Table Of Content

FY 1998 ANNUAL REPORT OF INTRAMURAL RESEARCH PROGRAM ACTIVITIES OF THE ON NATIONAL INSTITUTE ALCOHOL ABUSE AND ALCOHOLISM US DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH FY 1998 ANNUAL REPORT OF INTRAMURAL RESEARCH PROGRAM ACTIVITIES OF THE NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM US DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH REPORTING COMPONENTS DIVISIONOF INTRAMURAL CLINICAL & BIOLOGICAL RESEARCH LABORATORY OF CLINICAL STUDIES Section ofBrainElectrophysiologic &Imaging-Daniel W. Hommer, M.D., Chief SectionofClinical Science- DavidT. George, M.D., ActingChief Section ofCognitiveNeurosciences -HerbertJ. Weingartner, PhD., Chief SectionofNeurochemistry &Neuroendocrinology- NormanSalemJr., PhD.,ActingChief UnitofClinical&BiologicalPharmacology -PaoloB. DePetrillo, M.D., Chief UnitofPharmacokineticStudies -SusanE. Shoaf, PhD., Chief LABORATORYOFMEMBRANE BIOCHEMISTRY& BIOPHYSICS Officeofthe Chief-NormanSalem, Jr., PhD., Chief Section ofFluorescence Studies -BurtonJ. Litman, Ph.D., Chief SectionofMass Spectrometry -Hee-YongKim, PhD., Chief Section ofNuclearMagneticResonance -KlausGawrisch, PhD., ActingChief UnitofMetabolicControl -Richard Veech, M.D., PhD., Chief UnitofMolecularBiology-Byoung-JoonSong, PhD., Chief LABORATORY OF MOLECULAR & CELLULAR NEUROBIOLOGY SectiononMolecularNeuroscience- ForrestF. Weight, M.D., ActingChief Section onPhysiology -ForrestF. Weight, M.D., Chief UnitonCellularNeuropharmacology-RobertPeoples, Ph.D., Chief LABORATORY OF NEUROGENETICS SectionofHumanNeurogenetics- DavidGoldman, M.D., Chief Section ofMolecularGenetics - DavidGoldman, M.D.,ActingChief SectionofMolecularNeurobiology- DavidGoldman, M.D.,ActingChief SectionofPopulation Genetics &Linkage -JeffreyLong, Ph.D., Chief TABLE OF IST8TUTESOFHEALTH IIH LIBRARY ACRONYMS Vll LABORATORY OF CLINICAL STUDIES SYNOPSIS 98-1 BIBLIOGRAPHY 98-7 &BETHESDAJViD 20892-1150 SECTIONOFBRAINELECTROPHYSIOLOGY IMAGING Z01 AA00002-06 LCS Eye movements in alcoholism and individualsat D.W. Hommer riskforalcoholism 98-11 Z01 AA00061-07 LCS Cerebral structure and metabolic correlates of D.W. Hommer aggressive and addictive behavior 98-16 Z01 AA00063-07 LCS EEG studies ofelectromotive generators affected D.W. Hommer byalcohol 98-17 Z01 AA00064-07 LCS Analysisofbrain images 98-19 D.E. Rio Z01 AA00065-07 LCS Semiautomated methods ofsegmentation ofbrain D.E. Rio images 98-21 Z01 AA00081-05 LCS Functional MRI ofemotion as related to D.W. Hommer alcoholism 98-31 Z01 AA00082-05 LCS Statistical analysis ofimage features 98-33 D.E. Rio SECTION OF CLINICAL SCIENCE Z01 AA00066-07 LCS Psychological/biological study ofpeople who D.T. George exhibit abusive behavior patterns 98-23 Z01 AA00067-07 LCS Psychological/biological characterization of D.T. George smokingwithdrawal in alcoholics 98-24 Z01 AA00094-03 LCS Yohimbine challenge to study noradrenergic D.T. George function in individuals 98-38 Z01 AA00278-09 LCS Behavioraland physiologicaleffects of2- D.T. George deoxyglucose infusions 98-50 Z01 AA00286-09 LCS Psychobiology ofalcoholism inwomen 98-51 D.T. George SECTIONOF COGNITIVE NEUROSCIENCES Z01 AA00059-07 LCS Determinants ofcognitive dysfunctions in