Anticancer Potential of Curcumin: PDF
Preview Anticancer Potential of Curcumin:
Anticancer Potential of Curcumin: An Old Spice With New Targets Bharat B. Aggarwal, Ph.D. Cytokine Research Section, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A. [email protected] www.apoptosis2005.org Oommen V. Oommen, Ph.D. Bharat B. Aggarwal, Ph.D. [email protected] or [email protected] oommenvo@yahoo. Golden Triangle Modern technology Traditional Knowledge Modern Knowledge (Ayurvedic medicine (Allopathic medicine) Egypcian medicine Kampo, TCM) Inflammation plays a major in development of most diseases Cancer Pulmonary Cardiovascular diseases diseases Neurological Inflammation Alzheimer diseases Autoimmune Diabetes II diseases Arthritis Hypothesis! NF-κB activation is a major mediator of inflammation in most diseases & inhibition of NF-κB activation can suppresses inflammation NF-κB has been linked to several diseases Cancer Chronic obstructive Heart failure pulmonary diseases Ischemia/Reperfusion Arthritis Cardiac hypertrophy AIDS Atherosclerosis Asthma Multiple sclerosis Headache Muscular dystrophy Diabetes type 1 and II NF-κB Alzheimer’s disease Aging Bone resorption Lupus Renal disease Sepsis Incontinentia pigmenti Gut disease Ectodermal dysplasia Skin disease Crohn’s disease Viral infections Neuropathological disease Sleep apnoea Helicobacter pylori- Systematic inflammatory associated gastritis response syndrome Hypothesis! (cid:190) Most carcinogens activate NF- κB (cid:190) NF-κB activation mediates carcinogenesis/tumorigenesis (cid:190) Inhibition of NF-κB activation suppresses tumorigenesis Inflammation and cancer: back to Virchow? Balkwill F, Mantovani A. Lancet. 2001;357:539-45. NF-kappa B: arresting a major culprit in cancer Haefner B Drug Discov Today. 2002;7:653-63 NF-kappaB in cancer: from innocent bystander to major culprit Karin M, Cao Y, Greten FR, Li ZW. Nat Rev Cancer. 2002;2:301-10.
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