Table Of Content

Subject Index .^k.canthocytosis, band 3 and, 424 neuroendocrine-immune, 353 Accumulative mechanisms, 454 pathological, 120, 317 N-Acetylserotonin, serum, circadian profile of, pineal affected by, 452 517 pinealocyte loss in, 59 N-Acetyltransferase, retina, circadian rhythms programmed theory of, 195 of, 147 protein kinase C activity during, 272 Acute phase response, 198 rate of, 137-143 Adenosine triphosphate, 220 and cancer, 454 synthesis of, in senile dementia, 231-233 and bromodeoxyuridine, 4%, 499 Adenylate cyclase, cAMP metabolic pathway and epithalamin, 485 and, 83 time structure loss and, 378 Adenylate cyclase activity, free-running zinc and, 360 circadian rhythms in, 89 Aging antigenic site, 427 Adenylate cyclase-cyclic AMP- Aldosterone, plasma, circadian rhythm of, 383 phosphodiesterase axis, 77, 91 Alkylation damage, 97 Adrenal corticotropic hormone, effects of, on Alzheimer’s disease NK cell activity, 329, 331 band 3 and senescent cell antigen in, 438 Adrenergic pathways, 337 pathogenesis of, 230-233 a- and /3-Adrenoceptors, 448-453 Amyloid deposition in Alzheimer’s disease, Adrenocorticotrophic hormone 232-233 cortisol production induced by, 286 Amyloid precursor protein, SDAT and, 252 plasma DHEA and DHEA-S response to, Anas platyrhynchos, 21 383 Antibody response, melatonin increases, 346 Adrenoreceptors, 36 Anticoagulation prophylaxis and therapy, xii Age as risk factor, 248 Antioxidant, melatonin as, 7 Aging Antisense RNA transgene, 316 acceleration and delay of, 458 Antitumoral defence, 267 acceleration of, mechanisms of Anurans, 16 bromodeoxyuridine-induced, 499 AP-1 protein, 195 adrenergic functions and, 448 structure of, 202 band 3, 421 APACHE HI scoring system, 285 band 3 and senescent cell antigen in, 438 Apoptosis, 212-213 benefits of, 475 Arrestin, 19 biomarkers of, 238 Astrocytes, 108 cellular, models for, 422 Astrocytic inclusions, 239 centralized clock for, 93 Atherosclerosis, DHEA value in, 568 delay of, xiii Athos, Mount, monks of, 478 DHEA and, 570 Aurintricarboxylic acid, 215 DNA damage and, 97 Axonlike processes, 23 energy rate during, 249 epigenetic approach to, 480 genetically programmed, 474 HPA axis and, 286 B ceUs, 310 intrinsic theory of, 195 Band 3, autoantibodies to, 419 law of necessary, 476 Basal processes, 19 mathematics of, 479 bcl-2, 217 mechanisms of caloric restriction affecting, Behavior, DHEA and, 564 159 Benign prostatic hyperplasia, 509 melatonin as a free radical scavenger and, 1 Beta-amyloid precursor protein, 230-233 melatonin rhythm in, 44 Beta-endorphin, NK cell activity and, 331 mice immunodepressed by, 349 Bible, life span in, 480 mutation theory of, bromodeoxyuridine Big scissors, 476 and, 500 Big-science effort, 479 natural cytotoxicity affected by, 339 Biomarker of aging, 238 579 580 ANNALS NEW YORK ACADEMY OF SCIENCES Bird, 16 Central nervous system diseases, age-related, biological clock mechanisms in. 36 238 lymphoid tissues of, 371 Cerebral parietotemporal cortex, 250 Body weight, effect of caloric restriction on, Chick embryo, pinealectomized, immune 160 functions in, 398 Brain, band 3 and senescent cell antigen in, Chicken, pineal organ of, 33 434 Chorioallantoic membrane, pocks on, 402 Brain cortex, 448-452 Chromatin fibers. 