annual Meeting and ToxExpoTM annual Meeting and ToxExpoTM

376 Pages·2009·28.16 MB·English

Program
Baltimore Convention Center
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March 15–19, 2009
www.toxicology.org
Baltimore, Maryland
2009
Dear Colleagues,
I cordially invite you to attend the 48th Annual Meeting of the Society
of Toxicology, (SOT) which will be held March 15–19 at the Baltimore
Convention Center in Baltimore, Maryland.
SOT’s Annual Meeting is the forum to showcase toxicology’s novel
discoveries. For the science of toxicology, this 5-day event is the culmination
of a year’s worth of achievements in research and education.
The Annual Meeting also affords every member the opportunity to come
together to learn about the latest scientific achievements from a myriad of
experts in the field of toxicology. The thematic program that SOT instituted
two years ago affords participants a unique opportunity to deepen their
knowledge in topical areas and interact with leaders in the respective areas.
M
Opportunities abound for members to meet other scientists they have never met
and to network with friends and colleagues. The Annual Meeting also affords I
the chance to pause and pay tribute to those scientists who have distinguished R
themselves in their field of expertise and are the recipients of the Society’s
T
most prestigious awards. Finally, SOT members can take advantage of the
Awards Ceremony
ToxExpo™, which is the world’s largest exposition of its kind. This exposition
Sunday, March 15
offers a comprehensive marketplace for product information and cutting-edge
5:15 PM–6:30 PM
technology in one place.
Room 321
SOT’s Annual Meeting is the premier event that the Society hosts every year
Welcoming
to meet the needs of the entire toxicology community. More importantly, the
Reception
Annual Meeting goes a long way toward fulfilling SOT’s strategy of building
Sunday, March 15
the future of toxicology, highlighting the significant scientific achievements
6:30 PM–7:30 PM
of members, and broadening the awareness of these accomplishments and
Ballroom
their potential impact. One news publication that covered our Annual Meeting
25-Year (Or More) last year referred to SOT as the “world’s foremost professional and scientific
Member Reception organization.” Indeed, SOT’s Annual Meeting brings together the foremost
Sunday, March 15 professionals in the field.
7:00 PM–8:00 PM
I urge you to join us for this event. Help us to make the 48th Annual Meeting
Charles Street VIP Suite/
Toxicology History Room an event to remember.
Sincerely,
SOT Annual Business
Meeting
Tuesday, March 17
4:30 PM–6:00 PM
Kenneth S. Ramos, B.S.Ph., Ph.D., ATS
Room 321
2008–2009 SOT President
The above events take place
in the Baltimore Convention
Center.
48th Annual Meeting & ToxExpo™
Scientific Program
Overview
A page reference follows the session information.
Sunday, March 15 Monday, March 16
7:00 AM–7:45 AM 8:00 AM–9:00 AM
COnTInuIng EduCATIOn SunRISE MInI-COuRSE PLEnARY OPEnIng LECTuRE
1. Topics in Ethics: Conflict of Interest—Real or Imagined?—PBDEs As Signal Transduction Pathway Used by Therapeutic Agents and Drugs
a Case Study (p76) of Abuse—Lecturer: Nobel Laureate Paul Greengard (p94)
8:15 AM–12:00 nOOn 9:15 AM–12:00 nOOn
COnTInuIng EduCATIOn MORnIng COuRSES SYMPOSIA SESSIOnS
2. Free Radicals for Toxicologists—From the Basics to Inflammation • Eat Well, Breathe Well: Nutritional Determinants of Susceptibility to
and Disease (p77) Airborne Pollutants (p94)
3. Characterizing Modes-of-Action and Their Relevance in Assessing • MicroRNAs in Biology and Toxicology (p95)
Human Health Risks (p77) • Superantigens, Cytokine Storm, and Toxic Reactions (p95)
4. Evaluation of Toxicity to Male and Female Reproductive Systems: • Zinc, Inflammation, and Diabetes (p96)
Biology, Study Design, and Data Interpretation (p78)
WORkSHOPS SESSIOnS
5. Immunology for Toxicologists (p78)
6. Principles and Applications of Toxicokinetics (p79) • Dose Selection and Design Considerations in Safety Studies for
7. Translation of Safety Biomarkers in Drug Discovery and Biotherapeutics (p96)
Development (p79) • From Genes to Organs: Advancements in Modeling Biological
Systems (p97)
1:15 PM–5:00 PM • Strategies to Integrate Systems Biology into In Vitro Screening in Early
COnTInuIng EduCATIOn AfTERnOOn COuRSES Nonclinical Safety Assessment (p98)
PLATfORM SESSIOnS
8. Free Radicals for Toxicologists—From the Basics to Inflammation
and Disease (p80) • Applications in ‘Omics Technologies to Problems in Toxicology (p98)
9. Characterizing Variability and Uncertainty with Physiologically- • Immunoregulation and Toxicity (p99)
Based Pharmacokinetic Models (p80)
• Mechanistic Insights for Reproductive Toxicology (p100)
10. Current Approaches in Mixture Risk Assessment (p81)
11. How Similar Is Similar and How Relevant Is Relevant? 9:30 AM–12:30 PM
Considerations in the Design of a Predictive Development Program
POSTER SESSIOnS
for Biotherapeutics (p81)
12. New Frontier in Metal Toxicology: Genetic Susceptibility, Early • Ah Receptor Mediated Signalling (p102)
Diagnosis, and Related Biological Indices (p82) • Apoptosis: Activators and Regulatory Pathways (p117)
13. Stress As a Confounding Factor in Toxicology Studies (p82) • Cardiovascular Toxicity I (p110)
• Dermal Absorption and Skin Toxicity (p103)
Thematic Approach
• Information and Education (p120)
• Insights in Endocrine Action and Toxicology (p105)
Session titles related to each theme are color coded in the Program overview. • Nanotoxicology In Vivo (p112)
Biomakers—Biomarkers are invaluable tools for investigating and • Neurotoxicity—Developmental (p107)
predicting toxic responses, and research from the toxicological sciences • Receptors (p101)
has contributed to the identification and validation of biomarkers at • Redox-Cycling, Reactive Oxygen Species (ROS), and Damage (p118)
the molecular, biochemical, and cellular levels. The contributions of • Xenobiotic Biotransformation (p115)
toxicology to biomarker research, as well as new discoveries related to
the identification, validation, and utilization of biomarkers to integrate 12:10 PM–1:30 PM
health and disease, will be highlighted in this theme.
