Angiotensin II Receptor Blockade Physiological and Clinical Implications

606 Pages·1998·17.835 MB·English

by  Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)

ANGIOTENSIN II RECEPTOR BWCKADE:
PHYSIOLOGICAL AND CLINICAL
IMPLICATIONS
PROGRESS IN EXPERIMENTAL
CARDIOLOGY
Edited by Naranjan S. DhaUa, Ph.D., M.D. (Hon.), D.Se. (Hon.)
1. S. Mochizuki, N. Takeda, M. Nagano, N.S. Dhalla (eels): Volume 1: The Ischemic Heart. 1998.
ISBN 0-7923-8105-X.
2. N.S. Dhalla, P. Zahradka, I. Dixon. R. Beamish (eels): Volume 2: Angiotensin II Receptor
Blockade: Physiological and Clinical Implications. 1998.
ISBN 0-7023-8147-5.
ANGIOTENSIN II RECEPTOR BLOCKADE
PHYSIOLOGICAL AND CLINICAL IMPLICATIONS
Edited by
NARANJAN S. DHALLA, Ph.D., M.D. (Hon.)
Distinguished Professor and Director
MRC Group in Experimental Cardiology
Institute of Cardiovascular Sciences
St. Boniface General Hospital Research Centre
Faculty of Medicine, University of Manitoba
Winnipeg. Canada
PETER ZAHRADKA, Ph.D.
Associate Professor
Institute of Cardiovascular Sciences
St. Boniface General Hospital Research Centre
Faculty of Medicine. University of Manitoba
Winnipeg, Canada
lAN M.C. DIXON, Ph.D.
Assistant Professor
Institute of Cardiovascular Sciences
St. Boniface General Hospital Research Centre
Faculty of Medicine, University of Manitoba
Winnipeg. Canada
ROBERT E. BEAMISH, M.D.
Professor Emeritus
Institute of Cardiovascular Sciences
St. Boniface General Hospital Research Centre
Faculty of Medicine, University of Manitoba
Winnipeg. Canada
~.
"
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data
Angiotensin II receptor blockade: physiological and clinical implications / editors, Naranjan S.
Dhalla ... [et al.].
p. cm.-(progress in experimental cardiology; 2)
"The Manitoba Cardovascular Forum on Angiotensin Receptor Blockade in Winnipeg was
convened October 18-20, 1996"-Pre(
Includes index.
ISBN 978-1-4613-7631-6 ISBN 978-1-4615-5743-2 (eBook)
DOI 10.1007/978-1-4615-5743-2
1. Angiotensin converting enzyme--Inhibitors--Congresses. 2. Angiotensin-
Congresses. 1. Dhalla, Naranjan S. II. Manitoba Cardovascular Forum on Angiotensin Receptor
Blockade (1996: Winnipeg, Man.) III. Series.
[DNLM: 1. Hypertension-drug therapy congresses. 2. Heart Diseases-drug therapy
congresses. 3. Receptors, Angiotensin--antagonists & inhibitors congresses. 4. Angiotensin
II-physiology congresses. 5. Renin-Angiotensin System-physiology congresses.
WG 340 A5885 1998]
RC684.A53A54 1998
616.1 '2061-dc21
DNLM/DLC
for Library of Congress 98-15948
CIP
Copyright © 1998 Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers, New York in 1998
Softcover reprint of the hardcover 1s t edition 1998
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or
ttansmitted in any form or by any means, mechanical, photo-copying, recording, or otherwise, without
the prior written permission of the publisher, Springer Science+Business Media, LLC
Printed on acidjree paper.
CONTENTS
Contributing Authors xi
Dedication xxxv
Preface xli
Acknowledgments xliii
A. PHARMACOLOGICAL INTERRUPTION OF RENIN
ANGIOTENSIN IN HYPERTENSION
1. Pharmacological Interruption of the Renin System and the Kidney:
Lessons from Comparative Pharmacology 3
NORMAN K. HOLLENBERG
2. The Brain Renin-Angiotensin System and Salt-Sensitive Hypertension 15
SHEREENI J. VEERASINGHAM AND FRANS H.H. LEENEN
3. AT! Angiotensin Receptor Blockade and Angiotensin-Converting
Enzyme Inhibition: Effects on Vascular Remodeling
and Endothelial Dysfunction in SHR 33
ERNESTO L. SCHIFFRIN, JIN-s. LI AND ALI M. SHARIFI
4. Cellular Physiology of Angiotensin II Receptors in
Vascular Smooth Muscle Cells 41
P. ZAHRADKA, D. WILSON, L. SAWARD, L. YAU AND P.K. CHEUNG
5. Angiotensin II Enhanced the Expression of Inhibitory Guanine
Nucleotide Regulatory Protein in Vascular Smooth Muscle Cells:
Blockade by AT! Antagonist 51
MADHU B. ANAND-SRIVASTAVA AND ANURADHA PALAPARTI
vi Contents
6. Comparison of the Inhibitory Actions of Angiotensin AT!
Receptor Antagonists in the Peripheral Vascular Bed 65
HUNTER C. CHAMPION, DAVID G. LAMBERT, TRINITY J. BIVALACQUA,
DENNIS B. MCNAMARA AND PHILIP J. KADOWITZ
7. Angiotensin II Receptor Antagonists in Patients
with Renal Failure and on Hemodialysis 87
DONALD ALLAN AND PETER BOLLI
8. The Place of Angiotensin II Antagonists in Relation to
the Canadian Hypertension Society Guidelines 93
S. GEORGE CARRUTHERS
9. Translating Clinical Guidelines for Management of Heart Failure
and Hypertension into Clinical Practice 105
SIMON W. RABKIN
10. Cough Induced by Pharmacological Modulation of the Renin
Angiotensin-Aldosterone System. Angiotensin-Converting Enzyme
Inhibitors and Angiotensin II Receptor Antagonists 115
YVES LACOURCIERE AND JEAN LEFEBVRE
B. ANGIOTENSIN BLOCKADE AND CARDIOVASCULAR DISEASE
11. Angiotensin II Receptors AT! and AT2 : New Mechanisms of
Signaling and Antagonistic Effects of AT! and AT2 129
TADASHI INAGAMI, SATORU EGUCHI, SATOSHI TSUZUKI AND
TOSHIHIRO ICHIKI
12. Angiotensin Receptor Antagonists and Cardiovascular Remodeling 141
K. SABRI, C. CHASSAGNE, B.I. LEVY, J.L. SAMUEL AND L. RAPPAPORT
13. Intersubject Variability in the Pharmacokinetics of Losartan 153
JACQUES TURGEON
14. Functional Analysis of Tissue Renin-Angiotensin
System Using "Gain and Loss of Function" Approaches:
In vivo Test of in vitro Hypothesis 163
RYUICHI MORISHITA, MOTOKUNI AOKI, HIDETSUGU MATSUSHITA,
SHIN-ICHIRO HAYASHI, SHiGEFUMI NAKAMURA, NOBUAKI NAKANO,
TADAHIKO NISHII, KEI YAMAMOTO, NARUYA TOMITA,
ATSUSHI MORIGUCHI, JITSUO HIGAKI AND TOSHIO OGIHARA
15. Exploring the Difference Between Angiotensin-Converting
Enzyme Inhibitors and Angiotensin II Receptor Antagonists.
A Focus on Bradykinin 175
COLIN C. BARNES
16. Role of Cytokines in Septic Cardiomyopathy 185
URSULA MULLER-WERDAN, HElKE SCHUMANN, RALPH FUCHS,
HARALD LOPPNOW, CHRISTOPHER REITHMANN, SUSANNE KOCH,
URSULA ZIMNY-ARNDT, FRITJOF SCHLEGEL, CHANG HE,
DOROTHEA DARMER, PETER JUNGBLUT, JOSEF STADLER,
JURGEN HOLTZ AND KARL WERDAN
Contents vii
17. In Pursuit of Optimal Care and Outcomes for Patients with
Congestive Heart Failure: Insights from the Past Decade 221
TERRENCE MONTAGUE, KOON TEO, LAUREL TAYLOR, FINLAY
MCALISTER, MARGARET ACKMAN AND ROSS TSUYUKI FOR
THE INVESTIGATORS AND STAFF OF THE HEART FUNCTION CLINIC,
UNIVERSITY OF ALBERTA HOSPITALS, AND THE CLINICAL QUALITY
IMPROVEMENT NETWORK (CQIN)
18. Atherosclerosis: Implications of Angiotensin II and the AT-l Receptor 233
M.R. (PETE) HAYDEN AND SURESH C. TYAGI
19. Influence of AT! Receptor Inhibition on Cardiac Function and
Structure of Diabetic Rats 245
PETER ROSEN, CARSTEN HONACK, KARSTEN MiiSSIG,
WILHELM BLOCH AND KLAUS ADDICKS
20. Role of Myocardial Tissue Angiotensin (Ang.) II in Cardiac Pathology 261
J.c. KHATTER, M. PASKVALIN, M. HA, S.D. SETH AND S.B. LAL
C. ANGIOTENSIN BLOCKADE AND CARDIAC HYPERTROPHY
AND HEART FAILURE
21. Mechanical Stress, Local Renin-Angiotensin System and
Cardiac Hypertrophy. An Overview 269
RICKY MALHOTRA AND SEIGO IZUMO
22. Role of Renin-Angiotensin System in Cardiac Hypertrophy and Failure 283
QIMING SHAO, VINCENZO PANAGIA, ROBERT E. BEAMISH
AND NARANJAN S. DHALLA
23. Effect of Angiotensin-Converting Enzyme Inhibition and of Angiotensin II
Receptor Blockade on the Development of Cardiac Hypertrophy in Rats 311
HEINZ-GERD ZIMMER, WOLFGANG ZIERHUT AND MICHAEL IRLBECK
