Alzheimer's Disease: A Century of Scientific And Clinical Research (Stand Alone) PDF
Preview Alzheimer's Disease: A Century of Scientific And Clinical Research (Stand Alone)
ALZHEIMER’S DISEASE: A CENTURY OF SCIENTIFIC AND CLINICAL RESEARCH This page intentionally left blank Alzheimer’s Disease: A Century of Scientific and Clinical Research Edited by George Perry Case Western Reserve University, USA Jesús Avila Universidad Autónoma de Madrid, Spain June Kinoshita Alzheimer Research Forum, USA and Mark A. Smith Case Western Reserve University, USA Amsterdam(cid:120) Berlin (cid:120) Oxford (cid:120) Tokyo (cid:120) Washington, DC © 2006, IOS Press and the authors All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without prior written permission from the publisher. ISBN 1-58603-619-X Library of Congress Control Number: 2006927920 This is the book edition of the Journal of Alzheimer’s Disease, Volume 9, No. 3 Supplement (2006), ISSN 1387-2877 Publisher IOS Press Nieuwe Hemweg 6B 1013 BG Amsterdam The Netherlands fax: +31 20 687 0019 e-mail: [email protected] Distributor in the UK and Ireland Distributor in the USA and Canada Gazelle Books IOS Press, Inc. Falcon House 4502 Rachael Manor Drive Queen Square Fairfax, VA 22032 Lancaster LA1 1RN USA United Kingdom fax: +1 703 323 3668 fax: +44 1524 63232 e-mail: [email protected] LEGAL NOTICE The publisher is not responsible for the use which might be made of the following information. PRINTED IN THE NETHERLANDS Contents List of contributors Preface, Alzheimer's disease: A century of scientific and clinical research 1 George Perry, Jesús Avila, June Kinoshita and Mark A. Smith Historical Perspective Progress in the history of Alzheimer’s disease: The importance of context 5 Jesse F. Ballenger 100 Years of Alzheimer’s disease (1906-2006) 15 José Manuel Martínez Lage Neuropathology The essential lesion of Alzheimer disease: A surprise in retrospect 29 Melvyn Ball Vulnerability of cortical neurons to Alzheimer’s and Parkinson’s diseases 35 Heiko Braak, Udo Rüb, Christian Schultz and Kelly Del Tredici Neurodegeneration and hereditary dementias: 40 Years of learning 45 Bernardino Ghetti Topographic study of Alzheimer’s neurofibrillary changes: A personal perspective 53 Asao Hirano and Maki Iida Clinicopathological analysis of dementia disorders in the elderly – An update 61 Kurt Jellinger The history of the paired helical filaments 71 Michael Kidd Synaptic Changes Vulnerability to Alzheimer’s pathology in neocortex: The roles of plasticity and columnar organization 79 Margaret Esiri and S.A. Chance Synaptic remodeling during aging and in Alzheimer’s disease 91 Eliezer Masliah, Leslie Crews and Lawrence Hansen Alzheimer’s disease-related alterations in synaptic density: Neocortex and hippocampus 101 Stephen Scheff and Douglas A. Price My own experience in early research on Alzheimer disease 117 Robert D. Terry Amyloid Molecular basis of memory loss in the Tg2576 mouse model of Alzheimer disease 123 Karen Ashe Soluble amyloid-(cid:69) in the brain: The scarlet pimpernel 127 Massimo Tabaton and Pierluigi Gambetti Mice as models: Transgenic approaches and Alzheimer’s disease 133 Dora Games, Manuel Buttini, Dione Kobayashi, Dale Schenk and Peter Seubert Alzheimer’s disease: The amyloid cascade hypothesis: An update and reappraisal 151 John Hardy Pathways to the discovery of the A(cid:69) amyloid of Alzheimer’s disease 155 Colin Masters and Konrad Beyreuther Amyloid (cid:69)-peptide is produced by cultured cells during normal metabolism: A reprise 163 Dennis Selkoe Tau Tau protein, the main component of paired helical filaments 171 Jesús Avila Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer’s disease 177 Jean-Pierre Brion The natural and molecular history of Alzheimer’s disease 187 André Delacourte Tau protein, the paired helical filament and Alzheimer’s disease 195 Michel Goedert, Aaron Klug and R. Anthony Crowther Neurofibrillary tangles/paired helical filaments (1981-83) 209 Yasuo Ihara Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: A personal historical perspective 219 Khalid Iqbal and Inge Grundke-Iqbal Tau phosphorylation and proteolysys: Insights and perspectives 243 Gail Johnson Traveling the tau pathway: A personal account 251 Kenneth Kosik Progress from Alzheimer’s tangles to pathological tau points towards more effective therapies now 257 Virginia M.