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Anemia of Chronic Disease - G. Weiss, et. al., (CRC, 2005) WW PDF

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BASIC AND CLINICAL ONCOLOGY Editor Bruce D. Cheson, M.D. National Cancer Institute National Institutes of Health Bethesda, Maryland 1. Chronic Lymphocytic Leukemia: Scientific Advances and Clinical Devel- opments, edited by Bruce D. Cheson 2. Therapeutic Applications of Interleukin-2, edited by Michael B. Atkins and James W. Mier 3. Cancer of the Prostate, edited by Sakti Das and E. David Crawford 4. Retinoids in Oncology, edited by Waun Ki Hong and Reuben Lotan 5. Filgrastim (r-metHuG-CSF) in Clinical Practice, edited by George Morstyn and T. Michael Dexter 6. Cancer Prevention and Control, edited by Peter Greenwald, Barnett S. Kramer, and Douglas L. Weed 7. Handbook of Supportive Care in Cancer, edited by Jean Klastersky, Stephen C. Schimpff, and Hans-Jörg Senn 8. Paclitaxel in Cancer Treatment, edited by William P. McGuire and Eric K. Rowinsky 9. Principles of Antineoplastic Drug Development and Pharmacology, edited by Richard L. Schilsky, Gérard A. Milano, and Mark J. Ratain 10. Gene Therapy in Cancer, edited by Malcolm K. Brenner and Robert C. Moen 11. Expert Consultations in Gynecological Cancers, edited by Maurie Markman and Jerome L. Belinson 12. Nucleoside Analogs in Cancer Therapy, edited by Bruce D. Cheson, Michael J. Keating, and William Plunkett 13. Drug Resistance in Oncology, edited by Samuel D. Bernal 14. Medical Management of Hematological Malignant Diseases, edited by Emil J Freireich and Hagop M. Kantarjian 15. Monoclonal Antibody-Based Therapy of Cancer, edited by Michael L. Grossbard 16. Medical Management of Chronic Myelogenous Leukemia, edited by Moshe Talpaz and Hagop M. Kantarjian 17. Expert Consultations in Breast Cancer: Critical Pathways and Clinical Decision Making, edited by William N. Hait, David A. August, and Bruce G. Haffty 18. Cancer Screening: Theory and Practice, edited by Barnett S. Kramer, John K. Gohagan, and Philip C. Prorok 19. Supportive Care in Cancer: A Handbook for Oncologists: Second Edi- tion, Revised and Expanded, edited by Jean Klastersky, Stephen C. Schimpff, and Hans-Jörg Senn 20. Integrated Cancer Management: Surgery, Medical Oncology, and Radiation Oncology, edited by Michael H. Torosian 21. AIDS-Related Cancers and Their Treatment, edited by Ellen G. Feigal, Alexandra M. Levine, and Robert J. Biggar 22. Allogeneic Immunotherapy for Malignant Diseases, edited by John Barrett and Yin-Zheng Jiang 23. Cancer in the Elderly, edited by Carrie P. Hunter, Karen A. Johnson, and Hyman B. Muss 24. Tumor Angiogenesis and Microcirculation, edited by Emile E. Voest and Patricia A. D’Amore 25. Controversies in Lung Cancer: A Multidisciplinary Approach, edited by Benjamin Movsas, Corey J. Langer, and Melvyn Goldberg 26. Chronic Lymphoid Leukemias: Second Edition, Revised and Expanded, edited by Bruce D. Cheson 27. The Myelodysplastic Syndromes: Pathology and Clinical Management, edited by John M. Bennett 28. Chemotherapy for Gynecological Neoplasms: Current Therapy and Novel Approaches, edited by Roberto Angioli, Pierluigi Benedetti Panici, John J. Kavanagh, Sergio Pecorelli, and Manuel Penalver 29. Infections in Cancer Patients, edited by John N. Greene 30. Anemia of Chronic Disease, edited by Günter Weiss, Victor R. Gordeuk, and Chaim Hershko ADDITIONAL VOLUMES IN PREPARATION Published in 2005 by CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW Boca Raton, FL 33487-2742 © 2005 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8247-5972-9 (Hardcover) International Standard Book Number-13: 978-0-8247-5972-8 (Hardcover) This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC) 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Catalog record is available from the Library of Congress Taylor & Francis Group is the Academic Division of T&F Informa plc. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com 3050_Discl Page 1 Wednesday, February 2, 2005 2:02 PM Contents Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii Introduction: Anemia of Chronic Disease: The Enigma and the Challenge Chaim Hershko, Victor R. Gordeuk and Gu€nter Weiss . . xvii PART I: BASICS 1. Regulation of Iron Metabolism . . . . . . . . . . . . . 1 Kostas Pantopoulos Biology of Iron . . . . 1 Iron’s Toxicity . . . . 3 Iron Distribution in the Body . . . . 5 Biomedical Aspects of Iron Metabolism . . . . 5 Mechanisms for Dietary Iron Absorption and Erythroid Iron Utilization . . . . 8 Regulation of Dietary Iron Absorption and Erythroid Iron Utilization . . . . 13 Cellular Iron Uptake . . . . 17 Intracellular Iron Storage . . . . 22 iii

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