Table Of Content

Volume contents Volume 6, Number 1, 1995 A comparative study of the in vitro and in vivo antiviral activities of acyclovir and penciclovir 1 Synthesis and antiviral activity of new 3,4- P. Ertl, W. Snowden, D. Lowe, W. Miller, P. dihydro-2-alkoxy-6-benzyl-4-oxopyrimidines Collins & E. Littler (DABOs), specific inhibitors of human Characterization of the antiviral activity of immunodeficiency virus type 1 highly substituted pyrroles: a novel class of S. Massa, A. Mai, M. Artico, G. Sbardella, non-nucleoside HIV-1 reverse transcriptase E. Tramontano, A.G. Loi, P. Scano & P. La Colla inhibitor Antiviral activity of N*-aminocytidine T. Antonucci, J. S. Warmus, J. C. Hodges & derivatives related to AZT D. G. Nickell D. Loakes, D.M. Brown, N. Mahmood, J. Balzarini In vitro inhibitory effects of combinations of & E. De Clercq anti-influenza agents Inhibition of infection of T-cells with human L. K. Madren, C. Shipman, Jr & F. G. Hayden immunodeficiency virus type 1 by In vitro antimyxovirus and anti-human dideoxynucleosides conjugated with immunodeficiency virus activities of oligopeptides polyoxometalates N. S. Shimizu, A. Handa, N. G. Shimizu, R. Ikeda, S. Shigeta, S. Mori, J. Watanabe, M. Baba, T. Uchiyama, K. Achiwa & H. Hoshino A M. Khenkin, C. L. Hill & R. F. Schinazi The X-ray crystal structure of the sulfonated azo dye Congo Red, a non-peptidic inhibitor of Short communication HIV-1 protease which also binds to reverse 123 Inhibition by azidothymidine triphosphate of transcriptase and amyloid proteins reverse transcriptase from paired AZT- W. H. Ojala, C. R. Ojala & W. B. Gleason susceptible and -resistant primary isolates of Potent inhibition of herpes simplex virus by human immunodeficiency virus type 1 MDL 101028, a novel biphenyl disulfonic acid S. W. Cox, G. Corrigan & S. Palmer urea co-polymer S. P. Ahmed, A. D. Cardin, C. G. Bridges, R. L. Jackson, M. J. Mullins & A. S. Tyms Volume 6, Number 3, 1995 Synthesis and anti-HIV evaluation of alkyl and alkoxyethyl phosphodiester AZT derivatives 127 The intracellular formation of a T. Calogeropoulou, M. Koufaki, A. Tsotinis, mononucleotide of the anti-influenza agent J. Balzarini, E. De Clercq & A. Makriyannis 1,3,4-thiadiazol-2-yicyanamide (LY217896) G. M. Birch, J. M. Colacino, W. J. Ehihardt & The use of 5'-phosphate derivatives of J. Balzarini nucleoside analogues as inhibitors of HIV-1 replication Stereochemical aspects of the anti-HCMV U. Nillroth, L. Vrang, G. Ahisén, Y. Besidsky, activity of cytidine nucleoside analogues J. Chattopadhyaya, |. Ugi & U. H. Danielson T. S. Mansour, A. R. Cimpoia, H. Jin, P. J. Hunter, C. A. Evans, H. L. A. Tse, J. W. Gillard, Peptides containing 2-,3- or 4-fluorophenyl- A. D. Borthwick, D. J. Knight & J. A. V. Coates alanine or 2,2- or 3,3-difluorophenylalanine as potential inhibitors of HIV protease Synergistic inhibition of human S. Viani, R. Condom, P. R. T. Frogier & R. Guedj immunodeficiency virus type 1 in vitro by 6-0- butanoyicastanospermine (MDL 28 574) in combination with inhibitors of the virus- encoded reverse transcriptase and proteinase Volume 6, Number 