Animal Virus Genetics PDF
Preview Animal Virus Genetics
Academic Press Rapid Manuscript Reproduction Proceedings of the 1980 ICN-UCLA Symposia on Animal Virus Genetics Held in Keystone, Colorado March 9-14, 1980 ICN—UCLA Symposia on Molecular and CeUufar Biology, Volume XVIII, 1980 ANIMAL VIRUS GENETICS edited by BERNARD N. FIELDS Department of Microbiology and Molecular Genetics Harvard Medical School Boston, Massachusetts RUDOLF JAENISCH Department of Tumor Virology Heinrich —Pette Institut Hamburg, West Germany Series Editor C. FRED FOX Department of Microbiology and Molecular Biology University of California, Los Angeles Los Angeles, Cahfornia Managing Editor Frances J. Stusser ICN—UCLA Symposia University of California, Los Angeles Los Angeles, California ACADEMIC PRESS 1980 A Subsidiary of Harcourt Brace Jovanovich, Publishers New York London Toronto Sydney San Francisco COPYRIGHT © 1980, BY ACADEMIC PRESS, INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. Ill Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NWl 7DX Library of Congress Cataloging in Publication Data ICN-UCLA Symposia on Animal Virus Genetics, Keystone, Colo., 1980. Animal virus genetics. (ICN-UCLA symposia on molecular and cellular biology; v. 18) Includes bibliographical references and index. 1. Viral genetics—Congresses. I. Fields, Bernard N. II. Jaenisch, Rudolf. III. Fox, C. Fred. IV. ICN Pharmaceuticals, inc. V. California. University. University at Los Angeles. VI. Title. VII. Series. QH434.I14 1980 576'.64 80-21830 ISBN 0-12-255850-2 PRINTED IN THE UNITED STATES OF AMERICA 80 81 82 83 9 8 7 6 5 4 3 2 1 CONTRIBUTORS Numbers in parentheses refer to chapter numbers. Cheryl Adler (9), Department of Microbiology, State University of New York, Stony Brook, New York 11794 R. Ahmed (56), Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115 S. M. Anderson (42), The Rockefeller University, New York, New York 10021 Ralph B. Arlinghaus (54), Department of Tumor Virology, M.D. Anderson Hospi- tal and Tumor Institute, Houston, Texas 77030 Lome A. Babiuk (61), Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, S7N OWO Canada Lee T. Bacheler (16), Tumor Virlogy Laboratory, The Salk Institute, San Diego, California 92138 David Baltimore (55, 72), Center for Cancer Research, El 7-517, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Ralph S. Baric (58), Department of Microbiology, North Carolina State Univer- sity, Raleigh, North Carolina 27650 Renato Baserga (28), Department of Pathology, Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 William Batterson (32), Kovler Viral Oncology Laboratories, University of Chi- cago, Chicago, Illinois 60637 Karen Beemon (43), Tumor Virology Laboratory, The Salk Institute, San Diego, California 92138 T. L. Benjamin (26, 27), Pathology Department, Harvard Medical School, Bos- ton, Massachusetts 02115 Eric J. Berman (20), Laboratory of Viral Carcinogenesis, National Cancer Insti- tute, N1H, Bethesda, Maryland 20205 xiii XIV CONTRIBUTORS Anton Berns (40), Laboratory of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands Hartmut Beug (47), Institut für Virusforschung, Deutsches Krebsforschungszen- trum, Im Neuenheimer Feld 280, 6900 Heidelberg, Federal Republic of Ger- many John Billelo (36), Department of Molecular Biology, University of Hamburg, D- 2000, Hamburg 13, West Germany E. Birkenmeier (17), National Cancer Institute, NIH, Bethesda, Maryland 20205 Klaus Bister (45), Department of Molecular Biology, University of California, Berkeley, California 94720 D. G. Blair (39), Laboratory of Viral Carcino gene sis, National Cancer Institute, NIH, Bethesda, Maryland 20205 Barry Bloom (59), Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461 Robert A. Bosselman (40), Tumor Virology Laboratory, The Salk Institute, San Diego, California 92138 David Botstein (2), Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Michael A. Bratt (57), Department of Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts Martin L. Breitman (44), University of Southern California Medical School, Los Angeles, California 90033 Trudy Breznik (35), Department of Microbiology, Tulane Medical Center, New Orleans, Louisiana 70112 S. Burstin (56), Department of Medicine, Peter Brent Hospital, Boston, Massa- chusetts 02115 R. Callahan (17), Laboratory of