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Allogeneic Immunotherapy for Malignant Diseases - J. Barrett, Y. Jiang (Marcel Dekker, 2000) WW PDF

404 Pages·2000·52.44 MB·English
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Preview Allogeneic Immunotherapy for Malignant Diseases - J. Barrett, Y. Jiang (Marcel Dekker, 2000) WW

N: This book is printed on acid-free paper. e a ~ ~ ~ a r t e r s Marcel Dekker, Inc. 270 Madison Avenue, New York, NY l0016 tel: 2 12-696-9000: fax: 2 12-685-4540 Marcel Dekker AG Wutgasse 4, Postfach 8 12, CH-4001 Basel, Switzerland tel: 4 1-6 -26 1-8482; fax: 4 1-6 -26 -8896 http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Neither this book nor any part may be reproduced or transmitted in any form by any means, electronic or mechanical, including photocopying, nlicro~lming, and recording, by any information storage and retrieval system, without permission in writing From the publisher. Current printing (last digit): I 0 9 8 7 6 5 4 3 2 1 all our patients, whose bravery in adversity is an inspiration for us to improve our understanding of disease processes and devise better ways to treat and cure. This Page Intentionally Left Blank The current volume, Allogeneic Il~ll~lull~)theru~~ ,for ~ u ~ i g ~ ~ u l ~ t Diseases, is the twenty-second in the Basic and Clinical Oncology series. Many of the advances in oncology have resulted from close interaction between the basic scientist and the clinical researcher. The current volume illustrates the success of this relation- ship demonstrated by new insights into clinical drug resistance and means of circumventing this potential obstacle to effective cancer treatment. editor of the series, my goal is to recruit volume editors who not only have established reputations based on their outstanding contributions to oncology, but who also have an appreciation for the dynamic interface between the labora- tory and the clinic. date, the series has consisted of monographs on topics that are of a high level of current interest. Allogeneic Il~~lnulz~tlleru~~y jbr ~ ~ ~ l i ~ l ~ ~ ~ l l t Diseases certainly fits into this category and is a most important addition to the series. Volumes in progress focus on tumor angiogenesis and microcirculation, and cancer in the elderly. anticipate that these books will provide valuable contribution to the oncology literature. Bruce D. Chesorz This Page Intentionally Left Blank Allogeneic stem-cell transplantation is becoming an essential component of clini- cal hematology and oncology practice. The curative effect of allogeneic stem cell transplantation attributed at least partially to an allogeneic immune response: the graft-versus-leukelnia (GVL) or graft-versus-tumor (GVT) effect. For the last decade or so, our perception of the GVL phenomenon has changed dramatically. We observed in the 1nid-’80s that depletion of cells from the graft dramatically increased the rate of leukemia relapse; subsequently it became evident that remis- sions could be reinduced by donor lymphocyte transfusions to patients with leuke- mia relapsing after bone marrow transplantation. Although variable in its expres- sion, the allogeneic GVT effect appears to extend to a variety of acute and chronic myeloid and lymphoid malignancies and possibly solid tumors. With new insights into the cellular and molecular biology of GVL, we have advanced from the stage of trying to prove the existence of a GVL effect to understanding it better and applying it more effectively. Anyone reading current publications on bone marrow transplantation will have noticed a growing number of original papers and review articles on GVL which signal an increased awareness and demand for information the topic. Alongside the applied research in GVL, there are continuing advances in cellular immunology and tumor immunology that improve our understanding of the response to l~alignancies, Looking forward to the next decade, the use of alloge- neic cells promises important therapeutic benefits for our patients. In this book, authors who are leaders in their respective fields provide a comprehensive review of the GVLlGVT effect, from descriptions of the alloimmune responses to the vii clinical applicatio~s of We hope this book will bring to its readership state- of-the-art knowledge on the subject and indicate directions for future re- search and therapeutic applications in GVL. To my parents for their diligent work to support me through my education; to my wife, Junhua, for her sacrifice to free me to pursue my career. Y-Z J Introduction: The Graft-Versus-Leukemia Effect 2. 3. 4. The Immune Response to Alloantigens Lord Robert I. Leclzler Experinlental Animal Models in the Study GVL Reactions Robert Truitt, Robert Ko~llgold, BIyon D. Robert To~~ll~~elld, md Bruce R. Effector Cells and Mechanisms of the GVL Effect Yirz-Zheng Jiang Minor Histocol~patibiIity Antigens in GVL ~ L t t i . ~ Ells Coulrny Tissue-Specific Antigens in GVL JeRrey V vii 13 75 135

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