Antimicrobial Peptides and Innate Immunity PDF
Preview Antimicrobial Peptides and Innate Immunity
Progress in Inflammation Research Series Editors MichaelJ.Parnham,UniversityHospitalforInfectiousDiseases,Zagreb,Croatia EugenFaist,KlinikumGrosshadern,Ludwig-Maximilians-University, Munich,Germany AdvisoryBoard G.Z.Feuerstein(WyethResearch,Collegeville,PA,USA) M.Pairet(BoehringerIngelheimPharmaKG,Biberacha.d.Riss,Germany) W.vanEden(UniversiteitUtrecht,Utrecht,TheNetherlands) For furthervolumes: http://www.springer.com/series/4983 . Pieter S. Hiemstra • Sebastian A. J. Zaat Editors Antimicrobial Peptides and Innate Immunity Editors PieterS.Hiemstra SebastianA.J.Zaat DepartmentofPulmonology Dept.MedicalMicrobiology LeidenUniversityMedicalCenter CtrforInfection&Immun.Amsterdam Leiden (CINIMA) Netherlands AcademicMedicalCenter UniversityofAmsterdam Amsterdam Netherlands SeriesEditors Prof.MichaelJ.Parnham,Ph.D. Prof.EugenFaist,MD,FACS VisitingScientist Ludwig-Maximilians-UniversityMunich Research&ClinicalImmunologyUnit KlinikumGrosshadern UniversityHospitalforInfectiousDiseases DepartmentofSurgery “Dr.FranMihaljevic´” Marchioninistr.15 Mirogojska8 81377Munich HR-10000Zagreb,Croatia Germany ISBN978-3-0348-0540-7 ISBN978-3-0348-0541-4(eBook) DOI10.1007/978-3-0348-0541-4 SpringerBaselHeidelbergNewYorkDordrechtLondon LibraryofCongressControlNumber:2012956531 #SpringerBasel2013 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerpts inconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeing enteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Duplication ofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthe Publisher’s location, in its current version, and permission for use must always be obtained from Springer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter. ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Preface Antimicrobialpeptideshavebeenthesubjectofintenseresearchinthepastdecades andarenowconsideredasanessentialpartofthedefensesysteminbacteria,plants, animals, and humans. Whereas lysozyme was identified in the 1920s, research on the smaller antimicrobial peptides started later. Pioneering work in, e.g., insects provided evidence for the central role that these so-called endogenous antibiotics playinhostdefenseagainstinfection.Thisisfurthersupportedbytheobservation that these peptides have been conserved throughout evolution and that they are present in vertebrates and invertebrates, plants, and microorganisms. Studies on antimicrobialpeptidesincysticfibrosisthatwereperformedinthe1990sprompted arangeofresearcheffortsthatwereaimedtodefinetheirroleindiseasedevelop- mentandprogression.Thisincreaseinresearchonantimicrobialpeptidesalsoled to the conclusion that they contribute to host defense against infection not only through a direct and broad-spectrum antimicrobial activity but also through a variety of other mechanisms. This explains why the name host defense peptides isanappropriatealternativethatiswidelyused.Theaimofthisbookistoprovide an update on these effector molecules of the innate immune system both for researchers that are already actively involved in the area and for those with a generalinterestinthetopic. Thefirstthreechaptersofthisvolume provide anoverviewofthe evolution of cysteine-containing antimicrobial peptides (including defensins) and the role of these peptides in host defense in plants and microorganisms. The realization that antimicrobialpeptidesalsodisplayfunctionsdistinctfromtheirdirectantimicrobial actionisthefocusofthenextfivechaptersandputsthesepeptidescenterstagein immunityandwoundrepair.Theremarkableincreaseinstructure–functionstudies hasprovidednewinsightsintohowthepeptidesfulfilltheirvariousactivities.The next block of chapters discusses the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptidesandadiscussionoftheirroleininflammatoryboweldisease,cysticfibrosis lungdisease,andchronicobstructivepulmonarydisease.Althoughbacteriadonot develop resistance against antimicrobial peptides as easily as they do to conven- tional antibiotics, bacteria do use resistance mechanisms to defend themselves v vi Preface against antimicrobial peptide attacks by the host. Studies on these interactions provide insight into the host–microbe interaction during infection. Our insight in the role of antimicrobial peptides in disease has also improved considerably in recent years through studies that focus on, e.g., genetic and epigenetic regulation andstudiesthatexploretheactivityofthesepeptidesincomplexenvironmentsthat arechangingasaresultoftheunderlyingdisease.Thefinaltwochaptersdescribe howknowledgeofthefunctionofantimicrobialpeptidesandtheirregulationcanbe used to design new therapies for inflammatory and infectious disorders. This is a veryimportantareaofresearch,inparticularbecauseoftheincreaseinresistanceof microorganisms to conventional antibiotics. Therefore, the use of synthetic or recombinant peptides, oragentsthatstimulate the endogenous production ofanti- microbialpeptides,providesanattractivealternativeforconventionalantibiotics. Eachchapterinthisbookwaswrittenbyexpertsinthefieldofantimicrobial/host defense peptide research and provides a state-of-the-art summary of their area of research.Thetimeandexpertiseoftheseexpertswereessential,andwewouldlike tothankthemfortheirexcellentcontributions. Contents EvolutionofAntimicrobialPeptides:AViewfrom theCystineChapel. