Antimicrobial growth promoters Where do we go from here? edited by D. Barug J. de Jong A.K. Kies M.W.A. Verstegen Antimicrobial growth promoters Antimicrobial growth promoters Where do we go from here? edited by: D. Barug J. de Jong A.K. Kies M.W.A. Verstegen WWaaggeenniinnggeenn AAccaaddeemmiicc PPPP uuuu bbbbb llll iiii ssssss hhhh eeeeee rrrr ssssss This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned. Nothing from this publication may be translated, reproduced, stored in a computerised system or published in any form or in any manner, including electronic, mechanical, reprographic or photographic, without prior written permission from the publisher, Wageningen Academic Publishers, P.O. Box 220, 6700 AE Wageningen, the Netherlands, www.WageningenAcademic.com ISBN: 978-90-76998-87-9 e-ISBN: 978-90-8686-570-3 The individual contributions in this DOI: 10.3920/978-90-8686-570-3 publication and any liabilities arising from them remain the responsibility of the authors. First published, 2006 The publisher is not responsible for possible damages, which could be a © Wageningen Academic Publishers result of content derived from this The Netherlands, 2006 publication. Foreword It is widely acknowledged that the inclusion of antimicrobial growth promoters (AGPs) in the diet of livestock increases growth rate. However, do the benefits outweigh the risks, or vice versa? Furthermore, recent legislative developments in the European Union and USA, recommendations by the World Health Organization, initiatives taken by the food chain, and consumer concerns all point to a (voluntary) widespread removal of antibiotic feed additives for animal growth promotion. In particular, Regulation (EC) 1831/2003 lays down provisions phasing out the authorisations of AGPs in the European Union as from 1 January 2006. How will this affect the use/non-use practice of AGPs? This book contains peer reviewed papers resulting from oral presentations at the international conference Antimicrobial Growth Promoters: Worldwide Ban on the Horizon? that was held in the Netherlands in January 2005. Putting it all together the book describes the current status and rational design of developments and strategies for animal feeding without the inclusion of AGPs. Topics covered include benefits and risks of AGPs, risk assessment, consumer concerns and demands, regulatory aspects and international developments, mode of action and innovative alternatives, and recent advances in the analysis of AGPs and related products. The book provides valuable information on the pros and cons of use of AGPs as well as on nutritional solutions beyond. The information provided herein is of great value for professionals and researchers in the feed and food industry. The editors thank the authors who gave their time and expertise to contribute to this book. The editors D. Barug J. de Jong A.K. Kies M.W.A. Verstegen Table of contents Foreword 7 Current use of antimicrobial growth promoters in food animals: the benefits 19 S.W. Page Abstract 19 1. Introduction 19 2. History 21 3. Mode of action 22 4. Applications and benefits of AGPs 26 5. Variation in response to AGPs 28 6. Recent reviews 30 7. Emerging applications 33 8. Conclusions 41 References 42 Use of antimicrobial growth promoters in food animals: the risks outweigh the benefits 53 H.C. Wegener Abstract 53 1. Introduction 53 2. European perspective on AGPs 54 3. Countries’ experience with phasing out AGPs 54 4. Risk-benefit considerations 56 5. Conclusions 58 References 58 Antimicrobial growth promoters: consumer concerns and demands 59 L. Reijnders Abstract 59 1. Introduction 59 2. Links with a wider debate about intensive animal husbandry 60 3. Alternatives 61 4. Trust in industry and regulators 61 5. Nature of NGO concerns with risks of antimicrobial growth promoters 62 Antimicrobial growth promoters
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