111 Bromodeoxyuridine Chromatin segments, 103 biological effects of, 498 Chronobiological alterations, xiii induction of aging and carcinogenesis by, Chronobiology, 529, 533-534 494 Chromosome aberration, bromodeoxyuridine Brown-Pierce carcinoma, 258 and, 4% Bum injury, DHEA and, 558 Circadian oscillator Bursa of Fabricius, pinealectomy and, 399 cell division cycle and, 77 model for ‘gating’ of cell division by, 94 Circadian rhythm, sympathetic innervation contributing to, 24 Circadian rhythm of central and peripheral C/EBP protein, 195 hormones, melatonin and, 503 Ca’^ channels, 337 Circadian variations, 385 Caenorhahditis, 212, 216 Clock Calcareous concretions, 17 aging. 93 Calcium, dark vs light pinealocytes pineal cross-transplantation and, 456 containing, 54-56, 58 biological Caloric restriction DHEAS and, 549 dopaminergic motor function and, 131 mechanisms of, 31, 36 glucocorticoids and, 171 pineal organ as component of, 13 mechanisms of, 159 centralized, 93, 477 Cancer circadian, properties of, 78 mammary, 511 endogenous aging, mechanisms of, xii 7,12-dimethylbenz[a]anthracene and, 519 melatonin the natural ‘hands’ of, 479 epithalamin and, 490 Coacervates in the pineal gland, 477 preventive treatment for, 454 Cognition enhancers, 279 prostate, 507 Cognitive function, 545-547, 549-550 war on, 479 CoUagenase, growing tissues and, 356 Carcinogenesis, initiation of, mechanisms of Compensatory changes, 280 bromodeoxyuridine-induced. 498 Cone opsin, 19 Catecholamines, NK cell activity negatively Conservation law, 476 modulated by, 337 Controller, master, melatonin as, 479 ced-9, 217 Corticostatins defensins, 329 Cell death Corticosterone, serum, caloric restriction and, calcium penneability and, 59 172 role of zinc in, 356 Corticotropin-releasing factor, lL-1 stimulation Cell division, model for ‘gating’ of, 94 of, 462 Cell division cycle Corticotropin-releasing hormone model for control of, 91 abnormal production of, 328 regulation of, by cAMP, 78 effects of, on NK cell activity, 331 signal transduction between circadian Cortisol oscillator and, 77 circadian rhythm and, 507 Cell division rhythm. 79 effects of, 329 Cell proliferation plasma, general patterns of, 382 effects of DHEA on, 566 prostate cancer and, 511 role of zinc in, 356 Criticality, 248 Cell-mediated immune response, 318 Cryptomys damarensis, 25, 27 Central endocrine disturbances, melatonin Cyclic AMP and, 513 cell division by, 84-85 Central nervous system, DHEA and, 564 circadian oscillations of, 80-81 SUBJECT INDEX 581 early failure of the cell and, 220 DNA damage, levels of, in aging, 97 ‘gating’ of cell division by circadian DNA degradation, 218 oscillator and, 94 DNA fragmentation, 213, 215 regulation of cell division cycle by, 78 Dopamine, pinealectomy-induced variations transcription and translation enhanced by, of, 404 28 Down’s syndrome Cyclic AMP-binding proteins, separation of, pineal development and, 465 92 zinc supplementation and, 361 Cyclic AMP-dependent kinases, 86-87 Drosophila, 78, 214 cAMP-analog specificities of, 93 separation of, 92 Cyclic GMP adenylate cyclase and phosphodiesterase Ebb phase, 286 regulation by, 85 Elderly, circadian rhythmicity of prolactin in, circadian rhythms of, 