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 RobertI.Lehrer InnateImmunityinPlants:TheRoleofAntimicrobialPeptides. . . . . . 29 H.U.Stotz,F.Waller,andK.Wang AntimicrobialPeptidesProducedbyMicroorganisms. . . . . . . . . . . . . . 53 AlineDiasPaivaandEefjanBreukink LL-37:AnImmunomodulatoryAntimicrobialHost DefencePeptide. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 PaulaE.Beaumont,Hsin-NiLi,andDonaldJ.Davidson WoundRepairandAntimicrobialPeptides. . . . . . . . . . . . . . . . . . . . . . 123 MonaSta˚hle WAPingOutPathogensandDiseaseintheMucosa:RolesforSLPI andTrappin-2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141 ThomasS.Wilkinson,AliRoghanian,andJean-MichelSallenave Histatins:MultifunctionalSalivaryAntimicrobialPeptides. . . . . . . . . . 167 Wimvan‘tHof,MennoJ.Oudhoff,andEnnoC.I.Veerman Structure–FunctionRelationshipsofAntimicrobial Chemokines. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 MauricioArias,SebastianA.J.Zaat,andHansJ.Vogel MechanismsandSignificanceofBacterialResistancetoHumanCationic AntimicrobialPeptides. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 MairaGoytia,JustinL.Kandler,andWilliamM.Shafer AntimicrobialPeptidesandInflammatoryBowelDisease. . . . . . . . . . . 255 SimonJa¨ger,EduardF.Stange,andJanWehkamp vii viii Contents CysticFibrosisandDefectiveAirwayInnateImmunity. . . . . . . . . . . . . 275 JenniferA.BartlettandPaulB.McCrayJr. AntimicrobialPeptidesinChronicObstructivePulmonaryDisease. . . . 307 GimanoD.AmatngalimandPieterS.Hiemstra HostDefensePeptides:ImmuneModulationandAntimicrobialActivity InVivo. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321 NicoleJ.Afacan,LaureM.Janot,andRobertE.W.Hancock HelpingtheHost:InductionofAntimicrobialPeptidesasaNovel TherapeuticStrategyAgainstInfections. . . . . . . . . . . . . . . . . . . . . . . . 359 BirgittaAgerberth,PeterBergman,andGudmundurH.Gudmundsson Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377 List of Contributors NicoleJ.Afacan CentreforMicrobialDiseasesandImmunityResearch,Univer- sityofBritishColumbia,Vancouver,BC,Canada Birgitta Agerberth Department of Medical Biochemistry and Biophysics, KarolinskaInstitutet,Stockholm,Sweden Gimano D. Amatngalim Department of Pulmonology, Leiden University MedicalCenter,Leiden,TheNetherlands Mauricio Arias Department of Biological Sciences, Biochemistry Research Group,UniversityofCalgary,Calgary,AB,Canada JenniferA.Bartlett DepartmentofPediatrics,UniversityofIowa,IowaCity, IA, USA Paula E. Beaumont MRC/University of Edinburgh Centre for Inflammation Research,Queens’MedicalResearchInstitute,W2.05,Edinburgh,Scotland,UK Peter Bergman Department of Medicine, Center for Infectious Medicine, KarolinskaInstitutet,Stockholm,Sweden Department of Laboratory Medicine, Division of Clinical Microbiology, KarolinskaUniversityHospital,Stockholm,Sweden Eefjan Breukink Membrane Biochemistry & Biophysics, Utrecht University, Padualaan8,3584CHUtrecht,TheNetherlands Donald J. Davidson MRC/University of Edinburgh Centre for Inflammation Research,Queens’MedicalResearchInstitute,W2.05,Edinburgh,Scotland,UK Maira Goytia Department of Microbiology and Immunology, School of Medicine,EmoryUniversity,RollinsResearchCenter,Atlanta,GA,USA Gudmundur H. Gudmundsson Institute of Biology, University of Iceland, Reykjavik,Iceland ix x ListofContributors Robert E.W. Hancock Centre for Microbial Diseases and Immunity Research, UniversityofBritishColumbia,Vancouver,BC,Canada Pieter S. Hiemstra Department of Pulmonology, Leiden University Medical Center,Leiden,TheNetherlands SimonJa¨ger DepartmentofInternalMedicineI,RobertBoschHospital,Stuttgart, Germany Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany Laure M.Janot Centre for MicrobialDiseases andImmunity Research, Univer- sityofBritishColumbia,Vancouver,BC,Canada Justin L. Kandler Department of Microbiology and Immunology, School of Medicine,EmoryUniversity,RollinsResearchCenter,Atlanta,GA,USA Robert I. Lehrer Department ofMedicine, David Geffen School ofMedicine at UCLA,LosAngeles,CA,USA Hsin-Ni Li MRC/University of Edinburgh Centre for Inflammation Research, Queens’MedicalResearchInstitute,W2.05,Edinburgh,Scotland,UK Paul B. McCray 240F EMRB, Department of Pediatrics, Roy J. and Lucille A.CarverCollegeofMedicine,UniversityofIowa,IowaCity,IA,USA Menno J. Oudhoff Section Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam,TheNetherlands Aline Dias Paiva Departamento de Microbiologia, Universidade Federal de Vic¸osa, Avenida P.H. Rolfs, s/n, Campus Universita´rio Cep: 36571-000, Vic¸osa/ MinasGerais,Brasil AliRoghanian AntibodyandVaccineGroup,CancerSciencesUnit,Universityof Southampton,Southampton,UK Jean-Michel Sallenave Institut Pasteur, Unite´ De´fense Inne´e et Inflammation, Paris,France INSERM,U874,Paris,France UFRSciencesduVivant,Universite´ ParisDiderotParis7,Paris,France William M. Shafer Department of Microbiology and Immunology, School of Medicine,EmoryUniversity,RollinsResearchCenter,Atlanta,GA,USA VeteransAffairsMedicalResearch, VeteransAffairs MedicalCenter, Decatur, GA, USA Mona Sta˚hle Unit of Dermatology and Venereology, Karolinska Institutet, Stockholm,Sweden
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