Viral Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20205 G. G. Carmichael (26), Department of Pathology, Harvard Medical School, Bos- ton, Massachusetts 02115 Donald R. Carrigan (64), Neurology Research Laboratory, V.A. Medical Center, San Francisco, California 94121 Suzie Chen (18), Department of Biological Sciences, Columbia University, New York, New York 10027 J. E. Clements (60), Department of Neurology, The Johns Hopkins School of Med- icine, Baltimore, Maryland 21205 Donald M. Coen (49), Sidney Färber Cancer Institute, Boston, Massachusetts 02115 John M. Coffin (38), Department of Microbiology and Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111 J. Craig Cohen (35), Department of Microbiology, Tulane University Medical Center, New Orleans, Louisiana 70112 Giulia Colletta (36), The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, G61 1BD, Scotland CONTRIBUTORS xv Robert J. Crouch (8), Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20205 N. D'Antonio (60), Tufts University School of Medicine, Boston, Massachusetts 02111 Edward Darzynkiewicz (10), Roche Institute of Molecular Biology, Nutley, New Jersey 07110 T. M. Dexter (37), Pater son Laboratories, Manchester, England Dino Dina (48), Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461 Richard A. F. Dixon (49), Sidney Färber Cancer Institute, Boston, Massachusetts 02115 Walter Doerfler (30), Institute of Genetics, University of Cologne, Weyertal 121, 5000 Cologne 41, West Germany David Dolberg (16), Department of Biology, University of California at San Diego, La Jolla, California 92093 Lawrence A. Donehower (23), Tumor Virus Genetics Laboratory, National Can- cer Institute, NIH, Bethesda, Maryland 20205 H. Donis-Keller (56), Department of Microbiology and Molecular Genetics, Har- vard Medical School, Boston, Massachusetts 02115 Ludvik Donner (46), Department of Viral Carcinogenesis, National Cancer Insti- tute, NIH, Bethesda, Maryland 20205 D. T. Drayna (56), Department of Microbiology and Molecular Genetics, Har- vard Medical School, Boston, Massachusetts 02115 W. Drohan (15), National Cancer Institute, NIH, Bethesda, Maryland 20205 Peter H. Duesberg (45), Department of Molecular Biology, Stanley Hall, Univer- sity of California, Berkeley, California 94720 Jeffrey C. Edman (25), Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 Melanie Ehrlich (35), Department of Biochemistry, Tulane Medical Center, New Orleans, Louisiana 70112 John D. Estes (20), Department of Pathology, University of Southern California School of Medicine, Los Angeles, California 90033 Hung Fan (16), Tumor Virology Laboratory, The Salk Institute, San Diego, Cali- fornia 92138 B. N. Fields (56, 69), Department of Microbiology and Molecular Genetics, Har- vard Medical School, Boston, Massachusetts 02115 Robert Z. Florkiewicz (63), Department of Cellular and Developmental Biology, University of Arizona, Tucson, Arizona 85721 Michèle M. Fluck (27), Microbiology Department, Michigan State University, East Lansing, Michigan 48824 Jeffrey A. Frelinger (21), Departments of Neurology and Microbiology, University of Southern California School of Medicine, Los Angeles, California 90033 David Frisby (36), The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland XVI CONTRIBUTORS Robert S. Fujinami (65), Scripps Clinic and Research Foundation, La Jolla, Cali- fornia 92037 Yasuhiro Furuichi (34), Department of Cell Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110 Murray B. Gardner (20), University of Southern California School of Medicine, Los Angeles, California 90032 Malcolm L. Gefter (31), Department of Biology, Massachusetts Institute of Tech- nology, Cambridge, Massachusetts 02139 Charles W. Gehrke (35), Experimental Station, Chemical Laboratories, University of Missouri, Columbia, Missouri 65211 J. Gentsch (56), Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115 Walter Gerhard (50), The Wistar Institute, Philadelphia, Pennsylvania 19104 Elizabeth Grabau (59), Department of Biology, University of California at San Diego, La Jolla, California 92093 Thomas Graf (47), Institut für Virusforschung, Deutsche Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900 Heidelberg Federal Republic of Germany Michael Graiser (48), Department of Genetics, Albert Einstein College of Medi- cine, Bronx, New York 10461 