andrology

122 Pages·2015·1.31 MB·English

ANDROLOGY
ISSN:2047-2919
WELCOME
OnbehalfoftheEuropeanAcademyofAndrology(EAA),welookforwardtoyourparticipationatthe8thEuropeanCon-
gressofAndrology(ECA2014)thatwillbeheldinBarcelonafrom15thto17thOctober,2014.Wehopeitwillbeamemora-
bleeventforallmembersoftheEAAandallprofessionalsengagedinthisfieldwhodecidedtojoinus.
The excellent scientific programme provides a forum for specialists to encourage discussion about the latest develop-
mentsinmalereproduction,onco-andrology,andro-genetics,maleandfemalesexualdysfunction,sexualtransmitteddis-
easesandsomeaspectsofandrologicalsurgery.Theprogrammeincludesplenarylecturesandoffersamultidisciplinary
platformforfurtheringourunderstandingofmen’ssexualandreproductivehealth.Weareconfidentthatthemeetingwill
beofmajorscientificinterest.
Asinthepreviousedition,ECA2014,togetherwiththeEuropeanSchoolofUrology(ESU)andtheEuropeanSocietyof
AndrologicalUrology(ESAU),hasorganizedthreecoursesfocusingonthesurgicalaspectsofNOA,varicoceleandPeyronie
disease.Inaddition,onOctober15thaPost-graduateCoursedealingwith‘StandardcareanddiagnosticproceduresinAn-
drology’willtakeplace.
WearewarmlywelcomingyoutoBarcelona!
OsvaldoRajmil CsillaKrausz
ChairoftheLOC ChairofthePOC
(LocalOrganisingCommittee) (ProgrammeOrganisingCommittee)
Andrology is the meeting point of many medical and veterinary specialties. It is also a
homeforthosewhoworkinthefieldofstemcellsandreproductivebiology.Wefacemany
challengesinmalereproductivehealth,suchasinfertility,lackofmalecontraceptives,male
sexual problems, secondary effects of cancer treatment and many more. We need a wide
frontofresearchersandclinicianswhotackletheandrologicalproblemsingoodcollabora-
tion.EuropeanAcademyofAndrologywantstogiveaforumforthisaction,andEuropean
Congress of Andrology in Barcelona will be the place to meet this year. Local organizers
andtheprogrammeorganizingcommitteehavecreatedawonderfulopportunityforusto
cometogethertopushandrologyforwardwithgreatscienceandgoodspirit.Onbehalfof
theEuropeanAcademyofAndrologyIwanttowelcomeyoutojoinusinBarcelona.
JormaToppari
PresidentoftheEuropean
AcademyofAndrology
©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology Andrology,2014,2(Suppl.2),1–3 1
PROGRAMMEORGANISING COMMITTEE
Chairperson StefanArver JacquesAuger AndreaIsidori
CsillaKrausz Sweden France Italy
Italy
NielsJoergensen WolfgangWeidner
RafelOliva
Denmark Germany
Spain
LOCALORGANISINGCOMMITTEE
OsvaldoRajmil Llu(cid:1)ısBassas PedroGuttie(cid:1)rez EduardRuiz-Castan~(cid:1)e
Barcelona Barcelona SantaCruzdeTenerife Barcelona
2 Andrology,2014,2(Suppl.2),1–3 ©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology
EXECUTIVECOUNCILOFFICERS
JormaToppari MarioMaggi HermannM.Behre
President Secretary Treasurer
EXECUTIVECOUNCILMEMBERS
GertDohle EmmanueleJannini OsvaldoRajmil DimitriosG.Goulis
EXOFFICIO
FrederickCWWu EwaRajpert-DeMeyts
PastPresident AndrologyEditor
©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology Andrology,2014,2(Suppl.2),1–3 3
ABSTRACTS ISSN: 2047-2919
8thEUROPEANCONGRESSOFANDROLOGY
PRE-CONGRESSEVENTS
15October2014
Post-GraduateCourse:StandardCareinAndrology
Chairpersons:C.Krausz(Italy)andO.Rajmil(Spain)
09:00–09:20 Semenparameters:whatisthenormalrange?
