Animal Cell Technology: Basic & Applied Aspects: Proceedings of the Fourth Annual Meeting of the Japanese Association for Animal Cell Technology, Fukuoka, Japan, 13–15 November 1991 PDF
Preview Animal Cell Technology: Basic & Applied Aspects: Proceedings of the Fourth Annual Meeting of the Japanese Association for Animal Cell Technology, Fukuoka, Japan, 13–15 November 1991
ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS The Fourth Annual Meeting of the Japanese Association for Animal Cell Technology (JAACT'91) JAACT'91 Organizers Meeting Chairman: Hiroki Murakami (Kyushu University) Meeting Secretary: Sanetaka Shirahata (Kyushu University) Program Committee David BARNES Department of Biochemistry and Biophysics, Oregon State University, Oregon, U.S.A. Shun'ichi DOSAKO Technical Research Institute, Snow Brand Milk Products Co., Ltd. Nobuo FUnYOSm Secretary General, Strategy & Planning Research & Development Division, Kyowa HakIm Co., Ltd Kazumori FUNATU Faculty of Engineering, Kyushu University Shuichi HASHIZUME Morinaga Institute of Biological Science Hiroyoshi Hosm Research Institute for the Functional Peptides Wei-ShouHU Department of Chemical Engineering and Materials Science, University of Minnesota, U.S.A. Shuichi KAMINOGAWA Vice-Chairman, Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo Kin'ichi KAWAMURA Komatsugawa Chemical Engineering Co. Ltd. YasuoKITAGAWA Institute for Biochemical Regulation, School of Agriculture, Nagoya University Anthony LUBINIECKI SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, U.S.A. TadaoOHNO Cell Bank, Riken Gene Bank Ryuzo SASAKI Department of Food Science and Technology, Kyoto University Kazuki SlITNOHARA National Food Research Institute, Ministry of Agriculture, Forestry and Fi.sheries Takamoto SUZUKI Pharmace6ii~'~ep~'l~; Kirin Brewery Co., Ltd. Advisory Boards Teruhiko BEPPU Professor, University of Tokyo Hideo ClllBA Professor Emeritus, Kyoto University MasaoFUllMAKI Professor Emeritus, University of Tokyo Fujio ISlITKAW A Executive Director, Japanese Bioindustry Association Kikuo NOMOTO Professor, Kyushu University MichioOISm Professor, University of Tokyo Yoshio OKADA Professor Emeritus, Osaka University Hirohisa OMURA Professor Emeritus, Kyushu University Takashi SUGIMURA President, National Cancer Center Syuichi SUZUKI Professor Emeritus, Tokyo Institute Technology University TomioTADA Professor, University of Tokyo Masaatsu YAMADA Professor Emeritus, University of Tokyo Ishao YAMANE Professor Emeritus, Tohoku University Kunio YAMAUCHI Professor Emeritus, University of Tokyo Animal Cell Technology: Basic & Applied Aspects Proceedings of the Fourth Annual Meeting of the Japanese Association for Animal CeH Technology, Fukuoka, Japan, 13-15 November 1991 Edited by H.MURAKAMI S. SHIRAHATA and H.TACHffiANA Graduate School o/Genetic Resources Technology, Kyushu University, Japan SPRINGER SCIENCE+BUSINESS MEDIA, B.V. ISBN 978-94-010-5263-4 ISBN 978-94-011-2844-5 (eBook) DOI 10.1007/978-94-011-2844-5 Printed on acid-free paper AII Rights Reserved © 1992 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1992 Softcover