H.J. Weingartner neuropsychiatric disorders 98-12 Z01 AA00060-07 LCS Drugeffects on memory and related cognitive H.J. Weingartner functions 98-14 SECTIONOFNEUROCHEMISTRY& NEUROENDOCRINOLOGY Z01 AA00068-07 LCS CNS serotonin and the regulation ofperipheral R.L. Eskay glucose metabolism 98-25 Z01 AA00077-05 LCS Impaired CNS serotonin activity: tolerance, J.D. Higley neuroimaging and neuroanatomy 98-26 Z01 AA00078-02 LCS Behavioral and neurochemical basis ofanimal D. W. Hommer models ofalcoholism 98-28 Z01 AA00079-05 LCS Psychobiology ofantisocial behavior and health 98-29 J.D. Higley Z01 AA00095-03 LCS Isolation/characterization of sulfonylurea-like R.L. Eskay compounds and insulin release 98-39 Z01 AA00212-01 LCS Organotypic culture ofethanol sensitive regions R.L. Eskay ofthe CNS: neurotoxicity model 98-43 Z01 AA00258-14LCS Violent behavior, neurotransmitters, glucose M. Linnoila metabolism and alcohol abuse 98-46 Z01 AA00277-10 LCS Models ofimpaired CNS serotonin, alcohol J.D. Higley consumption and excessive aggression 98-47 Z01 AA00287-08 LCS Stress axis activation, ethanol and site-specific R.L. Eskay CNS neurodegeneration 98-52 UNIT OF CLINICAL & BIOLOGICAL PHARMACOLOGY Z01 AA00092-03 LCS Monitoringofheart ratevariability duringalcohol 98-35 P. DePetrillo withdrawal syndrome Z01 AA00093-03 LCS Interaction ofethyl alcohol with cellular cysteine P. DePetrillo proteases 98-37 Z01 AA00225-02 LCS Platelet calcium-related signal transduction P. DePetrillo proteins in alcohol withdrawal 98-44 Z01 AA00226-01 LCS Modulation ofCalpaastatin-Calpain interactions P. DePetrillo by ethanol 98-45 UNIT OF PHARMACOKINETIC STUDIES Z01 AA00097-03 LCS Comparative ethanol metabolism in normal S.E. Shoaf volunteers 98-40 Z01 AA00098-03 LCS Distribution ofserotonergic neurons using (11C) S.E. Shoaf compoundsand PET imaging 98-41 Z01 AA00120-01 LCS Ethanol pharmacokinetics following intravenous S.E. Shoaf infusion to humans 98-42 LABORATORY OF MEMBRANE BIOCHEMISTRY& BIOPHYSICS SYNOPSIS 98-55 BIBLIOGRAPHY 98-59 OFFICE OF THE CHIEF Z01 AA00069-07 LMBB Sodium potassium ATPase-function and N. Salem regulation, alcoholism, neuroscience 98-67 Z01 AA00235-16 LMBB Nutritional effects on essential fatty acid N. Salem composition 98-79 Z01 AA00262-14 LMBB Desaturation ofessential fatty acids using stable N. Salem isotope GC-MS 98-81 SECTION OF FLUORESCENCE STUDIES Z01 AA00072-07LMBB Fluorescence studies ofbiophysical properties of B.J. Litman polyunsaturated phospholipids 98-68 Z01 AA00080-05 LMBB Influence ofprotein/lipid interactions on signal B.J. Litman transduction 98-70 SECTIONOFMASS SPECTROMETRY Z01 AA00089-04 LMBB Measurements and metabolism ofneurosteroids H-Y. Kim in the central nervous system 98-72 Z01 AA00284-09 LMBB Alterations in lipid metabolism in the nervous H-Y. Kim system by ethanol 98-83 SECTIONOFNUCLEAR MAGNETIC RESONANCE Z01 AA00003-06 LMBB NMRinvestigations ofcell membrane structure 98-63 K. Gawrisch UNIT OFMETABOLIC CONTROL Z01 AA00099-03 LMBB Ion gradients and metabolic energy in animal 98-75 R. Veech tissue Z01 AA00110-01 LMBB Metabolic control analysis 98-78 R. Veech UNIT OFMOLECULAR BIOLOGY Z01 AA00036-12 LMBB Regulation ofbiological roles ofethanol-inducible 