Patrick Gray (5, 25), Departments of Biochemistry and Biophysics, University of California, San Francisco, California 94143 Doris Grotkopp (24), Heinrich-Pette-Institute, Martinistrasse 52, 2000 Hamburg 20, Federal Republic of Germany David J. Grunwald (19), McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706 Gordon L. Hager (23), Tumor Virus Genetics Laboratory, National Cancer Insti- tute, N1H, Bethesda, Maryland 20205 H. Hanafusa (42), The Rockefeller University, New York, New York 10021 T. Hanafusa (42), The Rockefeller University, New York, New York 10021 Douglas Hanahan (13), Cold Spring Harbor Laboratories, Cold Spring Harbor, New York 11724 W. S. Haseltine (60), Harvard Medical School, Boston, Massachusetts 02115 Michael J. Hay man (47), Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, P.O. Box 123, London WC2A3PX, England Gary S. Hay ward (4), Department of Pharmacology and Experimental Therapeu- tics, Physiology 314, The Johns Hopkins University School of Medicine, Bal- timore, Maryland 21205 W. S. Hayward (42), The Rockefeller University, New York, New York 10021 Martinez J. Hewlett (63), Department of Cellular and Developmental Biology, Bioscience West, University of Arizona, Tucson, Arizona 85721 Lawrence E. Hightower (52), Microbiology Section, University of Connecticut, Storrs, Connecticut 06268 John Holland (59), Department of Biology, University of California at San Diego, La Jolla, California 92093 CONTRIBUTORS XVll Frans V.d. Hoorn (40), Laboratory of Biochemistry, University of Nijmegen, Nij- megen, The Netherlands J. Peltier Horn (54), Department of Tumor Virology, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 Frank Horodyski (59), Department of Biology, University of California at San Diego, La Jolla, California 92093 D. Hrdy (56), Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115 Chung-H. Hsu (51), Division of Virology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101 Shiu-Lok Hu (31), Cold Spring Harbor Laboratories, Cold Spring Harbor, New York 11724 Alice S. Huang (70), Division of Infectious Diseases, Children's Hospital Medical Center, Boston, Massachusetts 02115 Tony Hunter (43), The Salk Institute, San Diego, California 92138 Linda E. Iverson (7), Tumor Virology Laboratory, The Salk Institute, San Diego, California 92138 Rudolf Jaenisch (24), Heinrich-Pette-Institut, Martinistrasse 52, 2000 Hamburg 20, Federal Republic of Germany Detlev Jahner (24), Heinrich-Pette-Institut, Martinistrasse 52, 2000 Hamburg 20, Federal Republic of Germany Burton Janis (59), Department of Medicine and Microbiology, University of Utah Medical School, Salt Lake City, Utah 84132 Patricia Jelen (19), McArdle Laboratory for Cancer Research, University of Wis- consin, Madison, Wisconsin 53706 Kenneth P. Johnson (64), Department of Neurology, University of California, San Francisco, California 94143 Robert E. Johnston (58), Department of Microbiology, North Carolina State Uni- versity, Raleigh, North Carolina 27650 Wolfgang K. Joklik (11, 71), Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710 Gerald J. Jonak (28), Department of Pathology, Fels Research Institute, Temple University School of Medicine, Philadelphia, Pennsylvania 19104 Charlotte Jones (59), Tumor Virology Laboratory, The Salk Institute, San Diego, California 92138 Matt Jones (40), Department of Biology, University of California at San Diego, La Jolla, California 92093 R. E. Karess (42), The Rockefeller University, New York, New York 10021 Jack D. Keene (11), Department of Microbiology and Immunology, Duke Univer- sity Medical Center, Durham, North Carolina 27710 David W. Kingsbury (51), Division of Virology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101 Naomi Kitamura (9), Department of Microbiology, State University of New York, Stony Brook, New York 11794 Will CONTRIBUTORS David M. Knipe (32), Department of Microbiology and Molecular Genetics, Har- vard Medical School, Boston, Massachusetts 02115 Gebhard Koch (36), Department of Molecular Biology, University of Hamburg, D-2000 Hamburg 13, Federal Republic of Germany M. Koga (62), Institute for Virology, University of Wurzburg, D-8700 Wurzburg, Federal Republic of Germany Hilary Koprowski (50), The Wistar Institute, Philadelphia, Pennsylvania 19104 Christine A. Kozak (14), Laboratory of Viral