Alzheimer's Disease and Related Disorders Annual 5 PDF
Preview Alzheimer's Disease and Related Disorders Annual 5
00-Prelims (5) 8/31/05 11:00 AM Page i ALZHEIMER’S DISEASE AND RELATED DISORDERS 5 ANNUAL 00-Prelims (5) 8/31/05 11:00 AM Page ii 00-Prelims (5) 8/31/05 11:00 AM Page iii ALZHEIMER’S DISEASE AND RELATED DISORDERS 5 ANNUAL Edited by Serge Gauthier, MD FRCPC Professor and Director Alzheimer’s Disease Research Unit McGill Centre for Studies in Aging Douglas Hospital Verdun PQ CANADA Philip Scheltens, MD PhD Department of Neurology / Alzheimer Center Academisch Ziekenhuis Vrije Universiteit Amsterdam The Netherlands Jeffrey L Cummings, MD Reed Neurological Research Center University of California, Los Angeles Los Angeles, CA USA 00-Prelims (5) 8/31/05 11:00 AM Page iv © 2006 Taylor & Francis, an imprint of the Taylor & Francis Group First published in the United Kingdom in 2006 by Taylor & Francis, an imprint of the Taylor & Francis Group, 2 Park Square, Milton Park, Abingdon, Oxon OX14 4RN Tel.: +44 (0)20 7017 6000 Fax.: +44 (0)20 7017 6699 E-mail: [email protected] Website: www.tandf.co.uk/medicine All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the publisher or in accordance with the provisions of the Copyright, Designs and Patents Act 1988 or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London W1P 0LP. Although every effort has been made to ensure that all owners of copyright material have been acknowledged in this publication, we would be glad to acknowledge in subsequent reprints or editions any omissions brought to our attention. Although every effort has been made to ensure that drug doses and other information are present- ed accurately in this publication, the ultimate responsibility rests with the prescribing physician. Neither the publishers nor the authors can be held responsible for errors or for any consequences arising from the use of information contained herein. For detailed prescribing information or instructions on the use of any product or procedure discussed herein, please consult the prescrib- ing information or instructional material issued by the manufacturer. A CIP record for this book is available from the British Library. Library of Congress Cataloging-in-Publication Data Data available on application ISBN 1 84184 561 2 978 1 84184 561 6 Distributed in North and South America by Taylor & Francis 2000 NW Corporate Blvd Boca Raton, FL 33431, USA Within Continental USA Distributed in the rest of the world by Tel: 800 272 7737; Thomson Publishing Services Fax: 800 374 3401 Cheriton House Outside Continental USA North Way Tel: 561 994 0555; Andover, Hampshire SP10 5BE, UK Fax: 561 361 6018 Tel: +44 (0)1264 332424 E-mail: [email protected] E-mail:[email protected] Composition by Creative Printed and bound in Great Britain by TJ International Ltd, Padstow, Cornwall 00-Prelims (5) 8/31/05 11:00 AM Page v Contents List of Contributors vii 1. Neuropathology of mild cognitive impairment 1 in the elderly Steven T DeKosky, Milos D Ikonomovic, Ronald L Hamilton, David A Bennett, and Elliot J Mufson 2. Cerebrospinal fluid markers for the diagnosis 17 of Alzheimer’s disease Niki Schoonenboom, Harald Hampel, Philip Scheltens, and Mony de Leon 3. Executive control function in ‘mild’ cognitive 35 impairment and Alzheimer’s disease Donald R Royall 4. Glycosaminoglycan mimetics in Alzheimer’s disease 63 Francine Gervais, Denis Garceau, Paul S Aisen, and Serge Gauthier 5. Immunotherapy for Alzheimer’s disease 73 David Wilkinson 6. Cholesterol, copper, and statin therapy in 89 Alzheimer’s disease D Larry Sparks, Suzana Petanceska, Marwan Sabbagh, Donald Connor, Holly Soares, Charles Adler, Jean Lopez, Nina Silverberg, Kathryn Davis, Suhair Stipho-Majeed, Sherry Johnson-Traver, Paul Volodarsky, Chuck Ziolkowski, Jeff Lochhead, and Patrick Browne v 00-Prelims (5) 8/31/05 11:00 AM Page vi 7. Insulin resistance in Alzheimer’s disease – 111 a novel therapeutic target Suzanne Craft, Mark A Reger, and Laura D Baker 8. Atypical antipsychotics in dementia 135 Lesley M Blake and Jacobo Mintzer 9. Treatment of vascular risk factors to delay 153 Alzheimer’s disease? Frank-Erik de Leeuw, Raj Kalaria, and Philip Scheltens 10. Cognitive dysfunction in multiple sclerosis 165 Julie A Bobholz and Angela Gleason 11. Cholinesterase inhibitors in the treatment of 181 dementia associated with Parkinson’s disease Murat Emre 12. Modern