ROundTABLE SESSIOnS
Epigenetics—Heritable DNA and chromatin modifications regulate
gene expression to direct many important biological processes. • Devils Lie in the Details: Practices and Problems in Neuropathology—
Alterations in epigenetic determinants including DNA methylation and Significance for Neurotoxicology (p121)
histone modifications contribute to the adverse health effect of many • The Use of Engineered Nanomaterials in Food and Food-Related
toxicants. The importance of epigenetics in health and disease and new Products: Is This a Concern for Human and Environmental Safety?
technologies for studying epigenetics will be featured in this theme on (p122)
advances in epigenetic research for the toxicological sciences.
HISTORICAL HIgHLIgHTS SESSIOn
Inflammation and disease—The inflammatory response contributes
• A Quarter of a Century (1984–2009) Since the Bhopal Disaster:
to many acute and chronic diseases. Inflammatory mediators such as
Lessons Learned (p122)
ROS, cytokines and eicosanoids, and acute-phase proteins such as
glucocorticoids, C-reactive protein and serum amyloids, play key roles InfORMATIOnAL SESSIOn
in this response. Inflammatory mediators also play a role in the adverse
response to many drugs and environmental agents. The important role • Peer Review of Toxicology, Exposure, and Risk Data: Ensuring the Best
of inflammation and inflammatory mediators in toxic responses and Science (p123)
disease will be highlighted in sessions featured in this theme.
12:30 PM–1:20 PM
nanotechnology—Nanomaterials are the building blocks for this
LEAdIng EdgE In BASIC SCIEnCE AWARd LECTuRE
promising new technology and are now routinely produced and
commercialized. These materials are currently being utilized in The Structural Pervasiveness of Estrogen Activity—Benefits and
many diverse areas such as engineering, information technology, Risks from the Eclectic Nature of Ligand Binding by the Estrogen
and diagnostics. More information is needed on their biology and Receptor—Lecturer: John Katzenellenbogen (p124)
the potential health impacts of these new products, and sessions
highlighted in this theme will explore the potential implication(s) of 1:00 PM–4:30 PM
their use.
POSTER SESSIOnS
neurodegenerative diseases—Neurodegenerative diseases caused
by loss of cells and/or cellular function in the brain and in dementias • Alternate Tests and Models I (p127)
and movement disorders are becoming increasingly more common. • Assessment of Chemical Mixtures (p141)
The role of environmental agents and inflammatory mediators in the • Biological Modeling (p134)
development of neurodegenerative disease and elucidation of sequelae • Chemical and Biological Weapons (p138)
from acute toxic exposures to the onset of disease will be highlighted in • Ecotoxicology (p132)
this theme as important areas of research for the toxicological sciences.
• In Vitro Methods, Models, and Mechanisms of Hepatotoxicity (p130)
• Neurotoxicity—Metals (p124)
• Safety Assessment for Non-Pharmaceuticals (p137)
• Toxicology of Kidney (p136)
1:40 PM–4:25 PM 9:00 AM–12:30 PM
Overview
SYMPOSIA SESSIOnS POSTER SESSIOnS
• Aromatase (CYP19) Gene Expression and Function: Current State of Knowledge • Biological Actions of Natural Products (p168)
As a Mode-of-Action for Toxicological Effects (p143) • Cardiovascular Toxicity II (p177)
• Genomic, Non-Genomic, and Epigenetic Mechanisms of Nuclear Hormone • Nanotoxicology In Vitro (p172)
Receptor Action (p144) • Reactive Oxygen Species (ROS) Stimulated Signalling (p179)
• In Vitro Models of Human Toxicity Pathways (p144) • Research in Disposition and Pharmacokinetics (p180)
• Nitrative and Oxidative Stress in Toxicology and Disease (p145) • Risk Assessment Applications (p170)
• Novel Signalling Mechanisms That Regulate Dopaminergic Neuronal Survival or • Role of PPAR and COX-2 in Chemical Carcinogenesis (p176)
Death: Implications in Parkinson’s Disease (p146)
• Safety Issues Concerning Food Products and Micronutrients (p165)
• Regulation of Drug Transporters in Different Disease States and Its Toxicological
and Clinical Implications (p146) 12:00 nOOn–1:20 PM
WORkSHOP SESSIOnS ROundTABLE SESSIOnS
• Agglomeration Versus Dispersion: How Nanoparticle Behavior Affects Exposure • Is There a Future for Animal Models in the Investigation of Idiosyncratic DILI in
and Toxicity In Vitro, In Vivo, and in the Real World (p147) Humans? (p185)
PLATfORM SESSIOnS • National Children’s Study: Opportunities and Challenges for Toxicologists (p185)
• Setting a Safe Starting Dose in Initial Clinical Trials with Biotherapeutics: Do I Use
• Cellular Responses to Chemical Weapons (p148) the NOAEL or the MABEL? (p186)
• Developmental Basis of Adult Disease (p148)
EduCATIOn-CAREER dEVELOPMEnT SESSIOn
• Epigenetic Mechanisms of Xenobiotics (p149)
• Mechanisms of Hypersensitivity (p150) • The Future of Environmental Health Science: Featuring NIEHS-Funded Early
• Mechanisms of PAH and Tobacco Carcinogenesis (p150) Career Investigators (p186)
4:30 PM–5:50 PM 12:30 PM–1:20 PM
SOT/EuROTOX dEBATE dISTInguISHEd TOXICOLOgY SCHOLAR AWARd LECTuRE
Nanotoxicology—Is It Much Ado About Nothing? (p152) Role of Reactive Metabolites, Protein Adducts, Immune System, and Other
Susceptibility Factors in Drug-Induced Liver Injury—Lecturer: Lance R. Pohl (p187)
4:35 PM–5:55 PM
1:00 PM–4:30 PM
ROundTABLE SESSIOnS
POSTER SESSIOnS
• Leveraging Nonclinical Disease Models for Early Perspective on Safety and Risk
during Drug Discovery (p152) • Bioinformatics and Prediction of Toxicity (p195)
• Role of Regulatory Cooperative Efforts in Food Protection (p153) • Epidemiology and Exposure Assessment (p203)
• Weight of Evidence Advancements in Risk Assessment: Conceptual Frameworks • Functional Genomics in Toxicology (p188)