90-91 389 early failure of the cell and, 220 Electric foot shock, 530 Cyclic nucleotide production, regulation by Electrophysiological phenomena, 257 melatonin of, 373 Embryo, mouse, apoptotic cell death in, 215 Cyclin, 78 Endocrine system, effect of epithalamin on, Cyclophosphamide, 344 487 Cytoevolution, 22 Endogenous oscillators, 13, 24, 36 Cytokines, 329 Energy-rich compounds, 250 withdrawal of, 219 Enkephalins, zinc interaction with, 357 Epigenetic approach to life extension, 474 Epiphysectomy, neonatal, 292 Epiphysis, regulation of immunity and, 294 Di'^ceptor, 129 Epithalamin Di-receptor-mRNA, 131 biological effects of, 486 D-^k cells, 57 experimental gerontology and oncology Dasypus novemdnctiis, 18 and, 483 DC potentials. 258 life-prolonging effect of, 477 Death, acceleration and delay of, 458 oncological diseases and, 293 Degeneration, signs of, in dark pinealocytes, Erinaceus europaeus, 18 51 Estradiol benzoate, exposure to Dehydroepiandrosterone bromodeoxyuridine and, 497 immunologic action of, 553 Estrogen, male rat sniffing behavior and, 132 mechanism of action of, 568 Estrus function, disturbances of, 486 physiological effects of, 564 Eugene, Oregon, clinical trial study in, 478 Dehydroepiandrosterone sulfate Eaglena, 79 HPA axis and, 382 Euglena gracilis, 77 oldest old and, 543 Evolution, invention of melatonin by, 154 Dense-core granules, 23 Evolutionary intermittent group selection, 476 Desynchronization, internal, 93 Extracellular matrix molecules, deposition of, Dexamethasone, WEHl 7.1 lymphocytes 244 treated with, 218 Extrapineal sites of melatonin synthesis, 147 Diabetes, long-term, 479 Didelphys virginiana, 18, 27 7,12-Dimethylbenz[a]anthracene-induced mammary tumors, 519 Falsification, methodology of, 479 Disease Fibrillar material, age-related, 238 effects of caloric restriction on, 162 Flow phase, 287 free radical damage in, 8 Follicle-stimulating hormone degenerative, treating, xii circadian rhythm and, 385 DNA prostate cancer and, 510 conformational transformation of, role of Food restriction, circulating melatonin and, zinc in, 356 151 extrachromosomal circular, 114 Forebears and offspring, competition hepatic, safrole damage to, 5 between, 476 582 ANNALS NEW YORK ACADEMY OF SCIENCES Forskolin Hormones, central and peripheral, melatonin adenylate cyclase activated by, 83 and, 503 cAMP increased by, 81 Human neutrophil peptide-1, 329 effect of, on cell division rhythm, 88 Human neutrophil peptide-4. 329 fos, 217 Humoral immune response Fos-Jun, 202 effect of pinealectomy on, 399 Free radical generating systems, 423 enhancement of, by static magnetic fields, Free radical scavenger, melatonin as, 1 411 Free radical-related disorders, zinc deficiency Hydroxyindole-o-methyltransferase, 25-26 and, 357 Harderian gland and, 147 Frontal organ, 15 Hyperphagia. 