Anatomy & Physiology

540 Pages·2014·46.01 MB·English

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Anatomy & Physiology
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Table of Contents (all volumes)
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Unit 1: Levels of Organization
Chapter1: An Introduction to the Human Body . . . . . . . . . . . . . . . . . . . . . . . . . 15
1.1 Overview of Anatomy and Physiology . . . . . . . . . . . . . . . . . . . . . . . . . . . 16
1.2 Structural Organization of the Human Body . . . . . . . . . . . . . . . . . . . . . . . . 17
1.3 Functions of Human Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
1.4 Requirements for Human Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
1.5 Homeostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
1.6 Anatomical Terminology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
1.7 Medical Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34
Chapter2: The Chemical Level of Organization . . . . . . . . . . . . . . . . . . . . . . . . . 45
2.1 Elements and Atoms: The Building Blocks of Matter . . . . . . . . . . . . . . . . . . . 46
2.2 Chemical Bonds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
2.3 Chemical Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
2.4 Inorganic Compounds Essential to Human Functioning . . . . . . . . . . . . . . . . . 60
2.5 Organic Compounds Essential to Human Functioning . . . . . . . . . . . . . . . . . . 66
Chapter3: The Cellular Level of Organization . . . . . . . . . . . . . . . . . . . . . . . . . . 87
3.1 The Cell Membrane . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
3.2 The Cytoplasm and Cellular Organelles . . . . . . . . . . . . . . . . . . . . . . . . . 96
3.3 The Nucleus and DNA Replication . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
3.4 Protein Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108
3.5 Cell Growth and Division . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
3.6 Cellular Differentiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119
Chapter4: The Tissue Level of Organization . . . . . . . . . . . . . . . . . . . . . . . . . . 131
4.1 Types of Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
4.2 Epithelial Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 136
4.3 Connective Tissue Supports and Protects . . . . . . . . . . . . . . . . . . . . . . . . 145
4.4 Muscle Tissue and Motion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
4.5 Nervous Tissue Mediates Perception and Response . . . . . . . . . . . . . . . . . . . 155
4.6 Tissue Injury and Aging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157
Unit 2: Support and Movement
Chapter5: The Integumentary System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171
5.1 Layers of the Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
5.2 Accessory Structures of the Skin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 182
5.3 Functions of the Integumentary System . . . . . . . . . . . . . . . . . . . . . . . . . . 187
5.4 Diseases, Disorders, and Injuries of the Integumentary System . . . . . . . . . . . . . 191
Chapter6: Bone Tissue and the Skeletal System . . . . . . . . . . . . . . . . . . . . . . . . 203
6.1 The Functions of the Skeletal System . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
6.2 Bone Classification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207
6.3 Bone Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
6.4 Bone Formation and Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218
6.5 Fractures: Bone Repair . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 224
6.6 Exercise, Nutrition, Hormones, and Bone Tissue . . . . . . . . . . . . . . . . . . . . . 227
6.7 Calcium Homeostasis: Interactions of the Skeletal System and Other Organ Systems . 231
Chapter7: Axial Skeleton . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
7.1 Divisions of the Skeletal System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 240
7.2 The Skull . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241
7.3 The Vertebral Column . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
7.4 The Thoracic Cage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
7.5 Embryonic Development of the Axial Skeleton . . . . . . . . . . . . . . . . . . . . . . 272
Chapter8: The Appendicular Skeleton . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287
8.1 The Pectoral Girdle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 288
8.2 Bones of the Upper Limb . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 292
8.3 The Pelvic Girdle and Pelvis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300
8.4 Bones of the Lower Limb . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 304
8.5 Development of the Appendicular Skeleton . . . . . . . . . . . . . . . . . . . . . . . . 313
Chapter9: Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329