N.Jorgensen(Denmark)
09:20–09:40 Semenanalysesaccordingto2010WHOguidelines:meritsandlimits
J.Auger(France)
09:40–09:50 Discussion
09:50–10:10 Imagingofthemalereproductivetract:towardsstandardization
F.Lotti(Italy)
10:10–10:30 Novelimagingmodalitiesfortesticulartumors
A.Isidori(Italy)
10:30–10:40 Discussion
10:40–11:00 Coffeebreak
11:00–11:20 Genetictesting:thenewEAA/EMQNGuidelinesforAZFdeletions
C.Krausz(Italy)
11:20–11:40 Genetictesting:karyotypeanomaliesandspermFISHanalysis
R.OlivaandM.Codina(Spain)
11:40–12:20 Pre-ARTstandarddiagnosticworkupof:
-TheAzoospermicman
L.Bassas(Spain)
-TheOligozoospermicman
J.L.Ballesca(Spain)
12:20–12:30 Discussion
12:30–12:50 Testosteronemeasurement:whatisthenormalrange?
F.Wu(UK)
12:50–13:10 Standarddiagnosticworkupinerectileandejaculatorydysfunction
S.Arver(Sweden)
13:10–13:20 Discussion
13:20–13:30 ClosingRemarks
AMSSymposium
Chair:E.Ruiz-Castan~(cid:2)e (Spain)
09:00–09:10 Welcomingremarks
E.Ruiz-Castan~(cid:2)e(Spain)
09:10–09:30 Lastgenerationonpenileprostheses
J.I.Mart(cid:2)ınez(Spain)
09:30–09:50 Strategiestoavoidcomplications
J.Sarquella(Spain)
09:50–10:20 Penileimplanttechniques.Tipsandtricks
C.Bettocchi(Italy)
10:20–10:30 Coffeebreak
10:30–11:10 Othercontingencies.Options
E.LLedo(cid:2) (Spain)
11:10–11:40 SurgicaloptionsinLaPeyronieDisease
O.Shaeer(Egypt)
11:40–12:30 Paneldiscussionandclosingremarks
4 Andrology,2014,2(Suppl.2),4–9 ©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology
ECACONGRESS
ECAMAINPROGRAMME
15October2014
15:15–16:15 WELCOMECEREMONY
16:15–17:00 PlenaryI:
Chairperson:J.Toppari(Finland)
Testicularcancer:fateorbadluck.
E.Rajpert-DeMeyts(Denmark)
PARALLELSESSIONS
ECAI:Sexualdevelopmentandgenderidentity
Chairpersons:G.Forti(Italy)andG.Haidl(Germany)
17:00–17:30 Sexdifferentiationandthebrain:relationtogenderidentity,sexualorientation
D.Swaab(TheNetherlands)
17:30–18:00 Hormonaltreatmentingenderdysphoria.
G.T’Sjoen(Belgium)
18:00–18:30 Longtermoutcomeofgenderdysphoria
C.Dhejne(Sweden)
ECAselectedoralI:Goldenpresentations
Chairpersons:A.Meinhardt(Germany)andO.Rajmil(Spain)
17:00–17:20 MutationsinanX-Linkedgeneareacommoncauseofmeioticarrestand
azoospermia.
A.N.Yatsenko(USA)
17:20–17:40 Differentialeffectsofperinatal,prepubertalorconceptiontoadulthoodexposures
toalowdosemixtureofgenisteinandvinclozolinonthegenitaltractand
testiculargeneexpressionintheexposedgenerationandtheunexposedprogeny.
F.Eustache(France)
17:40–18:00 Evaluationofintratesticularperfusionbycolor-codedduplexsonography(CCDS)in
TESE-patientswithazoospermia:aprospectivestudy.
B.Altinkilic(Germany)
18:00–18:20 Associationbetweenendogenoustestosterone(T)levels,sexualdysfunctionand
PDE-5inhibitor(PDE5i)useintheregistryofhypogonadisminmen(RHYME).
G.Rastrelli(Italy)
BayerSymposium
CardiovascularRisk:aConcernfortheAndrologist?
Chairperson:M.Maggi(Italy)
17:00–17:30 Effectsoflong-termtestosteronetreatmentinobesemenwithandwithouttype2
diabetes.
F.Saad(Germany)
17:30–18:00 Testosteroneandcardiovascularrisk–whatistheevidence?