and Case Studies Illustrating Fundamentals of Application (p153) • Gene Regulation (p191)
• Genotoxicity I (p193)
EduCATIOn-CAREER dEVELOPMEnT SESSIOn
• Hepatotoxicity of NSAIDS and Acetaminophen (p198)
• Grantsmanship Forum: Tools and Skills Needed to Navigate Toxicology Research • Hepatotoxicity: In Vivo Studies (p199)
Funding (p154)
• Pesticide—Toxicity (p201)
Tuesday, March 17 1:30 PM–4:15 PM
SYMPOSIA SESSIOnS
7:30 AM–8:50 AM
• Aquatic Species As Sentinels for Human Health: Comparative Toxicology of
ROundTABLE SESSIOnS Metals, Nanoparticles, and PCB’s (p206)
• Biomarkers of Cardiac Hypertrophy and Skeletal Muscle Toxicity—Successes and • Mammalian Retrotranspositional Elements: Epigenetic Regulation, Species
Challenges Related to Their Implementation in Drug Development (p155) Differences, and Potential Roles As Mediators of Cellular Responses to Toxic
• The Regulatory Frontier: Addressing Products of Nanotechnology (p156) Stress (p207)
• The Good, the Bad, and the Ugly of Toxicant-Induced Pulmonary Inflammation
HISTORICAL HIgHLIgHTS SESSIOn (p208)
• Dioxin, Forty Years of Science: Are We Any Closer to Assessing Potential Risk? WORkSHOP SESSIOnS
(p156)
• Improved Safety Biomarkers for Monitoring Kidney Injury (p208)
InfORMATIOnAL SESSIOn
• Oxidative Stress As a Regulator of Normal Function and Mediator of Toxicant-
• NIH Genes, Environment, and Health Initiative: Biomarkers and Biosensors for Induced Damage with Impacts on Reproduction and Development (p209)
Detecting Response to Environmental Stress (p157) • Pesticides and Parkinson’s Disease: Implications of New Epidemiology and
Exposure Data to Risk Assessment (p210)
8:00 AM–8:50 AM
• Safety of High-Intensity Sweeteners: Bittersweet Controversy (p210)
TRAnSLATIOnAL IMPACT AWARd LECTuRE PLATfORM SESSIOnS
Keap1 One Eye on the Target—Translating Molecular Toxicology into Cancer • Advances in Disposition and Pharmacokinetics (p211)
Prevention—Lecturer: Thomas W. Kensler (p157)
• Advances in Risk Assessment Science (p212)
9:00 AM–11:45 AM • Effects of Inhaled Pollutants—Cardiopulmonary Toxicity (p212)
• Mechanisms in Immunotoxicology (p213)
SYMPOSIA SESSIOnS
• New Insights in Ecotoxicology (p213)
• Does Metal Toxicity Play a Role in the Etiology of Alzheimer’s Disease? (p158)
• Epigenetic Implications for Toxicology (p158) Wednesday, March 18
• Immunomodulation during Complementary and Alternative Medicine (CAM)
Therapy: Risks and Benefits (p159) 7:30 AM–8:50 AM
• Nanotoxicology and Drug Delivery (p160)
ROundTABLE SESSIOn
WORkSHOP SESSIOnS
• Characterization and Application of PBPK Models in Risk Assessment (p216)
• Low-Dose Non-Linearity: What Can Emerging Technologies Tell Us? (p160)
InfORMATIOnAL SESSIOn
• Maternal Toxicity and Its Impact on Study Design and Data Interpretation (p161)
• Pesticide Mixtures: Experimental Evaluation and Computational Modeling (p161) • Novel Translational Safety Biomarkers and Safety First at the FDA (p216)
PLATfORM SESSIOnS EduCATIOn-CAREER dEVELOPMEnT SESSIOn
• Advances in Animal and Alternative Models (p162) • Toxicologists: The Next Generation (p217)
• Advances in Biological Modeling (p162)
SPECIAL SESSIOn
• Cellular and Biological Sources for Biomarkers (p163)
• Metal-Induced Carcinogenesis (p164) U.S. FDA Advisory Panel Appointments (p215)
• Xenobiotic Modulation of Signal Transduction Pathways and Gene Regulation
(p164)
8:00 AM–8:50 AM 1:30 PM–4:15 PM
kEYnOTE MEdICAL RESEARCH COunCIL (MRC) LECTuRE SYMPOSIA SESSIOnS
The Ubiquitin Proteolytic System—From Basic Mechanisms through Human • Biomarkers: New Breakthroughs in the World of Air Pollution Studies (p268)
Disease and on to Drug Targeting—Lecturer: Nobel Laureate Aaron Ciechanover • New Insights into Skin Homeostasis and Carcinogenesis (p268)
(p217) • Pulmonary Effects of In Utero and Early Postnatal Exposure to Arsenic (p269)
9:00 AM–11:45 AM • The Role of Inflammation during Metabolic Liver Disease and Drug-Induced Liver
Toxicity: Novel Insights (p270)
SYMPOSIA SESSIOnS
WORkSHOP SESSIOnS
• From Mechanisms to Biomarkers: Basic and Applied Metabolomics in Toxicology
(p218) • Food Allergy—Basic Mechanisms and Applications to Identifying Risks
Associated with Plant Incorporated Pesticides and Other Genetically Modified
• Incorporating ‘Omics in the Study of Reproduction and Development (p218)
Crops (p270)
• Interactomes and Their Application in Toxicology (p219)
• The Impact of Transcript Profiling in Drug Safety Assessment (p271)
• Transcriptional Changes in Immunotoxicology: Transcription Factors, Signal
• The Road to Personalized Medicine (p271)
Transduction, and Epigenetics (p219)
PLATfORM SESSIOnS
WORkSHOP SESSIOnS
• Bioinformatics and Computational Toxicology (p272)
• Developing Brain: Safety Assessment for Pediatric Use of Pharmaceuticals (p220)
• Expression and Modulation of Cytochrome P450 (p272)
• Toxicology of Unintentional and Intentional Disasters (p220)
• Mechanisms in Nanomaterial Toxicology (p273)
REgIOnAL InTEREST SESSIOn • Signal Transduction and Metal-Induced Toxicity (p274)
• Biofuels and the Bay: Characterizing Health and Ecosystem Impacts in the
1:30 PM–2:30 PM
Chesapeake (p221)
SPECIAL SESSIOn
PLATfORM SESSIOnS
Update from the NIH Center for Scientific Review—Speaker: Antonio Scarpa, NIH
• Cardiopulmonary Toxicity of Inhaled Particles and Nanoparticles (p222)
CSR (p268)
• Endocrine-Toxicant Interactions (p222)
• Hot Topics in Metal-Induced Neurodegeneration (p223) 4:30 PM–5:50 PM
• Mechanisms of Persistent Organic Compound Toxicity (p224) ROundTABLE SESSIOn
• Mechanisms of Pesticide-Induced Toxicity (p224)
• What Is an Adverse Effect in the Age of ‘Omics? (p274)
9:00 AM–12:30 PM
EduCATIOn-CAREER dEVELOPMEnT SESSIOn
POSTER SESSIOnS
• Career Opportunities and Transitions in Toxicology (p275)
• Advances in Reproductive Toxicology (p228)
• Animal Models II (p226) Thursday, March 19