9.1 Classification of Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330
9.2 Fibrous Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332
9.3 Cartilaginous Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334
9.4 Synovial Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 336
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9.5 Types of Body Movements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345
9.6 Anatomy of Selected Synovial Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . 350
9.7 Development of Joints . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
Chapter10: Muscle Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
10.1 Overview of Muscle Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 378
10.2 Skeletal Muscle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379
10.3 Muscle Fiber Contraction and Relaxation . . . . . . . . . . . . . . . . . . . . . . . . 384
10.4 Nervous System Control of Muscle Tension . . . . . . . . . . . . . . . . . . . . . . . 392
10.5 Types of Muscle Fibers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 397
10.6 Exercise and Muscle Performance . . . . . . . . . . . . . . . . . . . . . . . . . . . 398
10.7 Cardiac Muscle Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 400
10.8 Smooth Muscle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 402
10.9 Development and Regeneration of Muscle Tissue . . . . . . . . . . . . . . . . . . . . 405
Chapter11: The Muscular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415
11.1 Interactions of Skeletal Muscles, Their Fascicle Arrangement, and Their Lever Systems416
11.2 Naming Skeletal Muscles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 420
11.3 Axial Muscles of the Head, Neck, and Back . . . . . . . . . . . . . . . . . . . . . . . 423
11.4 Axial Muscles of the Abdominal Wall and Thorax . . . . . . . . . . . . . . . . . . . . 433
11.5 Muscles of the Pectoral Girdle and Upper Limbs . . . . . . . . . . . . . . . . . . . . 439
11.6 Appendicular Muscles of the Pelvic Girdle and Lower Limbs . . . . . . . . . . . . . . 448
Unit 3: Regulation, Integration, and Control
Chapter12: The Nervous System and Nervous Tissue . . . . . . . . . . . . . . . . . . . . . 469
12.1 Basic Structure and Function of the Nervous System . . . . . . . . . . . . . . . . . . 470
12.2 Nervous Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 477
12.3 The Function of Nervous Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 484
12.4 The Action Potential . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 487
12.5 Communication Between Neurons . . . . . . . . . . . . . . . . . . . . . . . . . . . . 495
Chapter13: Anatomy of the Nervous System . . . . . . . . . . . . . . . . . . . . . . . . . . 513
13.1 The Embryologic Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 514
13.2 The Central Nervous System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 520
13.3 Circulation and the Central Nervous System . . . . . . . . . . . . . . . . . . . . . . 532
13.4 The Peripheral Nervous System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 539
Chapter14: The Brain and Cranial Nerves . . . . . . . . . . . . . . . . . . . . . . . . . . . . 561
14.1 Sensory Perception . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 562
14.2 Central Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 581
14.3 Motor Responses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 593
Chapter15: The Autonomic Nervous System . . . . . . . . . . . . . . . . . . . . . . . . . . 611
15.1 Divisions of the Autonomic Nervous System . . . . . . . . . . . . . . . . . . . . . . 612
15.2 Autonomic Reflexes and Homeostasis . . . . . . . . . . . . . . . . . . . . . . . . . 621
15.3 Central Control . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 629
15.4 Drugs that Affect the Autonomic System . . . . . . . . . . . . . . . . . . . . . . . . . 633
Chapter16: The Neurological Exam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 647
16.1 Overview of the Neurological Exam . . . . . . . . . . . . . . . . . . . . . . . . . . . 648
16.2 The Mental Status Exam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 652
16.3 The Cranial Nerve Exam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 658
16.4 The Sensory and Motor Exams . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 667
16.5 The Coordination and Gait Exams . . . . . . . . . . . . . . . . . . . . . . . . . . . . 672
Chapter17: The Endocrine System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 685
17.1 An Overview of the Endocrine System . . . . . . . . . . . . . . . . . . . . . . . . . . 686
17.2 Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 689
17.3 The Pituitary Gland and Hypothalamus . . . . . . . . . . . . . . . . . . . . . . . . . 697
17.4 The Thyroid Gland . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 705