M.Maggi,(Italy)
18:00–18:30 ErectileDysfunctionasacardiovascularriskmarkerandpredictorofpoorqualityof
life.
E.Garc(cid:2)ıa–Cruz(Spain)
18:30–19:30 POSTERGUIDEDTOUR:
Chairpersons:L.Bassas(Spain),C.Boitani(Italy),G.Corona(Italy),J.Erenpreiss(Latvia),
M.Gonzalez-Fernandez(Spain),Zs.Kopa(Hungary),H.C.Schuppe(Germany),O.Shaeer(Egypt)
andJ.Slowikowska-Hilzer(Poland)
19:30–21:00 WELCOMERECEPTION
16October2014
09:00–9:45 PlenaryII:
Chairperson:E.Baldi(Italy)
ASAExchangeLecture:FromtheEpydidimistotheEgg.
P.Cuasnicu(Argentina)
(continued)
©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology Andrology,2014,2(Suppl.2),4–9 5
ECACONGRESS
09:45–10:15 Coffeebreak
PARALLELSESSIONS
ECA2.MaleSexuality
Chairpersons:H.Behre(Germany)andG.Papp(Hungary)
10:15–10:45 PDE5iortestosterone:whichisthefirstinandrologicalclinicalpractice.
E.Jannini(Italy)
10:45–11:15 Anewviewonlifelongprematureejaculation:erectiopraecox,ejaculatiopraecox
anddetumescentiapraecox
M.D.Waldinger(TheNetherlands)
11:15–11:45 Hypersexuality.
K.Go€rtsO€berg(Sweden)
ECASelectedOralII:Spermatology
Chairpersons:D.Goulis(Greece)andS.Francavilla(Italy)
10:15–10:30 Characterizationandkineticofthehumanspermatogonialcompartment.
EVicini(Italy)
10:30–10:45 InvestigationontheoriginofspermDNAfragmentation:roleofapoptosis,
immaturityandoxidativestress.
E.Baldi(Italy)
10:45–11:00 Routineuseofflowcytometryforcountinghumanspermatozoaandroundcells:
lessonsfroma5-yearexperiencerepresentingmorethan20.000analyses.
J.Auger(France)
11:00–11:15 Influencesofage,daysofabstinence,andBMIonresultsofsemenanalysisfrom
Swedishmenofsub-fertilecouples.
J.N.Flanagan(Sweden)
11:15–11:30 Glycationadductsinspermandactivinregulationofinflammationinducedby
diabetes.
C.Maresch(Germany)
EAA/ESAU/ESUCourse:SpermRetrievalinnon-obstructiveAzoospermia.
Chairperson:E.Ruiz-Castan~(cid:2)e(Spain)
10:15–10:45 Clinicaldiagnosticsandprognosticfactorsforspermretrieval.
Zs.Kopa(Hungary)
10:45–11:15 SurgicaltreatmentofKlinefelterpatients.
H.Tournaye(Belgium)
11:15–11:45 Surgicaltreatment(M-TESE).
W.Weidner(Germany)
11:45–12:45 POSTERGUIDEDTOUR
Chairpersons:Chairs:L.Bassas(Spain),C.Boitani(Italy),G.Colpi(Italy),J.Ramalho-Santos
(Portugal),A.Giwercman(Sweden),O.Shaeer(Egypt)andJ.Erenpreiss(Latvia)
12:45–14:00 LUNCH
MenariniSymposium
Understandingprematureejaculation.Anewapproachtotheanatomy,
neurophysiologyandtreatment
Chairperson:A.Ferna(cid:2)ndez-Lozano(Spain)
12:45–13:05 Theroleofanatomyonprematureejaculation.
F.Giuliano(France)
13:05–13:25 Adifferentlookattheneurophysiology.
M.Waldinger(TheNetherlands)
13:25–13:45 What’snewonprematureejaculationtreatment?
A.Ferna(cid:2)ndezLozano(Spain)
13:45–14:00 Discussion
PARALLELSESSIONS
ECA3.Prostate:newsandviews
Chairpersons:J.Palou(Spain)andM.Maggi(Italy)
14:00–14:30 Associationsbetweenprostatepathologiesandsexualdysfunction
F.Wagenlehner(Germany)
14:30–15:00 BenignProstatichyperplasia:anewmetabolicsyndrome-relateddisease.