applications of electroencephalography 191 in dementia diagnosis CJ Stam Index 207 00-Prelims (5) 8/31/05 11:00 AM Page vii Contributors Charles AdlerPhD Julie A BobholzPhD Mayo Clinic Assistant Professor of Neurology Scottsdale, AZ Medical College of Wisconsin USA Milwaukee, WI USA Paul S AisenMD Department of Neurology Patrick Browne MD Georgetown University Medical Center Center for Chest Disease Washington, DC Division of Cardiology USA Boswell Hospital Sun City, AZ Laura D BakerPhD USA Assistant Professor of Psychiatry and Behavioral Sciences, University of Donald Connor PhD Washington School of Medicine, Cleo Roberts Clinical Research Center Geriatric Research, Education and Sun Health Research Institute Clinical Center, Veterans Affairs Puget Sun City, AZ Sound Health Care System USA Seattle, WA USA Suzanne Craft PhD Professor of Psychiatry and Behavioral David A BennettMD Sciences Rush Alzheimer’s Disease Center University of Washington School of Rush university Medical Center Medicine Chicago, IL Associate Director, USA Geriatric Research, Education and Clinical Center Lesley M BlakeMD Veterans Affairs Puget Sound Health Division of Geriatric Psychiatry Care System Northwestern University Medical Seattle, WA School USA Chicago, IL USA vii 00-Prelims (5) 8/31/05 11:00 AM Page viii viii ALZHEIMER’SDISEASEANDRELATEDDISORDERSANNUAL Jeffrey L CummingsMD Department of Neurology Serge Gauthier MD FRCPC David Geffen School of Medicine at Professor and Director UCLA Alzheimer’s Disease Research Unit Los Angeles, CA McGill Centre for Studies in Aging USA Douglas Hospital Verdun PQ Kathryn DavisBA Canada Sun Health Research Institute Sun City, AZ Francine GervaisPhD USA Vice-President, R&D Neurochem Steven T DeKoskyMD Laval Department of Neurology Quebec University of Pittsburgh School of Canada Medicine Pittsburgh, PA Angela Gleason PhD USA Postdoctoral Fellow Department of Neurology FE De Leeuw MD PhD Medical College of Wisconsin Department of Neurology Milwauke, WI University Medical Center St. Radboud USA Nijmegen The Netherlands Ronald L HamiltonMD Division of Neuropathology Mony de LeonPhD Department of Pathology New York University School of University of Pittsburgh School of Medicine Medicine Center for Brain Health Pittsburgh, PA New York, NY USA USA Murat EmreMD Harald Hampel PhD Department of Psychiatry Professor of Neurology University of Munich Head, Behavioral Neurology and Nussbaumstr. 7 Movement Disorders Unit Munich Department of Neurology Germany Istanbul Faculty of Medicine Çapa, Istanbul Milos D Ikonomovic MD Turkey Alzheimer’s Disease Research Center Denis GarceauPhD University of Pittsburgh School of Drug Development Medicine Neurochem Pittsburgh, PA Laval, Quebec USA Canada 00-Prelims (5) 8/31/05 11:00 AM Page ix CONTRIBUTORS ix Sherry Johnson-Traver Mark A RegerPhD Sun Health Research Institute Acting Assistant Professor of Psychiatry Sun City, AZ and Behavioral Sciences USA University of Washington School of Medicine Raj N KalariaMD Geriatric Research, Education and Wolfson Research Centre Clinical Center Institute for Ageing and Health Veterans Affairs Puget Sound Health Newcastle General Hospital Care System Westgate Road Seattle, WA Newcastle upon Tyne USA UK Donald R Royall MD Jeff Lochhead BS Julia and Van Buren Parr Professor Sun Health Research Institute for Alzheimer’s research in psychiatry Sun City, AZ Chief: Geriatric Psychiatry Division USA The University of Texas Health Sciences Center at San Antonio Jean LopezRN MSN San Antonio, TX Cleo Roberts Clinical Research Center USA Sun Health Research Institute Sun City, AZ Marwan Sabbagh MD USA Cleo Roberts Clinical Research Center Sun Health Research Institute Jacobo E MintzerMD Sun City, AZ Medical University of South Carolina USA Charleston, SC USA Philip Scheltens MD PhD Department of Neurology/Alzheimer Elliot J MufsonPhD Center Division of Neuroscience VU University Medical Center Rush University Amsterdam Rush Presbyterian St Luke’s Medical The Netherlands Center Chicago, IL Niki Schoonenboom MD USA Department of Neurology/Alzheimer Center Suzana PetanceskaPhD VU University Medical Center Nathan Kline Institute and Amsterdam Deptartments of Psychiatry and The Netherlands Pharmmacology New York University Medical Center Nina Silverberg PhD Orangeburg, NY Sun Health Research Institute USA Sun City, AZ USA
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