17.5 The Parathyroid Glands . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 710
17.6 The Adrenal Glands . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 713
17.7 The Pineal Gland . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 716
17.8 Gonadal and Placental Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . 716
17.9 The Endocrine Pancreas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 718
17.10 Organs with Secondary Endocrine Functions . . . . . . . . . . . . . . . . . . . . . 723
17.11 Development and Aging of the Endocrine System . . . . . . . . . . . . . . . . . . . 725
Unit 4: Fluids and Transport
Chapter18: The Cardiovascular System: Blood . . . . . . . . . . . . . . . . . . . . . . . . . 737
18.1 An Overview of Blood . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 738
18.2 Production of the Formed Elements . . . . . . . . . . . . . . . . . . . . . . . . . . . 742
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18.3 Erythrocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 745
18.4 Leukocytes and Platelets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 752
18.5 Hemostasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 757
18.6 Blood Typing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 762
Chapter19: The Cardiovascular System: The Heart . . . . . . . . . . . . . . . . . . . . . . 777
19.1 Heart Anatomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 778
19.2 Cardiac Muscle and Electrical Activity . . . . . . . . . . . . . . . . . . . . . . . . . . 799
19.3 Cardiac Cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 812
19.4 Cardiac Physiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 816
19.5 Development of the Heart . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 826
Chapter20: The Cardiovascular System: Blood Vessels and Circulation . . . . . . . . . . . 837
20.1 Structure and Function of Blood Vessels . . . . . . . . . . . . . . . . . . . . . . . . 838
20.2 Blood Flow, Blood Pressure, and Resistance . . . . . . . . . . . . . . . . . . . . . . 849
20.3 Capillary Exchange . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 859
20.4 Homeostatic Regulation of the Vascular System . . . . . . . . . . . . . . . . . . . . 861
20.5 Circulatory Pathways . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 871
20.6 Development of Blood Vessels and Fetal Circulation . . . . . . . . . . . . . . . . . . 903
Chapter21: The Lymphatic and Immune System . . . . . . . . . . . . . . . . . . . . . . . . 919
21.1 Anatomy of the Lymphatic and Immune Systems . . . . . . . . . . . . . . . . . . . . 920
21.2 Barrier Defenses and the Innate Immune Response . . . . . . . . . . . . . . . . . . 932
21.3 The Adaptive Immune Response: T lymphocytes and Their Functional Types . . . . . 938
21.4 The Adaptive Immune Response: B-lymphocytes and Antibodies . . . . . . . . . . . 946
21.5 The Immune Response against Pathogens . . . . . . . . . . . . . . . . . . . . . . . 951
21.6 Diseases Associated with Depressed or Overactive Immune Responses . . . . . . . . 954
21.7 Transplantation and Cancer Immunology . . . . . . . . . . . . . . . . . . . . . . . . 958
Unit 5: Energy, Maintenance, and Environmental Exchange
Chapter22: The Respiratory System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 973
22.1 Organs and Structures of the Respiratory System . . . . . . . . . . . . . . . . . . . . 974
22.2 The Lungs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 985
22.3 The Process of Breathing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 988
22.4 Gas Exchange . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 996
22.5 Transport of Gases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1000
22.6 Modifications in Respiratory Functions . . . . . . . . . . . . . . . . . . . . . . . . 1007
22.7 Embryonic Development of the Respiratory System . . . . . . . . . . . . . . . . . . 1008
Chapter23: The Digestive System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1021
23.1 Overview of the Digestive System . . . . . . . . . . . . . . . . . . . . . . . . . . . 1022
23.2 Digestive System Processes and Regulation . . . . . . . . . . . . . . . . . . . . . 1027
23.3 The Mouth, Pharynx, and Esophagus . . . . . . . . . . . . . . . . . . . . . . . . . 1031
23.4 The Stomach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1040
23.5 The Small and Large Intestines . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1046
23.6 Accessory Organs in Digestion: The Liver, Pancreas, and Gallbladder . . . . . . . . 1056
23.7 Chemical Digestion and Absorption: A Closer Look . . . . . . . . . . . . . . . . . . 1060
Chapter24: Metabolism and Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1079
24.1 Overview of Metabolic Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . . 1080
24.2 Carbohydrate Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1084