L.Vignozzi(Italy)
(continued)
6 Andrology,2014,2(Suppl.2),4–9 ©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology
ECACONGRESS
15:00–15:50 Facetofaceonprostatecancerscreening:PSAversusnovelbiomarkers.
M.Roobol(TheNetherlands)andM.Lazzeri(Italy)
ECA4.BoneTestiscrosstalk
Chairperson:N.Joergensen(Denmark)
14:00–14:30 VitaminDandmalereproduction.
M.BlombergJensen(Denmark)
14:30–15:00 Testisversusbone.
A.Ferlin(Italy)
ECASelectedOralIII:ReproductiveHealth
Chairpersons:M.Punab(Estonia)andG.Balercia(Italy)
15:00–15:15 SpermDNAdamagesafterchemotherapyorradiotherapyfortesticularcancer.
N.Rives(France)
15:15–15:30 Prenatalphthalateexposureandreproductiveindicesinadolescentmales.
J.Axelsson(Sweden)
15:30–15:45 Doesreproductivetractinflammationmediatereproductivedysfunctioninmales
withthemetabolicsyndrome?
K.Leisegang(SouthAfrica)
ESU/ESAU/EAACourse:Peyronie’sDisease
Chairperson:E.Meuleman(theNetherlands)
14:00–14:30 Pathophysiologyanddiagnosticmanagement.
F.Fusco(Italy)
14:30–15:00 Drugtreatmentandothernon-operativetherapy.
D.Ralph(UK)
15:00–15:30 Surgicaltreatment.
E.Meuleman(TheNetherlands)
15:50–16:00 “Andrology”AwardCeremony
Chaipersons:E.RajpertDeMeyts(Denmark)andD.Carrell(USA)
“HormonesuppressionwithGnRHantagonistpromotesspermatogenicrecovery
fromtransplantedspermatogonialstemcellsinirradiatedcynomolgusmonkeys”
M.L.Meistrich(USA)
16:00–16:35 PlenaryIII
Chairperson:C.Krausz(Italy)
Thebrightsideofthemalegamete:thetelomerelength
A.Aviv(USA)
16:35–16:55 Coffeebreak
PARALLELSESSIONS
ECA5.ImaginginAndrology
Chairperson:A.Isidori(Italy)
16:55–17:30 Imagingofthemalegenitaltract:2014update.
F.Lotti(Italy)
17:30–18:10 Pictorialreviewofcutaneousgenitallesions.
A.Vives(Spain)
ECA6.FrombasictoClinicalAndrology
Chairpersons:R.Oliva(Spain)andG.Mieusset(France)
16:55–17:25 Profilinghumansperm:fromfunctionalstudiestoomicsanalyses,andbackagain.
J.Ramalho-Santos(Portugal)
17:25–17:55 Intra-testicularcellulardynamicsandregulationofLeydigcellfunction.
P.O’Shaughnessy(UK)
17:55–18:10 SelectedOralpresentation:Serumdelta4pathwaysteroidsprofilingbyisotopic
diluition-liquidchromatography-massspectrometry(ID-LC-MS/MS)afterhuman
chorionicgonadotropin(HCG)stimulationinmenwithklinefelter’ssyndrome(KS)
andineugonadiccontrols(ec).
S.Belli(Italy)
ECASelectedOralIV:Infertility
Chairs:K.Kula(Poland)andJ.Hera(cid:3)cek(CzechRepublic)
16:55–17:10 InhibinBasamarkerofsuccessaftervaricocelectomyinsevereoligozoospermia.
A.Khelaia(Georgia)
(continued)
©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology Andrology,2014,2(Suppl.2),4–9 7
ECACONGRESS
17:10–17:25 Motilespermcount,DNAfragmentationandmitochondrialmembranepotential
arenotusefulinpredictingintrauterineinseminationformixedindications:a
prospectivestudy.
B.Zorn(Slovenia)
17:25–17:40 Subcapsularorchiectomyasanalternativemethodforidentificationandisolation
oftesticularspermfrommenwithKlinefelter’ssyndrome.
J.Fedder(Denmark)
17:40–17:55 Geneexpressionanalysisofhumanspermneedsdifferentialnormalizers.
