternetWebsitesreferredtoin thispublicationanddoesnotguaranteethatanycontentonsuchWebsites is,orwillremain,accurateorappropriate. Contents Contributors pageix I. GENERALPRINCIPLESOFCELLDEATH 1 HumanCaspases–ApoptosisandInflammationSignalingProteases.............1 GuyS.Salvesen 2 InhibitorofApoptosisProteins............................................. 11 JasonB.Garrison,AndreasKrieg,KateWelsh,YunfeiWen,andJohnC.Reed 3 DeathDomain–ContainingReceptors–DecisionsbetweenSuicideandFire ..... 23 HenningWalczakandChahrazadeKantari 4 MitochondriaandCellDeath..............................................37 GavinP.McStayandDouglasR.Green 5 TheControlofMitochondrialApoptosisbytheBCL-2Family.................. 44 AnthonyLetai 6 EndoplasmicReticulumStressResponseinCellDeathandCellSurvival.........51 MichaelBoyce,MartaM.Lipinski,Be´ne´dicteF.Py,andJunyingYuan 7 Autophagy–TheLiaisonbetweentheLysosomalSystemandCellDeath......... 63 HiroshiKogaandAnaMariaCuervo 8 CellDeathinResponsetoGenotoxicStressandDNADamage.................. 74 PabloLopez-BergamiandZe’evRonai 9 CeramideandLipidMediatorsinApoptosis ................................. 88 ThomasD.Mullen,RussellW.Jenkins,LinaM.Obeid,andYusufA.Hannun 10 CytotoxicGranulesHousePotentProapoptoticToxinsCriticalfor AntiviralResponsesandImmuneHomeostasis.............................. 106 KatherineBaran,IliaVoskoboinik,NigelJ.Waterhouse,VivienR.Sutton, andJosephA.Trapani II. CELLDEATHINTISSUESANDORGANS 11 CellDeathinNervousSystemDevelopmentandNeurologicalDisease.........123 JuyingLiandJunyingYuan 12 RoleofProgrammedCellDeathinNeurodegenerativeDisease................135 DaleE.Bredesen v vi CONTENTS 13 ImplicationsofNitrosativeStress-InducedProteinMisfolding inNeurodegeneration...................................................145 TomohiroNakamuraandStuartA.Lipton 14 MitochondrialMechanismsofNeuralCellDeathinCerebralIschemia.........153 LucianSoane,BrianM.Polster,andGaryFiskum 15 CellDeathinSpinalCordInjury–AnEvolvingTaxonomywith TherapeuticPromise .................................................... 164 RajivR.RatanandMosesV.Chao 16 ApoptosisandHomeostasisintheEye.....................................176 JerryY.Niederkorn 17 CellDeathintheInnerEar ............................................... 182 LisaL.CunninghamandJustinTan 18 CellDeathintheOlfactorySystem......................................... 194 PawelKermer 19 ContributionofApoptosistoPhysiologicRemodelingoftheEndocrine PancreasandPathophysiologyofDiabetes ................................. 201 NikaN.Danial 20 ApoptosisinthePhysiologyandDiseasesoftheRespiratoryTract ............. 221 ChristianTaubeandMartinSchuler 21 RegulationofCellDeathintheGastrointestinalTract........................231 MariaEugeniaGuicciardiandGregoryJ.Gores 22 ApoptosisintheKidney..................................................240 JuanAntonioMoreno,AdrianMarioRamos,andAlbertoOrtiz 23 PhysiologicandPathologicalCellDeathintheMammaryGland............... 250 ArmelleMeletandRoyaKhosravi-Far 24 TherapeuticTargetingApoptosisinFemaleReproductiveBiology.............. 273 KaisaSelesniemiandJonathanL.Tilly 25 ApoptoticSignalinginMaleGermCells....................................283 AmiyaP.SinhaHikim,YueJia,Yan-HeLue,ChristinaWang,andRonaldS.Swerdloff 26 CellDeathintheCardiovascularSystem.................................... 295 VladimirKaplinskiy,MartinR.Bennett,andRichardN.Kitsis 27 CellDeathRegulationinMuscle........................................... 313 AyeshaSaleem,LawrenceKazak,MichaelO’Leary,andDavidA.Hood 28 CellDeathintheSkin....................................................323 SaskiaLippens,EstherHoste,PeterVandenabeele,andWimDeclercq 29 ApoptosisandCellSurvivalintheImmuneSystem .......................... 333 DelphineMe´rinoandPhilippeBouillet 30 CellDeathRegulationintheHematopoieticSystem.......................... 350 PaulA.Ney 31 ApoptoticCellDeathinSepsis............................................363 PavanBrahmamdam,JaredT.Muenzer,RichardS.Hotchkiss,andJonathanE.McDunn 32 Host–PathogenInteractions..............................................372 MayaSaleh CONTENTS vii III. CELLDEATHINNONMAMMALIANORGANISMS 33 ProgrammedCellDeathintheYeastSaccharomycescerevisiae................. 389 ValterD.LongoandCristinaMazzoni 34 CaenorhabditiselegansandApoptosis ..................................... 397 BrianL.HarryandDingXue 35 ApoptoticCellDeathinDrosophila........................................407 KathleenGalindoandJohnM.Abrams 36 AnalysisofCellDeathinZebrafish......................................... 412 UjwalJ.PyatiandA.ThomasLook Color plates follow page 226 .
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