Diseases, National Institute of Al- lergy and Infectious Diseases, NIH, Bethesda, Maryland 20205 E. L. Kuff (17), National Cancer Institute, NIH, Bethesda, Maryland 20205 Ingrid Kuhlman (30), Institute of Genetics, University of Cologne, Cologne, Fed- eral Republic of Germany Robert L. LaFemina (4), Department of Pharmacology and Experimental Thera- peutics, The Johns Hopkins University School of Medicine, Baltimore, Mary- land 21205 Jeri L. Lane (33), Department of Microbiology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110 Wen-Hwa Lee (45), Department of Molecular Biology, University of California, Berkeley, California 94720 Arnold J. Levine (67), Department of Microbiology, State University of New York, Stony Brook, New York 11794 James B. Lewis (29), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 Joseph K.-K. Li (11), Department of Microbiology and Immunology, Duke Uni- versity Medical Center, Durham, North Carolina 27710 Frank Lilly (18), Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461 D. Linemeyer (37, 41), National Cancer Institute, NIH, Bethesda, Maryland 20205 K. K. Lueders (17), National Cancer Institute, NIH, Bethesda, Maryland 20205 Deidre D. Lyons (54), Department of Tumor Virology, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 Charles H. Madansky (57), Department of Microbiology, University of Massachu- setts Medical School, Worcester, Massachusetts Jacob V. Maizel (8), Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20205 John E. Majors (22), Department of Microbiology and Immunology, University of California, San Francisco, California 94143 James L. Manley (31), Department of Biology, Massachusetts Institute of Technol- ogy, Cambridge, Massachusetts 02139 Michael B. Mathews (29), Cold Spring Harbor Laboratories, Cold Spring Harbor, New York 11724 Kenneth McClain (8), Box 356, Mayo Memorial Hospital, Minneapolis, Minne- sota 55455 CONTRIBUTORS XIX W. L. McClements (39), Laboratory of Molecular Virology, National Cancer Institute, NIH, Bethesda, Maryland 20205 Marcella A. McClure (33), Department of Microbiology and Immunology, Wash- ington University School of Medicine, St. Louis, Missouri 63110 John G. Menke (41), National Cancer Institute, NIH, Bethesda, Maryland 20205 Marnin Merrick (12), Department of Biology, Center for Cancer Research, Mas- sachusetts Institute of Technology, Cambridge, Massachusetts 02139 V. ter Meulen (62), Institute for Virology, University of Wurzburg, D-8700, Würz- burg, West Germany Lois K. Miller (6), Department of Bacteriology and Biochemistry, The University of Idaho, Moscow, Idaho 83843 Nagahiro Minato (59), Department of Microbiology and Immunology, Albert Ein- stein College of Medicine, Bronx, New York 10461 Vikram Misra (61), Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N OWO, Canada S.-M. Mong (54), Department of Tumor Virology, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 D. B. Moore (58), Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27650 Edwin C. Murphy (54), Department of Tumor Virology, M.D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 O. Narayan (60), The Johns Hopkins School of Medicine, Baltimore, Maryland 21205 James C. Neil (44), University of Southern California Medical School, Los Angeles, California 90033 Rainer Neumann (30), Institute of Genetics, University of Cologne, Cologne, Fed- eral Republic of Germany Stephen J. O'Brien (20), Laboratory of Viral Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20205 Michael B. A. Oldstone (65),Department of Immunology, Scripps Clinic and Re- search Foundation, La Jolla, California 92037 A. Oliff (37), Laboratory of Tumor Virus Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20205 M. Oskarsson (39), Laboratory of Molecular Virology, National Cancer Institute, NIH, Bethesda, Maryland 20205 Wolfram Ostertag (36), The Beatson Institute for Cancer Research, Garscube Es- tate, Glasgow G61 1BD, Scotland L. C. Padhy (12), Department of Biology, Center for Cancer Research, Massa- chusetts Institute for Technology, Cambridge, Massachusetts 02139 Bijay K. Pal (20), Department of Pathology, University of Southern California School of Medicine, Los Angeles, California 90033 F. S. Pederson (60), Harvard Medical School, Boston, Massachusetts 02115
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