Antibodies, Antigens, and Molecular Mimicry

876 Pages·1989·22.17 MB·English

by  John J. Langone (Eds.)

Contributors to Volume 178
Article numbers are in parentheses gniwollof the names of .srotubirtnoc
snoitailiffA listed are current.
LEO G. ABOOD (15), Department of Phar- search Facility, Frederick, Maryland
macology, University of Rochester, 10712
School of Medicine and Dentistry, Roch- E. J. BUNSCHOTEN (26), Department oflm-
ester, New York 24641 munobiology, National Institute of Public
GEORGE ALBRIGHT (3), Department of Pa- Health and Environmental Protection,
thology and Laboratory Medicine, Uni- 3720 BA Bilthoven, The Netherlands
versity of Texas Health Science Center at ANDR~ CAPRON (27), Centre d'Immunolo-
Houston, Houston, Texas 52277 gie et de Biologie, Parasitaire, Unitd
T. AMIT (21), Rappaport Family Research Mixte INSERM U167-CNRS 624, Institut
Institute, Faculty of Medicine, Tech- Pasteur, 59019 Lille Cedex, France
nion--lsrael Institute of Technology, BERWYN E. CLARKE (42), Department of
Haifa, Israel Virology, Wellcome Biotechnology Lim-
RONNIE J. BARKEY (21), Rappaport Family ited, Beckenham, Kent BR3 3BS, England
Research Institute, Faculty of Medicine, IRUN R. COHEN (20), Department of Cell
Technion--lsrael Institute of Technology, Biology, The Weizmann Institute of Sci-
Haifa, Israel ence, 00167 Rehovot, Israel
ETTY N. BENVENISTE (4), Department of MARCO COLOMBATTI (28), Istituto di
Neurology, University of Alabama at Bir- Scienze Immunologiche, University of
mingham, Birmingham, Alabama 49253 Verona, 37134 Verona, Italy
DAVID J. BERLOVE (15), The Neuroendo- JAMES L. CORNETTE (40), Department of
crine Unit, University of Rochester, Mathematics, Iowa State University,
School of Medicine and Dentistry, Roch- Ames, Iowa 11005
ester, New York 24641 JEAN-YVES COURAUD (19), Ddpartement de
JAY A. BERZOFSKY (40), Metabolism Biologie, Section de Pharmacologie et
Branch, National Cancer Institute, Na- d'Immunologie, Commissariat d l'Ener-
tional Institutes of Health, Bethesda, gie, 9119 Gif-sur-Yvette Cedex, France
Maryland 29802 CHARLES DELISl (40), Department of -DiB
MARC BETTER (33), International Genetic mathematical Sciences, Mount Sinai
Engineering, Inc. (INGENE), Santa School of Medicine, New York, New York
Monica, California 40409 92001
J. EDWIN BLALOCK (4), Department of LORENA DELL'ARCIPRETE (28), Istituto di
Neurology, University of Alabama at Bir- Scienze lmmunologiche, University of
mingham, Birmingham, Alabama 49253 Verona, 37134 Verona, Italy
KENNETH L. BOST (4), Department of Phys- DANA ELIAS (20), Department of Cell Biol-
iology and Biophysics, University of Ala- ogy, ehT Weizmann Institute of Science,
bama at Birmingham, Birmingham, Ala- 00167 Rehovot, Israel
bama 49253 NADIR R. FARID (14), Thyroid Research
SANDRA BRIDGES (24), Medicine Branch, Laboratory, Health Sciences Centre, Me-
Division of Cancer Treatment, National morial University of Newfoundland, St.