M.Barragan(Spain)
17:55–18:10 Evaluationoftesticularbiopsiesfrominfertilemen:correlationsbetween
histopathology,protaminemRNAexpression,andspermretrieval
H-CSchuppe(Germany)
18:10–19:30 EAAGENERALASSEMBLY
20:30–23:00 CONFERENCEDINNER
17October2014
PARALLELSESSIONS
ECA7.AndrogensandHypogonadism
Chairs:S.Arver(Sweden)andF.Wu(UK)
8:45–9:15 AbuseofAndrogens.
E.Nieschlag(Germany)
9:15–9:45 Thevulnerableuremicman-roleofhypogonadism.
P.Stenvinkel(Sweden)
9:45–10:00 SelectedOralpresentation:Novelproteomicbiomarkersofandrogendeficiencyfrom
seminalplasmaprofilingusinghigh-resolutionmassspectrometry.
G.Grande(Italy)
10:00–10:15 SelectedOralpresentation:Testosteronesupplementationandsexualfunction:ameta-
analysisstudy.
G.Corona(Italy)
ECA8.SessionoftheINYRMF
Chairs:C.Chianese(Italy)andJ.Castillo(Spain)
8:45–9:15 Pharmacogeneticsinmaleinfertility:whataboutpersonalisedFSH-treatmentin
2014?
F.Tuettelmann(Germany)
9:15–9:30 SelectedOralpresentation:High-resolutionprofilingofnoveltranscriptionalevents
duringhumanspermatogenesis.
F.Chalmel(France)
9:30–9:45 SelectedOralpresentation:Whyaresomehumanspermimmotile?Adifferential
proteomicsapproach.
9:45–10:00 C.Paiva(Spain)
SelectedOralpresentation:ExpressionoffunctionalhistamineH4receptorsinmurine
andhumanLeydigtumorcells.
C.Mondillo(Argentina)
10:00–10:15 SelectedOralpresentation:Differentialactivationofinflammatorypathwaysin
testicularmacrophagesprovidesarationalefortheirsubduedinflammatory
capacity.
S.Bhushan(Germany)
ESU/ESAU/EAACourse:Varicocele
Chairperson:W.Weidner(Germany)
8:45–9:15 Roleininfertilityandclinicaldiagnosis.
N.Sofikitis(Greece)
9:15–9:45 Surgicaltherapy.
G.Dohle(TheNetherlands)
(continued)
8 Andrology,2014,2(Suppl.2),4–9 ©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology
ECACONGRESS
9:45–10:15 Sclerozationandembolization.
C.Bettocchi(Italy)
PARALLELSESSIONS
ECA9.InfertilityI:DrugsandReproductiveHealth
Chair:J.Auger(France)andM.Simoni(Italy)
10:15–10:40 Theheadacheofanalgesicsduringpregnancyandthefetalreproductivesystem:
howandwhy.
B.J(cid:2)egou(France)
10:40–11:05 Commondrugintakeandhumanspermatogenesis
A.Giwercman(Sweden)
11:05–11:30 Lateconsequencesofchildhoodandadolescencecancertreatment
G.Dohle(TheNetherlands)
ECA10.InfertilityII:GeneticsandEpigenetics
Chairpersons:A.Calogero(Italy)andY.Giwercman(Sweden)
10:15–10:40 Thespermepigenome.
D.Carrell(USA)
10:40–11:05 Spermnuclearproteomeanditsepigeneticpotential.
J.Castillo(Spain)
11:05–11:20 SelectedOralpresentation:Xchromosome-linkedCNVsinmaleinfertility:discoveryof
overallduplicationloadandrecurrent,patient-specificgainswithpotential
clinicalrelevance.
C.Chianese(Italy)
11:20–11:35 SelectedOralpresentation:ImpairmentofDAZ-AZFcgeneexpressioninpostmeiotic
humanmalegermcellsofmenwithseverehypospermatogenesis.
P.H.Vogt(Germany)
ECASelectedOralV:SexualDysfunction
Chair:P.Guti(cid:2)errez(Spain)andK.Shaeer(Egypt)
10:15–10:30 Developmentofsecondaryhypogonadisminagingmen:riskfactorsandclinical
picture:longitudinalresultsfromtheEuropeanMaleAgingStudy(EMAS).
