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Antibody Production in Man: In Vitro Synthesis and Clinical Implications PDF

413 Pages·1979·10.88 MB·English
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ANTIBODY PRODUCTION IN MAN In Vitro Synthesis and Clinical Implications ACADEMIC PRESS RAPID MANUSCRIPT REPRODUCTION Proceedings of the Catharijne Conference on immunology held in Utrecht, Holland on March 15-18, 1978. ANTIBODY PRODUCTION IN MAN In Vitro Synthesis and Clinical Implications edited by ANTHONY S. FAUCI Clinical Physiology Section Laboratory of Clinical Investigation National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, Maryland and RUDY BALLIEUX Clinical Immunology University Hospital Utrecht, Holland ACADEMIC PRESS New York San Francisco London 1979 A Subsidiary of Harcourt Brace Jovanovich, Publishers COPYRIGHT © 1979, BY ACADEMIC PRESS, INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. Ill Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NW1 7DX Library of Congress Cataloging in Publication Data Main entry under title: Antibody production in man. Proceedings of a workshop held in Utrecht, Holland, Mar. 15-18, 1978. Includes index. 1. B cells—Congresses. 2. Immunoglobulins— Congresses. 3. Human cell culture—Congresses. 4. Immune response—Regulation—Congresses. 5. Immunological deficiency syndromes—Congresses. I. Fauci, Anthony S. II. Ballieux, R. E. [DNLM: 1. Antibody formation—Congresses. QW575 C361a Library of Congress Cataloging in Publication Data 1978] QR185.8.L9A47 616.07'93 79-928 ISBN 0-12-249950-6 PRINTED IN THE UNITED STATES OF AMERICA 79 80 81 82 9 8 7 6 5 4 3 2 1 CONTENTS Contributors ix Preface xiii 1 Consideration of Antibody Deficiency Diseases in Relation to Normal B-Cell Development 1 M. D. Cooper, E. R. Pearl, and A. R. Lawton 2 Pokeweed Mitogen-Induced Responses of Human Peripheral Blood Lymphocytes: Regulation of B-Cell Triggering 17 Anthony 5. Fauci and Barton F. Haynes 3 Induction of Antibody Synthesis in Human Lymphocytes from Different Organs by Different PBA Substances 35 B. Rynnel-Dagöö, Ί. Kunbri, O. Ringden, and E. Möller 4 The Plaque-Forming Cell Response of Human Blood Lympho- cytes . Cocultivation of Lymphocytes from Different Individuals 49 Marc E. Weksler, Abby Schwartz, Jay Blum, and Young Tai Kim General Discussion Mitogen-Induced B-Cell Activation. I. 61 Moderator: Göran Möller 5 T—T Interactions in the Generation of Human Suppressor Effector Cells in Vitro 69 Samuel Broder, Linda Muul, Mary Durm, Carolyn Goldman, Dean Mann, and Thomas A. Waldmann 6 Biosynthesis and Secretion of Immunoglobuhns by Human Peripheral Blood Lymphocytes 85 Yong Sung Choi, F. Kingsley Sanders, and Robert A. Good VI Contents 7 Antigen-Specific and Antigen-Nonspecific Triggering of Human B Lymphocytes 101 Raif S. Geha and Fuad B. Mudawwar General Discussion Mitogen-Induced B-Cell Activation. II. 115 Moderator: Göran Möller 8 Antigen-Induced Regulation of the PFC Response in Man 121 Hans-Michael Dosch and Erwin W. Gelfand 9 Human B-Cell Activation in Vitro: Regulation by Antigen- Specific Human Suppressor T Cells 141 F. UytdeHaag, CobiJ. Heijnen, C. H. Pot, and R. E. Ballieux 10 Primary in Vitro Antibody Response to TNP-PAA: Cellular Basis 159 P. Galanaud, J. F. Delfraissy, and J. Dormont General Discussion Antigen-Induced B-Cell Activation. I. 167 Moderator: Erwin W. Gelfand 11 T-B Collaboration in the in Vitro Ab Response to Diphtheria Toxoid: Evidence Favoring a Role for B Cells in the Generation ofT-CellHelp 173 T. Platts-Mills, G. Oldham, E. G. de la Concha, and M. J. Snajdr 12 Antigen-Dependent PFC Induction in Cultures of Human Peripheral Blood Lymphocytes 185 A. L. Luzzati 13 Human Antigen-Specific Helper T-Cell Factors in B-Cell Responses 193 James N. Woody, Ann Rees, Nathan Zvaifler, Sarah Howie, Aftab Ahmed, Michael Strong, Robert J. Hartzman, Fred Kantor, and Marc Feldmann General Discussion Antigen-Induced B-Cell Activation. II. 209 Moderator: Erwin W. Gelfand Contents νπ 14 Clinical Relevance of Subpopulation of Human T Lymphocytes 215 L. Moretta, D. Santoli, A. Moretta, M. C. Mingari, P. Perlmann, and H. Koprowski 15 Further Studies