Cancer Institute, Frederick Cancer Re- John's, Newfoundland A1B 3V6, Canada
xi
xii CONTRIBUTORS TO VOLUME 178
S. FERRONE (5), Department of Microbiol- J. HCIVOMIAH (25), Department of Human
ogy and Immunology, New York Medical Microbiology, Sackler School of Medi-
College, Valhalla, New York 59501 cine, leT Aviv University, leT Aviv ,97996
LEAHCIM J. FRANCIS (42), Department of Israel
Virology, Wellcome Biotechnology Lim- AHMED H. S. HASSAN 07), Department of
ited, Beckenham, Kent BR3 3BS, England Anatomy and Histology, Faculty of Vet-
YVELINE FROBERT (19), D(partement ed erinary Medicine Assuit, University As-
Biologie, Section de Pharmacologie et suit, Egypt
d'lmmunologie, Commissariat d l'Ener- ALBERT HERZ (17), Department of
gie, 19119 Gif-sur-Yvette Cedex, France Neuropharmacology, Max-Planck-Insti-
ARAS FUCHS (30), Department of Chemical tur fiir Psychiatrie, D-8033 Planegg-Mar-
Immunology, The Weizmann Institute of tinsried, Federal Republic of Germany
Science, 76100 Rehovot, Israel SAMOHT P. HOPP (38), Protein Research
M. GILBERT (9), Ddpartement d'lmmunocy- Laboratories, Seattle, Washington 61189
tochimie, lnstitut Pasteur, 75015 Paris, ARNOLD H. HORWITZ (33), International
France
Genetic Engineering, Inc. (INGENE),
YAJ A. GLASEL (16), Department of -DiB Santa Monica, California 40409
chemistry, ehT University of Connecticut
E. HURWlTZ (25), Department of Chemical
Health Science Center, Farmington, Con-
Immunology, The Weizmann Institute of
necticut 23060
Science, 00167 Rehovot, Israel
JOHN W. GNANN, JR. (44), Division of Infec-
MARC G. JACQUEMIN (10), Experimental
tious Diseases, Department of Medicine,
Medicine Unit, Institute of Cellular and
University of Alabama at Birmingham,
Molecular Pathology, Brussels, Belgium
Birmingham, Alabama 49253
YELRIHS A. JOSEPH (15), The Neuroendo-
NAITSIRHC HCSMARG (17), Gramsch Labo-
crine Unit, University of Rochester,
ratories, D-8061 Schwabhausen, Federal
School of Medicine and Dentistry, Roch-
Republic of Germany
ester, New York 24641
SEUQCAJ GRASSI (19), D~partement de
T. KAGESHITA (5), Department of Microbi-
Biologie, Section de Pharmacologie et
ology and Immunology, New York Medi-
d'Immunologie, Commissariat d l'Ener-
cal College, Valhalla, New York 59501
gie, 19119 Gif-sur-Yvette Cedex, France
SAVINIRS KAVERi (1), IDEC Pharmaceuti-
MARK I. GREENE (22), Division of Pathol-
cals Corporation, La Jolla, California
ogy, University of Pennsylvania School of
73O29
Medicine, Philadelphia, Pennsylvania
40191 DLANOR C. KENNEDY (2), Department of
Virology and Immunology, Southwest
JEAN-MARIE GRZYCH (27), Centre d'lm-
Foundation for Biomedical Research,
munologie et de Biologie, Parasitaire,
San Antonio, Texas 48287
Unitd Mime INSERM U167-CNRS 624,
Institut Pasteur, 59019 Lille Cedex, SAMOHT SNOMME-REBEIK (1), IDEC Phar-
France maceuticals Corporation, La Jolla, Cali-
fornia 73029
J. GuY (21), Laboratory of Cell Biology,
National Institutes of Health, Bethesda, KARL M. KNIGGE (15), The Neuroendocrine
Maryland 50202 Unit, University of Rochester, School of
RAGDE HABER (35), Massachusetts General Medicine and Dentistry, Rochester, New
Hospital, Boston, Massachusetts ,41120 York 24641
and The Squibb Institute for Medical Re- HEINZ KOHLER (1), IDEC "slacituecamrahP
search, Princeton, New Jersey 34580 Corporation, La Jolla, California 73029
CONTRIBUTORS TO VOLUME 178 xiii
OIHSOY KOIDE (29), Pola Pharmaceutical versity of Texas Health Science Center at
R & D Laboratory, Tozuka, Yokohama Houston, Houston, Texas 52277
244, Japan HANAH MARGALIT (40), Laboratory of