reprint of the hardcover 1s t edition 1992 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the copyright owner. Contents Preface xiii THE VALUE OF MODELS IN ANIMAL CELL BIOTECHNOLOGY R. E. Spier THE MANZANAR PROJECT -A UNIQUE WAY TO END WORLD HUNGER G. H. Sato 7 I. CELL CHARACTERIZATION AND V ALIDA TION EXPERIENCE IN CELL LINE TESTING W.A. Moore 9 VIRUS REMOVAL AND INACTIVATION IN PROCESS V ALIDA TION S.Manabe 15 MULTILOCUS DNA FINGERPRINTING IN THE ANALYSIS OF CELL STOCKS: STABILITY STUDIES AND APPLICATION TO A WIDE RANGE OF SPECIES G. N. Stacey, B. J. Bolton and A. Doyle 31 ALTERATION OF CELL SURFACE GLYCOPROTEINS THROUGH DIFFERENTIATION FROM A HUMAN HISTIOCYTIC LYMPHOMA CELL LINE, U- 937, TO A MACROPHAGE-LIKE CELL LINE, U-M K. Hata, M. Kobori, Z.-L. Kong and K. Shinohara 41 RE·MOVABILITY OF VIRUS PARTICLES AND PERMEABILITY OF PROTEIN FROM CELL CULTURE MEDIUM USING CUPRAMMONIUM REGENERATED CELLULOSE HOLLOW FIBER (BMMTM) T. Hirasaki, T. Tsuboi, T. Noda, S. Uematsu, G. Ishikawa, A. Kono and N. Yamamoto 49 II. ANIMAL CELL BIOPROCESS ENGINEERING AN EVALUATION OF HYBRIDOMA CELL-SPECIFIC PRODUCTIVITY: PERFUSED IMMOBILIZED, CONTINUOUS SUSPENSION, AND BATCH SUSPENSION CULTURES P. W. Runstadler, S. S. Ozturk, N. G. Ray 57 DYNAMICS OF AGGREGATE CULTURE OF MAMMALIAN CELLS Y.-S. Kyung, M. V. Peshwa, C. M. Perusich and W.-S. Hu 65 vi EFFECT OF PROTEIN ADSORPTION ON CELL ATTACHMENT ON SOLID SURFACES M. Suzuki and Y. Sakai 71 CHARACTERIZA TION OF CELL GROWTH AND IMPROVEMENT OF ATTACHMENT KINETICS ON MACROPOROUS MICROCARRIERS J.-H. Kim, H.-S. Lim and B.-K. Han 77 APPLICATION OF THREE DIMENSIONAL CULTURE OF ADULT RAT HEPATOCYTES IN PUP PORES FOR ARTIFICIAL LIVER SUPPORT SYSTEM H. Ijima, Y. Taniguchi, T. Matsushita and K. Funatsu 81 NOVEL VALIDATION METHOD OF VIRUS-REMOVABILITY FOR BIOLOGICAL CELL CULTURE PRODUCTS USING POLYMERIC MEMBRANE FILTERS H. Nakano, S. Manabe, S. Uematsu, T. Sato, N. Osawa, T. Hirasaki,T. Yamashiki, S. Sekiguchi and N. Yamamoto 87 SELECTIVE FORMATION AND IMMOBILIZATION BY RE-ATTACHMENT OF FLOATING SPHEROIDS OF RAT HEPATOCYTES Y. Sakai and M. Suzuki 103 ENGINEERING OF UL TRAFIL TRA TION HOLLOW FIBER BIOREACTORS FOR MAMMALIAN CELL PROTEIN PRODUCTION A. Y. Patkar, D. G. Taylor, B. D. Bowen and J. M. Piret 109 PRODUCTION OF hEPO BY RECOMBINANT CI27 CELLS USING HOLLOW FIBER CULTURE SYSTEM H. Takasugi, N. Fujikawa and S. Shimizu 115 OSCILLATORY BEHAVIOR IN CONTINUOUS AGGREGATE CULTURES OF MAMMALIAN CELLS H. Vits, M. V. Peshwa and W.-S. Hu 121 DETECTION OF MAMMALIAN CELL ATTACHMENT AND LYSIS ON A METAL SURFACE USING A PIEZOELECTRIC SENSOR D. M. Gryte, M. V. Peshwa, W.-S. Hu and M. D. Ward 129 III. HIGH DENSITY CULTURE AND CELL CULTURE SYSTEM STRATEGIES FOR ECONOMIC GMP PRODUCTION OF MAMMALIAN CELL EXPRESSED PROTEINS F. K. Hofmann 135 USE OF MEDIUM CONCENTRATES TO IMPROVE BIOREACTOR PRODUCTIVITY D. W. Jayme, D. M. Disorbo, J. M. Kubiak and R. M. Fike 143 vii SEPARATION OF ANIMAL CELLS IN CONTINUOF~ CELL CULTURE SYSTEMS S. Apelman 149 AN AUTOMATED SYSTEM FOR HOLLOW FIBER CELL CULTURE S. H. Bond, K. Chaput, S. Downing and C. Pelletier 155 AUTOMATIC SELECTION SYSTEM OF MONOCLONAL ANTIBODY PRODUCING CELLS R. Tanaka, M. Matsuda, H. Takahashi, S. Niwa, Y. Shibata and H. Matsubara 165 CONTINUOUS MONOCLONAL ANTIBODY PRODUCTION BY A COMPOSITE GEL PERFUSION BIOREACTOR IN A PROTEIN-FREE MEDIUM B. Q. Shen, S. Reid and P. F. Greenfield 173 HIGH DENSITY CULTIVATION OF HYBRIDOMA CELLS BY USING PERMEABLE CAPILLARIES I.