• Biomarker Discovery and Detection (p240)
• Biomonitoring and Exposure Assessment (p242) 7:30 AM–8:50 AM
• Cytoprotective Strategies Against Reactive Oxygen Species (p237)
ROundTABLE SESSIOn
• Genetic Polymorphisms (p225)
• Hypersensitivity and Autoimmunity (p233) • Phototoxicology: A Passing Fancy or Enduring Concern? (p276)
• Risk Assessment Research (p231) InfORMATIOnAL SESSIOn
• Metals—In Vivo (p238)
• Lead: Children’s Exposures and Current Regulatory Standards (p276)
• Parkinson’s Disease (p236)
ISSuES SESSIOn
12:00 nOOn–1:20 PM
National Research Council (NRC) Vision: The ‘Vision’ for Toxicity Testing in the 21st
SYMPOSIA SESSIOn Century: Promises and Conundrums (p276)
• Gene-Environment Interactions: Epigenetic Pathways in Chronic Disease 8:30 AM–12:00 nOOn
Promotion and Progression (p245)
POSTER SESSIOnS
ROundTABLE SESSIOn
• Cardiopulmonary Toxicity (p284)
• Preclinical Evaluation of Cancer Hazard and Risk of Biopharmaceuticals (p245)
• Chemical-Induced Neurotoxicity (p288)
InfORMATIOnAL SESSIOn • Epigenetics (p277)
• Kinase Inhibitors As Targeted Therapeutics in Inflammation and Oncology— • Neurotoxicity—Pesticides (p286)
Approaches to Predict and Manage Clinical Toxicities (p246) • New Applications in Animal Models (p290)
• Non-Clinical Safety Testing: Biological and Small Molecule Therapeutics (p280)
SPECIAL SESSIOn
• Persistent Organic Compounds (p278)
Meet the Director of NIEHS, Linda Birnbaum (p244) • Regulations and Policy Implications in Toxicology (p279)
12:30 PM–1:20 PM • Signal Transduction: Kinases (p294)
• Toxicology of Carbon Nanotubes (p292)
MERIT AWARd LECTuRE
9:00 AM–11:45 AM
Chemical Hepatocarcinogenesis—Mechanisms, Pathogenesis, and Thresholds
Lecturer: Gary M. Williams (p246) SYMPOSIA SESSIOn
1:00 PM–4:30 PM • Heat Shock Proteins and the Toxicological Response (p295)
POSTER SESSIOnS WORkSHOP SESSIOnS
• Alternate Tests and Models II (p259) • Biomarkers for Assessing the Systemic Inflammatory Response Syndrome in
• Chemical Carcinogenesis (p247) Toxicology Studies (p296)
• Developmental Basis of Disease (p250) • Is Modulation of the Immune System by Perfluoroalkyl Acids a Human Health
Concern? (p296)
• Developmental Toxicology (p252)
• The Molecular Mechanism of Alpha, Beta-Unsaturated Carbonyl Toxicity: Getting
• Genotoxicity II (p266)
in Touch with the Soft Side of Chemistry (p297)
• Inflammation (p264)
• Immunotoxicology (p253)
• Mechanisms of Chemoprevention in Chemical Carcinogenesis (p249)
• Metals—In Vitro (p256)
• Steatosis and Cholestasis in Hepatic Disfunction (p263)
• Stem Cell Biology and Toxicology (p262)
SOT Resource Pavilion
How can you advance the science of toxicology?
Stop by the SOT Resource Pavilion in the Charles Street
Lobby of the Baltimore Convention Center to:
•  Access Information About SOT Membership
•  Support the SOT Endowment
•  Connect with SOT Volunteers
•  Swap Communication Tips and Materials 
for Topics Important to Toxicologists
Animals in Research
k–12 Education
Public Outreach
Regulatory and Legislative Affairs
The Resource Pavilion is your connection
to key resources and people in toxicology.
49 th
Annual Meeting and ToxExpo™
Salt Lake City, Utah
March 7–11, 2010 • Salt Palace Convention Center
2 0 1 0
Photos courtesy of Salt Lake Convention and Visitors Bureau. Photographed by Richard Cheski,
Steve Greenwood, and Eric Schramm.
48th AnnSuocaiel tMy oefe Ttoinxigc o&lo Tgoy x2E00x9po™
March 15–19, 2009
Program Contents
President’s Letter .........................................................Inside Front Cover Registration Desk Hours ............................................................................51
Scientific Program Overview ............................................Front Foldout Safety and Security......................................................................................51
How to Use this Program ..............................................................................2 SOT Headquarters Office ...........................................................................52
SOT Resource Pavilion ................................................................................52
Sponsorship Speaker Ready Room ..................................................................................52
Sponsorship Opportunities ....................................................................368 Sponsorship ...................................................................................................52
2009 Annual Meeting Sponsors Tour Information ..........................................................................................53
and The Toxicologist on CD-ROM ....................Inside Back Cover The Toxicologist/Itinerary Planner ..........................................................53
2009 Annual Meeting Diamond Sponsors ........................Back Cover Toxicology History Room ..........................................................................54
Transportation ...............................................................................................54
Events and Maps
Career Resources and Development
Daily Pocket Calendar....................................................................................3
Schedule by Event Name ..........................................................................17 Career Resources and Development Services...................................58
Baltimore Convention Center Maps ......................................................26
Baltimore Hotel Accommodations ........................................................28 Education and Outreach Activities
Map of Baltimore Hotel Locations .........................................................30 K–12 Education and Public Outreach ....................................................60
