2019 Annual Update in Intensive Care and Emergency Medicine 2019 Edited by Jean-Louis Vincent 123 Annual Update in Intensive Care and Emergency Medicine 2019 The series Annual Update in Intensive Care and Emergency Medicine is the con tinuation of the series entitled Yearbook of Intensive Care and Emergency Medicine in Europe and Intensive Care Medicine: Annual Update in the United States. Jean-Louis Vincent Editor Annual Update in Intensive Care and Emergency Medicine 2019 Editor Prof. JeanLouis Vincent Dept. of Intensive Care Erasme Hospital Université libre de Bruxelles Brussels, Belgium [email protected] ISSN 21915709 ISSN 21915717 (electronic) Annual Update in Intensive Care and Emergency Medicine ISBN 9783030060664 ISBN 9783030060671 (eBook) https://doi.org/10.1007/9783030060671 Library of Congress Control Number: 2019931833 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recita tion, broadcasting, reproduction on microfilms or in any other physical way, and transmission or infor mation storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publica tion does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover design: WMXDesign GmbH, Heidelberg This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Contents Part I Precision Medicine 1 Precision Medicine in the Intensive Care Unit: Identifying Opportunities and Overcoming Barriers . . . . . . . . . . . . . . . . . . . . . . . . 3 T. L. Palmieri and N. K. Tran 2 Precision Delivery in Critical Care: Balancing Prediction and Personalization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 V. X. Liu and H. C. Prescott Part II Acute Respiratory Failure and ARDS 3 Acute Respiratory Failure in the Oncologic Patient: New Era, New Issues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 B. L. Ferreyro and L. Munshi 4 Universal Low Tidal Volume: Early Initiation of Low Tidal Volume Ventilation in Patients with and without ARDS . . . . . . . 47 J.T. Chen and M. N. Gong 5 Recruitment Maneuvers and Higher PEEP, the So-Called Open Lung Concept, in Patients with ARDS . . . . . . . . . . . . . . . . . . . . . 59 P. van der Zee and D. Gommers 6 ARDS in Obese Patients: Specificities and Management . . . . . . . . . . . 71 A. De Jong, D. Verzilli, and S. Jaber Part III Extracorporeal Respiratory Support 7 ECMO After EOLIA: The Evolving Role of Extracorporeal Support in ARDS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 M. Salna, D. Abrams, and D. Brodie 8 Physiological and Technical Considerations of Extracorporeal CO Removal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 2 C. Karagiannidis, F. Hesselmann, and E. Fan v vi Contents Part IV Cardiac Arrest 9 Cardiac Arrest in the Intensive Care Unit . . . . . . . . . . . . . . . . . . . . . . . 113 J. Tirkkonen, I. Efendijev, and M. B. Skrifvars 10 Targeted Temperature Management After Cardiac Arrest: Where Are We Now? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 A. Ray, S. Paulich, and J. P. Nolan Part V Cardiac Function 11 Left Diastolic Function in Critically Ill Mechanically Ventilated Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139 P. Formenti, M. Brioni, and D. Chiumello 12 The Effects of Disease and Treatments on Ventriculo-Arterial Coupling: Implications for Long-term Care . . . . . . . . . . . . . . . . . . . . . 155 F. Guarracino, P. Bertini, and M. R. Pinsky Part VI Shock 13 Mechanical Circulatory Support Devices for Cardiogenic Shock: State of the Art . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 L. A. Hajjar and J.L. Teboul 14 Sodium Thiosulfate: A New Player for Circulatory Shock and Ischemia/Reperfusion Injury? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 M. Bauer, P. Radermacher, and M. Wepler 15 Lactate in Critically Ill Patients: At the Crossroads Between Perfusion and Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199 M. Greco, A. Messina, and M. Cecconi Part VII Hemodynamic and Respiratory Monitoring 16 Continuous Non-invasive Monitoring of Cardiac Output and Lung Volume Based on CO Kinetics . . . . . . . . . . . . . . . . . . . . . . . . 215 2 F. SuarezSipmann, G. Tusman, and M. Wallin 17 Should We Abandon Measuring SvO or ScvO in Patients 2 2 with Sepsis? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231 J.L. Teboul, X. Monnet, and D. De Backer 18 Perioperative Hemodynamic Monitoring: MERCI to Predict Economic Impact . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239 F. Michard and G. Manecke 19 The Pulmonary Artery Catheter in the Management of the High-Risk Surgical Patient . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 M. Heringlake, S. Brandt, and C. Schmidt Contents vii Part VIII Fluid Issues 20 Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259 E. M. Milford and M. C. Reade 21 Should Albumin be the Colloid of Choice for Fluid Resuscitation in Hypovolemic Patients? . . . . . . . . . . . . . . . . . . . . . . . . . 