176 Hypothalamic-pituitary-adrenal axis aging and, 286 (gastrointestinal tract, melatonin in, 148 glucocorticoids regulate, 308 Gene mcxiifications or repair, xiii injury and, 287 Genetic engineering, xii-xiii Hypothalamic-pituitary-adrenal system, excess Genome, instability of, bromodeoxyuridine activity of, 328 and, 499 Hypothalamus, immune regulatory system Genome reorganization, 110 and, 291 Geomagnetic field, horizontal component H Hypoxia, severe chronic, aged pineal gland of, 520 and, 67 Gerontology, epithalamin in, 483 Glial cell, 117 Glucocorticoid levels, DHEA and, 556, 570 IkB proteins, 200 Glucocorticoid production, melatonin and, 304 IBMX, 83 Glucocorticoid receptor, type 11, 308 lL-2 production, effect of melatonin on, 348 Glucocorticoids Immortalization, spontaneous, 113 activation of HPA system in stress and, 337 Immune function, effect of epithalamin on, caloric restriction and, 171 489 zinc turnover and, 304 Immune inflammatory reactions, potentiation Gluconeogenesis, 176 of, by static magnetic fields, 411 Glutathione reductase, 198 Immune response Gnosis, Flellenistic, death and, 475 cell-mediated, 318 Goethe, conjecture about death made by, 475 effect of DHEA on, 555 Gompertz curve, 476 neurohumoral shifts and, 267 Gompertz’s model, 137, 139 sexual dimorphism of, 313 Gonadotropins, circadian rhythm and, 506 Immune system Granules, clusters of, 238 pineal gland and, 398 Growth factors, withdrawal of, 219 role of zinc in, 358 Growth hormone Immunity, pineal gland and, 291 circadian rhythm and, 385, 505 Immunodepression, melatonin restores, 343 glucocorticoids and. 179 Immunoglobulin G, senescent cell, 428 prostate cancer and, 509 In situ hybridization, 28, 277 Inbred mouse strains, 240 Indian palm squirrel, female, 537 Ha-Ras, 203 Inflammation Habenular nuclei, 20, 31-32 effects of glucocorticoids on, 177 Heat shock factors, 195 HPA axis activity and, 322 Heat shock protein 70, 217 Inflammatory response, 198 labial gland involution and, 219 Injury Heparan sulfate proteoglycan-like molecules. endocrine-metabolic response to, 286 239 HPA axis and, 287 Heterochromatin, 112 Inositol-tris-phosphate, 337 Hippocampus, fibrillar material in, 238 Insulin metabolism, role of zinc in, 357 HIV infection, DHEA and, 556 Interleukin-1, pineal network and, 461 Hormonal treatments, thymus rejuvenation in Intracellular free calcium trafficking, 337 old age by, 363 Intrinsic theory of aging, 195 SUBJECT INDEX 583 IP3, eariy failure of the cell and, 220 circadian rhythm and, 379 Isoproterenol, epithalamin and, 488 circadian rhythm of central and peripheral hormones and, 503 circannual rhythmicity of, 520 Lacertilians, 16 epithalamin and, 488 Lampetra japonk a, 21 free radical scavenger role of, 1 Lampreys, 16 gastrointestinal tract as source of, 148 Lanthanum glucocorticoid production and, 304 analysis of, 45 hydroxyl radicals and, xiii permeability of pineal gland to, 47 IL-2 production and, 348 Learning, brain protein kinase C in, 276 mechanisms of, 469 Leukemia, effect of caloric restriction on, 162 melanosome aggregation and, 33 Leydig cells, zinc and, 357 neonatal, female Indian palm squirrel and, Life extension, artificial, 474 537 Life prolongation, pineal cross-transplantation neuroendocrine message of, 13 and, 456 NK cell responsiveness enhanced by, 337 Life span plasma a-MSH and, 464 bromodeoxyuridine and, 4% prostate cancer and, 507 effect of epithalamin on, 484 side effects of, 477, 480 mean and maximal, 142-144 specific binding of, 369 Lighting conditions, 531, 532, 534 TTi cell activity and, 347 Locomotor activity, 213 zinc and, 302 Longevity, selection for, 476 Melatonin biosynthesis