2, 1995 D. L. Taylor, T. M. Brennan, C. G. Bridges, M. S. Kang & A. S. Tyms 73 Isolation and characterization of human Efficacy and toxicity of long-term administration immunodeficiency virus type-1 mutants of 2',3'-dideoxycytidine in the LP-BM5 murine- resistant to the non-nucleotide reverse induced immunodeficiency model transcriptase inhibitor MKC-442 G. Brandi, A. Casabianca, G. F. Schiavano, M. Seki, Y. Sadakata, S. Yuasa & M. Baba L. Rossi, A. Fraternale, A. Albano & M. Magnani Multiple mutations in the human Synthesis and antiviral evaluation of immunodeficiency virus protease gene are fluorinated dipyridodiazepinones and responsible for decreased susceptibility to dipyridodiazepines (nevirapine derivatives) protease inhibitors B. P. Boyode, M. Sinet, A. Farese, R. W. King, S. Garber, D. L. Winslow, C. Reid, M.-A. Forestier-Roux, R. Condom, I.A. Ayi, A. L. T. Bacheler, E. Anton & M. J. Otto Kirn, C. Moog & R. Guedj iv 169 Oxathiin carboxanilide derivates: a class of Design and synthesis of a quenched non-nucleoside HIV-1-specific reverse fluorogenic peptide substrate for human transcriptase inhibitors (NNRTIs) that are active cytomegalovirus proteinase against mutant HIV-1 strains resistant to other B. K. Handa, E. Keech, E. A. Conway, NNRTIs A. Broadhurst & A. Ritchie J. Balzarini, H. Jonckheere, W. A. Harrison, 2'-Deoxyuridines with a 5-heteroaromatic D. C. Dao, J. Anné, E. De Clercq & A. Karlsson substituent: synthesis and biological 179 Anti-HIV and anti-HCMV activities of new evaluation aurintricarboxylic acid analogues |. Luyten, L. Jie, A. Van Aerschot, M. Cushman, P. Wang, D. Reymen, J. Esté, C. Pannecouque, P. Wigerinck, J. Rozenski, M. Witvrouw, J. Neyts & E. De Clercq C. Hendrix, C. Wang, L. Wiebe, J. Balzarini, E. De Clercq & P. Herdewijn Short communication Sulfated alkyl oligosaccharides inhibit human 187 Inhibition of the production of HIV-1 from immunodeficiency virus in vitro and provide chronically infected H9 cells by metal sustained drug levels in mammals compounds and their complexes with L- H. Nakashima, K. Inazawa, K. Ichiyama, M. Ito, cysteine or N-acetyl-L-cysteine N. Ikushima, T. Shoji, K. Katsuraya, T. Uryu, N. Mahmood, A. Burke, S. Hussain, R. M. Anner N. Yamamoto, A. S. Juodawikis & R. F. Schinazi & B. M. Anner Volume 6, Number 5, 1995 Volume 6, Number 4, 1995 281 Penciclovir-resistance mutations in the herpes Review simplex virus DNA polymerase gene Progress in the clinical management of H. C. Chiou, K. Kumura, A. Hu, K. M. Kerns & D. M. Coen herpesvirus infections P. D. Griffiths Synthesis and anti-herpes activity of a series of indolizines The effects of delayed-onset chemotherapy C. Foster, M. Ritchie, D. L. Selwood & using famciclovir or valaciclovir in a murine W. Snowden immunosuppression model for HSV-1 H. J. Field & A. M. Thackray In vitro evaluation of the anti-picornavirus activities of new synthetic flavonoids Kinetic interaction of the diphosphates of 9-(2- N. Desideri, C. Conti, | Sestili, P. Tomao, phosphony!methoxyethyl)adenine and other M. L. Stein & N. Orsi anti-HIV active purine congeners with HIV reverse