Hilton Baltimore Hotel Map .....................................................................31 Undergraduate Education ........................................................................60
Baltimore Restaurant Listings..................................................................32 Outreach Program .......................................................................................61
Poster Session Schedule and Board Surface Maps ..........................34
Social Functions
2009 ToxExpo™
Social Events ..................................................................................................62
ToxExpo™ Information ...............................................................................39
ToxExpo™ Floor Plan ...................................................................................40 Award and Honor Recipients
ToxExpo™ 2009 Exhibitors ........................................................................42 2009 Award Recipients ..............................................................................66
Exhibitor Hosted Session Index ..............................................................44 2009 Honorary Memberships .................................................................75
Registration Continuing Education
Registration Information ...........................................................................46 Continuing Education Courses ...............................................................76
General Information Sessions Index
Accessibility for Persons with Disabilities ...........................................47 Scientific Session Index ..............................................................................83
Attire .................................................................................................................47
Badges ..............................................................................................................47 Program
Baltimore Information Desks ...................................................................47 Program Description...................................................................................91
Business Center —ABC Imaging ..............................................................47 Author Index ................................................................................................299
Climate .............................................................................................................47 Abstract Key Word Index .........................................................................318
Exhibitor Information .................................................................................47
Exhibit Hall (Hours/Location)...................................................................47 SOT Leadership
First Aid and Emergency Services 2008–2009 Council ....................................................................................328
at the Convention Center ................................................................48 Officers and Councilors ............................................................................330
Food Services ................................................................................................48 Past Presidents ............................................................................................330
Growing Greener ..........................................................................................48 Elected Committees ..................................................................................331
Guest Hospitality Center ...........................................................................49 Appointed Committees ...........................................................................331
Housing Information and Reservations ...............................................49 Officers—Regional Chapters .................................................................335
Internet Access ..............................................................................................50 Officers—Special Interest Groups .......................................................337
Lost and Found .............................................................................................50 Officers—Specialty Sections..................................................................338
Luggage/Coat Check ..................................................................................50
Lunch with an Expert Information Board ...........................................51 SOT References
Media Support Services .............................................................................51 SOT Awards and Honors (Descriptions and History) ...................340
Meeting Pole ..................................................................................................51 Endowment Fund (Donor Form) ..........................................................353
Memorabilia ...................................................................................................51 SOT Affiliates ................................................................................................361
Message Boards ............................................................................................51 Headquarters Staff ....................................................................................362
Photography Policy for Exhibit Hall and
Session Etiquette for Attendees ...................................................51
All text and graphics are ©2009 by the Society of Toxicology unless noted. Some Baltimore
photos are courtesy of the Baltimore Area Convention and Visitors Association unless
up-to-date information at www.toxicology.org 1
otherwise noted. For promotional use only. No advertising use is permitted.