Lower vertebrates, 36 chicken pineal organ, 35 Luteinizing hormone serotonin-N-acetyltransferase activity and, circadian rhythm and, 385 28 epithalamin and, 487 true pineal photoreceptors capable of, 20 prostate cancer and, 510 Melatonin levels, circulating, 147 Lymphocyte population, effect of Melatonin profiles, lawfully changed, 478 pinealectomy on, 401 Melatonin signal, 478-479 Lymphocytes, human, specific binding sites Melatonin synthesis for melatonin in, 369 cAMP regulation of, 77 Lymphokine production, DHEA and, 558 extrapineal sites of, 147 Lymphoma, caloric restriction inhibiting Memory, brain protein kinase C in, 276 expression of, 167 Metabolic changes in senile dementia, 232-233 Metabolic clearance rate, 289 l^^alignant transfonnation, 93 Metabolism, effect of DHEA on, 555, 567 Mammals Metastasis, 529, 533 melatonin biosynthesis in, 36 3-Methyladenine-DNA glycosylase repair pineal organ of, 25 enzyme, 102 Man, rod-opsin in, 25 7-Methylguanine, 97 Mathematical models, 141-143 Methyl-nitroso-urea, 99 Maturation (M phasel-promoting factor, 78 5-Methoxytriptamine, 537 Mechanisms Microsomal ladders, 213 immune, 294 Morphological changes, 238 neuroendocrine, 328 Mortality kinetics, 136-137 Mechanisms of caloric restriction, 159 Mortality rate, 137-140 a-Melanocyte-stimulating hormone, circadian Motor fiiinction, impaired, 129 rhythm of, 464 Mouse Melanophores, dermal, 33 nude, pineal aging and, 463 Melatonin pineal organ and epithalamic region of, 32 administration of, 533, 534 senescence-accelerated, 240 a- and j3-adrenoceptors and, 448, 451-452 Mouse brain, fibrillar material in, 238 antioxidant role of, 7 Muscle fibers chronic circadian (night) administration of, pineals of old rats containing, 70 456 striated, 73 584 ANNALS NEW YORK ACADEMY OF SCIENCES myc, 217 Oxidative phosphorylation in senile dementia, Myotubes, 117 231-233 Oxidative stress, 205 Oxygen-centered radicals, production of, 2 INatural killer cells, 329 R Necrosis, 213 34cdc2^ 78 Neoplastic disease, relationship of Ixxly 1.218 weight and, 166 Parabiosis experiments, 479 Nerve bundles, pineals of old rats containing, Parapineal organ, 15 70 Parasympathetic system, 31 Nerve growth factor, 219, 221 Parietal foramen, 15 zinc dependence of, 357 Pep-COOH peptide, 428 Nervous system Peroxidase, 198 effect of epithalamin on, 487 Phagocytic cells, increases in CS-defensins role of zinc in, 358 from, 337 Neurodegenerative disease, human, model of, Pharmacokinetics, age-related changes in, 390 238 Phase-response curve, 85 Neuroendocrine effectors, 13, 24 Phorbol ester binding, 273 Neuroendocrine-immune aging, role of zinc Phosphodiesterase, cAMP metabolic pathway in, 353 and, 83 Neuroendocrine-immune interactions, 328 Phosphodiesterase activity, free-running Neuroendocrine-immune system, aging of, circadian rhythms in, 89 308 Phospholipase C, 337 Neuronal loss, 130 Phospholipase D, 337 Neurons, 18, 31 Photoneuroendocrine unit, 24 protein synthesis in, 217 Photoreceptors, 13, 24, 36 second-order, 20 Photosensitivity, direct, 24 Neuropathology, 238 Pineal, aged, 64 Neuropeptides, pineal metabolism controlled Pineal antitumor activity, 522 by, 30 Pineal cross-transplantation, aging clock and, Neuropil formations, 19 456 NFkB protein, 