Anabolic Treatments for Osteoporosis PDF
Preview Anabolic Treatments for Osteoporosis
Library of Congress Cataloging-in-Publication Data Anabolic treatments for osteoporosis / edited by James F. Whitfield and Paul Morley. p. cm. — (Pharmacology and toxicology) Includes bibliographical references and index. ISBN 0-8493-8556-3 (alk. paper) 1. Osteoporosis—Hormone therapy. 2. Parathyroid hormone- -Therapeutic use. 3. Somatomedin—Therapeutic use. I. Whitfield, James F. II. Morley, Paul, Ph.D. III. Series: Pharmacology & toxicology (Boca Raton, Fla.) [DNLM: 1. Osteoporosis—drug therapy. 2. Parathyroid Hormones- -therapeutic use. 3. Prostaglandins E—therapeutic use. 4. Fluorides—therapeutic use. WE 250 A532 1997] RC931.073A53 1997 616.7′16—dc21 DNLM/DLC for Library of Congress 97-15242 CIP This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. All rights reserved. Authorization to photocopy items for internal or personal use, or the personal or internal use of specific clients, may be granted by CRC Press LLC, provided that $.50 per page photocopied is paid directly to Copyright Clearance Center, 27 Congress Street, Salem, MA 01970 USA. The fee code for users of the Transactional Reporting Service is ISBN 0-8493-8556- 3/98/$0.00+$.50. The fee is subject to change without notice. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. The consent of CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works, or for resale. Specific permission must be obtained in writing from CRC Press LLC for such copying. Direct all inquiries to CRC Press LLC, 2000 Corporate Blvd., N.W., Boca Raton, Florida 33431. © 1998 by CRC Press LLC No claim to original U.S. Government works International Standard Book Number 0-8493-8556-3 Library of Congress Card Number 97-15242 Printed in the United States of America 1 2 3 4 5 6 7 8 9 0 Printed on acid-free paper T E HE DITORS James F. Whitfield, B.Sc. (McGill University), M.Sc. (University of Western Ontario), Ph.D. (University of Western Ontario) After receiving his Ph.D. in 1955, Dr. Whitfield joined the Biology and Health Physics Division of Atomic Energy of Canada at Chalk River, Ontario, where he carried out pioneering research on the insertion of bacteriophageλ into its host cell’s genome. But he soon joined forces with Ray Rixon to discover and characterize the potent radioprotective and radiotherapeutic actions of the parathyroid hormone. He left Chalk River in 1962 to set up a cell biology laboratory at the European Joint Research Center at Ispra in northern Italy, where he carried out some of the first studies of the mechanisms, and the role of Ca2+ in the mechanisms, un- derlying radiation-triggered apoptosis in human and rat thymocytes. Dr. Whitfield returned to Canada in 1965 to start a cell biology laboratory at the National Research Council of Canada. Since then he has participated in research that has led to the discovery of the controlling roles of Ca2+ and cyclic AMP in normal cell proliferation and the loss of these controls during carcinogenesis. He and his group have established the key roles of the parathyroid hormone and the parathyroid hormone-related protein (PTHrP) in the control of the proliferation and differentiation of kerati- nocytes, hepatocytes in the regenerating liver, and spleen and thymic lymphocytes. As will be seen in this book, he and his colleagues have, most recently, mapped the parathyroid hormone’s two signaling regions and are now applying this knowledge to the design of new parathyroid hormone fragments for stimulating bone growth in osteoporotic humans. Paul Morley, B.Sc. (University of Waterloo), M.Sc. (University of Western Ontario), Ph.D. (University of Western Ontario) Paul Morley trained in the field of reproductive endocrinology with David T. Armstrong and Franco Calaresu and received his Ph.D. degree in 1990. His thesis work investigated the hormonal and neural regulation of ovarian thecal cell androgen production. He then held a Medical Re- search Council of Canada Postdoctoral Fellowship at the Loeb Medical Research Institute in Ottawa, where he studied the roles of ions and ion channels in ovarian steroidogenesis. In 1992 he joined the National Re- search Council of Canada as a research associate and since then has become an Associate Research Officer. He heads the Ions & Ion Channels Laboratory, which has made important discoveries concerning the contri- butions of calcium ions and calcium-conducting ion channels in endocrine and neural systems. He also works as part of the group involved in the design and testing of novel parathyroid hormone fragments/analogs for treating osteoporosis. C ONTRIBUTORS Kristina Åkesson, M.D., Ph.D. A. B. Hodsman, M.B., ERCP Department of Medicine Department of Medicine Loma Linda University Lawson Research Institute Mineral Metabolism Unit St. Joseph’s Health Centre Jerry L. Pettis Memorial V.A. Medical London, Ontario, Canada Center Loma Linda, California Anna Johansson Department of Internal Medicine Zafrira Avnur, Ph.D. University Hospital Osteoporosis and Endocrine Research Uppsala, Sweden Roche Bioscience Palo Alto, California John L. Krstenansky Osteoporosis and Endocrine Research David J. Baylink, M.D. Roche Bioscience Department of Medicine Palo Alto, California Loma Linda University Chief, Mineral Metabolism Unit R. M. Langille, Ph.D. Jerry Pettis Memorial V.A. Medical Center Institute for Biological Sciences Loma Linda, California National Research Council of Canada Ottawa, Ontario, Canada L. J. Fraher, Ph.D. Department of Medicine K.-H. William Lau, Ph.D. Lawson Research Institute Department of Medicine St. Joseph’s Health Centre Loma Linda University London, Ontario, Canada Mineral Metabolism Unit Jerry L. Pettis Memorial V.A. Medical Harold M. Frost, M.D., Dr.Sc. Center Southern Colorado Clinic Loma Linda, California Pueblo, Colorado Mei Li, M.D. Esther Hill, Ph.D. Department of Physiological Sciences Osteoporosis and Endocrine Research College of Veterinary Medicine Roche Bioscience University of Florida Palo Alto, California Gainesville, Florida
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