24.3 Lipid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1097
24.4 Protein Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1103
24.5 Metabolic States of the Body . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1108
24.6 Energy and Heat Balance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1111
24.7 Nutrition and Diet . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1113
Chapter25: The Urinary System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1127
25.1 Physical Characteristics of Urine . . . . . . . . . . . . . . . . . . . . . . . . . . . 1128
25.2 Gross Anatomy of Urine Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . 1131
25.3 Gross Anatomy of the Kidney . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1135
25.4 Microscopic Anatomy of the Kidney . . . . . . . . . . . . . . . . . . . . . . . . . . 1140
25.5 Physiology of Urine Formation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1144
25.6 Tubular Reabsorption . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1147
25.7 Regulation of Renal Blood Flow . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1156
25.8 Endocrine Regulation of Kidney Function . . . . . . . . . . . . . . . . . . . . . . . 1157
25.9 Regulation of Fluid Volume and Composition . . . . . . . . . . . . . . . . . . . . . 1159
25.10 The Urinary System and Homeostasis . . . . . . . . . . . . . . . . . . . . . . . . 1161
Chapter26: Fluid, Electrolyte, and Acid-Base Balance . . . . . . . . . . . . . . . . . . . . 1173
26.1 Body Fluids and Fluid Compartments . . . . . . . . . . . . . . . . . . . . . . . . . 1174
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26.2 Water Balance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1182
26.3 Electrolyte Balance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1185
26.4 Acid-Base Balance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1189
26.5 Disorders of Acid-Base Balance . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1194
Unit 6: Human Development and the Continuity of Life
Chapter27: The Reproductive System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1203
27.1 Anatomy and Physiology of the Male Reproductive System . . . . . . . . . . . . . . 1204
27.2 Anatomy and Physiology of the Female Reproductive System . . . . . . . . . . . . 1214
27.3 Development of the Male and Female Reproductive Systems . . . . . . . . . . . . 1229
Chapter28: Development and Inheritance . . . . . . . . . . . . . . . . . . . . . . . . . . . 1239
28.1 Fertilization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1240
28.2 Embryonic Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1244
28.3 Fetal Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1255
28.4 Maternal Changes During Pregnancy, Labor, and Birth . . . . . . . . . . . . . . . . 1260
28.5 Adjustments of the Infant at Birth and Postnatal Stages . . . . . . . . . . . . . . . . 1266
28.6 Lactation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1268
28.7 Patterns of Inheritance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1271
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1312
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PREFACE 7
PREFACE
WelcometoHumanAnatomyandPhysiology,anOpenStaxCollegeresource.Wecreatedthistextbookwithseveralgoals
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relevanttoyoursyllabusandcreateatextbookthataddressestheneedsofyourclass.Thiscustomizationfeaturewillensure
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Curation
Tobroadenaccessandencouragecommunitycuration,HumanAnatomyandPhysiologyis“opensource”underaCreative
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Our textbooks are available for free online, and in low-cost print and tablet editions.
About (cid:6)(cid:29)(cid:23)(cid:14)(cid:24)(cid:1)(cid:2)(cid:24)(cid:14)(cid:28)(cid:25)(cid:23)(cid:31)(cid:1)(cid:14)(cid:24)(cid:16)(cid:1)(cid:10)(cid:20)(cid:31)(cid:27)(cid:21)(cid:25)(cid:22)(cid:25)(cid:19)(cid:31)
Human Anatomy and Physiology is designed for the two-semester anatomy and physiology course taken by life science
andalliedhealthstudents.Itsupportseffectiveteachingandlearning,andpreparesstudentsforfurtherlearningandfuture
careers.Thetextfocusesonthemostimportantconceptsandaimstominimizedistractingstudentswithmoreminordetails.
The development choices for this textbook were made with the guidance of hundreds of faculty who are deeply
involved in teaching this course. These choices led to innovations in art, terminology, career orientation, practical
applications, and multimedia-based learning, all with a goal of increasing relevance to students. We strove to make the
disciplinemeaningfulandmemorabletostudents,sothattheycandrawfromitaworkingknowledgethatwillenrichtheir
future studies.
Coverage and Scope
TheunitsofourHumanAnatomyandPhysiologytextbookadheretothescopeandsequencefollowedbymosttwo-semester
courses nationwide.