SABINE KOSIN (17), Department of Mathematical Biology, National Cancer
Neuropharmacology, Max-Planck-lnsti- Institute, National Institutes of Health,
tut fi~r Psychiatrie, D-8033 Planegg-Mar- Bethesda, Maryland 29802
tinsried, Federal Republic of Germany J. McCRAY (43), 8200 South Lafayette Ave-
VIKTOR KA~IHCRK (39), Research Institute nue, Chicago, Illinois 02606
for Feed Supplements, and Veterinary HAMUTAL MEIRI (45), Rappaport Family
Drugs, 452 94 Jtlovd u Praha, Czechoslo- Institute for Research in the Medical Sci-
vakia ences, Technion--Israel Institute of Tech-
KEITH A. KCILORK (31), Department of Mi- nology, Haifa 31096, Israel
crobiology, University of Texas Health YROGERG J. MICHAEL (15), The Neuroendo-
Science Center at San Antonio, San Anto- crine Unit, University of Rochester,
nio, Texas 48287 School of Medicine and Dentistry, Roch-
PAut. H. KUSSIE (3, 6), Department of Pa- ester, New York 24641
thology and Laboratory Medicine, Uni- DAVID R. MILICH (41), Department of Mo-
versity of Texas Health Science Center at lecular Biology, Scripps Clinic and Re-
Houston, Houston, Texas 52277 search Foundation, La Jolla, California
D. SCOTT LIr~TmCUM (3, 6), Department of 73029
Veterinary Microbiology, College of Vet- SHERIE L. NOSIRROM (32), Department of
erinary Medicine, Texas A & M Univer- Microbiology, Molecular Biology Insti-
sity, College Station, Texas 34877 tute, University of California at Los
DAN L. LONGO (24), Division of Cancer Angeles, Los Angeles, California 42009
Treatment, National Cancer Institute, W. JOHN W. MORROW (l), IDEC Pharma-
Frederick Cancer Research Facility, ceuticals Corporation, La Jolla, Califor-
Frederick, Maryland 10712 nia 73029
TED W. LOVE (35), Cardiac Research, Mas- ELLIBYS RELLO~M (l), 1DEC Pharmaceuti-
sachusetts General Hospital, and Har- cals Corporation, La Jolla, California
vard Medical School, Boston, Massachu- 73029
setts 41120
ECARG R. AMAYAKAN (37), Department of
DAVID S. LUDWIG (11), Department of Mi- Chemistry, University of California,
crobiology and Immunology, Stanford Berkeley, California 02749
University School of Medicine, Stanford,
MITCHELL J. NELLES (12), Ortho Diagnos-
California 50349
tic Systems, Inc., Raritan, New Jersey
RAKATO MACH (39), Institute of Molecular 96880
Genetics, Czechoslovak Academy of Sci-
MICHAEL B. A. OLDSTONE (44), Depart-
ences, 661 37 Prague ,6 Czechoslovakia
ment of Immunology, Scripps Clinic and
SYLVIE MAILLET (19), D~partement de Research Foundation, La Jolla, Califor-
Bhdogie, Section de Pharmacologie et nia 73029
d'lmmunologie, Commissariat ~ l'Ener-
R. ONO (5), Department of Microbiology
gie, 19119 Gif-sur- Yvette Cedex, France
and Immunology, New York Medical Col-
NINOTNA MAL~ (39), Institute of Molecular lege, Valhalla, New York 59501
Genetics, Czechoslovak Academy of Sci- A. D. M. E. SUAHRETSO (26), Department
ences, 661 37 Prague ,6 Czechoslovakia of Immunobiology, National Institute of
DARIO ITTEHCRAM (6), Department of Pa- Public Health and Environmental Protec-
thology and Laboratory Medicine, Uni- tion, 3720 BA Bilthoven, ehT Netherlands
xiv CONTRIBUTORS TO VOLUME 178
LENDON G. PAYNE (47), Applied bioTech- 624, lnstitut Pasteur, 59019 Lille Cedex,
nology Inc., Cambridge, Massachusetts France
2412O KENNETH H. ROUX (8), Department of Bio-
F. ASOREP (5), Department of Microbiology logical Science, Florida State University,
and Immunology, New York Medical Col- Tallahassee, Florida 60323
lege, Valhalla, New York 59501 LLAHCSRAM S. RUNGE (35), Cardiac Divi-
C. PETIT (9), Ddpartement de Recombi- sion, Emory University, Atlanta, Georgia