195 Hneal gland NFkB-IkB complex, 198 aging clock in, xii, xiii NFkB-IkB phosphorylation, 200 cell division cycle and, 77 n-Nitrosomethylurea, bromodeoxyuridine coacervates in, 477 and, 496-497 epithalamin and, 484 Noradrenaline, 24 immune mechanisms and, 343 Norepinephrine, pinealectomy-induced immune system and, 398 variations of, 404 immunity and, 291 Nutritional state, tryptophan a marker of, 154 magnetosensitivity of, 413 Nutritional treatments, thymus rejuvenation in melatonin production by, 43 old age by, 363 melatonin rhythm in, 379 modulatory influence of, on a- and /3- adrenoceptors, 448-453 Obesity, effects of DHEA on, 567 old, 456 Oldest old, DHEAS and, 543 young, 456 Oncogenes, potential of cells to senesce or Pineal inclusions, 66 immortalize and, 121 Pineal melatonin biosynthesis, 519 Oncology, epithalamin in, 483 Pineal organ Ontogenetic development, 31 bovine, 26 Ontogenetic mechanisms, 454 chicken, 33 Opiatergic pathways, 337 human, measurement of, 18 Opioid compounds, NK cells and, 331 mammalian, 25 Osteoblasts, 114 mouse, 26 Outer segment, 19 ontogenetic development of, 31 Oxidation, vitamin E and, 422 Pineal peptide preparation, 483 SUBJECT INDEX 585 Pineal photoreceptors. 33 Regression. 34 modified, 19, 22 Regulation, endocrine, 291 true, 19 Repair, DNA, 102 Pineal tissue, engraftment of, 477 Reproductive function, bromodeoxyuridine Pineal tract, 20 and, 4% Pinealocyte processes, S-antigen Reproductive system, effect of epithalamin immunoreactive, 32 on, 485 Pinealocytes, 18, 22 Restraint stress, 530 calcification of, 69 11-cis Retinal, 24, 29 displaced, 31 Rhodopsin, 34 Pinealocytes sensu stricto, 19, 25 Rhythms, aging and, 378 Pituitary tumors, effect of caloric restriction Risk factor, age as, 248 on, 164 Rod-opsin, 19, 24-25, 27, 29, 33-35 Plaque-forming cell response, effect of Rodent, lymphoid tissues of, 371 pinealectomy on, 401 Rodents, 16 Plasma proteins, age-related changes in, 390 Rotational stress, 529, 533 Pock formation, pinealectomy and, 402 Postmitotic cells, DNA damage in, 97 Postnatal development, specific binding of S-antigen. 19, 21, 24-25, 27, 34-35 melatonin during. 369 Saccharomyces, 79 Pregnenolone, 555 Safrole, damage to hepatic DNA by, 5 Pretectal area, 20, 31-32 Salivary glands, thymus and, 294 Programmed cell death, 212-213 Salmonella typhimuriim infection, Programmed theory of aging, 195 pinealectomy and, 292 Prolactin Scanning electron microscopy, 44 circadian rhythm and, 385, 505 Schizosaccharomyces pombe, 78 male rat grooming behavior and, 132 Seasonal effects, 529, 533-534 prostate cancer and, 507-509 Second messengers, 30 Proopiomelanocortin, pituitary peptides intrinsic and extrinsic stress factors acting derived from, 329, 337 as, 200 Protease activity, 279 Senescence, postponing, 478 Protein kinase C, brain aging and, 272 Senescence-accelerated mouse, 240 Protein kinase C isoforms, 275 Senescent cell antigen. Band 3 and, 419, 425 Protein kinase C translocation, 274 Senile dementia of the Alzheimer’s type, Protein phosphorylation, calcium and, 271 HPA system and, 328 Protein synthesis, 214 Serotonin, 26 cell death and, 216 distribution of, in pinealocytes, 25 K-I\roantimonate method, 53 pineal photoreceptors lacking, 20 Pyrogens, fever