on the IgM Receptors Located on the Surface of B Cells 223 M. Ferrarini, Giovanna Viale, and Elisabetta Cosulich 16 Distinct Human T-Cell Subpopulations Regulating the Antigen-Induced Antibody Response 231 Cobi J. Heijnen, F. UytdeHaag, I. Dollekamp, and R. E. Bailieux General Discussion Subpopulations of Lumphocytes Involved in the in Vitro Regulation of B-Cell Function. I. 253 Moderator: Max D. Cooper 17 Generation of Plaque-Forming Cells: Allogenic Effect and Significance of Monocyte Removal 259 Nicholas Chiorazzi, Manlio Ferrarini, Ghodrat Montazeri, Thomas Hoffman, and Shu Man Fu 18 Regulation of Human B-Cell Differentiation by T-Cell Subclasses 273 Steven M. Friedman, Oscar H. Irigoyen, and Leonard Chess 19 Effect of Hydrocortisone on the Kinetics and Function of Peripheral Blood Immunoregulatory Cells in Man 291 Barton F. Haynes, Paul Katz, and Anthony S. Fauci General Discussion Subpopulations of Lymphocytes Involved in the in Vitro Regulation of B-Cell Function. II. 303 Moderator: Max D. Cooper 20 In Vitro Functional Heterogeneity of Humoral and Cellular Immune Deficiency States 309 Erwin W. Gelfand and Hans-Michael Dosch Vlll Contents 21 Immoglobulin Secreting Cells in the Circulating Blood and Mitogen-Stimulated Cultures from Patients with Immunodeficiency Diseases 325 R. Michael Blaese, E. Clinton Lawrence, Andrew V. Muchmore, Jane Grayson, Nancy J. Dooley, and Irma R. Koski 22 Polyclonal B-Cell Activation in the Analysis of Immunodeficiency States 333 C. Möller and C. Fernandez General Discussion Clinical Implications in the Study of in Vitro B-Cell Function. I. 345 Moderator: Anthony S. Fauci 23 Aberrant Regulation of B-Cell Function in Immunologically Mediated Diseases: Systemic Lupus Erythematosus and Sarcoidosis 351 Paul Καίζ, Barton F. Haynes, and Anthony S. Fauci 24 The Cellular Defeat in IgA Deficiency: Possible Links to Hypogammaglobulinemia 367 T. A. E. Platts-Mills, G. Oldham, J. T. Cassidy, A. D. B. Webster, and E. G. de la Concha 25 Subpopulation of Human T Lymphocytes: Functional Characteristics 379 L. Moretta, M. C. Mingari, A. Moretta, G. W. Canonica, and M. D. Cooper General Discussion Clinical Implications in the Study of in Vitro B-Cell Function. II. 389 Moderator: Anthony S. Fauci Summary of Workshop Human B-Cell Function: Recent Advances, Unanswered Questions, and Future Directions 393 Anthony S. Fauci and Rudy E. Ballieux Index 397 CONTRIBUTORS Numbers in parentheses indicate the pages on which authors' contributions begin. AFT AB AHMED (193), Department of Immunology, Naval Medical Re- search Institute, Bethesda, Maryland R. E. BALLIEUX (141, 231), University Children's Hospital, Het Wilhel- mina Kinderziekenhuis, and University Hospital, Utrecht, The Nether- lands R. MICHAEL BLAESE (325), Cellular Immunology Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland JAY BLUM (49), The Department of Medicine, Cornell University Medical College, New York SAMUEL BRODER (69), Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland G. W. CANONICA (379), Istituto di Microbiologia, University ofGenova, Genova, Italy J. T. CASSIDY (367), The Arthritis Division, University Hospital, The Uni- versity of Michigan, Ann Arbor, Michigan 48109 LEONARD CHESS (273), Department of Medicine, College of Physicians and Surgeons, Columbia University, New York NICHOLAS CHIORAZZI (259), The Rockefeller University, New York YONG SUNG CHOI (85), Sloan-Kettering Institute for Cancer Research, Rye, New York E. G. DE LA CONCHA (173, 367), Centro Especial "Ramon Y. Cajal," Apartado 37, Madrid 34, Spain M. D. COOPER (1, 379), The Cellular Immunobiology Unit of the Tumor Institute, Departments of Pediatrics and Microbiology and the Com- prehensive Cancer Center, University of Alabama, Birmingham, Alabama ELISABETTA COSULICH (223), Istituto di Chimica Biologica, Cattedra di Immunologia Clinica, Universita di Genova, Genova, Italy J. F. DELFRAISSY (159), Universite Paris-Sud and INSERM U 131, Höpi- tal Antoine Beclere, Clamart, France I. DOLLEKAMP (231), University Children's Hospital, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands ix

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