naison Expression G~n~tique, lnstitut 22303
Pasteur, 51057 Paris, France JEAN-MARIE R. SAINT-REMY (10), Experi-
DIANE T. PIEKUT (15), The Neuroendocrine mental Medicine Unit, Institute of Cellu-
Unit, University of Rochester, School of lar and Molecular Pathology, Brussels,
Medicine and Dentistry, Rochester, New Belgium
York 24641
MAREI RAMMAS (45), Rappaport Family In-
SAERDNA PLOCKTHUN (34), Genzentrum stitute for Research in the Medical Sci-
der Universitiit Miinchen, Max-Planck- ences, Technion--Israel Institute of Tech-
Institut far Biochemie, D-8033 Mar- nology, Haifa 31096, Israel
tinsried, Federal Republic of Germany
IHSEKAT SASAKI (29), The Second Depart-
TTOCS J. POLLACK (37), Department of ment of Internal Medicine, Tohoku Uni-
Chemistry, University of California, versity School of Medicine, Sendal ,089
Berkeley, California 02749 Japan
DAVID N. TTENSOP (46), Division of Allergy M. E. NORUAS (9), Ddpartement d'Immuno-
and Immunology, Department of Medi- cytochimie, Institut Pasteur, 51057 Paris,
cine, Cornell University Medical College, France
New York, New York 12001
MICHAEL R. SCHICK (2), Department of
PHILIPPE SELLEDARP (19), Ddpartement de
Virology and Immunology, Southwest
Biologie, Section de Pharmacologie et
Foundation for Biomedical Research,
d'Immunologie, Commissariat d l'Ener-
San Antonio, Texas 48287
gie, 19119 Gif-sur- Yvette Cedex, France
DIANE REDEOLHCS (36), Department of Mo-
SAMOHT SUOMRETREUQ (35), Cardiac Re-
lecular Biology, Scripps Clinic and Re-
search, Massachusetts General Hospital,
search Foundation, La Jolla, California
and Harvard Medical School, Boston,
73029
Massachusetts 41120
MICHA TROPOPAR (20), Department of In- YRAG K. KINLOOHCS (ll), Department of
ternal Medicine B, Asaf Harofeh Hospi- Microbiology and Immunology, Stanford
tal, Zerifin, Israel University School of Medicine, Stanford,
California 50349
RIND RAPPUOLI (28), Centro di Recherche
Sclavo, 53100 Siena, Italy PETER G. SCHULTZ (37), Department of
LAMAYS IRUHDUAHCYAR (1), IDEC Phar- Chemistry, University of California,
maceuticals Corporation, La Jolla, Cali- Berkeley, California 02749
fornia 73029 RODIGER SCHULZ (17), Institut fiir Phar-
G. F. NAAWZLEMMIR (26), Department of makologie, Toxikologie und Pharmazie
Immunobiology, National Institute of der Universitiit Miinchen, D-8000 Miin-
Public Health and Environmental Protec- chen ,22 Federal Republic of Germany
tion, 3720 BA Bilthoven, The Netherlands ARIELA ZTRAWHCS (45), Rappaport Family
ECNEROLF ROUSSEL-VELGE (27), Centre Institute for Research ni the Medical Sci-
d'lmmunologie et de Biologie, Parasi- ences, Technion--Israel Institute of Tech-
taire, Unit~ Mixte INSERM UI67-CNRS nology, Haifa 31096, Israel
CONTRIBUTORS TO VOLUME 871 XV
MAROY RETHCEHS (20), Department of Hor- Pharmaceutical Research Institute, San
mone Research, The Weizmann Institute Diego, California 12129
of Science, 76100 Rehovot, Israel OSNOFLA ONATNOMART (36), Department
KRAM A. NAMREHS (6), Department of Biol- of Molecular Biology, Scripps Clinic and
ogy, Beckman Research Institute at The Research Foundation, La Jolla, Califor-
City of Hope, Duarte, California 01019 nia 92037
DNAMHSOOH NARADAREBHSEHS (47), De- EPPESUIG TmDENTE (28), lstituto di Scienze
partment of Biochemistry, Molecular Bi- Immunologiche, University of Verona,
ology, and Cell Biology, Northwestern 37134 Verona, Italy
University, Evanston, Illinois 60208 F. G. C. M. UYTDEHAAG (26), Department
of Immunobiology, National Institute of
SEUNG-UON SHIN (32), Department of Mi-
Public Health and Environmental Protec-
