and genetics

331 Pages·2017·2.65 MB·English

A DEMI
AC A S
A CI SCRIPTA VARIA 137
I E
C N
I T
FI AI
T R
NOP M V
Edited by Edward M. De Robertis
Marcelo Sánchez Sorondo
CELL BIOLOGY
AND GENETICS
Workshop | 23-24 October 2017
Casina Pio IV | Vatican City
Libreria Editrice Vaticana Vatican City 2018
Cell Biology and Genetics

Pontificiae Academiae Scientiarvm Scripta Varia 137
The Proceedings of the Workshop on
Cell Biology and Genetics
23-24 October 2017
Edited by
Edward M. De Robertis
Marcelo Sánchez Sorondo
EX AEDIBVS ACADEMICIS
IN CIVITATE VATICANA • MMXVIII
The Pontifical Academy of Sciences
Casina Pio IV, 00120 Vatican City
Tel: [phone] • Fax: [phone]
Email: [email protected] • Website: www.pas.va
The opinions expressed with absolute freedom during the presentation of the papers of
this meeting, although published by the Academy, represent only the points of view of the
participants and not those of the Academy.
ISBN 978-88-7761-112-3
© Copyright 2018
All rights reserved. No part of this publication may be reproduced, stored in a retrieval
system, or transmitted in any form, or by any means, electronic, mechanical, recording, pho-
tocopying or otherwise without the expressed written permission of the publisher.
PONTIFICIA ACADEMIA SCIENTIARVM
LIBRERIA EDITRICE VATICANA
VATICAN CITY
Here I would recall the balanced position of Saint John Paul II,
who stressed the benefits of scientific and technological progress
as evidence of “the nobility of the human vocation to participate
responsibly in God’s creative action”, while also noting that “we
cannot interfere in one area of the ecosystem without paying
due attention to the consequences of such interference in oth-
er areas”. He made it clear that the Church values the benefits
which result “from the study and applications of molecular bi-
ology, supplemented by other disciplines such as genetics, and
its technological application in agriculture and industry”. But he
also pointed out that this should not lead to “indiscriminate ge-
netic manipulation” which ignores the negative effects of such
interventions. Human creativity cannot be suppressed. If an artist
cannot be stopped from using his or her creativity, neither should
those who possess particular gifts for the advancement of science
and technology be prevented from using their God-given talents
for the service of others. We need constantly to rethink the goals,
effects, overall context and ethical limits of this human activity,
which is a form of power involving considerable risks.
Pope Francis, Laudato Si’, §131.
Saint John Paul II at the foundational meeting of the Academia de
Ciencias de América Latina (ACAL) at the Vatican in 1982. Pro-
fessor Carlos Chagas filho as President of the Pontifical Academy
of Sciences called a meeting to promote science in Latin America.
In the photo Dr. Chagas (left) is introducing Sergio Mascarehnas
(right) to Pope John Paul II. As a result of the meeting at the Casi-
na Pio IV, headquarters of the Pontifical Academy of Sciences,
the attendees constituted ACAL. Founding members were Carlos
Chagas, Jorge E. Allende, Héctor Croxatto, Leopoldo de Meis,
Sonia Dietrich, Patricio J. Garrahan, Armando Gómez Poyou, G.
B. Marini-Bettolo, Sergio Mascarenhas, A. Paes Carvalho, Carlos
Monge, M. Peixoto, Marcel Roche, Fernando Rosas, P. Rudomín,
Andrés Stopanni, Jorge Villegas y Raimundo Villegas. Thirty-five
years later the PAS welcomed many members of ACAL for the
Cell Biology and Genetics Workshop recorded in these pages.
6 Cell Biology and Genetics
Cell Biology and Genetics 7
8 Cell Biology and Genetics
Contents
Objectives of the Workshop (Edward M. De Robertis) ........................... 13
Programme ............................................................................................. 16
List of Participants ................................................................................. 20
 Biophysics and MeMBrane Biology session
Biochemistry and Biophysics in Singulo: When Less is More
Carlos Bustamante and Sara Tafoya ............................................................ 25
Sensing Pain and Temperature
Ramon Latorre, Karen Castillo, and Ignacio Díaz-Franulic ........................ 44
Does Inflammatory Response Cause Tissue Dysfunction
in Chronic Diseases?
Juan C. Sáez ............................................................................................. 64
Free Radicals, Oxidants and Antioxidant Systems
in Physiology and Disease
Rafael Radi .............................................................................................. 73
How Glycans in Glycoproteins Provide the Cell with Information
on the Folding Status of the Protein Moieties
Armando J. Parodi ..................................................................................... 85
 genetics session
Design of Novel Regulatory Gene Circuits In Plant
and Mammalian Cells Utilizing Recombinase Serine Integrases
and Sustainable Intensification of S&T In Latin America
Elibio Rech ............................................................................................ 103
Cell Biology and Genetics 9