-H. Kim, B. S. Kim, D. J. Lim, Y. J. Chung and Y. H. Park 179 RECOGNITION AND COUNTING METHOD OF MAMMALIAN CELLS ON MICRO CARRIER USING IMAGE PROCESSING AND NEURAL NETWORK T. Fukuda, H. Ishigami, S, Shiotani, F. Arai, M. Nakajima, H. Asama, T. Nagamune and I. Endo 185 MITOCHONDRIAL GENOME TRANSCRIPTION IN CULTURED ANIMAL CELLS Y. Kitagawa 193 LARGE-SCALE MAMMALIAN CELL CULTURES BY APPLICATION OF MACROPOROUS CELLULOSE CARRIERS M. Ogata, K. Arikawa, H. Matsukura, Y. Yamazaki and A. Suzuki 201 HIGH DENSITY PERFUSION CULTURE OF ANIMAL CELLS USING A NOVEL CONTINUOUS FLOW CENTRIFUGE V.Jager 209 MEMBRANE DIALYSIS BIOREACTOR WITH INTEGRATED RADIAL-FLOW FIXED BED -A NEW CONCEPT FOR CONTINUOUS CULTIVATION OF ANIMAL CELLS R. P6rtner, A. Bohmann and H. Markl 217 EFFECT OF GLUTAMINE SUPPLEMENTATION ON THE GROWTH OF HYBRIDOMA CELLS CULT IV ATED IN A REACTOR COUPLED WITH AN AMMONIA REMOVING SYSTEM F. R. P. Nayve Jr., M. Matsumura and H. Kataoka 225 VIRUS CONTAINMENT CONTINUOUS CULTURE OF ANIMAL CELLS T. Sugahara, T. Noda, T. Tsuboi, T. Hirasaki, N. Yamamoto, S. Sakaeda,and H. Murakami 233 viii A NOVEL BIOREACTOR PROCESS FOR ANCHORAGE-INDEPENDENT ANIMAL CELLS IMMOBILIZED WITHIN POROUS BIOMASS SUPPORT PARTICLES H. Yamaji and H. Fukuda 239 IV. PHYSIOLOGICAL FACTORS FOR CELL GROWTH AND PRODUCTIVITY EFFECTS OF ENVIRONMENTAL PARAMETERS ON CHO CELL GROWTH IN BATCH AND CHEMOSTAT CULTURES AND ON HUMAN IFN-y SYNTHESIS AND FIDELITY A. T. Bull, A. J. Baines, E. M. A. Curling, P. M. Hayter, N. Jenkins, I. Salmon and P. G. Strange 245 DESIGN AND CHARACTERIZATION OF ELECTRIC ALL Y CONTROLLED BIOREACTOR J. Kojima, E. Kobatake, Y. Ikariyama, S. Morioka, K. Nagaike and M. Aizawa 251 MODULATION OF THE PROLIFERATION OF CULTURED HEPATOMA CELLS BY UREA CYCLE-RELATED AMINO ACIDS K. Yagasaki, T. Tanabe, K. Ishihara and R. Funabiki 257 THE EFFECTS OF GLUTAMINE CONCENTRATION ON GROWTH AND MONOCLONAL ANTIBODY PRODUCTION IN FED-BATCH OPERATION T. Omasa, M. Ishimoto, K. Higashiyama, S. Shioya and K. Suga 265 STIMULATION OF ANIMAL CELL METABOLISM BY SHEAR STRESS N. Shiragami, H. Oda, H. Honda and H. Unno 271 EFFECTS OF CONDITIONED MEDIUM ON THE GROWTH KINETICS AND THE MONOCLONAL ANTIBODY PRODUCTIVITY OF HYBRIDOMA CELLS Y. Shirai, T. Yoshimi and K. Hashimoto 279 FACTORS INFLUENCING EXPRESSION AND POST-TRANSLATIONAL MODIFICATION OF RECOMBINANT PROTEIN C T. Sugiura and H. B. Maruyama 287 A SIMPLE AUTOMATIC CONTROL SYSTEM OF PH AND DO T. Yano and Y. Nishizawa 295 V. SERUM FREE CULTURE HYBRIDOMA CULTURE IN IRON-RICH PROTEIN-FREE MEDIUM: CELL GROWTH, APOPTOSIS, AND NATURE OF MACROMOLECULES RECOVERED FROM THE CULTURE FLUID F. Franek, J. Dolnfkova and T. Vomastek 303 ix A NOVEL VERO CELL LINE FOR USE AS A MAMMALIAN HOST-VECTOR SYSTEM IN SERUM-FREE CULTURE T.Ohno 311 SERUM FREE CULTURE OF