crobiology, Molecular Biology Institute,
tion, 3720 BA Bilthoven, The Netherlands
University of California at Los Angeles,
Los Angeles, California 90024 DAVID B. WEINER (22), Division oflmmu-
nology, Department of Pathology and
ARNE ARREKS (34), Genzentrum der Univer-
Laboratory Medicine, University of Penn-
sitdt Miinchen, Max-Planck-lnstitut fiir
sylvania School of Medicine, Philadel-
Biochemie, D-8033 Martinsried, Federal
phia, Pennsylvania 40191
Republic of Germany
G. WERNER (43), Sandoz-Forschungsinsti-
LAURA L. SMITH (44), Department of im-
tut GmbH, A-1235 Vienna, Austria
munology, Scripps Clinic and Research
Foundation, La Jolla, Californm 92037 JOHN N. WHITAKER (4), Department of
Neurology, University of Alabama at Bir-
MIRIAM C. SOUROUJON (30), Department
mingham, Birmingham, Alabama 35294
of Chemical Immunology, The Weiz-
WILLIAM V. WILLIAMS (22), Division of
mann Institute of Science, 76100 Re-
Rheumatology, Department of Medicine,
hovot, Israel, and The Open University of
University of Pennsylvania School of
Israel, Tel Aviv 61392, Israel
Medicine, Philadelphia, Pennsylvania
FRED J. STEVENS (7), Biological, Environ- 40191
mental, and Medical Research Division,
Lu XIN (15), Research Institute, Montreal
Argonne National Laboratory, Argonne,
General Hospital, Montreal, Quebec
Illinois 60439
GDH IA4, Canada
EGROEG T. STEVENSON (23), Lymphoma
KAORU AGAGIHSOY (29), The Second De-
Research Unit, Tenovus Laboratory,
partment of Internal Medicine, Tohoku
General Hospital, Southampton $09 4XY,
University School of Medicine, Sendai
England
980, Japan
A. D. GREBSORTS (13, 18), Laboratory of ASSUOM B. H. YOUDIM (21), Rappaport
Molecular Biology of Receptors, Institut
Family Research Institute, Faculty of
Pasteur, 75724 Cedex ,51 Paris, France
Medicine, Technion--lsrael Institute of
SEMAJ P. TAM (46), The Rockefeller Univer- Technology, Haifa, Israel
sity, New York, New York 12001 DRAHCIR J. YOULE (24), Biochemistry Sec-
J. THgZE (9), Ddpartement d'Immunocyto- tion, Surgical Neurology Branch, Na-
chimie, Institat Pasteur, 75015 Paris, tional Institute of Neurological, and
France Communicative Diseases and Stroke, Be-
EGROEG B. NOTNROHT (41), R. W. Johnson thesda, Maryland 29802
Preface
Anti-idiotypic and catalytic antibodies, designei peptide antigens, and
genetically engineered reagents are some of the areas that have sparked a
renewed and widespread interest in the development of novel immunolog-
ical techniques based on a revitalized view of the structural relationships
between antibodies and antigens and the cooperative participation of cel-
lular immune components.
Since Jerne formalized the network theory that describes the immune
system in terms of a fine-tuned balance and dynamic interplay between
idiotypes and anti-idiotypes, the conceptual differences between antibod-
ies and antigens have, in some respects, essentially been eliminated. The
concept of anti-idiotype as the "internal image" of the ligand has led to
techniques for selecting and characterizing antibodies that are specific for
the binding sites on biological receptors and that may have physiological
activity at least qualitatively similar to that of the original ligand. These
developments offer a new approach for producing antireceptor antibodies
which circumvents the still formidable task of preparing active native
receptor for immunization. Inhibition of idiotype-antiparatope binding by
homologous antigen as a necessary, if not sufficient, operational criterion
for defining antiparatypic antibodies also has led to novel immunoassay
methods.