277 J. Montomoli, A. Donati, and C. Ince 22 What the Intensive Care Physician Should Know About the Transurethral Resection Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . 293 R. G. Hahn 23 Relationship Between Central Venous Pressure and Acute Kidney Injury in Critically Ill Patients . . . . . . . . . . . . . . . . . . . . . . . . . . 303 P. M. Honoré, C. Pierrakos, and H. D. Spapen 24 Fluid Management in Acute Kidney Injury . . . . . . . . . . . . . . . . . . . . . . 313 M. Ostermann, A. More, and S. Jog Part IX Altered Renal Function 25 Diagnostic Implications of Creatinine and Urea Metabolism in Critical Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327 R. W. Haines and J. R. Prowle 26 New Insights into the Renal Microcirculation in Sepsis-Induced Acute Kidney Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 A. Harrois, N. Libert, and J. Duranteau 27 Atypical Sepsis-Associated Acute Kidney Injury . . . . . . . . . . . . . . . . . . 347 J. A. Kellum, K. F. Kernan, and J. A. Carcillo 28 Latest Developments in Perioperative Acute Kidney Injury . . . . . . . . 355 M. Meersch and A. Zarbock 29 Renal Replacement Therapy During Septic Renal Dysfunction . . . . . 365 S. Romagnoli, Z. Ricci, and C. Ronco 30 Acid-Base Disorders and Regional Citrate Anticoagulation with Continuous Renal Replacement Therapy . . . . . . . . . . . . . . . . . . . . . . . . 383 C. Ichai, H. Quintard, and L. Velly 31 Acute Kidney Injury and Delirium: Kidney–Brain Crosstalk . . . . . . . 397 R. Y. Y. Wan and M. Ostermann viii Contents Part X The Neurological Patient 32 Brain Ultrasound in the Non- neurocritical Care Setting . . . . . . . . . . . 407 C. Robba, L. Ball, and P. Pelosi 33 Brain Fog: Are Clearer Skies on the Horizon? A Review of Perioperative Neurocognitive Disorders . . . . . . . . . . . . . . 423 S. Saxena, A. Joosten, and M. Maze 34 Uncovering Consciousness in Unresponsive ICU Patients: Technical, Medical and Ethical Considerations . . . . . . . . . . . . . . . . . . . 431 B. Rohaut, A. Eliseyev, and J. Claassen Part XI Infection and Antibiotics 35 From Influenza-Induced Acute Lung Injury to Multiorgan Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 449 B. M. Tang, T. Cootes, and A. S. McLean 36 Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia . . . . . . . . . . . . . . . . . . . . . . . . . . . 459 C. Cillóniz, C. Dominedò, and A. Torres 37 Light and Shade of Antibiotics Recently Approved and in Advanced Development for Critically Ill Patients . . . . . . . . . . . . . . . 477 M. Bassetti, E. Righi, and A. Carnelutti 38 Target Controlled Infusion in the ICU: An Opportunity to Optimize Antibiotic Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 497 P. Colin, K. Ferdinande, and J. J. De Waele 39 Antimicrobial Stewardship in Sepsis . . . . . . . . . . . . . . . . . . . . . . . . . . . 507 E. PlataMenchaca, E. Esteban, and R. Ferrer Part XII Sepsis 40 Heterogeneity in Sepsis: New Biological Evidence with Clinical Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 523 A. Leligdowicz and M. A. Matthay 41 The Role of Mitochondrial Dysfunction in Sepsis: What Is New? . . . . 537 Y. Wang, M. Chakraborty, and A. McLean 42 Potential Harm Related to Fluid Resuscitation in Sepsis . . . . . . . . . . . 547 F. van Haren, L. Byrne, and E. Litton 43 Extracorporeal Cytokine Removal in Septic Shock . . . . . . . . . . . . . . . . 559 F. Hawchar, N. Öveges, and Z. Molnár Contents ix Part XIII Iron Metabolism 44 Iron Metabolism: An Emerging Therapeutic Target in Critical Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 573 E. Litton and J. Lim 45 Transferrin as a Possible Treatment for Anemia of Inflammation in the Critically Ill . . . . . . . . . . . . . . . . . . . . . . . . . . . . 585 M. Boshuizen, G. Li Bassi, and N. P. Juffermans Part XIV Extremes of Age 46 Functional Impairments in Pediatric Critical Illness Survivors. . . . . . 599 C. S. Ong and Z. A. Puthucheary 47 Care of the Critically Ill Older Adult . . . . . . . . . . . . . . . . . . . . . . . . . . . 611 C. A. Gao and L. E. Ferrante Part XV Patient Comfort 48 Inhaled Sedation and Reflection Systems . . . . . . . . . . . . . . . . . . . . . . . . 627 A. Meiser and H. V. Groesdonk 49 Intensity Matched Algorithm for Comfort in Intensive Care Patients: I-MAC ICU . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641 Y. Shehabi, A. Pakavakis, and W. AlBassam 50 Sleep and Circadian Rhythm in Critical Illness . . . . . . . . . . . . . . . . . . . 651 I. Telias and M. E. Wilcox Part XVI Medical Education 51 Social Media in Critical Care: Entering an Exciting New Era . . . . . . . 667 J. N. Wilkinson, A. V. K. Wong, and M. L. N. G. Malbrain Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 675