How to Use this Program
The Society of Toxicology’s (SOT) Annual Meeting is always an exciting opportunity to highlight advancements in the science of toxicology.
In order to maximize the value of your Annual Meeting attendance, we offer this Program Publication Layout Overview, the Scientific Session Reference,
and Scientific Session Type Legend to assist you. We hope that you find this information useful and welcome your comments.
Program Publication Layout Overview
Section Description
Front Fold-Out This quick reference guide lists the Annual Meeting scientific sessions with corresponding page numbers in the Program
Cover —Scientific Description section. Color-coded presentation titles assist you in identifying sessions within each theme. A brief description for
Program Overview each theme is available as well.
Daily Pocket This at-a-glance calendar is your guide to the daily activities of the Annual Meeting including special sessions; Specialty
Calendar Section, Regional Chapter, Special Interest Group, and ancillary functions; and SOT committee meetings. We encourage you
(pages 3–15) to tear out the daily guide for easy reference. Please note that the scientific session details are included at the end of each day’s
guide.
Schedule by Event This is an alphabetical listing of all the functions held during the Annual Meeting. You may use this easy-to-read schedule to
Name quickly locate an event. Please note that for the scientific sessions detail, you must refer to the Scientific Program Overview on
(pages 17–25) the front fold out cover or Daily Pocket Calendar on pages 3–15.
Poster Session The Poster Session Schedule and Poster Board Surface Maps are displayed with a mock layout of the ToxExpo™ Exhibit Hall to
Schedule and Board assist you in finding poster sessions. Each poster schedule and surface map shows the poster session abstract numbers and the
Surface Maps— poster surface locations for each poster session time. Posters are displayed in the Exhibit Hall Monday–Wednesday and Ballroom
(pages 34–37) I on Thursday.
Scientific Session This index lists the scientific sessions by type, date, and time. In addition, this information includes the session titles with
Index abstract numbers, poster boards, session locations, and corresponding page numbers in the Program Description section.
(pages 83–90)
Author Index The numerals following the author’s names refer to the abstract numbers referenced in this Program and The Toxicologist.
(pages 299–317) The asterisk after the abstract number indicates the author is the first presenter.
Abstract Key Word This index provides a listing of key words by subject or chemical and the relevant abstract(s) referenced in this Program and
Index The Toxicologist.
(pages 318–327)

Program Description Scientific Session Reference (pages 91–297)
The Program Description layout is ordered by date and start time. Please refer to the description below. Each scientific session listing includes a session
abstract and list of speakers or the featured presenters.
Listing Description
Session Type and Session type and title display in bold type and are formatted in uppercase. A brief description for each scientific session type is
Title listed below.
Sponsors or This section lists the sponsors and endorsers from SOT Special Interest Groups, Specialty Sections, Regional Chapters, or
Endorsers SOT Committees. For each scientific session, the sponsor, the group that developed the session, is listed first and followed by the
endorsers. The list of endorsers, groups that support the session, is sorted alphabetically.
Abstract Number or The first number listed is the abstract number, or the SOT final identifying number. For scientific sessions (but not Continuing
Presentation Time Education Courses or Poster Presentations), the second number is the presentation time. Individual abstracts can be found on
The Toxicologist CD-ROM (free to all attendees), The Toxicologist publication (available for purchase on-site for $20), and on the
SOT Web site.
Poster Sessions The poster board surface number is listed above the title of each individual poster presentation for easy reference.