Prediction of immunodominant structures, use of molecular biological
techniques to assemble uniquely constructed antibodies, antibodies that
mimic receptors or are designed to stabilize transition statc analogues and
function like enzymes, the design and application of synthetic peptide
antigens that incorporate immunodominant structural features of proteins
as well as B and T cell determinants to exploit multiple aspects of the
immune response, novel immunodiagnostic and immunotherapeutic re-
agents, and anti-idiotype and peptide vaccines that circumvent problems
inherent in the use of intact microorganisms are the topics covered in this
volume. They represent vibrant research areas that will continue to
evolve thanks to the ingenuity of the investigator and the need to develop
innovative approaches to solving complex problems.
The greater insights into how antibodies are assembled and interact
with antigens, with the more sophisticated ability to take advantage of B
and T cell participation, will lead to further technological developments
that will serve essentially all areas of biological research.
JOHN J. LANGONE
iivx
METHODS IN ENZYMOLOGY
EMULOV I. Preparation and Assay of Enzymes
Edited by YENDIS P. KCIWOLOC DNA NAHTAN O. NALPAK
EMULOV II. Preparation and Assay of Enzymes
Edited by YENDIS P. KCIWOLOC DNA NAHTAN O. NALPAK
EMULOV III. Preparation and Assay of Substrates
Edited by YENDIS P. KCIWOLOC DNA NAHTAN O. NALPAK
EMULOV IV. Special Techniques for the Enzymologist
Edited by YENDIS P. KCIWOLOC DNA NAHTAN O. NALPAK
EMULOV V. Preparation and Assay of Enzymes
Edited by YENDIS P. KCIWOLOC DNA NAHTAN O. NALPAK
EMULOV VI. Preparation and Assay of Enzymes (Continued)
Preparation and Assay of Substrates
Special Techniques
Edited by YENDIS P. KCIWOLOC DNA NAHTAN O. NALPAK
EMULOV VII. Cumulative Subject Index
Edited by YENDIS P. KClWOLOC DNA NAHTAN O. NALPAK
EMULOV VIII. Complex Carbohydrates
Edited by HTEBAZILE F. DLEFUEN AND VICTOR GRUBSNIG
EMULOV IX. Carbohydrate Metabolism
Edited by SILLIW A. DOOW
EMULOV X. Oxidation and Phosphorylation
Edited by DLANOR W. KOORBATSE DNA DRANYAM E. NAMLLUP
VOLUME XI. Enzyme erutcurtS
Edited by C. H. W. SRIH
EMULOV XII. Nucleic Acids (Parts A and B)
Edited by LAWRENCE GROSSMAN AND KIVlE MOLDAVE
xix
XX METHODS IN ENZYMOLOGY
VOLUME XIII. Citric Acid Cycle
Edited by J. M. LOWENSTEIN
VOLUME XIV. Lipids
Edited by J. M. N1ETSNEWOL
VOLUME XV. Steroids and Terpenoids
Edited by RAYMOND B. NOTYALC
VOLUME XVI. Fast Reactions
Edited by KENNETH KUSTIN
VOLUME XVII. Metabolism of Amino Acids and Amines (Parts A and B)
Edited by HERBERT TABOR DNA CELIA WHITE ROBAT
VOLUME XVIII. Vitamins and Coenzymes (Pans A, B, and C)
Edited by DONALD B. MCCORMICK DNA LEMUEL D. WRIGHT
VOLUME XIX. Proteolytic Enzymes
Edited by GERTRUDE E. PERLMANN DNA LASZLO DNAROL
VOLUME XX. Nucleic Acids and Protein Synthesis (Part C)
Edited by K1VIE MOLDAVE DNA LAWRENCE NAMSSORG
VOLUME XXI. Nucleic Acids (Part D)