G.Rastrelli(Italy/UK)
10:30–10:45 Mechanismofestrogen-orantiandrogen-inducedpenilemaldevelopment.
H.Goyal(USA)
10:45–11:00 Tadalafilamelioratesmetabolicsyndrome-inducedalterationsinvisceraladipose
tissueandliver:anexperimentalstudyintherabbit.
L.Vignozzi(Italy)
11:00–11:15 Sub-albugineanadipocyteaccumulationisassociatedwitherectiledysfunction:
firstclinicalevidenceandpathophysiologicalimplications.
J.I.Vinay(Chile)
11:15–11:30 Penileenlargementandaugmentation:411cases.
M.Rossello(cid:2)Gaya(cid:2)(Spain)
11:40–12:15 BRUNCH
12:15–13:00 Plenary4.
Chair:S.Schlatt(Germany)
Spermatogonialstemcellpreservationandtransplantationanno2014:whatevery
clinicianshouldknow.
H.Tournaye(Belgium)
13:00–13:15 ClosingRemarks
©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology Andrology,2014,2(Suppl.2),4–9 9
ABSTRACTS ISSN: 2047-2919
INVITEDSPEAKERABSTRACTS promotedanongoingmulticentrestudyaimedatinvesti-
gatingtheCDUSfeaturesoftheentireMGTinhealthy,fer-
tile men, in order to obtain ‘normative’ parameters for
INVITEDTALKS:POST-GRADUATE
both scrotal and transrectal CDUS. The project has been
COURSE discussed in Florence on October 20th, 2012 (practical
investigator meeting) and in Berlin on November 29th,
IOP1 2012,duringtheEuropeanCongressofAndrology(proto-
col discussion). So far, approval from Ethical Committee
has been submitted in several Centers and already
Imagingofthemalereproductivetract:towards
obtainedinsomeofthem.Thecharacteristicsofthestudy
standardization
are available at http://www.andrologyacademy.net/stud-
F.LOTTI1,S.ARVER2,G.BALERCIA3,A.BARBONETTI4,
ies.php. The aim of the study is: primary, to evaluate the
H.M.BEHRE5,A.E.CALOGERO6,S.FRANCAVILLA4,
CDUS features of the scrotal and prostate-vesicular
A.GIOIA3,A.M.ISIDORI7,N.JØRGENSEN8,S.KLIESCH9,
regions in healthy fertile men; secondary: to correlate
K.KULA10,S.LAVIGNERA6,A.LENZI7,M.MARCOU5, CDUS findings with clinical, seminal and biochemical
U.PAASCH11,A.PILATZ12,O.POOLAMETS13, parametersevaluatedduringthesameCDUSsession.The
M.PUNAB13,C.QUINTIAN14,O.RAJMIL14, study is designed as a prospective, cohort, multicentric,
W.WEIDNER12ANDM.MAGGI1 international,observationalstudy.14EAACenterspartici-
1SexualMedicineandAndrologyUnit,Departmentof pateinthestudy(Ancona,Italy;Barcelona,Spain;Catania,
ExperimentalandClinicalBiomedicalSciences,University Italy;Copenhagen,Denmark;Florence,Italy;Giessen,Ger-
ofFlorence,Florence,Italy;2CenterforAndrologyand many;Halle-Saale,Germany;L’Aquila,Italy;Leipzig,Ger-
SexualMedicine,KarolinskaUniversityHospital/Huddinge, many; Lodz, Poland; Muenster, Germany; Rome, Italy;
Stockholm,Sweden;3DivisionofEndocrinology, Stockholm, Sweden; Tartu, Estonia). The Florence EAA
DepartmentofClinicalandMolecularSciences,Polytechnic Centeriscoordinatingthestudy.Thestudywillenroll200
UniversityofMarche,Ancona,Italy;4AndrologyUnit, adulthealthy,fertilesubjects.Themaininclusionscriteria
DepartmentofLife,HealthandEnvironmentSciences, concern males aged ≥18 years, without serious organic
UniversityofL’Aquila,L’Aquila,Italy;5Centerfor disease, partners of a pregnant woman in the second or
ReproductiveMedicineandAndrologyoftheUniversity, thirdtrimestersofpregnancyormenwhofatheredachild
Halle,Germany;6SectionofEndocrinology,Andrologyand during the last year, following natural conception. All