reaction to, 462 pinealectomy-induced variations of, 404 serum, circadian profile of, 517 Serotonin metabolism, effect of epithalamin on, 487 bbits, treatment of, with epithalamin, 488 Serotonin-N-acetyltransferase, 519 Raf-1, 203 rhythm of melatonin biosynthesis and. 13 Rapid eye movement sleep, Down’s Serum antibodies, naturally occurring, 435 syndrome and, 465 Sex hormones, type II glucocorticoid receptor Rat, pineal organ and epithalamic region of, and, 312 32 Sexual dimorphism, type II glucocorticoid Rat brain, 273 receptor and, 313 Rat strain differences, 278 Signal transduction Recoverin, 19, 25 adenylate cyclase-cAMP-phosphodiesterase Red cell aging panel, 424 axis in, 77, 91 Redox factor-1, 198 intermediates of, 202 enhancement of DNA-binding properties Signal transduction-redox pathways, 195 by, 203 Sleep, diet and life style overlap with, 478 Redox modification, 200 Sleep patterns, disturbances of, 462 Redox pathway, intermediates of, 206 Splenomegaly, pinealectomy and, 403 586 ANNALS NEW YORK ACADEMY OF SCIENCES Sporadic dementia of the Alzheimer's type, Thyrotropin-releasing hormone, pineal age as risk factor for, 248 deficiency and, 465 Src, 203 Thyroxine Static magnetic fields, enhancement of epithalamin and, 488 humoral immune response by, 411 total Steroid-immune interactions, 311 circadian rhythm and, 505 Stone-age conditions, 479 prostate cancer and, 510 Stress hyporesponsive peritxl, 319 Transcription factors, 195 Stress proteins, effects of caloric restriction a-Transducin, 19, 24, 33 on, 184 Transforming growth factor-/3, 219 Stress response, increase in CRH, ACTH, Transgenic animals, 308 and /3-endorphin in, 337 Transglutaminase. 217 Stress response genes, 195 Transmission electron microscopy, 44 Striatal neurons, 130 Transport function, senescent cell antigen, 425 Stromboli Cocktail, xi, 93 Triiodothyronine, epithalamin and, 488 Sulcus parieto-occipitalis, 65 TRPM-2, 217 6-Sulfatoxymelatonin, 516 Tryptophan, nutritional state and. 154 Superior cervical ganglion, 14 Tumor, spontaneous, epithalamin and, Supporting (glial) cells, 18 489-490 Suprachiasmatic nucleus, 14, 28, 36 Tumor growth, 529, 533-534 circadian pacemaking function of, 43 epithalamin and, 489 Survival, 545-547, 549-550 experimental, 257 Sympathetic innervation, 14, 28, 36 melatonin and, 516 Sympathetic nerve fibers, 34-35 Tumor necrosis factor, 219 Syphilis, DHEA and, 558 Tyrosine kinases, 203 T cells, 310 tl^biquitin, 217 Talpa etiropaea, 18 Ultramicroscopy, 67 Telosts, 16 Urethan, exposure to bromodeoxyuridine Temperature-constant place in the body, 477 and. 497 Testosterone circadian rhythm and, 506 plasma, circadian rhythm of, 383 V-raf, 218 prostate cancer and, 510 Vascular endothelium, effects of DHEA on, 12-oTetradecanoylphorbol-13-acetate, 568 exposure to bromodeoxyuridine and, VIP-receptors, 30 498 Vitamin E, oxidation and, 422 Th cell activity, effect of melatonin on, 347 Thermogenesis, effects of glucocorticoids on, 178 Water, nightly drinking, melatonin added Thermoregulation, 463 to, 477 Thioredoxin, 198 WEHl 7.1, 218 Thymic engraftment, new method of, 479 Werner’s syndrome, 113 Thymocytes, protein synthesis in, 217 Thymulin, zinc and. 3(X) X Thymus -irradiation, bromodeoxyuridine