-Y. Lee and John Q. Trojanowski Disease Mechanisms A long trek down the pathways of cell death in Alzheimer’s disease 265 Peter Davies Inflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years 271 Patrick L. McGeer, Joseph Rogers and Edith G. McGeer Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease 277 Ralph A. Nixon and Anne M Cataldo Aluminium and Alzheimer’s disease, a personal perspective after 25 years 291 Daniel Perl and Sharon Moalem Solving the insoluble 301 George Perry Oxidative stress and iron imbalance in Alzheimer disease: How rust became the fuss! 305 Mark A. Smith GSK-3 is essential in the pathologenesis of Alzheimer’s disease 309 Akihiko Takashima Frameshift proteins in Alzheimer’s disease and in other conformational disorders: Time for the ubiquitin-proteasome system 319 F.W. van Leeuwen, E.M. Hol and D.F. Fischer Genetics Studies on the first described Alzheimer’s disease amyloid (cid:69) mutant, the Dutch variant 329 Efrat Levy, Frances Prell and Blas Frangione Segregation of a missense mutation in the amyloid (cid:69)-protein precursor gene with familial Alzheimer’s disease 341 Alison Goate The discovery and mapping to chromosome 21 of the Alzheimer amyloid gene. My story. 349 Dmitry Goldgaber On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease 361 Allen Roses Early Alzheimer’s disease genetics 367 Gerard Schellenberg Mutations in the tau gene (MAPT) in FTDP-17: The family with Multiple System Tauopathy with presenile Dementia (MSTD) 373 Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin Farlow, Aaron Klug and Bernardino Ghetti Genetic complexity of Alzheimer’s disease: Successes and challenges 381 Ekaterina Rogaeva,, Toshitaka Kawaraiand Peter St George-Hyslop Genetics and pathology of alpha-secretase site A(cid:69)PP mutations in understanding of Alzheimer’s disease 389 C. van Broeckhoven and Samir Kumar-Singh Diagnosis and Treatment Preclinical characterization of amyloid imaging probes with multiphoton microscopy 401 Jesse Skoch, Bradley T. Hyman and Brian J. Bacskai Diagnosis of Alzheimer’s disease: Two-decades of progress 409 Zaven Khachaturian Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop 417 Ian McKeith Immunotherapy for Alzheimer’s disease 425 David Morgan Alzheimer’s disease immunotherapy: From in vitro amyloid immunomodulation to in vivo vaccination 433 Beka Solomon Tacrine, and Alzheimer’s treatments 439 William Summers Quality of Life: The bridge from the cholinergic basal forebrain to cognitive science and bioethics 447 Peter Whitehouse Subject index 455 Contributor’s Index Ashe, K.H., University of Minnesota, USA and Minneapolis Veterans Affairs, Medical Center, USA 123 Avila, J., Universidad Autónoma de Madrid, Spain 1, 171 Bacskai, B.J., Massachusetts General Hospital, USA 401 Ball, M.J., Oregon Health & Science University, USA 29 Ballenger, J.F., Pennsylvania State University, USA 5 Beyreuther, K., The University of Heidelberg, Germany 155 Braak, H., J.W. Goethe University, Germany 35 Brion, J.-P., Université Libre de Bruxelles, Belgium 177 Buttini, M., Elan Pharmaceuticals, USA 133 Cataldo A.M., McLean Hospital, USA 277 Chance, S.A., University of Oxford, UK 79 Crews, L., University of California, San Diego, USA 91 Crowther, R.A., MRC Laboratory of Molecular Biology, UK 195 Davies, P., Albert Einstein College of Medicine, USA 265 Del Tredici, K., J.W. Goethe University, Germany 35 Delacourte, A., Unit Inserm 422, France 187 Esiri, M.M., University of Oxford, UK and Oxford Radcliffe NHS Trust, UK 79 Farlow, M., Indiana University of Medicine, USA 373 Fischer, D.F., Vrije Universiteit and VU Medical Center, The Netherlands 319 Frangione, B., New York University School of Medicine, USA 329 Gambetti, P., Case Western Reserve University, USA 127 Games, T., Elan Pharmaceuticals, USA 133 Ghetti, B., Indiana University School of Medicine, USA 45, 373 Goate, A., Washington University School of Medicine, USA 341 Goedert, M., MRC Laboratory of Molecular Biology, UK 195, 373 Goldgaber, D., State University of New York at Stony Brook, USA 349 Grundke-Iqbal, I., New York State Institute for Basic Research in Developmental Disabilities, USA 219 Hansen, L., University of California, San Diego, USA 91 Hardy, J., National Institute on Aging, USA 151 Hirano, A., Montefiore Medical Center, USA 53 Hol, E.M., Netherlands Institute for Brain Research, The Netherlands 319 Hyman, T., Massachusetts General Hospital, USA 401 Ihara, Y., University of Tokyo, Japan 209 Iida, M., Montefiore Medical Center, USA 53 Iqbal, K., New York State Institute for Basic Research in Developmental Disabilities, USA 219
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