Antiphospholipid Syndrome: Current Research Highlights and Clinical Insights PDF
Preview Antiphospholipid Syndrome: Current Research Highlights and Clinical Insights
Doruk Erkan · Michael D. Lockshin Editors Antiphospholipid Syndrome Current Research Highlights and Clinical Insights 123 Antiphospholipid Syndrome Doruk Erkan • Michael D. Lockshin Editors Antiphospholipid Syndrome Current Research Highlights and Clinical Insights Editors Doruk Erkan, MD, MPH Michael D. Lockshin, MD Associate Physician-Scientist Director The Barbara Volcker Center for Women The Barbara Volcker Center for Women and Rheumatic Diseases and Rheumatic Diseases Associate Attending Physician Attending Physician Hospital for Special Surgery Hospital for Special Surgery Associate Professor of Medicine Professor of Medicine and Weill Cornell Medicine Obstetrics-Gynecology New York, NY, USA Weill Cornell Medicine New York, NY, USA ISBN 978-3-319-55440-2 ISBN 978-3-319-55442-6 (eBook) DOI 10.1007/978-3-319-55442-6 Library of Congress Control Number: 2017935363 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland To: ARIN, AYDIN, & RACHEL (DE) AMANDA & JANE (MDL) Preface “Advancing the Field Together” – The Journey that started in planning for the 15th International Congress on Antiphospholipid Antibodies continues with a State-of- the-Art Antiphospholipid Syndrome book The International Congress on Antiphospholipid Antibodies (aPL) takes place every three years; its purpose is to discuss aPL and antiphospholipid syndrome (APS) research and clinical care. The Congress is a venue in which scientists and clinicians, from multiple disciplines, present and review the most recent innovative and important research to improve understanding of the syndrome, prioritize research questions, and set a roadmap for future research. The 15th International Congress on aPL took place on September 21–24, 2016, in North Cyprus, having been relocated from the original congress location of Istanbul, Turkey1. The Congress offered a comprehensive program, including evidence-b ased state-of-the art presentations from 70 internationally recognized physicians and scien- tists. At the Congress, there were 24 main sessions including 4 from different task forces, 147 oral and poster abstract presentations, 14 meet-the-e xpert sessions, 2 satel- lite symposia, and 1 patient education workshop; the objectives of which were to discuss the biology and new mechanisms of the disease, describe ongoing and planned clinical trials, explore potential new treatments, and strengthen established and/or cre- ate new international collaborations for both basic and clinical research in the field. A novel aspect of the Congress was that multiple teams, chaired by Scientific Planning Committee members, used evidence-based literature reviews and expert discussions to answer specific predefined aPL/APS questions. These teams included points of view from experts in rheumatology, hematology, cardiovascular medicine, obstetrics, neurology, and immunology. The Scientific Planning Committee mem- bers also chaired the congress sessions and supervised completion of the reports that are the bases of the chapters of this book. The journey that had started as a planning exercise for the 15th International Congress on aPL did not stop in September 2016, when the Congress ended, but 1 www.apsistanbul2016.org. vii viii Preface continues with this state-of-the-art book. This book is presented in six sections, each section focusing on a different aspect of aPL/APS: history; basic science; clinical and diagnostic features; current and future therapies; task forces; and patient educa- tion. We want to thank all the authors who participated in this journey, and hope that this book will add value to the field of thrombosis and APS. New York, NY, USA Doruk Erkan* Michael D. Lockshin** * Congress Chair ** Congress Honorary Chair Acknowledgment We want to express our gratitude to: Our Patients The Authors The Committee Members, Speakers, Registrants, Sponsors, and Grant Supporters of the 15th International Congress on Antiphospholipid Antibodies Doruk Erkan Michael D. Lockshin I want to express my personal gratitude to Dr Michael D. Lockshin for his invaluable guidance and support over the years. Doruk Erkan ix Contents Part I Historical Aspects of Antiphospholipid Syndrome 1 History of Antiphospholipid Antibody .................................................. 