Edited by LAWRENCE NAMSSORG DNA KIVIE EVADLOM
VOLUME XXII. Enzyme Purification and Related Techniques
Edited by WILLIAM B. YBOKAJ
VOLUME XXIII. Photosynthesis (Part A)
Edited by ANTHONY NAS PIETRO
VOLUME XXIV. Photosynthesis and Nitrogen Fixation (Part B)
Edited by ANTHONY NAS PIETRO
VOLUME XXV. Enzyme Structure (Part B)
Edited by C. H. W. HIRS DNA SERGE N. EEEHSAMIT
VOLUME XXVI. Enzyme Structure (Part C)
Edited by C. H. W. HIRS DNA SERGE N. EFEHSAMIT
METHODS IN ENZYMOLOGY xxi
VOLUME XXVII. Enzyme Structure (Part D)
Edited by C. H. W. HIRS DNA SERGE N. TIMASHEFF
VOLUME XXVIII. Complex Carbohydrates (Part B)
Edited by VICTOR GRUBSNIG
VOLUME XXIX. Nucleic Acids and Protein Synthesis (Part E)
Edited by LAWRENCE NAMSSORG DNA KIVIE EVADLOM
VOLUME XXX. Nucleic Acids and Protein Synthesis (Part F)
Edited by KIVlE MOLDAVE DNA LAWRENCE NAMSSORG
VOLUME XXXI. Biomembranes (Part A)
Edited by SIDNEY FLEISCHER DNA LESTER REKCAP
VOLUME XXXII. Biomembranes (Part B)
Edited by SIDNEY FLEISCHER DNA LESTER REKCAP
VOLUME XXXIII. Cumulative Subject Index Volumes I-XXX
Edited by MARTHA G. DENNIS DNA EDWARD A. DENNIS
VOLUME XXXIV. Affinity Techniques (Enzyme Purification: Part B)
Edited by WILLIAM B. YBOKAJ DNA MEIR WILCHEK
VOLUME XXXV. Lipids (Part B)
Edited by JOHN M. LOWENSTEIN
VOLUME XXXVI. Hormone Action (Part A: Steroid Hormones)
Edited by BERT W. O'MALLEY DNA JOEL G. NAMDRAH
VOLUME XXXVII. Hormone Action (Part B: Peptide Hormones)
Edited yb BERT W. O'MALLEY DNA JOEL G. NAMDRAH
VOLUME XXXVIII. Hormone Action (Part C: Cyclic Nucleotides)
Edited by JOEL G. HARDMAN DNA BERT W. O'MALLEY
EMULOV XXXIX. Hormone Action (Part D: Isolated Cells, Tissues, and
Organ Systems)
Edited by JOEL G. HARDMAN DNA BERT W. O'MALLEY
VOLUME XL. Hormone Action (Part E: Nuclear Structure and Function)
Edited by BERT W. O'MALLEY DNA JOEL G. NAMDRAH
xxii SDOHTEM NI YGOLOMYZNE
EMULOV XLI. Carbohydrate Metabolism (Part )B
Edited by W. A. DOOW
EMULOV XLII. Carbohydrate Metabolism (Part C)
Edited by W. A. Wood
EMULOV XLIII. Antibiotics
Edited by NHOJ H. HSAH
EMULOV XLIV. Immobilized Enzymes
Edited by SUALK HCABSOM
EMULOV XLV. Proteolytic Enzymes (Part B)
Edited by OLZSAL DNAROL
EMULOV XLVI. Affinity Labeling
Edited yb WILLIAM B. AND JAKOBY MEIR WILCHEK
EMULOV XLVII. Enzyme Structure (Part E)
Edited by C. H. W. HIRS DNA EGRES N. FFEHSAMIT
EMULOV XLVIII. Enzyme Structure (Part F)
Edited by C. H. W. HIRS DNA EGRES N. FEEHSAMIT
EMULOV XLIX. Enzyme Structure (Part G)
Edited by C. H. W. SRIH DNA EGRES N. FFEHSAMIT
EMULOV L. Complex Carbohydrates (Part )C
Edited by ROTCIV GRUBSNIG
EMULOV LI. Purine and Pyrimidine Nucleotide Metabolism
Edited yb PATRICIA A. HOFFEE AND MARY ELLEN JONES
EMULOV LII. Biomembranes (Part C: Biological Oxidations)
Edited yb SIDNEY FLEISCHER AND LESTER PACKER
EMULOV LIII. Biomembranes (Part :D Biological Oxidations)
Edited by SIDNEY FLEISCHER AND LESTER PACKER
EMULOV LIV. Biomembranes (Part E: Biological Oxidations)
Edited by SIDNEY FLEISCHER AND LESTER PACKER