and, 497 a- and /3-adrenoceptors and, 448, 452-453 X-ray microanalysis, 45 cAMP activity and, 292 Xenopus oocytes, 78 early involution of, 114 pinealectomy and, 399 rejuvenation of, in old age, 363 ZiC mutant, 79 type II glucocorticoid receptor and, 312 Zinc Thyroid function, pineal aging and, 463 glucocorticoids and, 304 Thyrotropin melatonin and, 302 circadian rhythm and. 505 role of, in neuroendtx;rineimmune aging, prostate cancer and, 510 353 Index of Contributors /Xngeli, A., 328-342 Jankovic, B. D., 398-409, 410-418 Anisimov, V. N., 483-493, 494-501 Joseph, J. A., 129-135 Jucker, M., 238-247 Darden, N., 308-327 Bartsch, C., 502-525 JValimi, M., 553-563, 564-575 Bartsch, H., 502-525 Kay, M. M. B., 419-447 Basso, A., 136-145 Khavinson, V. Kh., 483-493 Bateman, A., 328-342 Kloeden, P. E., 474-482 Battaini, F., 271-284 Kneievic, Z., 398-409 Batticane, N., 308-327 Kojic, L., 398-409 Bergamaschi, S., 271-284 Koljada, T., 291-297 Bertoni-Freddari, C., 230-237 Korf, H-W., 13-42 Birkenhager-Gillesse, E. G., 543-552 Kosich, V., 291-297 Blank, K., 159-170 Bulian. D., 298-307, 448-453 Ladisa, V., 271-284 Lagaay, A. M., 543-552 Calvo, J. R., 369-377 Lazzero, A., 328-342 Caroleo, M. C., 343-352 Leakey, J. E. A., 171-194 Cervos-Navarro, J., 64-76 Lesnikov, V. A., 456-460, 461-473 Chen, L-D., 1-12 Lippert, T. H., 502-525 Chen, S., 171-194 Lockshin, R. A., 212-229 Cupic, V., 410-418 Lopez-Gonzalez, M. A., 369-377 D. Loria, R., 553-563 'erksen, J., 543-552 Lucchi, L., 271-284 Oilman, V. M., 454-455 Doria, G., 343-352 Mala cieira-Coelho, A., 108-128 Duffy, P. H., 171-194 Manjgaladze, M., 171-194 Marchetti, B., 308-327 Edmunds, L. N., Jr., 77-96 Masera, R. G., 328-342 Mecke, D., 502-525 Fabris, N., 298-307, 353-368 Meier-Ruge, W., 230-237 Fluchter, S-H., 502-525 Menendez-Pelaez, A., 1-12 Mocchegiani, E., 298-307 Morale, M. C., 308-327 Gallo, F., 308-327 Morozov, V. G., 483-493 Gaubatz, J. W., 97-107 Murasko, D., 159-170 Giraldi, T., 526-536 Goodman, J., 419-447 Ni, Govoni, S., 271-284 likolic, P., 410-418 Griot, G., 328-342 Nikolic, V., 398-409 Guerrero, J. M., 369-377 Nistico, G., 343-352 O Haidar, C., 537-542 suna, C., 369-377 Hart, R., 159-170, 171-194 Haus, E., 378-397 Jl apaconstantinou, 195-211 Hladni, K., 410-418 Peiffer, A., 308-327 Horan, M. A., 285-290 Perissin, L., 526-536 Hoyer, S., 248-256 Pevet, P., 43-63 Huether, G., 146-158 Piantanelli, L., 136-145, 448-453 Humbert, W., 43-63 Pierpaoli, W., xi-xv, 298-307, 448-453, 456-460, 461-473 Ingram, D. K., 238-247 Pipkin, J. L., 171-194 Iwangoff, P., 230-237 Poeggeler, B., 1-12 587 588 ANNALS NEW YORK ACADEMY OF SCIENCES Prokopovich, S. K., 257-270 Prosenc, N., 64-76 Tan B. H., 97-107 Tan, D-X., 1-12 Tibaldi, A., 298-307 IRapozzi, V., 526-536 Touitou, Y., 378-397 Regeison, W., 553-563, 564-575 Trabucchi, M., 271-284 Reiter, R. J., 1-12, 576-578 Turturro, A., 159-170, 171-194 Rossler, O. E., 474-482 Rossler, R., 474-482 Rossolini, G., 136-145 A^assiljev, N., 291-297 Roth, G. S., 129-135 Vinnitsky, V. B., 257-270 Viticchi, C., 448-453 Volyansky, Ju., 291-297 Saarela, S., 1-12 Santarelli, L., 298-307 Sartori, M. L., 328-342 Wyant, T., 419-447 Slepushkin, V., 291-297 Solomon, S., 328-342 Zakeri, Z., 212-229 Staurenghi, A. H., 328-342 Zorzet, S., 526-536