Antibody Drug Discovery

486 Pages·2011·26.514 MB·English

by  Clive R. Wood, Clive R. Wood

Antibody Drug
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P743.9781848166288-tp.indd 1 10/11/11 3:45 PM
Molecular Medicine and Medicinal Chemistry
Book Series Editors: Professor Colin Fishwick (School of Chemistry, University
of Leeds, UK)
Dr Paul Ko Ferrigno and Professor Terence Rabbitts FRS,
FMedSci (Leeds Institute of Molecular Medicine,
St. James’s Hospital, UK)
Published:
MicroRNAs in Development and Cancer
edited by Frank J. Slack (Yale University, USA)
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w.on DNA Deamination and the Immune System: AID in Health and Disease
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Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical
Aspects to Clinical Applications
edited by Véronique Gouverneur (University of Oxford, UK) and
Klaus Müller (F Hoffmann-La Roche AG, Switzerland)
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Clive R Wood

Bayer HealthCare, Germany
Editor
Imperial College Press
ICP
P743.9781848166288-tp.indd 2 10/11/11 3:45 PM
Published by
Imperial College Press
57 Shelton Street
Covent Garden
London WC2H 9HE
Distributed by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
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For photocopying of material in this volume, please pay a copying fee through the Copyright
Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to
photocopy is not required from the publisher.
ISBN-13 978-1-84816-628-8
ISBN-10 1-84816-628-1
Typeset by Stallion Press
Email: [email protected]
Printed in Singapore.
XiaoLing - Antibody Drug Discovery.pmd 2 9/7/2011, 12:00 PM
b1153_FM.qxd 10/12/2011 3:31 PM Page v
b1153 Antibody Drug Discovery
Contents
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worldscieal use onl CFoornetwriobrudtors vxiii
www.person John McCafferty
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y Downloa79 on 10/0 Chapter 1 OHluivmiearn Lizéagteiro ann odf JAosnét iWbo.dSaielsdanha 1
over96.1 Chapter 2 Selection and Screening ofAntibody Phage Display Libraries 25
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Drug 146.1 David Lowe and Tristan J.Vaughan
dy by Chapter 3 Affinity Maturation Approaches for Antibody Lead 85
o
ntib Optimization
A David Lowe,Trevor Wilkinson and Tristan J.Vaughan

Chapter 4 Transgenic Mice Rearranging Human Antibodies 121
Sean Stevens
Chapter 5 Isotype Selection and Fc Engineering:Design and 147
Construction ofFit-for-Purpose Therapeutic
Antibodies
William R.Strohl
Chapter 6 Antibody Expression from Bacteriato Transgenic 221
Animals
Paul Stephens and Berni M.Sweeney
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vi Contents
Chapter 7 Current Trends in Antibody Purification and Lead 271
Selection
Jie Chen and Andrew Nixon
Chapter 8 Design and Application ofImmunoconjugates for 315
Cancer Therapy
SherifEl Sheikh,Hans-Georg Lerchen,Beate Müller-Tiemann
and Jörg Willuda
Chapter 9 Dual-Targeting Bispecific Antibodies as New Therapeutic 373
Modalities for Cancer
Zhenping Zhu
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ntifiy. Lioudmila Tchistiakova,William J.J.Finlay,
cieonl Stephane Olland,HelenDooleyand Davinder Gill
w.worldsonal use Editor Biography 441
wwpers Index 443
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Contributors
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cieonl Foreword
worldsal use John McCafferty,University of Cambridge,Department of Biochemistry,Tennis
www.person Court Road,Cambridge,CB2 1QW,UK
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Drug 146.1 David R.Buckler, Dyax Corp., 300 Technology Square, Cambridge, MA 02139,
dy by USA
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Helen Dooley,Pfizer,Inc.,Foresterhill,Aberdeen,AB25 2ZS,UK
William J.J.Finlay,Pfizer,Inc.,Grange Castle Business Park,Clondalkin,Dublin
22,Ireland
Davinder Gill,Pfizer,Inc.,Global Biotherapeutic Technologies,87 Cambridgepark
Drive,Cambridge,MA 02140,USA
Olivier Léger,Merck Serono International S.A.,Protein Engineering & Antibody
Technologies, Geneva Research Center, Merck Serono International S.A., 9,
chemin des Mines,1202 Geneva,Switzerland
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b1153 Antibody Drug Discovery
viii Contributors
Hans-Georg Lerchen,Bayer HealthCare AG,Medicinal Chemistry,Aprather Weg
18a,42096 Wuppertal,Germany
David Lowe,MedImmune Ltd.,Milstein Building,Granta Park,Cambridge,CB21
6GH,UK
Beate Müller-Tiemann, Bayer HealthCare AG, Global Biologics, Aprather Weg
18a,42096 Wuppertal,Germany
Andrew Nixon,Dyax Corp.,300 Technology Square,Cambridge,MA 02139,USA
Stephane Olland, Pfizer, Inc., Global Biotherapeutic Technologies, 87
m Cambridgepark Drive,Cambridge,MA 02140,USA
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ntifiy. José W. Saldanha, National Institute for Medical Research, Division of
cieonl Mathematical Biology,The Ridgeway,Mill Hill,London NW7 1AA,UK
worldsal use Darren Schofield,MedImmune Ltd.,Milstein Building,Granta Park,Cambridge,
w.on CB21 6GH,UK
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ver6.1 Paul Stephens, UCB Celltech, Discovery Biology, 216 Bath Road, Slough,
co19 Berkshire SL1 4EN,UK
Dis51.
Drug 146.1 Sean Stevens,Ablexis LLC,409 Illinois Street,San Francisco,CA 94158,USA
dy by William R.Strohl,Centocor R&D,Inc.,Biologics Research,145 King of Prussia
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Berni M. Sweeney, UCB Celltech, Discovery Biology, 216 Bath Road, Slough,
Berkshire,SL1 4EN,UK
Lioudmila Tchistiakova, Pfizer, Inc., Global Biotherapeutic Technologies, 87
Cambridgepark Drive,Cambridge,MA 02140,USA
Tristan J. Vaughan, MedImmune Ltd., Milstein Building, Granta Park,
Cambridge,CB21 6GH,UK
Trevor Wilkinson,MedImmune Ltd.,Milstein Building,Granta Park,Cambridge,
CB21 6GH,UK
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b1153 Antibody Drug Discovery
Contributors ix
Jörg Willuda, Bayer HealthCare AG, Therapeutic Research Group Oncology,
Muellerstrasse 178,13353 Berlin,Germany
Zhenping Zhu, Kadman Pharmaceuticals, 450 East 29th Street, New York, NY
10016,USA
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b1153 Antibody Drug Discovery
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