Angiogenesis: From the Molecular to Integrative Pharmacology

371 Pages·2000·6.628 MB·English

by  Michael E. Maragoudakis (auth.), Michael E. Maragoudakis (eds.)

ANGIOGENESIS
FROM THE MOLECULAR
TO INTEGRATIVE
PHARMACOLOGY
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAITHA, N. S. Kline Institute for Psychiatric Research
RODOLFO PAOLETII, University of Mi/an
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ANGIOGENESIS
FROM THE MOLECULAR
TO INTEGRATIVE
PHARMACOLOGY
Edited by
Michael E. Maragoudakis
University of Patras Medical School
Patras, Greece
Springer Science+Business Media, LLC
Library of Congress Cataloging-in-Publication Data
Angiogenesis: from the molecular to integrative pharmacology/edited by Michael E.
Maragoudakis.
p. cm.-(Advances in experimental medicine and biology: v.476)
"Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the
Molecular 10 Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece"-T.p. verso
Includes bibliographical references and index.
ISBN 978-1-4613-6895-3 ISBN 978-1-4615-4221-6 (eBook)
DOI 10.1007/978-1-4615-4221-6
1. Neovascularizalion-Congresses. 2. Neovascularization inhibilors-Congresses.
3. Growth factors-Congresses. 1. Maragoudakis, Michael E. II. International
Meeting on Angiogenesis (5th: 1999: Crete, Greece) III. Series.
[DNLM: 1. Angiogenesis Factor-Physiology-Congresses. 2. Cell Transformation,
Neoplastic-Congresses. 3. Neovascularization, Pathologic. 4.
Neovascularization, Physiologic-Drug Effects-Congresses. 5. Signal
Transduction-Congresses. WG 500 A5843 2000]
QPI06.6 .A195 2000
612.l'3-dc21 00-022405
Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to
Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece.
ISSN: 0065-2598
ISBN 978-1-4613-6895-3
©2ooo Springer Science+Business Media New York
Originally published by Kluwer Academic I Plenum Publishers New York in 2000
Softcover reprint of the hardcover 1s t edition 2000
Ali rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by
any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written
permission from the Publisher
PREFACE
Interest in angiogenesis research remains strong in recent years and
hundreds of laboratories around the world are making exciting new
discoveries, about modulators of angiogenesis, their receptors, the
transduction mechanisms, and the angiogenic genes, involved. These
discoveries have increased our understanding of this complex biological
process and provided the basis for many bio-pharmaceutical companies to
start clinical trials with modulators of angiogenesis in oncology and other
clinical conditions.
This monograph contains the contributions to the 5th Biannual
Meeting on "Angiogenesis: From the Molecular to Integrative
Pharmacology", which was held in the island of Crete, Greece, from July
1-7, 1999. This international meeting was aiming to bring together basic
scientists from many disciplines with clinicians in order to exchange ideas,
disseminate new knowledge, establish collaborations, and discuss the
present status and potential new directions in this fast moving area of
biomedical research.
The International Organizing Committee that included Drs. D. Grant,
C. Haudenschild, C. Hellerqvist, P. Lelkes, M. Presta, and D.W.
Thompson, has provided invaluable help with their insightful suggestions
in the formulation of the program for which I am grateful. I wish to thank
all the participants for their enthusiastic participation and their
complementary comments on the success of the conference.
Special thanks are due to the following organizations that
contributed grants for the organization of the meeting, the support of young
scientists, and also for publication of this book: Abbott (Greece),
Boehringer (Greece), Bristol-Myers-Squibb (Greece), Elpen (Greece),
v
VI
EntreMed (USA), Galenica (Greece), Gap (Greece), GenVec (USA),
Glaxo Wellcome (USA), Hoechst Marrion Roussel (Greece), Janssen-Cilag
(Greece), Merck-Vianex (Greece), S~hering Plough (Greece, USA), Sigma
Tau (IT), SmithKline Beecham (USA, Greece), Viannex (Greece).
I am particularly grateful to Mrs. Anna Marmara and Mrs. Georgia
Tziora for their enthusiastic and dedicated work throughout the
organization of the meeting and the editing of this monograph.
Michael E. Maragoudakis (Greece)
CONTENTS
Introductory Comments .•..•..•.••.•••..••••.••••.••.•••••••••.•...•...•.
M.E. Maragoudakis
ANGIOGENIC FACTORS AND THEIR RECEPTORS
Examining New Models for the Study of Autocnne and Paracrine
Mechanisms of Angiogenesis through FGF -Transfected
2
Endothelial and Tumour Cells ..................................... 7
M. Presta, M. Rusnati, P. Dell'Era, E. Tanghetti, C. Urbinati, R.
Giuliani, and D. Leali
Tie-l Receptor Tyrosine Kinase Endodomain Interaction with