98-65 B-J Song cytochromeP450 2E1 (CYP2E1) Z01 AA00090-04 LMBB Role ofALDH2-transgenic mice carryingAsian B-J Song ALDH2-2 variant allele 98-73 Z01 AA00100-03 LMBB Computerassisted molecular modeling 98-76 B-J Song Z01 AAOO102-02 LMBB Molecular characterization offetal alcohol B-J Song syndrome pathogenesis 98-77 LABORATORY OF MOLECULAR & CELLULAR NEUROBIOLOGY SYNOPSIS 98-85 BIBLIOGRAPHY 98-91 SECTIONONMOLECULAR NEUROSCIENCE Z01 AA00007-06LMCN Molecular neurobiology and alcohol actions 98-93 F.F. Weight SECTIONONPHYSIOLOGY Z01 AA00479-15 LMCN Synaptic mechanisms and alcohol actions 98-97 F.F. Weight Z01 AA00480-15 LMCN Nerve cell excitability and alcohol actions 98-98 F.F. Weight UNIT ON CELLULAR NEUROPHARMACOLOGY Z01 AA00448-01 LMCN Cellular neuropharmacology and alcohol actions 98-95 R. Peoples LABORATORY OF NEUROGENETICS SYNOPSIS 98-99 BIBLIOGRAPHY 98-105 SECTIONOFHUMANNEUROGENETICS Z01 AA00019-06LNG ALDH2 deficiency-population genetics and G. Goldman relationship to phenotype 98-113 Z01 AA00280-09 LNG Genetic studiesofEEG and ERPtraitsrelated to 98-121 M-A. Enoch alcoholism Z01 AA00281-09 LNG Molecular genetic studies on alcoholism in G. Goldman American Indians - Southwestern tribe 98-122 Z01 AA00290-08 LNG Molecular genetic studies ofdisturbed serotonin G. Goldman function 98-123 Z01 AA00291-04 LNG In Situreconstitution ofvariants ofhuman 5HT G. Goldman receptor subtypes 98-125 Z01 AA00293-02 LNG Role ofthe serotonin transporter promoter G.Goldman polymorphism in psychiatric disorders 98-126 ZOl AA00294-02 LNG Evolution andvariation ofMacaca 5HT1A 5-127 G. Goldman Z01 AA00295-02 LNG Y chromosome population genetics 98-128 G. Goldman Z01 AA00296-02 LNG Alcohol dependence and chromosome lip15.5 98-129 G. Goldman Z01 AA00297-02 LNG Evolution and variation ofRPS4Y 98-130 G. Goldman ZOl AA00298-02 LNG Mu opioid receptorpolymorphisms and alcohol G. Goldman dependence 98-131 ZOl AA00299-02 LNG Tryptophan 2,3-Dioxygenase--candidate gene for M-A. Enoch serotonin metabolism disorders 98-132 ZOl AA00300-01 LNG 5HT2Areceptorpromoterpolymorphism, -1438G/ M-A. Enoch A and serotonin dysfunction 98-133 SECTIONOFMOLECULAR GENETICS ZOl AA00008-06LNG Serotonergic gene function and behavior in D.A. Nielsen transgenic mice 98-109 ZOl AA00086-05LNG Molecular studies on genetic variants of D.A. Nielsen tryptophan hydroxylase and 5HT1A 98-116 ZOl AA00087-05LNG Studies on DNA single-strand conformation D.A. Nielsen prediction 98-118 ZOl AA00234-16 LNG Molecular studies on serotonergic gene 98-120 D.A. Nielsen expression SECTIONOFMOLECULAR NEUROBIOLOGY ZOl AA00083-05 LNG DNAdamage, DNArepairand alcohol 98-115 P.J. Brooks ZOl AA00091-04 LNG Genetic and neurobiological factors in an animal P.J. Brooks model ofantidepression 98-96 ZOl AA00101-03LNG Manipulation ofspecific proteins involved in P.J. Brooks alcohol intake and behavior 98-119 SECTIONOFPOPULATIONGENETICS & LINKAGE ZOl AA00016-06 LNG Gene mapping and linkage studieswith short J. Long tandem repeat (STR) markers 98-110 ZOl AA00017-06LNG Population genetics ofNative American tribes 98-112 J. Long ZOl AA00025-02 LNG Transmission and geneticsofalcohol disorders in J. Long a Native American tribe 98-114 (INTENTIONAL BLANK)