Antiparasitic and Antibacterial Drug Discovery

512 Pages·2009·10.26 MB·English

by  Paul M. Selzer

SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
Antiparasitic and Antibacterial Drug Discovery
From Molecular Targets to Drug Candidates
Edited by
Paul M. Selzer
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
Antiparasitic and Antibacterial
Drug Discovery
Edited by
Paul M. Selzer
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
Book Series
Drug Discovery in Infectious Diseases
ForthcomingTopics:
(cid:1)Viruses
(cid:1)Helminths
(cid:1)Apicomplexa
Related Titles
Chorghade, M.S. (ed.)
Drug Discovery and Development
2VolumeSet
2008
ISBN:978-0-471-39846-2
Jungblut,P.R.,Hecker, M.(eds.)
Proteomics of Microbial Pathogens
2007
ISBN:978-3-527-31759-2
zur Hausen, H.
Infections Causing Human Cancer
2006
ISBN:978-3-527-31056-2
Deretic, V. (ed.)
Autophagy in Immunity and Infection
ANovelImmuneEffector
2006
ISBN:978-3-527-31450-8
Frosch, M.,Maiden,M. C. J.(eds.)
Handbook of Meningococcal Disease
InfectionBiology,Vaccination,ClinicalManagement
2006
ISBN:978-3-527-31260-3
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
Antiparasitic and Antibacterial Drug Discovery
From Molecular Targets to Drug Candidates
Edited by
Paul M. Selzer
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
TheEditor AllbookspublishedbyWiley-VCHarecarefully
produced.Nevertheless,authors,editors,and
Prof.Dr.PaulM.Selzer publisherdonotwarranttheinformationcontained
BioChemInformatics inthesebooks,includingthisbook,tobefreeof
IntervetInnovationGmbH errors.Readersareadvisedtokeepinmindthat
ZurPropstei statements,data,illustrations,proceduraldetailsor
55270Schwabenheim otheritemsmayinadvertentlybeinaccurate.
Germany
LibraryofCongressCardNo.: appliedfor
[email protected]
BritishLibraryCataloguing-in-PublicationData
Acataloguerecordforthisbookisavailablefromthe
Cover BritishLibrary.
LightmicroscopicimageofthehelminthSchistosoma
mansoni–withamalehostingafemaleinthecanalis Bibliographicinformationpublishedby
gynaecophorus:courtesyofDr.ConorR.Caffrey, theDeutscheNationalbibliothek
UniversityofCaliforniaSanFrancisco,USA. DieDeutscheNationalbibliothekliststhis
Scanningelectronmicroscopicimageofthegram- publicationintheDeutscheNationalbibliografie;
negativebacteriaMannheimiaheamolytica:courtesy detailed bibliographicdataareavailableonthe
ofProf.Dr.LotharH.Wieler,FreieUniversitätBerlin, Internetathttp://dnb.d-nb.de.
Dr.HeikeKaspar,andDr.ChristophSchaudinn,
RobertKochInstitutBerlin,Germany.Thechemical #2009WILEY-VCHVerlagGmbH&Co.KGaA,
structureistakenfromchapter19authoredby Weinheim
ThorstenMeyeretal.,figure19.9.
Allrightsreserved(includingthoseoftranslationinto
otherlanguages).Nopartofthisbookmaybe
reproducedinanyform–byphotoprinting,
microfilm,oranyothermeans–nortransmittedor
translatedintoamachinelanguagewithoutwritten
permissionfromthepublishers.Registerednames,
trademarks,etc.usedinthisbook,evenwhennot
specificallymarkedassuch,arenottobeconsidered
unprotectedbylaw.
Typesetting ThomsonDigital,Noida,India
Printing StraussGmbH,Mörlenbach
Binding Litges&DopfGmbH,Heppenheim
CoverDesign Adam-Design,Weinheim
PrintedintheFederalRepublicofGermany
Printedonacid-freepaper
ISBN:978-3-527-32327-2
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
V
Foreword
Itisironicthatthreedecadesagoinfectiousdiseaseswereviewedasaproblemofthe
past.Malariaandtuberculosisweregoingtobeeradicated,effectivevaccineswere
available for major childhood infections, and an armamentarium of antibiotics
was available for common community and hospital-acquired infections. Young
physicians were advised not to enter infectious disease specialties because they
were becoming irrelevant. The AIDS epidemic was the first wakeup call that
infectious diseases would again become a major global health problem. Drug-
resistant malariaand tuberculosis are nowalmost ubiquitous and new and emer-
ginginfectiousdiseasesarealmostaweeklystapleofthepopularpress.Indeedthe
needfornewdrugsforinfectiousdiseaseshasneverbeengreater.Globalindustry
and global travel means that formerly exotic diseases can rapidly establish them-
selvesatanyportofentry.Effectivevaccinesagainstthemostprevalentinfectious
diseaseslikeAIDSandmalariahaveprovendifficulttodevelop.Multidrug-resistant
organismsareanissueinanyclinicalsetting.Thispublicationprovidesawindowon
new approaches to drug discovery and development targeting infectious diseases.
Fortunately,technologyandtraininginnewmethodologiesofdrugdiscoveryhave
expandedrapidlyinthepast10years.Thechallengeishowtoeffectivelyapplythis
technology to the thorny problems of global infections and to maintain a drug
development pipeline for infectious diseases in light of the immense cost now
associatedwithbringingnewdrugstomarket.
SanFrancisco,USA JamesH.McKerrow
November2008
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir
VII
Contents
Foreword V
Preface XI
List of Contributors XIII
PartOne DrugDiscoveryApproaches 1
1 TargetIdentificationandMechanism-BasedScreeningforAnthelmintics:
ApplicationofVeterinaryAntiparasiticResearchProgramstoSearchfor
NewAntiparasiticDrugsforHumanIndications 3
TimothyG.Geary(cid:1),DebraJ.Woods,TraceyWilliams,andSolomonNwaka
2 AnthelminticResistanceasaGuidetotheDiscoveryofNewDrugs? 17
Georgv.Samson-Himmelstjerna(cid:1),RogerK.Prichard,and
AdrianJ.Wolstenholme
3 DrugDiscoveryforNeglectedDiseases:ViewofAPublic–Private
Partnership 33
RobDon(cid:1)andEricChatelain
4 BioinformaticsandChemoinformatics:KeyTechnologiesinthe
DrugDiscoveryProcess 45
AndreasKrasky,AndreasRohwer,RichardJ.Marhöfer,andPaulM.Selzer(cid:1)
5 TargetIdentificationandValidationinAntiparasiticDrugDiscovery 59
ChristianWolfandNikolasGunkel(cid:1)
6 SelectiveDrugTargetsinParasites 75
PeterKöhler(cid:1)andRichardJ.Marhöfer
SOFTbank E-Book Center Tehran, Phone: [phone] For Educational Use. www.ebookcenter.ir