Scientific Session Type Legend
Education-Career Development Sessions (80 minutes)—Sessions that Poster Sessions (180–210 minutes)—Topic specific presentations that
provide the tools and resources to toxicologists that will enhance their cover new areas, concepts, or data
professional and scientific development
Regional Interest Session (165 minutes)—Central topics of relevance
Exhibitor Hosted Sessions (60 minutes)—Informative sessions that describe public health and/or ecological problems of a particular
developed by an exhibiting company region
Featured Sessions (50–60 minutes)—Keynote and other special Roundtable Sessions (80 minutes)—Controversial subjects
lectures
Symposia Sessions (80 or 165 minutes)—Cutting-edge science; new
Historical Highlights (80 minutes)—Review of a historical body of areas, concepts, or data
science that has impacted toxicology
Thematic Sessions (80–210 minutes)—Timely topics of relevance to
Informational Sessions (80 minutes)—Scientific planning or member- toxicology
ship development
Workshop Sessions (165 minutes)—State-of-the-art knowledge in
Platform Sessions (165 minutes)—Oral presentations that cover new toxicology
areas, concepts, or data 2 SOT 48th Annual Meeting
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_ _ _ _ Daily Pocket Calendar For your convenience, please tear out and carry with you. Cal
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_ _ _ Ethvee envtse nnta smtaerst atirme eli.sted alphabetically by 4C:o0u0n PciMl O troi e7n:t0a0ti oPnM M eeting 7C:o0u0n PciMl O troi e1n0t:a0ti0o nP MRe ception & Dinner
_ _ Events at the Baltimore Convention Center Hilton Marshall Room Hilton Carroll Room
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_ Saturday March 14, 2009
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_ _ Events are listed alphabetically by the event 1:00 PM to 6:00 PM 4:00 PM to 7:00 PM 5:30 PM to 8:00 PM
_ start time. American Board of Toxicology SOT Office Graduate Fellowship Interviews by Awards
_ Board of Directors Meeting CC Room 332 Committee
_ _ Earvee nntost eadt tahse C BCa.ltimore Convention Center Hilton Calloway A Room 4:00 PM to 7:00 PM CC Room 333
_ _ _ _ _ 8CH:oi0lut0on Anc iMPl oM etoe Re 1toi:on3mg0 PM 2SOH:Ori0liTt0eon nPCta MoHtimoo tlnmoi d i5 att:ye0 eB0/ TaPalMlsrko oFmor 1ce Chair SC4:pC0e0 aR kPoeMor mR t eo3a 37d1:y0 R0 oPoMm 5PAC:owC3s0 atRdr PdoosMco tmCo tor oa3m l37 mF4:0eilt0lt oePewM sh ip Interviews by
_ _ 8:00 AM to 5:00 PM 4:00 PM to 7:00 PM TCoCu rP Draetts kS treet Lobby 5:45 PM to 7:00 PM
_ _ IHUilTtoOnX T uMbmeeatnin Rgso oms E-mail Center/Message Boards 4:15 PM to 5:45 PM Undergraduate Education Program
_ _ 8:00 AM to 5:00 PM CC Pratt Street Lobby Undergraduate Education Program— RCeCc eRpotoiomn 339
_ _ ToxExpo™ Set Up 4H:o0u0s PinMg Dtoe s7k: 00 PM Oanrdie Antdavtiiosonr fso r SOT Hosts, Peer Mentors, 7:00 PM to 9:00 PM
ndar _ _ C1JGo1Crh:o3 nuE0spx oA hnMiM b&eie t t JtoHion h6agln: l0s0o nP TMox icology Interest C4R:Ce0g0 Pi sPrtarMattt i Stootnr e7e:t0 0L oPbMby C5C:Co0n0 Rt iPnoMuoimn tg o3 E350d:4u5c aPtiMon Committee Walk- 2CaC0neCtdlh e RAobrorngaonatmiinvo ien3zr e4(srA3a ralylr peU ainsntdv epitrregodrg)ardaumat pe aPrrtoicgirpaamn ts
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r start time. IUTOX Meetings Alliance for Risk Assessment: Steering Awards Ceremony
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age f Earvee nntost eadt tahse C BCa.ltimore Convention Center H8:i0lt0o An MTu btom 4a:n0 R0 oPoMm s CHoilmtomn iLttaeter oMbee eRtionogm (CACll RAottoemnd 3e2es1 Welcome)
Tear out p 7C(CT:oC0icn0 kLt ieAentv uMReinel tgq3o u0E 7i0rd: e4(udS5c)ea Aeti MoSnig Snaugneri sfoe rM Rionoi-mC ourse TC8T:ooC0ux0 rEP ADrxapMetots ™k St otr Se5ee:t0t L0U oPpb Mby 1TMHo2iex:lt0eioct0ino n NlPgoO ogeiOc AaNl R Stocooi e3mn:0c0es P AMss ociate Editors 6W(CA:C3elll0 BcA oPatmtMlelrinon dtogoem eR7s:e 3Wc0ee plPctiMoomn e )
_ Location) CC Exhibit Hall 12:30 PM to 1:55 PM 7:00 PM to 8:00 PM
_ _ _ _ 7E:-0m0a Ail MCe tnot e6r:/0M0e PssMag e Boards 8U:n0d0e ArgMra dtuoa 1t1e :E3d0u AcMati on Program— CUPlCnadn Renroignorgma df ou3ra1 tG1e rEadduuactaet iSocnh Poroolg ram— 2(CB5Cy-Y CIenhavari tr(alOetisro SnMt rOoerneetl )yV )MIPe mSubietre Reception
