Alzheimer's disease and related disorders annual. / 2004 PDF
Preview Alzheimer's disease and related disorders annual. / 2004
Alzheimer’s Disease and Related Disorders Annual 2004 Alzheimer’s Disease and Related Disorders Annual 2004 Edited by Serge Gauthier MD FRCPC Professor and Director Alzheimer’s Disease Research Unit The McGill Center for Studies in Aging Douglas Hospital Verdun PQ Canada Philip Scheltens MD Pho Department of Neurology Academisch Ziekenhuis Vrije Universiteit Postbus 7057 1007 MB AMSTERDAM The Netherlands Jeffrey L Cummings MD Director, UCLA Alzheimer’s Disease Center Augustus S Rose Professor of Neurology Professor of Psychiatry and Biobehavioral Sciences UCLA School of Medicine Los Angeles CA USA Martin Dunitz Taylor & Francis Group LONDON AND NEW YORK © 2004 Martin Dunitz, an imprint of the Taylor & Francis Group plc First published in the United Kingdom in 2004 by Martin Dunitz Ltd, an imprint of the Taylor & Francis Group plc, 11 New Fetter Lane, London EC4P 4EE Tel.: +44 (0) 20 7583 9855 Fax.: +44 (0) 20 7842 2298 E-mail: [email protected] Website: http://www.dunitz.co.uk This edition published in the Taylor & Francis e-Library, 2005. “To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk.” All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the publisher or in accordance with the provisions of the Copyright, Designs and Patents Act 1988 or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London W1P 0LP. Although every effort has been made to ensure that all owners of copyright material have been acknowledged in this publication, we would be glad to acknowledge in subsequent reprints or editions any omissions brought to our attention. A CIP record for this book is available from the British Library. ISBN 0-203-49285-4 Master e-book ISBN ISBN 0-203-59599-8 (Adobe eReader Format) ISBN 1 84184 348 2 (Print Edition) Distributed in the USA by Fulfilment Center Taylor & Francis 10650 Toebben Drive Independence, KY 41051, USA Toll Free Tel.: +1 800 634 7064 E-mail: [email protected] Distributed in Canada by Taylor & Francis 74 Rolark Drive Scarborough, Ontario M1R 4G2, Canada Toll Free Tel.: +1 877 226 2237 E-mail: [email protected] Distributed in the rest of the world by Thomson Publishing Services Cheriton House North Way Andover, Hampshire SP10 5BE, UK Tel.: +44 (0)1264 332424 E-mail: [email protected] Composition by Tek Art, Croydon, UK Contents Contributors vi Preface x 1 Innervation of senile plaques: A link between amyloid and 1 neurofibrillary pathology? Benoit DelatourVeronique BlanchardLaurent PradierCharles Duyckaerts 2 Vascular factors and Alzheimer’s disease 21 Ingmar SkoogDeborah GustafsonMagnus Sjögren 3 The role of white matter lesions in dementia 48 Leonardo Pantoni 4 Subclassification of mild cognitive impairment in research and 62 clinical practice Serge GauthierJacques Touchon 5 Neuropsychiatric symptoms of mild cognitive impairment 72 Tzung J HwangJeffrey L Cummings 6 Cognitive rehabilitation in mild cognitive impairment and 82 prodromal Alzheimer’s disease Martial van der LindenAnne-Claude JuilleratXavier Delbeuck 7 Clinical trial design in the age of dementia treatments: 99 Challenges and opportunities Erich MohrC Lynn BarclayRoberta AndersonJohn Constant 8 Ethics of research in dementia 126 Jason Karlawish 9 Memantine: A glutamate antagonist for treatment of 141 Alzheimer’s disease Rachelle Smith DoodyBengt WinbladVesna Jelic v 10 Management of comorbidity in Alzheimer’ disease 149 Roy Jones 11 Nutritional prevention in Alzheimer’s disease 166 Olivier GuerinBruno Vellas Index 177 Contributors Roberta Anderson PRA International Victoria BC, Canada C Lynn Barclay PRA International Victoria BC, Canada Veronique Blanchard Aventis Pharma Centre de Recherche de Vitry-Alfortville Vitry-sur-Seine France John Constant PRA International Victoria BC, Canada Benort Delatour Laboratoire NAM CNRS UMR 8620 Orsay France Laboratoire de Neuropathologie escourolle La Salpetriere Hospital Paris France Xavier Delbeuck Cognitive Pyschopathology Unit University of Geneva Memory Clinic Department of Geriatrics University Hospitals of Geneva Geneva, Switzerland vii Rachelle Smith Doody Effie Marie Cain Professor in Alzheimer’s Disease Research Baylor College of Medicine Department of Neurology Houston TX, USA Charles Duyckaerts Laboratoire de Neuropathologie Escourolle La Salpetriere Hospital Paris France Olivier Guerin Department of Gerontology (P Brocker) University Hospital Nice Nice, France Deborah Gustafson Institute of Clinical Neuroscience Section of Psychiatry Sahlgrenska University Hospital Goteborg University Goteborg, Sweden Tzung J Hwang Department of Neurology David Geffen School of Medicine atUCLA Los Angeles CA, USA Vesna Jelic Department of Clinical Neuroscience and Family Medicine Division of Geriatric Medicine Karolinska Institute Stockholm Sweden Roy Jones Director, The Research Institute for the Care of the Elderly St Martin’s Hospital Bath, UK Anne-Claude Juillerat Memory Clinic Department of Geriatrics University Hospitals of Geneva viii Geneva, Switzerland Jason Karlawish Institute of Aging University of Pennsylvania Philadelphia PA, USA Martial van der Linden Cognitive Pyschopathology Unit University of Geneva Geneva, Switzerland Erich Mohr PRA International Victoria BC, Canada Leonardo Pantoni Department of Neurological Sciences University of Florence Florence, Italy Laurent Pradier Aventis Pharma Centre de Recherche de Vitry-Alfortville Vitry-sur-Seine France Magnus Sjögren Institute of Clinical Neuroscience Section of Psychiatry Sahlgrenska University Hospital Goteborg University Goteborg, Sweden Ingmar Skoog Institute of Clinical Neuroscience Section of Psychiatry Sahlgrenska University Hospital Goteborg University Goteborg, Sweden Jacques Touchon Professor and Dean Faculty of Medicine Montpellier University Montpellier France ix Bruno Vellas Department of Internal Medicine and Clinical Gerontology University Hospital INSERM U 558 Toulouse, France Bengt Winblad Department of Clinical Neuroscience and Family Medicine Division of Geriatric Medicine Karolinska Institute Stockholm Sweden
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