InternalMedicine,DepartmentofMedicalandPediatric patients enrolled will undergo, during the same day, the
Sciences,UniversityofCatania,Catania,Italy; followingprocedures:(i)Bloodsamplesforthedetermina-
7DepartmentofExperimentalMedicine,Sapienza tionofLH,FSH,PRL,totaltestosterone,SHBG,TSH,FT3,
UniversityofRome,Rome,Italy;8DepartmentofGrowth FT4,PSA,glycaemia,insulinlevels,totalcholesterol,HDL,
andReproduction,Rigshospitalet,Copenhagen,Denmark; triglycerides, 17 bestradiol. Biochemical analyses will be
9CenterofReproductiveMedicineandAndrology-Clinical performedinacentrallabattheendofthestudy.(ii)Per-
Andrology,UniversityHospitalofMu€nster,Mu€nster, sonalandmedicalhistoryassessment.(iii)Physicalexami-
Germany;10DepartmentofAndrology&Reproductive nation. (iv) Scrotal and transrectal CDUS evaluation
Endocrinology,MedicalUniversityofŁo(cid:2)d(cid:2)z,Poland; before and after ejaculation. (v) Semen analysis, per-
11DepartmentofDermatology/AndrologyUnit,University formedaccordingtotheWorldHealthOrganization,2010.
ofLeipzig,Leipzig,Germany;12DepartmentofUrology, New knowledge generated by our multicenter research
PediatricUrologyandAndrology,JustusLiebigUniversity consortium will create a step change in defining the
Giessen,Giessen,Germany;13AndrologyUnit,Tartu impact of MGT-CDUS on reproductive medicine. Stan-
UniversityHospital,Tartu,Estonia;14AndrologyService, dardizationofMGT-CDUSparametersinahealthy,fertile
Fundacio(cid:2)Puigvert,UniversitatAuto(cid:3)nomadeBarcelona, populationwillleadtotheimprovementofourdiagnostic
InstitutodeInvestigacionesBiom(cid:2)edicasSantPau(IIB-Sant skillsinidentifyingetiologicalfactorsofmaleinfertility.
Pau),Barcelona,Spain
Even if medical care of the man suffering of involuntary
childlessness is growing faster, in andrology, diagnostic IOP2
and therapeutic measures have not reached yet a critical
masstoensureareasonableunderstandingoftheunderly-
Genetictesting:thenewEAA/EMQNGuidelinesforAZF
ing problem and the consequent, evidence-based, treat-
deletions
ment. Nowadays, scrotal and transrectal imaging of the C.KRAUSZ1,L.HOEFSLOOT2,M.SIMONI3AND
malegenitaltract(MGT)havegreatlyhelpedindecipher- F.TU€TTELMANN4
inganatomy,physiologyandpathologyofmaleinfertility.
1SexualMedicineandAndrologyUnit,Departmentof
However, sonographic imaging of MGT still suffers from
ExperimentalandClinicalBiomedicalSciences,University
lackofstandardizationandoftentendstoproducesubjec-
ofFlorence,Florence,Italy;2DepartmentofClinical
tiveandvaguediagnosis.Inaddition,scrotalandtransrec-
Genetics,ErasmusMC,UniversityMedicalCenter
talcolour-Dopplerultrasound(CDUS)inrelationtomale
Rotterdam,theNetherlands;3DepartmentofBiomedicine,
fertility has not resulted in clear cut-offs, discriminating
MetabolismandNeuralSciences,UniversityofModena
normal or pathological CDUS parameters. Finally, the
andReggioEmilia,Modena,Italy;4InstituteofHuman
association between CDUS findings and male infertility/ Genetics,UniversityofMu€nster,Mu€nster,Germany
semen parameters has been poorly studied. This is the
The molecular diagnosis of Y-chromosomal microdele-
reason why the European Academy of Andrology (EAA)
tionsisacommonroutinegenetictestwhichispartofthe
10 Andrology,2014,2(Suppl.2),10–28 ©2014TheAuthors.Andrology©2014AmericanSocietyofAndrologyandEuropeanAcademyofAndrology