_ CC Pratt Street Lobby Toxicology Lectures
_ CC Room 343 1:00 PM to 3:00 PM 7:00 PM to 9:00 PM
_ _ _ _ _ _ _ 7HC7L::uCo00gu00 Pgs AAiarnagMMgtet /D SCttooteor sea58ket:: t03C L00h oePPbcMMbky 8C(CLT:ooC1iccn5 akLt ietAenitov uMRneinsel t)gq3o u0E 1i0rd2 e(u:dS0c)ea0 et i NoSniOg MnOaNogre n ifnogr RCoooumrs es EC1C(T:nCo1idcn5 kRot iePwnotM uomRimnee tgq no3 ut E0 5iF6rd:ue0udn0c)d a P tBiMoona Ardf tMereneotoinng C ourses JJ97UHHt:hn0 UUFi0vl/- eoPEBroMHslroiSto yt/mo To Ob9f e:WX0rg0 aA sSPlhcuMihmnog notiol nRo feA cPleuupmbtliniocin &H e alth
_ _ CC Pratt Street Lobby 10:00 AM to 5:00 PM CC Level 300 (See Signage for Room Friends Reception
_ _ 7R:e0g0i sAtrMati oton 8:00 PM Paracelsus Outside the Classroom Locations) Hilton Key Ballroom 9
_ _ CC Pratt Street Lobby (POapgeen 9 t2o) the Public; See Details on 2U:n0d0e PrgMra dtou a2t:e4 E0d PuMca tion Program—Career 7L:o3v0e lPaMce tRoe 9sp:3ir0a tPoMry Research Institute
__ 7:00 AM to 5:30 PM Port Discovery Children’s Museum Opportunities in Toxicology Reception
_ _ _ SCOCT R Oooffmic e3 32 1Jo0b:0 B0a AnMk C teon 4te:r3 0 PM C3:C00 R PoMom t o3 359:00 PM H7:i3lt0o nP MBl atkoe 8 R:3o0o PmM
_ _ _ 7S:p0e0a kAeMr R teoa d5y:3 R0 oPoMm C11C:0 R0o AoMm 3to4 72:00 PM UAncaddeergmraicd uTaotxei cEodluocgayt iPorno gPrraomgrsa man—d (STtiucdkeent tR/Peoqsutidroecdt)oral Fellow Mixer
_ _ _ C7:C30 R AoMom t o3 391:30 AM SCOCT C Rhaersloeusr Scetr ePeatv Liloiobnb y ICnCte rRnosohmip s3 43 C8:C00 C PaMmd teon 1L0o:b3b0y PM
_ _ _ _ _ _ CCC7:aoC3rm0 eR emAor iMoRtmtee tes o3o M 1u22r:ec3ee0t i anPngMd I D evelopment 1CSV1poo:eln4uat5nkin teAeureMsinr, sgC t oEo md1u:m1c5aitt tiPeoeMn, aL nudn cShtueodnen fto r 3UMC:Cn0ed0n Re tPorogrMo rama ndt dou3 a1P3t1e:e3e E0r d MPuMcean ttioornin Pgr oMgeraemtin—g Host AH8IU:ri0liTtz0oOo nPnX MaH ENo txlioiegd ch1aut0y t: iB0v0ea lPClrMoomo mm 1ittee Dinner
_ Concession Stands (By Invitation Only) 4:00 PM to 5:15 PM Restaurant TBD
_ _ _ _ _ C8G:Cu0e0 Ls Ate HvMeol s t3po0i t50a:l0it0y PCMen ter C1U1Cn:d4 Re5ro AgorMmad u3toa2t 41e 2E:d3u0c PaMtio n Program— AC4:wC45 aRr PdosMo mR te o3c 2i5p4:i1e5n tPs MPh otographed
_ Hilton Douglass Room Lunch and Networking Awards Ceremony Music—Performed by
_ (By Invitation Only) Maryland Sings
_ _ CC Room 339 CC Room 321
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_ up-to-date information at www.toxicology.org 3
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48th Annual Meeting & ToxExpo™ _ _
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7:00 AM–7:45 AM 8:15 AM–12:00 nOOn 1:15 PM–5:00 PM _ _
COnTInuInG EDuCATIOn SunRISE MInI- COnTInuInG EDuCATIOn MORnInG COuRSES COnTInuInG EDuCATIOn AFTERnOOn _ _
COuRSE 2. Free Radicals for Toxicologists—From the COuRSES _ _
1. Topics in Ethics: Conflict of Interest—Real or Basics to Inflammation and Disease 8. Free Radicals for Toxicologists—From the _
Imagined?—PBDEs As a Case Study 3. Characterizing Modes-of-Action and Their Basics to Inflammation and Disease __
Relevance in Assessing Human Health Risks 9. Characterizing Variability and Uncertainty with _ _
4. Evaluation of Toxicity to Male and Female Physiologically-Based Pharmacokinetic Models _
Reproductive Systems: Biology, Study Design, 10. Current Approaches in Mixture Risk Assessment _ _
CE cboouorthse fso rh erlodo omn a Lsesvigenl m30e0n t(sS.)ee signage at the CE 5. aImndm Duantoal oIngtye rfoprr eTtoaxtiiocnologists 11. HIso Rwe lSeivmanilta?r CIso Snsimidielraart aionnds Hino wth eR Deleesviagnnt _ _ _
6. Principles and Applications of Toxicokinetics of a Predictive Development Program for _ _
7. Translation of Safety Biomarkers in Drug Biotherapeutics _
Discovery and Development 12. New Frontier in Metal Toxicology: Genetic _ _
Susceptibility, Early Diagnosis, and Related _
Biological Indices _ _
13. SSttruedsise sA s a Confounding Factor in Toxicology _ _ _
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4 SOT 48th Annual Meeting _ _
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