Unit 1: Levels of Organization
Chapters 1–4 provide students with a basic understanding of human anatomyand physiology, including its language, the
levelsoforganization,andthebasicsofchemistryandcellbiology.Thesechaptersprovideafoundationforthefurtherstudy
8 PREFACE
of the body. They also focus particularly on how the body’s regions, important chemicals, and cells maintain homeostasis.
Chapter 1 An Introduction to the Human Body
Chapter 2 The Chemical Level of Organization
Chapter 3 The Cellular Level of Organization
Chapter 4 The Tissue Level of Organization
Unit 2: Support and Movement
In Chapters5–11, studentsexploretheskin, thelargestorganof thebody,andexaminethebody’s skeletalandmuscular
systems,followingatraditionalsequenceoftopics.Thisunitisthefirsttowalkstudentsthroughspecificsystemsofthe
body, and as it does so, it maintains a focus on homeostasis as well as those diseases and conditions that can disrupt it.
Chapter 5 The Integumentary System
Chapter 6 Bone and Skeletal Tissue
Chapter 7 The Axial Skeleton
Chapter 8 The Appendicular Skeleton
Chapter 9 Joints
Chapter 10 Muscle Tissue
Chapter 11 The Muscular System
Unit 3: Regulation, Integration, and Control
Chapters12–17helpstudentsanswerquestionsaboutnervousandendocrinesystemcontrolandregulation.Inabreakwith
the traditional sequence of topics, the special senses are integrated into the chapter on the somatic nervous system. The
chapterontheneurologicalexaminationoffersstudentsauniqueapproachtounderstandingnervoussystemfunctionusing
five simple but powerful diagnostic tests.
Chapter 12 Introduction to the Nervous System
Chapter 13 The Anatomy of the Nervous System
Chapter 14 The Somatic Nervous System
Chapter 15 The Autonomic Nervous System
Chapter 16 The Neurological Exam
Chapter 17 The Endocrine System
Unit 5: Energy, Maintenance, and Environmental Exchange
InChapters22–26,studentsdiscovertheinteractionbetweenbodysystemsandtheoutsideenvironmentfortheexchange
ofmaterials,thecaptureofenergy,thereleaseofwaste,andtheoverallmaintenanceoftheinternalsystemsthatregulate
the exchange. The explanations and illustrations are particularly focused on how structure relates to function.
Chapter 22 The Respiratory System
Chapter 23 The Digestive System
Chapter 24 Nutrition and Metabolism
Chapter 25 The Urinary System
Chapter 26 Fluid, Electrolyte, and Acid–Base Balance
Unit 6: Human Development and the Continuity of Life
Theclosingchaptersexaminethemaleandfemalereproductivesystems,describetheprocessofhumandevelopmentand
the different stages of pregnancy, and end with a review of the mechanisms of inheritance.
Chapter 27 The Reproductive System
Chapter 28 Development and Genetic Inheritance
Pedagogical Foundation and Features
HumanAnatomyandPhysiologyisdesignedtopromotescientificliteracy.Throughoutthetext,youwillfindfeaturesthat
engage the students by taking selected topics a step further.
Homeostatic Imbalancesdiscusses the effects and results of imbalances in the body.
Disorders showcases a disorder that is relevant to the body system at hand. This feature may focus on a specific
disorder, or a set of related disorders.
Diseasesshowcases a disease that is relevant to the body system at hand.
Agingexplores the effect aging has on a body’s system and specific disorders that manifest over time.
Career Connections presents information on the various careers often pursued by allied health students, such as
medicaltechnician,medicalexaminer,andneurophysiologist.Studentsareintroducedtotheeducationalrequirements
for and day-to-day responsibilities in these careers.
Everyday Connections tie anatomical and physiological concepts to emerging issues and discuss these in terms of
everyday life. Topics include “Anabolic Steroids” and “The Effect of Second-Hand Tobacco Smoke.”
Interactive Links direct students to online exercises, simulations, animations, and videos to add a fuller context
to core content and help improve understanding of the material. Many features include links to the University of
Michigan’sinteractiveWebScopes,whichallowstudentstozoominonmicrographsinthecollection.Theseresources
werevettedbyreviewersandothersubjectmatterexpertstoensurethattheyareeffectiveandaccurate.Westrongly
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