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Antiparasitic and Antibacterial Drug Discovery PDF

512 Pages·2009·10.26 MB·English
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SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir Antiparasitic and Antibacterial Drug Discovery From Molecular Targets to Drug Candidates Edited by Paul M. Selzer SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir Antiparasitic and Antibacterial Drug Discovery Edited by Paul M. Selzer SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir Book Series Drug Discovery in Infectious Diseases ForthcomingTopics: (cid:1)Viruses (cid:1)Helminths (cid:1)Apicomplexa Related Titles Chorghade, M.S. (ed.) Drug Discovery and Development 2VolumeSet 2008 ISBN:978-0-471-39846-2 Jungblut,P.R.,Hecker, M.(eds.) Proteomics of Microbial Pathogens 2007 ISBN:978-3-527-31759-2 zur Hausen, H. Infections Causing Human Cancer 2006 ISBN:978-3-527-31056-2 Deretic, V. (ed.) Autophagy in Immunity and Infection ANovelImmuneEffector 2006 ISBN:978-3-527-31450-8 Frosch, M.,Maiden,M. C. J.(eds.) Handbook of Meningococcal Disease InfectionBiology,Vaccination,ClinicalManagement 2006 ISBN:978-3-527-31260-3 SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir Antiparasitic and Antibacterial Drug Discovery From Molecular Targets to Drug Candidates Edited by Paul M. Selzer SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir TheEditor AllbookspublishedbyWiley-VCHarecarefully produced.Nevertheless,authors,editors,and Prof.Dr.PaulM.Selzer publisherdonotwarranttheinformationcontained BioChemInformatics inthesebooks,includingthisbook,tobefreeof IntervetInnovationGmbH errors.Readersareadvisedtokeepinmindthat ZurPropstei statements,data,illustrations,proceduraldetailsor 55270Schwabenheim otheritemsmayinadvertentlybeinaccurate. Germany LibraryofCongressCardNo.: appliedfor [email protected] BritishLibraryCataloguing-in-PublicationData Acataloguerecordforthisbookisavailablefromthe Cover BritishLibrary. LightmicroscopicimageofthehelminthSchistosoma mansoni–withamalehostingafemaleinthecanalis Bibliographicinformationpublishedby gynaecophorus:courtesyofDr.ConorR.Caffrey, theDeutscheNationalbibliothek UniversityofCaliforniaSanFrancisco,USA. DieDeutscheNationalbibliothekliststhis Scanningelectronmicroscopicimageofthegram- publicationintheDeutscheNationalbibliografie; negativebacteriaMannheimiaheamolytica:courtesy detailed bibliographicdataareavailableonthe ofProf.Dr.LotharH.Wieler,FreieUniversitätBerlin, Internetathttp://dnb.d-nb.de. Dr.HeikeKaspar,andDr.ChristophSchaudinn, RobertKochInstitutBerlin,Germany.Thechemical #2009WILEY-VCHVerlagGmbH&Co.KGaA, structureistakenfromchapter19authoredby Weinheim ThorstenMeyeretal.,figure19.9. Allrightsreserved(includingthoseoftranslationinto otherlanguages).Nopartofthisbookmaybe reproducedinanyform–byphotoprinting, microfilm,oranyothermeans–nortransmittedor translatedintoamachinelanguagewithoutwritten permissionfromthepublishers.Registerednames, trademarks,etc.usedinthisbook,evenwhennot specificallymarkedassuch,arenottobeconsidered unprotectedbylaw. Typesetting ThomsonDigital,Noida,India Printing StraussGmbH,Mörlenbach Binding Litges&DopfGmbH,Heppenheim CoverDesign Adam-Design,Weinheim PrintedintheFederalRepublicofGermany Printedonacid-freepaper ISBN:978-3-527-32327-2 SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir V Foreword Itisironicthatthreedecadesagoinfectiousdiseaseswereviewedasaproblemofthe past.Malariaandtuberculosisweregoingtobeeradicated,effectivevaccineswere available for major childhood infections, and an armamentarium of antibiotics was available for common community and hospital-acquired infections. Young physicians were advised not to enter infectious disease specialties because they were becoming irrelevant. The AIDS epidemic was the first wakeup call that infectious diseases would again become a major global health problem. Drug- resistant malariaand tuberculosis are nowalmost ubiquitous and new and emer- ginginfectiousdiseasesarealmostaweeklystapleofthepopularpress.Indeedthe needfornewdrugsforinfectiousdiseaseshasneverbeengreater.Globalindustry and global travel means that formerly exotic diseases can rapidly establish them- selvesatanyportofentry.Effectivevaccinesagainstthemostprevalentinfectious diseaseslikeAIDSandmalariahaveprovendifficulttodevelop.Multidrug-resistant organismsareanissueinanyclinicalsetting.Thispublicationprovidesawindowon new approaches to drug discovery and development targeting infectious diseases. Fortunately,technologyandtraininginnewmethodologiesofdrugdiscoveryhave expandedrapidlyinthepast10years.Thechallengeishowtoeffectivelyapplythis technology to the thorny problems of global infections and to maintain a drug development pipeline for infectious diseases in light of the immense cost now associatedwithbringingnewdrugstomarket. SanFrancisco,USA JamesH.McKerrow November2008 SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir VII Contents Foreword V Preface XI List of Contributors XIII PartOne DrugDiscoveryApproaches 1 1 TargetIdentificationandMechanism-BasedScreeningforAnthelmintics: ApplicationofVeterinaryAntiparasiticResearchProgramstoSearchfor NewAntiparasiticDrugsforHumanIndications 3 TimothyG.Geary(cid:1),DebraJ.Woods,TraceyWilliams,andSolomonNwaka 2 AnthelminticResistanceasaGuidetotheDiscoveryofNewDrugs? 17 Georgv.Samson-Himmelstjerna(cid:1),RogerK.Prichard,and AdrianJ.Wolstenholme 3 DrugDiscoveryforNeglectedDiseases:ViewofAPublic–Private Partnership 33 RobDon(cid:1)andEricChatelain 4 BioinformaticsandChemoinformatics:KeyTechnologiesinthe DrugDiscoveryProcess 45 AndreasKrasky,AndreasRohwer,RichardJ.Marhöfer,andPaulM.Selzer(cid:1) 5 TargetIdentificationandValidationinAntiparasiticDrugDiscovery 59 ChristianWolfandNikolasGunkel(cid:1) 6 SelectiveDrugTargetsinParasites 75 PeterKöhler(cid:1)andRichardJ.Marhöfer SOFTbank E-Book Center Tehran, Phone: 66403879,66493070 For Educational Use. www.ebookcenter.ir

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Helminths . Target Identification and Validation in Antiparasitic Drug Discovery 59 Recruiting the Host Defense Mechanisms: Roles for Vaccines .. perhaps the first example of a screen of a collection of chemicals for any.
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