transcriptase and human DNA Basis of relative insensitivity of HIV-infected polymerases o, B and y JM cells to AZT J. M. Cherrington, S. J. W. Allen, N. R. D. Snyder, T. Brennan, D. L. Taylor & Bischofberger & M. S. Chen A. S. Tyms Host cell dependence of human immuno- Inhibition of HIV-1 and LP-BM5 replication in deficiency virus type-1 drug resistance macrophages by dideoxycytidine and profiles and tissue culture selection patterns dideoxycytidine 5'-triphosphate H. Salomon, Z. Gu, Q. Gao, K. Nagai, J. Hiscott & M. Magnani, A. Casabianca, L. Rossi, M. A. Wainberg A. Fraternale, G. Brandi, L. Silvotti & G. Piedimonte Lymphatic targeting of anti-HIV nucleosides: distribution of 3'-azido-3'-deoxythymidine Synthesis and in vitro antiviral properties of (AZT) and 3'-azido-2',3'-dideoxyuridine (AZdU) amphiphilic dinucleoside phosphate after administration of derivatives of 2',3'-dideoxycytidine (ddC) dipalmitoylphosphatidy! prodrugs to mice H. Schott, M. P. Haussler, P. Gowland, A. K. K. Manouilov, |. |. Fedorov, F. D. Boudinot, Bender, H. von Briesen & R. A. Schwendener C. A. White, L. P. Kotra, R. F. Schinazi, Potent and orally bioavailable HIV-1 Chung II Hong & Chung K. Chu proteinase inhibitors containing the 2- Inhibition of herpes simplex virus type-1 aminobenzylstatine moiety multiplication by meliacine, a peptide of plant A. Billich, D. Scholz, B. Charpiot, H. Gstach, origin P. Lehr, P. Peich! & B. Rosenwirth S. M. Villamil, L. E. Alché & C. E. Coto Dimeric macrocyclic polyamines with potent Novel azolylaikyloxy compounds with inhibitory activity against human antipicornaviral activity immunodeficiency virus M. D. Abel, A. D. Cameron, C. M. Ha, C. A. Koski, Y. Inouye, T. Kanamori, M. Sugiyama, T. H. T. Luu, R. G. Micetich, D. Q. Nguyen, Yoshida, T. Koike, M. Shionoya, K. Enomoto, K. M. L. Tempest & M. Daneshtalab Suehiro & E. Kimura Volume 6, Number 6, 1995 Zalcitabine (ddC) phosphorylation and drug interactions 345 The effect of absolute configuration on the G.J. Veal, M.G. Barry & D.J. Back anti-HIV and anti-HBV activity of nucleoside analogues Effects of plant-derived polysaccharides on P. A. Furman, J. E. Wilson, J. E. Reardon & murine cytomegalovirus and G. R. Painter encephalomyocarditis virus infections in mice D. F. Smee, & A. J. Verbiscar A comparative study of 5-ethyl-2'- deoxyuridine and selected lipophilic 5,6- Antiviral activities of peptides with sequences dihydro double/triple prodrugs related to the cytoplasmic domain of the A. M. Cheraghali, R. Kumar, K. W. Morin, respiratory syncytial virus glycoproteins E. De Clercq, E. E. Knaus & L. |. Wiebe C. Ryan, J. Mo & M. Schlesinger Synthesis and anti-HIV-1 activity of [1-[2',5'- Indexes Bis-O-(tert-butyldimethylsilyl)-B-t- 399 Subject index ribofuranosyl]thymine]-3'-spiro-5"-(4"-amino-1 " 2"-oxathiole-2",2"-dioxide) ((-TSAO-T), the 401 Author Index L-enantiomer of the highly specific HIV-1 reverse transcriptase inhibitor TSAO-T 403 Referees S. T. Ingate, M.-J. Camarasa, E. De Clercq & J. Balzarin Antiviral activity of bicyclic pyrimidine nucleosides D. Loakes, D. M. Brown, N. Mahmood, J. Balzarini & E. De Clercq