24. Effects of Inhibition of Angiotensin-Converting Enzyme on
Myocardial and Myocyte Remodeling in Chronic Volume
Overload-Induced Cardiac Hypertrophy in the Dog 323
SANFORD P. BISHOP AND LOUIS J. DELL'ITALIA
25. The Site of Angiotensin Generation: Focus on the Heart 345
LARISSA M. DE LANNOY AND A.H. JAN DANSER
26. Angiotensin II-Mediated STAT Signal Transduction: Studies in Neonatal Rat
Cardiac Fibroblasts and CHO-Kl Cells Expressing AT!A Receptors 357
G. JAYARAMA BHAT AND KENNETH M. BAKER
27. Cardiac Angiotensin II Subtype 2 Receptor Signal Transduction Pathways:
Embryonic Cardiomyocytes and Human Heart 367
SIMON W. RABKIN
28. Angiotensin II Stimulates Contractility and C-fos Gene
Expression in Isolated Atrial Human Myocardium 385
STEPHEN WIESE, STEPHEN SCHMIDT-SCHWEDA, ERNST-
MARTIN FiicHTBAUER, FRIEDHELM BEYERSDORF AND CHRISTIAN
HOLUBARSCH
viii Contents
29. Stimulation of the Na+ /Ca2+ Exchanger by Angiotensin II 395
CHERRY BALLARD-CROFT AND STEPHEN SCHAFFER
30. Developmental Regulation of the Cardiac Renin-Angiotensin System:
Expression and Association with Growth and Apoptosis 403
DAVID E. DOSTAL, RACHEL A. HUNT, CHRIS E. KULE AND
KENNETH M. BAKER
31. Angiotensin II-Regulated Apoptosis in Cardiovascular Remodeling 415
MASATSUGA HORIUCHI, HIROYUKI YAMADA,
MASAHIRO AKISHITA AND VICTOR J. DZAU
32. The Role of Angiotensin II in Stretch-Activated Signal Transduction
of the Normal, Hypertrophied, and Failing Adult Heart 423
RICHARD A. WALSH
D. ANGIOTENSIN BLOCKADE AND REMODELING OF
HEART IN MYOCARDIAL INFARCTION
33. Role of Angiotensin II Receptor Blockade During
Remodeling After Myocardial Infarction 437
BODH I. JUGDUTT
34. Local Angiotensin II and Tissue Repair Post-Myocardial Infarction 451
YAO SUN
35. Losartan Pretreatment Inhibits an Early Activation of Matrix
Metalloproteinases in Acute Myocardial Infarction 459
NAOKI MAKINO, KAZUHIRO MASUTOMO, SHOJI OHTSUKA,
MASAHIKO NOZAKI, HIROSUKE MATSUI AND TOMOJI HATA
36. The Role of Angiotensin II in Post-Translational Regulation of
Fibrillar Collagens in Fibrosed and Failing Rat Heart 471
IAN M.C. DIXON, HAISONG JU AND NICOLE L. REID
37. Characteristics and Mechanisms of Angiotensin
II-Related Myocardial Damage 499
JEFFREY R. HENEGAR, GREGORY L. BROWER AND JOSEPH S. JANICKI
38. Comparison of Direct Angiotensin II Receptor Blockade with
Converting Enzyme Inhibition in the Rat Model of Heart Failure 515
EUGENE MORKIN, THOMAS E. RAYA, JAMES J. MILAVETZ,
CYNTHIA S. JOHNSON AND STEPHEN GOLDMAN
39. Effects of Captopril on Myocardial Oxidative
Stress Changes in Post-MI Rats 527
NEELAM KHAPER, MICHAEL F. HILL,
JULIETA PICHARDO AND PAWAN K. SINGAL
40. Role of Angiotensin in Angiogenesis and Cardiac Fibrosis in
Heart Failure 537
SURESH c. TYAGI, MELVIN R. HAYDEN AND JOHN E. HALL
41. Role of Angiotensin II in Myocardial Ischernia/Reperfusion Injury 551
GIUSEPPE AMBROSIO AND ISABELLA TRITTO
Contents ix
42. Effects of Angiotensin II Receptor Antagonist on Cardiac
Remodeling in Cardiomyopathic Hamster Hearts 561
HIDEAKI KAWAGUCHI, MASASHI WATANABE AND
AKIRA KITABATAKE
Index 571
CONTRIBUTING AUTHORS
Margaret Ackman
Division of Cardiology
University of Alberta
Edmonton, AB T6G 2G7
Canada
K. Addicks
Anatomical Institute of the University of Cologne
Joseph-Stelzmann-Str. 9
0-50931 Cologne
Germany
Masahiro Akishita
Cardiovascular Division
Department of Medicine
Brigham and Women's Hospital
Harvard Medical School
75 Francis Street, Thom-12
Boston, MA 02115
USA