3 Michael D. Lockshin and E. Nigel Harris Part II Basic Science Aspects of Antiphospholipid Syndrome 2 Natural Proteins Involved in Antiphospholipid Syndrome ................. 15 Philip G. de Groot, Bas de Laat, Jacob Rand, Panayiotis G. Vlachoyiannopoulos, Fatima El-Assaad, Steven A. Krilis, and Bill Giannakopoulos 3 Origin of Antiphospholipid Antibodies ................................................. 29 Joyce Rauch, Miri Blank, Philip G. de Groot, Kathryn M. Dupnik, Martin Alexander Kriegel, Jerrold S. Levine, Yehuda Shoenfeld, and Rohan Willis 4 Recent Advances in Understanding of the Genetics of Antiphospholipid Syndrome .............................................................. 53 Niti Goel and Thomas L. Ortel 5 Mechanisms of Antiphospholipid Antibody- Mediated Thrombosis .............................................................................................. 77 Rohan Willis, Hannah Cohen, Ian Giles, Jason S. Knight, Steven A. Krilis, Anisur Rahman, and Philip G. de Groot 6 Mechanisms of Antiphospholipid Antibody- Mediated Pregnancy Morbidity .............................................................................. 117 Jane E. Salmon, Chieko Mineo, Ian Giles, Larry W. Chamley, Pier Luigi Meroni, and Vikki M. Abrahams xi xii Contents Part III Clinical and Diagnostic Aspects of Antiphospholipid Syndrome 7 Definition and Epidemiology of Antiphospholipid Syndrome ............ 147 Ozan Unlu, Vinicius Domingues, Guilherme Ramires de Jesús, Stéphane Zuily, Gerard Espinosa, Ricard Cervera, Roger Abramino Levy, Denis Wahl, Doruk Erkan, and Michael D. Lockshin 8 Clinical and Prognostic Significance of Non- criteria Antiphospholipid Antibody Tests ........................................................... 171 Maria Laura Bertolaccini, Olga Amengual, Bahar Artim-Eser, Tatsuya Atsumi, Philip G. de Groot, Bas de Laat, Katrien M.J. Devreese, Ian Giles, Pier Luigi Meroni, Maria Orietta Borghi, Anisur Rahman, Jacob Rand, Véronique Regnault, Rajesh Kumar, Angela Tincani, Denis Wahl, Rohan Willis, Stéphane Zuily, and Giovanni Sanna 9 Disease and Risk Measurement Criteria in Antiphospholipid Syndrome .............................................................. 189 Mary-Carmen Amigo, Kenji Oku, Savino Sciascia, María Victoria Goycochea Robles, Stéphane Zuily, Olga Amengual, Dario Roccatello, Kotaro Otomo, Tatsuya Atsumi, Maria Laura Bertolaccini, and Denis Wahl 10 Neuropsychiatric Manifestations of Antiphospholipid Syndrome ..... 201 Cécile M. Yelnik, Simone Appenzeller, Giovanni Sanna, Elizabeth Kozora, and Maria Laura Bertolaccini Part IV Therapeutic Aspects of Antiphospholipid Syndrome 11 Prevention and Treatment of Thrombotic Antiphospholipid Syndrome ................................................................................................. 223 Mark Crowther, Kimberly J. Legault, David A. Garcia, Maria G. Tektonidou, Amaia Ugarte, Ian N. Bruce, Doruk Erkan, and Guillermo Ruiz-Irastorza 12 Prevention and Treatment of Obstetric Antiphospholipid Syndrome ................................................................................................. 235 Guilherme Ramires de Jesús, Karen J. Gibbins, Robert M. Silver, and D. Ware Branch 13 Treatment of Non-criteria Manifestations in Antiphospholipid Syndrome ................................................................................................. 247 Michelle Remião Ugolini-Lopes, Paulo Ricardo Criado, Kurosh Parsi, Reyhan Diz Kucukkaya, Mary-Carmen Amigo, Maria G. Tektonidou, and Danieli Andrade
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