Alzheimer's disease decoded : the history, present, and future of Alzheimer's disease and dementia

285 Pages·2017·4.11 MB·English

by  Chen

Alzheimer’s Disease Decoded
The History, Present, and Future of
Alzheimer’s Disease and Dementia
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Alzheimer’s Disease Decoded
The History, Present, and Future of
Alzheimer’s Disease and Dementia
Ronald Sahyouni
UC Irvine
Aradhana Verma
UC San Francisco
Jefferson Chen
UC Irvine
World Scientiic
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UK oice: 57 Shelton Street, Covent Garden, London WC2H 9HE
Library of Congress Cataloging-in-Publication Data
Names: Sahyouni, Ronald, author. | Verma, Aradhana, author. | Chen, Jeferson, author.
Title: Alzheimer's disease decoded : the history, present, and future of Alzheimer’s disease and
dementia / Ronald Sahyouni, Aradhana Verma, Jeferson Chen.
Description: New Jersey : World Scientiic, 2016. | Includes bibliographical references and index.
Identiiers: LCCN 2016033859| ISBN 9789813109247 (hardcover : alk. paper) |
ISBN 9813109246 (hardcover : alk. paper) | ISBN 9789813109254 (pbk. : alk. paper) |
ISBN 9813109254 (pbk. : alk. paper)
Subjects: | MESH: Alzheimer Disease | Dementia
Classiication: LCC RC523 | NLM WT 155 | DDC 616.8/31--dc23
LC record available at https://lccn.loc.gov/2016033859
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
Copyright © 2017 by World Scientiic Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
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For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance
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is not required from the publisher.
Printed in Singapore
Najib Okko,
And all those who lost their lives to Alzheimer’s disease.
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Contents
About the Authors ix
Building a Community xv
Foreword xvii
Preface xix
Quick Reference Guide xxvii
Part I: Introduction, History, and Overview 1
Chapter 1: Introduction to the Brain and Nervous System 3
Chapter 2: Dysfunction 31
Chapter 3: Senility and Normal Aging 49
Chapter 4: What is Dementia? 59
Chapter 5: Introduction to Alzheimer’s Disease 73
Chapter 6: Epidemiology of Alzheimer’s Disease 99
Chapter 7: The History of Alzheimer’s Disease 121
Chapter 8: An Interesting Link 139
Part II: Novel Therapies and Future Directions 153
Chapter 9: Surgical Treatments for Dementia 155
Chapter 10: Is There a Link to Traumatic Brain Injury? 165
Chapter 11: What’s going on Now? 175
Chapter 12: Novel Therapies 191
Chapter 13: How Can We Solve the Problem? 221
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viii Alzheimer’s Disease Decoded
Chapter 14: What Resources Exist? 235
Acknowledgements 245
Note to Readers 247
Glossary/Abbreviations 249
Index 255
About the Authors
Ronald Sahyouni
Biography
My interest in the brain developed early on, during a wonderful
psychology class I took in high school. This interest became realized and
personalized when I watched my grandfather die of Alzheimer’s disease.
This heartbreaking experience made me hope to never again see anyone
die of such a disease, and although this hope may be unrealistic, it has
led me to ight towards reaching a goal of a world without Alzheimer’s
disease. After high school, my undergraduate studies took place at the
University of California, Berkeley, double majoring in Neurobiology
and Psychology in order to understand the brain at a microscopic and
systemic level. Concurrently, I worked at the University of California,
Davis Alzheimer’s Disease Center, conducting neuropsychological
evaluations of patients who were referred to our research clinic. These
experiences taught me that there was a tremendous lack of progress
being made in treating Alzheimer’s disease, which pushed me to pursue
a career as a physician scientist. This brought me to the Medical Scientist
Training Program (MSTP; an MD/PhD program) at the University of
California, Irvine School of Medicine, where I have been fortunate
to participate in a variety of projects aimed at better understanding
the brain, from traumatic brain injuries (TBI) and brain tumors to
Alzheimer’s disease.
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