Antiepileptic Drugs - Combination Therapy and Interactions - J. Majkowski, et al., (Cambridge, 2005) WW PDF
Preview Antiepileptic Drugs - Combination Therapy and Interactions - J. Majkowski, et al., (Cambridge, 2005) WW
This page intentionally left blank Antiepileptic Drugs Combination Therapy and Interactions This book reviews the use of antiepileptic drugs focussing on the interactions between these drugs, and between antiepileptics and other drugs. These interactions can be beneficial or can cause harm. The aim of this book is to increase awareness of the possible impact of combination pharmacotherapies. Pharmacokinetic and pharmacodynamic interactions are discussed sup- ported by clinical and experimental data. The book consists of five parts covering the general concepts and advantages of combination therapies, the principles of drug interactions, the mechanisms of interactions, drug interactions in specific populations or in patients with co-mor- bid health conditions, concluding with a look at the future directions for this field of research. The book will be of interest to all who prescribe antiepileptics to epileptic and non-epileptic patients, including epileptologists, neurologists, neuropediatricians, psychiatrists and general practitioners. Antiepileptic Drugs Combination Therapy and Interactions Edited by Jerzy Majkowski The Foundation of Epileptology, Warsaw Blaise F. D. Bourgeois Harvard Medical School, USA Philip N. Patsalos Institute of Neurology, UK and Richard H. Mattson Yale University School of Medicine, USA cambridge university press Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo Cambridge University Press The Edinburgh Building, Cambridge cb2 2ru, UK First published in print format isbn-13 978-0-521-82219-0 isbn-13 978-0-511-12593-5 © Cambridge University Press 2005 2005 Information on this title: www.cambridge.org/9780521822190 This publication is in copyright. Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. isbn-10 0-511-12593-3 isbn-10 0-521-82219-x Cambridge University Press has no responsibility for the persistence or accuracy of urls for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. Published in the United States of America by Cambridge University Press, New York www.cambridge.org hardback eBook (NetLibrary) eBook (NetLibrary) hardback Contents List of contributors Page ix Foreword Giuliano Avanzini xiii Foreword Torbjörn Tomson xv Acknowledgements xvii Part I Introduction 1 1 Combination therapy of diseases: general concepts 3 Emma Mason and Philip A. Routledge 2 Combination therapy with antiepileptic drugs: potential advantages and problems 16 Richard H. Mattson 3 Pharmacogenetic aspects 26 Matthew C. Walker, Michael R. Johnson and Philip N. Patsalos Part II Pharmacokinetic interactions 45 4 Pharmacokinetic principles and mechanisms of drug interactions 47 Philip N. Patsalos 5 Predictability of metabolic antiepileptic drug interactions 57 Edoardo Spina, Emilio Perucca and Rene Levy 6 Influence of food and drugs on the bioavailability of antiepileptic drugs 93 Carlos A. Fontes Ribeiro 7 Interactions between antiepileptic drugs 111 Bernhard Rambeck and Theodor W. May 8 Interactions between antiepileptic and non-antiepileptic drugs 139 Jerzy Majkowski and Philip N. Patsalos v Part III Pharmacodynamic interactions 179 9 Pharmacodynamic principles and mechanisms of drug interactions 181 Blaise F. D. Bourgeois 10 Methods for assessing pharmacodynamic interactions 193 Blaise F. D. Bourgeois 11 Experimental studies of pharmacodynamic interactions 208 Stanislaw J. Czuczwar 12 Clinical studies of pharmacodynamic interactions 228 John R. Pollard and Jacqueline French 13 Clinical studies of pharmacodynamic interactions between antiepileptic drugs and other drugs 241 Gaetano Zaccara, Andrea Messori and Massimo Cincotta Part IV Drug interactions in specific patient populations and special conditions 255 14 Antiepileptic drug interactions in children 257 Olivier Dulac, Elizabeth Rey and Catherine Chiron 15 Antiepileptic drug interactions in the elderly 273 Jeannine M. Conway and James C. Cloyd 16 Antiepileptic drug interactions in pregnancy 294 Mark S. Yerby 17 Antiepileptic drug interactions in handicapped and mentally retarded patients 325 Matti Sillanpää 18 Antiepileptic drugs and sex steroids 341 Richard H. Mattson 19 Antiepileptic drug interactions in patients requiring psychiatric drug treatment 350 Michael R. Trimble and Marco Mula 20 Antiepileptic drugs in non-epileptic health conditions: possible interactions 369 Jerzy Majkowski 21 Drug monitoring in combination therapy 392 Walter Fröscher vi Contents 22 Cognitive side-effects due to antiepileptic drug combinations and interactions 403 Albert P. Aldenkamp, Mark de Krom, Irene Kotsopoulos and Jan Vermeulen Part V Conclusions and future perspectives 419 23 Selection of drug combinations in clinical practice: current and future perspectives 421 Jerzy Majkowski 24 Future research: an experimental perspective 441 Rob A. Voskuyl, Daniel M. Jonker and Fernando H. Lopes da Silva 25 Future research: a clinical prospective 458 Carlos A. Fontes Ribeiro Index 475 vii Contents List of contributors Professor Albert P. Aldencamp Department of Neurology, University Hospital of Maastricht, PO Box 21, NL 2100 AB, Heeze, The Netherlands Professor Blaise F. D. Bourgeois Children’s Hospital – HU2, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA Dr Catherine Chiron Hospital Necker-Enfants Malades, 149 Rue de Sevres, Paris 75015, France Dr Massimo Cincotta Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy Dr James C. Cloyd College of Pharmacy, University of Minnesota, Room 7101, Weaver Densford Hall, 308 Harvard St SE, Minneapolis, MN 55455 0353, USA Dr Jeannine M. Conway College of Pharmacy, University of Minnesota, 7-170 WDH, 308 Harvard St SE, Minneapolis, MN 55455, USA Professor Stanislaw J. Czuczwar Department of Pathophysiology, Medical Academy, Jaczewskiego 8, 820-090 Lublin, Poland Dr Mark de Krom Department of Neurology, University Hospital of Maastricht, PO Box 21, NL 2100 AB, Heeze, The Netherlands Professor Olivier Dulac Hospital Necker-Enfants Malades, 149 Rue de Sevres, Paris 75015, France Professor Carlos A. Fontes Ribeiro Department of Pharmacology, Faculty of Medicine, 3000 Coimbra, Portugal Professor Jacqueline French Department of Neurology, 3 West Gates, Hospital of the University of Pennsylvania, 3400 Spruce St, PA 19104, USA Professor Walter Fröscher Department of Neurology and Epileptology, Die Weissenau (Department of Psychiatry I), University of Ulm, D-88214 Ravensburg, Germany Dr Michael R. Johnson Division of Neurosciences and Psychological Medicine, Imperial College London, Charing Cross Hospital, London, W6 8RP, UK Dr Daniel M. Jonker Epilepsy Institute of the Netherlands (SEIN), Achterweg 5, NL 21 03 SW, Heemstede, The Netherlands ix
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