antibiotics and

494 Pages·2013·8.53 MB·English

ANTIBIOTICS AND
ANTIBIOTIC THERAPY
A Clinical Manual
ALLEN E. HUSSAR,
M.D., F.A.C.P.
ClIlEF OF MEDICAL SERVICE, FRANKLIN DELANO ROOSEVELT
VI>TERANS ADMINISTRATION HOSPITAL, MONTROSE, NEW
YORK
HOWARD L. HOLLEY,
M.D., F.A.C.P.
ASSOCIATE PROFESSOR OF MEDICINE, MEDICAL COLLEGE OF
ALABAMA, BIRMINGHAM, ALABAMA; CONSULTANT IN INTER
N,\L MEDICINE, VETERANS ADMINISTRATION HOSPITAL, TUS
C~LOOS~, ALABAMA
New York The Macmillan Company 1954
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ANTIBIOTICS AND ANTIBIOTIC THERAPY
A Clinical Manual
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THE MACMILLAN COMPANY
NEW YORK' CHICAGO
DALLAS· ATLANTA· SAN FRANCISCO
LONDON· MANILA
THE MACMILLAN COMPANY
OF CANADA. LIMITED
TORONTO
COPYRIGHT, 1954, lIY THE MACMILLAN COMPANY
PUBLISHED SIMULTANEOUSLY IN CANADA.
All rights reserved-no part of this book may be reproduced
in any form without permission in writing from the pub
lisher, except by a reviewer who wishes to quote brief pas
sages in connection with a review written for inclusion in
magazine or newspaper.
First Printing, November, 1954.
PRINTED IN THE UNITED STATES
To
H. L. H. and M. H. H.

preface
IT HAS now been a little more than a decade since penicillin was
first made available for general use, yet in this brief span of time
antibiotic therapy has advanced the practice of medicine farther
than any other single factor of any of the previous centuries. Man,
at last, is apparently winning his long and tumultuous battle against
ipfectious organisms. Certainly not all the pages of this illustrious
era have yet been recorded, but it seems timely to take stock of what
has so far been accomplished.
Since penicillin made its appearance, many new antibiotics have
been introduced. A great amount of knowledge concerning their
use, limitations, and mode of action has been acquired through ex
tensive laboratory and clinical investigations. Today, manufac
turers are engaged in producing these substances on a tremendous
scale. Every physician, be he general practitioner or specialist, uses
more antibiotics than any other drugs.
Although we do not yet possess an effective agent against all
known organisms, and certain limitations prevent any of the known
antibiotics from being considered the ideal one, we are now able to
effectively prevent infections and" successfully treat a great variety
of infections, thus producing far-reaching effects upon the life span
of man. The question arises, "Where do we go from here?"
First of all, the search should continue for an ideal, omnipotent
antibiotic, with no limitations as to its use. For the present, how
ever, clinicians should strive to acquire skill in the usage of presently
available agents so that they can be utilized with the utmost benefit
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