HUMAN-HUMAN HYBRIDOMA SECRETING MONOCLONAL ANTIBODIES AGAINST STOMACH CANCER A. M. Ali, M. Hayashida, T. Sugahara, K. Akiyama, M. M. Dahan and H. Murakami 321 SERUM-FREE MEDIA FOR THE GROWTH AND MAINTENANCE OF THE DIFFERENTIATED STATE OF KERATINOCYTES, HEPATOCYTES, AND NEURAL CELLS D. W. Jayme, J. P. Daley and P. J. Price 327 CHARACTERIZATION OF AN AIRWAY EPITHELIAL CELL FROM NEONATAL RAT P. E. Roberts, C. Chichester, C. G. Plopper, J. Lakritz, D. M. Phillips and J. P. Mather 335 PRODUCTION OF HUMAN ANTITHROMBIN-III IN A SERUM-FREE CULTURE OF CHOCELLS E. Asakura, T. Yamauchi, Y. Amatsuji, S. Uno, R. Furuta, M. Tsujikawa, T. Tanabe and K. Yokoyama 345 A NOVEL PROTEIN- AND HORMONE-FREE MEDIUM: ITS APPLICATION TO HYBRIDOMA CULTURE AND MONOCLONAL ANTIBODY PRODUCTION K. Inouye, K. Toyoda, M. Kondo and K. Maki 353 EDF (ERYTHROID DIFFERENTIATION FACTOR = ACTIVIN A) PRODUCTION IN RECOMBINANT CHO CELLS N. Koyama, M. Washitake, Y. Takahara and Y. Eto 361 A NOVEL SERUM FREE MEDIUM FOR MOUSE HYBRIDOMAS AND HUMAN L YMPHOBLASTOID CELL LINES T. Tamura, K. Ishii, K. Matsumoto, A. Hamano, H. Kato, J. Hata, S. Yamashita and K. Onodera 369 VI. ENHANCEMENT OF PRODUCTIVITY A SIMPLE STRUCTURED MODEL PREDICTED POSITIVELY -, NEGATIVELY -, OR NON-GROWTH ASSOCIATED ANTIBODY PRODUCTION RATE DEPENDING ON CULTURE CONDITIONS E. Suzuki, K. Takahashi and D. F. Ollis 375 CHANGE IN MONOCLONAL ANTIBODY PRODUCTIVITY IN IMMOBILIZED HYBRIDOMA CELLS AT LOW DISSOLVED OXYGEN CONCENTRATIONS Y. Shirai, K. Hashimoto and L. M. Steele 383 x IMPROVED MONOCLONAL ANTIBODY PRODUCTION OF A HYBRIDOMA BY VARYING THE OXYGEN TENSION DURING A SUSPENSION CULTURE R.-B. Sheu, S. Reid and P. F. Greenfield 391 ENHANCEMENT OF PRODUCTIVITY BY YIELD IMPROVEMENTS USING SIMULATION TECHNIQUES J. P. Barford, P. J. Phillips and C. Harbour 397 STUDIES ON THE PRODUCTION OF RECOMBINANT HUMAN NF-IL6 IN MOUSE LCELL Y. H. Choi, B. S. Kim, T. Kishimoto and C. Y. Choi 405 ENHA..l\lCING EFFECT OF INTERLEUKIN-6 ON ANTIBODY PRODUCTIVITY OF A HYBRIOOMA CELL LINE S. Terada, F. Makishima and H. Takamatsu 41'1 IMPROVED PRODUCTION OF RECOMBINANT PROTEINS BY THE BACULOVIRUS EXPRESSION SYSTEM K. M. Radford, S. Reid and P. F. Greenfield 419 PRODUCTION AND PRODUCT INTEGRITY OF RECOMBINANT HIV -1 gag PARTICLES (P55) WITH THE BACULOVIRUS EXPRESSION SYSTEM S. M. Deutschmann and V. Jager 425 ENHANCEMENT OF BIOLOGICAL PRODUCTIVITY IN SERUM-FREE CULTURE S. A. Weiss, S. F. Gorfien and D. W. Jayme 431 ENHANCEMENT OF IGM PRODUCTION OF HB4C5 CELLS BY CHITOSAN M. Maeda and Y. Mori 439 REPRESSION OF OVALBUMIN GENE EXPRESSION IN THE CHICKEN OVIDUCT CELL T. Muranlatsu and M. M. Sanders 445 CONSTITUTIVE LONG-TERM PRODUCTION OF RECOMBINANT HUMAN INTERFERON-GAMMA BY TRANSFORMED MOUSE C127 CELLS CULTURED IN SERUM FREE MEDIUM E. Sano, R. Sawada, H. Shimizu, Y. Kagawa and S. Kobayashi 453 VII. BIOLOGICAL PROPERTIES OF PROTEINS PRODUCED BY ANIMAL CELLS POSSIBLE INVOLVEMENT OF PROTEIN TYROSINE SULFATION IN THE POLARIZED PROTEIN TARGETING IN FILTER-GROWN MADIN-DARBY CANINE KIDNEY (NU)CK) CELLS M.-C. Liu, I. R. Han and M. Suiko 463
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