SHP2: Potential Signalling Mechanisms and Roles in
Angiogenesis ••••...••...••.•...•...•....••..•..•....•.........•...•.. 35
M. Marron, D. Hughes, M. McCarthy, E. Beaumont, and N.
Brindle
On the Mechanism(s) of Thrombin Induced Angiogenesis •...••.••• 47
M.E. Maragoudakis and N.E. Tsopanoglou
Endothelial Receptor Tyrosine Kinases in Involved Blood Vessel
Development and Tumor Angiogenesis........ ••• .............. 57
G. Breier
Ontogeny of the Endothelial System in the Avian Model .•.•••• ••••• 67
L. Pardanaud and F. Dieterlen-Lievre
Vll
Vlll
REGULATION OF ANGIOGENESIS AND TRANSDUCTION
MECHANISMS INVOLVED
The Role of Pericytes in Controlling Angiogenesis In Vivo......... 81
S. Egginton, A-L. Zhou, M.D. Brown, and O. Hudlicka
Insights into the Vasodilation of Rat Retinal Vessels Evoked by
Vascular Endothelial Growth Factor (VEGF 101
121 l2l) ••••••••••••
H.M. Hassessian
Signal Transduction and Transcriptional Regulation of
Angiogenesis ............................................................... 109
Y. Sato, M. Abe, K. Tanaka, C. Iwasaka, N. Oda, S. Kanno,
M. Oikawa, T. Nakano and T. Igarashi
Differential Contribution of Bradykinin Receptors in Angiogenesis 117
L. Morbidelli, A. Parenti, S. Donnini, H. Granger, F. Ledda,
and M. Ziche
Sensitivity of Different Vascular Beds in the Eye to
Neovascularization and Blood-Retinal Barrier Breakdown in
VEGF Transgenic Mice ............................................. 129
S.A. Vinores, N.L. Derevjanik, M.A. Vinores, N. Okamoto,
and P .A. Campochiaro
Revascularization of Ischemic Tissues with SIKVA V and
Neuropeptide Y (NPY) .............................................. 139
D.S. Grant and Z. Zukowska
Cellular Effects and Signalling Pathways Activated by the Anti-
Coagulant Factor, Protein S, in Vascular Cells .................. 155
C. Kanthou and o. Benzakour
ROLE OF EXTRACELLULAR MATRIX AND ADHESION
MOLECULES IN ANGIOGENESIS
Targeting Integrins a b and ab for Blocking Tumor-Induced-
v 3 v 5
Angiogenesis ........................................................... 169
C. Kumar, L. Armstrong, Z. Yin, M. Malkowski, E.
Maxwell, He. Ling, B. Yaremko, M. Liu., J. Varner, E.M.
Smith, B. Neustadt, and T. Nechuta
IX
Suppression of Human Microvascular Endothelial Cell Invasion
and Morphogenesis with Synthetic Matrixin Inhibitors..... ... 181
M-C Jia, M.A. Schwartz, and Q.x. Sang
INHIBITORS OF ANGIOGENESIS AND THEIR MECHANISMS OF
ACTION
Tunicamycin Inhibits Capillary Endothelial Cell Proliferation by
Inducing Apoptosis •••..••..•...............•.••.••••.•••••••.•••... 197
J.A. Martinez, I. Torres-Negron, L.A. Amigo, R.A. Roldan, A.
Mendez, and D.K Banerjee
The Characterization of Angiogenesis Inhibitor from Shark
Cartilage •••......••••••••••.•••.••••••.••.••••••.••.••••.•••.....•• .... 209
J. H. Liang and KP. Wong
Quantitatlve Assays for the Chick Chorioallantoic Membrane ••••.• 225
D.W. Thompson and A. Reid
ANGIOGENESIS AND MALIGNANT TRANSFORMATION
MYCN Oncogene and Angiogenesis: Down-Regulation of
Endothelial Growth Inhibitors in Human Neuroblastoma Cell 239
E. Hatzi, S. Breit, A. Zoephel, K Ashman, U. Tontsch, H.
Ahorn, C. Murphy, L. Schweigerer, and Th. Fotsis
From Hyperplasia to Neoplasia and Invasion: Angiogenesis in the
Colorectal Adenoma -Carcinoma Model ...•..••..•••••.••.••••. 249
L. Kaklamanis, S. Kakolyris, M. Koukourakis, K. Gatter, and
A. Harris
Tumor Angiogenesis, Macrophages, and Cytokines .................. 267
H. Bando and M. Toi
Microvessel Density, Thymidine Phosphorylase Expression, and
Resistance of Head and Neck Cancer to Chemo-Radiotherapy 285
M. Koukourakis
x
Differential Expression of Angiogenic and of Vascular Survival
Factors in Non-Small Cell Lung Cancer (NSCLC) .............. 291
A. Gatromanolaki
Thymidine Phosphorylase Activity in Normal, Hyperplastic and
Neoplastic Endometrium-Correlation with Intratumoral
Angiogenesis.......................................................... 297
E. Sivridis
PRECLINICAL DEVELOPMENTS OF ANGIOGENESIS
INIDBITORS
Inhibition of VEGF Signal Transduction............................... 307
S. Wedge and D. Ogilvie
Combretastatins: Novel Vascular Targeting Drugs for Improving
Anti-Cancer Therapy ................................................. 311
M. Horsman, R. Murata, T. Breidahl, F. Nielsen, R. Maxwell,
H. St0kilde-J0rgensen, and J. Overgaard
CLINICAL APPLICATIONS
Therapeutic Angiogenesis for Ischemic Heart Disease ......•.... .•.. 327
A. Helisch and J.A. Ware
ABSTRACTS OF POSTERS ••..•.......•........................ ••.... 351
PARTICIPANTS' PHOTO ............................................ 375
LIST OF PARTICIPANTS ..•..•.••...•..••••...••.••......•.....••..•• 377
INDEX .. ...•..•.. ..•...•.....•.. ....•.•.•. ...•...•. .... .•.••....•.•••••••••• 381